Chloroform and carbon tetrachloride induce intrachromosomal recombination and oxidative free radicals in Saccharomyces cerevisiae

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 397, Issue 2, 1998, Pages 271-278

  Brennan, Richard J ^a   Schiestl, Robert H ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Carbon tetrachloride; Carcinogenicity; Chloroform; Intrachromosomal recombination; Saccharomyces cerevisiae; Trichloroethane

Indexed keywords

CARBON TETRACHLORIDE; CHLOROFORM; DRINKING WATER; FREE RADICAL; MUTAGENIC AGENT; TRICHLOROETHANE;

ANIMAL CELL; ARTICLE; CHLORINATION; CHROMOSOME ANALYSIS; DOSE RESPONSE; GENETIC RECOMBINATION; LIVER CARCINOGENESIS; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

CARBON TETRACHLORIDE; CHLOROFORM; FLUORESCEINS; FREE RADICALS; MUTAGENS; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE;

ANIMALIA; RODENTIA; SACCHAROMYCES CEREVISIAE;

EID: 0032472889     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00225-X     Document Type: Article

References (63)

1. Young T.B., Wolf D.A., Kanarek M.S. Case-control study of colon cancer and drinking water trihalomethanes in Wisconsin. Int. J. Epidemiol. 16:1987;190-197.
2. Cantor K.P., Hoover R., Mason T.J., McCabe L.J. Associations of cancer mortality with halomethanes in drinking water. J. Natl. Cancer Inst. 61:1978;979-985.
3. NCI, Report on the Carcinogenesis Bioassay of Chloroform, Carcinogenesis Program, National Cancer Institute, Bethesda, MD, 1976.
4. Gocke E., King M.T., Eckhardt K., Wild D. Mutagenicity of cosmetics ingredients licensed by the European Communities. Mutation Res. 90:1981;91-109.
5. Van Abbe N.J., Green T.J., Jones E., Richold M., Roe F.J. Bacterial mutagenicity studies on chloroform in vitro. Food Chem. Toxicol. 20:1982;557-561.
6. Varma M.M., Ampy F.R., Verma K., Talbot W.W. In vitro mutagenicity of water contaminants in complex mixtures. J. Appl. Toxicol. 8:1988;243-248.
7. Land P.C., Owen E.L., Linde H.W. Morphologic changes in mouse spermatozoa after exposure to inhalational anesthetics during early spermatogenesis. Anesthesiology. 54:1981;53-56.
8. Morimoto K., Koizumi A. Trihalomethanes induce sister chromatid exchanges in human lymphocytes in vitro and mouse bone marrow cells in vivo. Environ. Res. 32:1983;72-79.
9. Anttila A., Pukkala E., Sallmen M., Hernberg S., Hemminki K. Cancer incidence among Finnish workers exposed to halogenated hydrocarbons. J. Occup. Environ. Med. 37:1995;797-806.
10. Quast J.F., Calhoun L.L., Frauson L.E. 1,1,1-trichloroethane formulation: a chronic inhalation toxicity and oncogenicity study in Fischer 344 rats and B6c3F1 mice. Fund. Appl. Toxicol. 11:1988;611-625.
11. NCI, Bioassay of 1,1,1-Trichloroethane for Possible Carcinogenicity, National Cancer Institute, 1977.
12. Maltoni C., Cotti G., Patella V. Results of long-term carcinogenicity bioassays on Sprague-Dawley rats of methyl chloroform, administered by ingestion. Acta Oncol. 7:1986;101-117.
13. USDHHS, Toxicological Profile for 1,1,1-Trichloroethane (Update), Public Health Service Agency for Toxic Substances and Disease Registry, 1995.
14. Gold L.S., Manley N.B., Slone T.H., Garfinkel G.B., Rohrbach L., Ames B.N. The fifth plot of the Carcinogenic Potency Database: results of animal bioassays published in the general literature through 1988 and by the National Toxicology Program through 1989. Environ. Health Perspect. 100:1993;65-168.
15. Nestmann E.R., Otson R., Kowbel D.J., Bothwell P.D., Harrington T.R. Mutagenicity in a modified Salmonella assay of fabric-protecting products containing 1,1,1-trichloroethane. Environ. Mutagen. 6:1984;71-80.
16. Milman H.A., Story D.L., Riccio E.S., Sivak A., Tu A.S., Williams G.M., Tong C., Tyson C.A. Rat liver foci and in vitro assays to detect initiating and promoting effects of chlorinated ethanes and ethylenes. Ann. NY Acad. Sci. 534:1988;521-530.
