Strategies for the dynamic integration of combinatorial synthesis and screening

Angewandte Chemie - International Edition

Volumn 37, Issue 20, 1998, Pages 2828-2831

  Ganesan, Arasu ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Combinatorial chemistry; Molecular evolution; Molecular recognition

Indexed keywords

CARBONATE DEHYDRATASE INHIBITOR; ORGANIC COMPOUND; RECOMBINANT DNA; TRYPSIN INHIBITOR; ZINC;

CHEMICAL STRUCTURE; DNA BINDING; DNA DETERMINATION; HYDROLYSIS; MOLECULAR DYNAMICS; SHORT SURVEY; STRUCTURE ANALYSIS; THERMODYNAMICS;

EID: 0032476782     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3773(19981102)37:20<2828::AID-ANIE2828>3.0.CO;2-G     Document Type: Short Survey

References (26)

1. For recent overviews on combinatorial chemistry, see a) Chem. Rev. 1997, 97(2);
2. b) Curr. Opin. Chem. Biol. 1997, 1(1);
3. Curr. Opin. Chem. Biol. 1998, 2(3);
4. N. K. Terrett, Combinatorial Chemistry, Oxford University Press, Oxford, 1998;
5. for a comprehensive, regularly updated Internet database, visit http://www.5z.com/divinfo.
6. The precise boundaries of "combinatorial chemistry" have been debated, see K. Burgess, Chem. Eng. News 1997, 75(6), 4;
7. D. P. Curran, P. Wipf, Chem. Eng. News 1997, 75(11), 6.
8. For a review of selection techniques, see P. A. Brady, J. K. M. Sanders, Chem. Soc. Rev. 1997, 26, 327-336.
9. For some recent examples of self-assembly, see a) S. J. Rowan, D. G. Hamilton, P. A. Brady, J. K. M. Sanders, J. Am. Chem. Soc. 1997, 119, 2578-2579;
10. b) B. Hasenknopf, J.-M. Lehn, N. Boumediene, A. Dupont-Gervais, A. Van Dorsselaer, B. Kniesel, D. Fenske, J. Am. Chem. Soc. 1997, 119, 10956-10962;
11. c) D. L. Caulder, K. N. Raymond, Angew. Chem. 1997, 109, 1508-1510;
12. Angew. Chem. Int. Ed. Engl. 1997, 36, 1440-1442;
13. d) S. Sakai, Y. Shigemasa, T. Sasaki, Tetrahedron Lett. 1997, 38, 8145-8148;
14. e) for a self-assembling catalyst, see C. L. Hill, X. Zhang, Nature 1995, 373, 324-326.
15. B. Hasenknopf, J.-M. Lehn, B. O. Kneisel, G. Baum, D. Fenske, Angew. Chem. 1996, 108, 1987-1990;
16. Angew. Chem. Int. Ed. Engl. 1996, 35, 1838-1840.
17. This terminology can be confusing, as it was previously used to describe libraries which are computationally modeled prior to synthesis; for a review, see J. H. Van Drie, M. S. Lajiness, Drug Discovery Today 1998, 3, 274-283.
18. P. A. Brady, J. K. M. Sanders, J. Chem. Soc. Perkin Trans. 1, 1997, 3237-3253.
19. S. J. Rowan, J. K. M. Sanders, J. Org. Chem. 1998, 63, 1536-1546.
20. a) A. V. Eliseev, M. I. Nelen, J. Am. Chem. Soc. 1997, 119, 1147-1148;
21. b) A. V. Eliseev, M. I. Nelen, Chem. Eur. J. 1998, 4, 825-834.
22. B. Klekota, M. H. Hammond, B. L. Miller, Tetrahedron Lett. 1997, 38, 8639-8642.
23. H. Hioki, W. C. Still, J. Org. Chem. 1998, 63, 904-905.
24. I. Huc, J.-M. Lehn, Proc. Natl. Acad. Sci. USA 1997, 94, 2106-2110.
25. P. G. Swann, R. A. Casanova, A. Desai, M. M. Frauenhoff, M. Urbancic, U. Slomczynska, A. J. Hopfinger, G. C. Le Breton, D. L. Venton, Biopolymers 1996, 40, 617-625.
26. M. T. Burger, P. A. Bartlett, J. Am. Chem. Soc. 1997, 119, 12697-12698.