17. Turina M.P., Colacci A., Grilli S., Mazzullo M., Prodi G., Lattanzi G. Short-term tests of genotoxicity for 1,1,1-trichloroethane. Res. Commun. Chem. Pathol. Pharmacol. 52:1986;305-320.
18. Tu A.S., Murray T.A., Hatch K.M., Sivak A., Milman H.A. In vitro transformation of BALB/c-3T3 cells by chlorinated ethanes and ethylenes. Cancer Lett. 28:1985;85-92.
19. Hatch G.G., Mamay P.D., Ayer M.L., Casto B.C., Nesnow S. Chemical enhancement of viral transformation in Syrian hamster embryo cells by gaseous and volatile chlorinated methanes and ethanes. Cancer Res. 43:1983;1945-1950.
20. NTP, Fifth Annual Report on Carcinogens Summary, US Department of Health and Human Services National Toxicology Program, Research Triangle Park, NC, 1989.
21. Wilcosky T.C., Checkoway H., Marshall E.G., Tyroler H.A. Cancer mortality and solvent exposures in the rubber industry. Am. Ind. Hyg. Assoc. J. 45:1984;809-811.
22. Blair A., Decoufle P., Grauman D. Causes of death among laundry and dry cleaning workers. Am. J. Public Health. 69:1979;508-511.
23. Heineman E.F., Cocco P., Gomez M.R., Dosemeci M., Stewart P.A., Hayes R.B., Zahm S.H., Thomas T.L., Blair A. Occupational exposure to chlorinated aliphatic hydrocarbons and risk of astrocytic brain cancer. Am. J. Ind. Med. 26:1994;155-169.
24. McCann J., Ames B.N. Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion. Proc. Natl. Acad. Sci. USA. 73:1976;950-954.
25. Khudoley V.V., Mizgireuv I., Pliss G.B. The study of mutagenic activity of carcinogens and other chemical agents with Salmonella typhimurium assays: testing of 126 compounds. Arch. Geschwulstforsch. 57:1987;453-462.
26. Mirsalis J.C., Tyson C.K., Butterworth B.E. Detection of genotoxic carcinogens in the in vivo-in vitro hepatocyte DNA repair assay. Environ. Mutagen. 4:1982;553-562.
27. Garberg P., Akerblom E.L., Bolcsfoldi G. Evaluation of a genotoxicity test measuring DNA-strand breaks in mouse lymphoma cells by alkaline unwinding and hydroxyapatite elution. Mutation Res. 203:1988;155-176.
28. 4 and lipoperoxide in Aspergillus nidulans. Mutation Res. 136:1984;109-114.
29. Shaw I.C., Jones H.B. Mechanisms of non-genotoxic carcinogenesis. Trends Pharmacol. Sci. 15:1994;89-93.
30. Tlsty T.D., Briot A., Gualberto A., Hall I., Hess S., Hixon M., Kuppuswamy D., Romanov S., Sage M., White A. Genomic instability and cancer. Mutation Res. 337:1995;1-7.
31. Sandberg A.A. Chromosome abnormalities in human cancer and leukemia. Mutation Res. 247:1991;231-240.
32. Brennan R.J., Swoboda B.E., Schiestl R.H. Oxidative mutagens induce intrachromosomal recombination in yeast. Mutation Res. 308:1994;159-167.
33. Carls N., Schiestl R.H. Evaluation of the yeast DEL assay with 10 compounds selected by the International Program on Chemical Safety for the evaluation of short-term tests for carcinogens. Mutation Res. 320:1994;293-303.
34. Schiestl R.H. Nonmutagenic carcinogens induce intrachromosomal recombination in yeast. Nature. 337:1989;285-288.
35. Zhang L.H., Jenssen D. Studies on intrachromosomal recombination in SP5/V79 Chinese hamster cells upon exposure to different agents related to carcinogenesis. Carcinogenesis. 15:1994;2303-2310.
36. Aubrecht J., Rugo R., Schiestl R.H. Carcinogens induce intrachromosomal recombination in human cells. Carcinogenesis. 16:1995;2841-2846.
37. Schiestl R.H., Aubrecht J., Khogali F., Carls N. Carcinogens induce reversion of the mouse pink-eyed unstable mutation. Proc. Natl. Acad. Sci. USA. 94:1997;4576-4581.
38. Schiestl R.H., Khogali F., Carls N. Reversion of the mouse pink-eyed unstable mutation induced by low doses of X-rays. Science. 266:1994;1573-1576.
39. Galli A., Schiestl R.H. Salmonella test positive and negative carcinogens show different effects on intrachromosomal recombination in G2 cell cycle arrested yeast cells. Carcinogenesis. 16:1995;659-663.
40. Galli A., Schiestl R.H. Effects of Salmonella assay negative and positive carcinogens on intrachromosomal recombination in g(1)-arrested yeast cells. Mutation Res. 370:1996;209-221.
41. Brennan R.J., Schiestl R.H. Cadmium is an inducer of oxidative stress in yeast. Mutation Res. 356:1996;171-178.
42. Brennan R.J., Schiestl R.H. Aniline and its metabolites generate free radicals in yeast. Mutagenesis. 12:1997;215-220.
43. Schiestl R.H., Gietz R.D., Mehta R.D., Hastings P.J. Carcinogens induce intrachromosomal recombination in yeast. Carcinogenesis. 10:1989;1445-1455.
44. Yurkow E.J., McKenzie M.A. Characterization of hypoxia-dependent peroxide production in cultures of Saccharomyces cerevisiae using flow cytometry: a model for ischemic tissue destruction. Cytometry. 14:1993;287-293.
45. McGregor D.B., Reynolds D.M., Zeiger E. Conditions affecting the mutagenicity of trichloroethylene in Salmonella. Environ. Mol. Mutagen. 13:1989;197-202.
46. de Groot H., Noll T. Halomethane hepatotoxicity: induction of lipid peroxidation and inactivation of cytochrome P-450 in rat liver microsomes under low oxygen partial pressures. Toxicol. Appl. Pharmacol. 97:1989;530-537.
47. Pohl L.R., Branchflower R.V., Highet R.J., Martin J.L., Nunn D.S., Monks T.J., George J.W., Hinson J.A. The formation of diglutathionyl dithiocarbonate as a metabolite of chloroform, bromotrichloromethane, and carbon tetrachloride. Drug Metab. Disposit. 9:1981;334-339.
48. Pohl L.R., Martin J.L., George J.W. Mechanism of metabolic activation of chloroform by rat liver microsomes. Biochem. Pharmacol. 29:1980;3271-3276.
49. Pohl L.R., Gillette J.R. Determination of toxic pathways of metabolism by deuterium substitution. Drug Metab. Rev. 15:1984;1335-1351.
50. Diaz Gomez M.I., Castro J.A. Nuclear activation of carbon tetrachloride and chloroform. Res. Commun. Chem. Pathol. Pharmacol. 27:1980;191-194.
51. Docks E.L., Krishna G. The role of glutathione in chloroform-induced hepatotoxicity. Exp. Mol. Pathol. 24:1976;13-22.
52. Aruoma O.I., Halliwell B., Hoey B.M., Butler J. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radical Biol. Med. 6:1989;593-597.
53. Testai E., Di Marzio S., Vittozzi L. Multiple activation of chloroform in hepatic microsomes from uninduced B6C3F1 mice. Toxicol. Appl. Pharmacol. 104:1990;496-503.
54. 2 in cultured endothelial cells. Arch. Biochem. Biophys. 302:1993;348-355.
55. Cathcart R., Schwiers E., Ames B.N. Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay. Anal. Biochem. 134:1983;111-116.
56. Cathcart R., Schwiers E., Ames B.N. Detection of picomole levels of lipid hydroperoxides using a dichlorofluorescein fluorescent assay. Methods Enzymol. 105:1984;352-358.
57. Mitoma C., Steeger T., Jackson S.E., Wheeler K.P., Rogers J.H., Milman H.A. Metabolic disposition study of chlorinated hydrocarbons in rats and mice. Drug Chem. Toxicol. 8:1985;183-194.
58. Schumann A.M., Fox T.R., Watanabe P.G. A comparison of the fate of inhaled methyl chloroform (1,1,1-trichloroethane) following single or repeated exposure in rats and mice. Fund. Appl. Toxicol. 2:1982;27-32.
59. Diaz Gomez M.I., Castro J.A. Covalent binding of carbon tetrachloride metabolites to liver nuclear DNA, proteins, and lipids. Toxicol. Appl. Pharmacol. 56:1980;199-206.
60. Diaz Gomez M.I., Castro J.A. Covalent binding of chloroform metabolites to nuclear proteins - no evidence for binding to nucleic acids. Cancer Lett. 9:1980;213-218.
61. Aoyama Y., Funae Y., Noshiro M., Horiuchi T., Yoshida Y. Occurrence of a P450 showing high homology to yeast lanosterol 14-demethylase (P450(14DM)) in the rat liver. Biochem. Biophys. Res. Commun. 201:1994;1320-1326.
62. Kelly S.L., Lamb D.C., Baldwin B.C., Kelly D.E. Benzo(a)pyrene hydroxylase activity in yeast is mediated by P450 other than sterol 14alpha-demethylase. Biochem. Biophys. Res. Commun. 197:1993;428-432.
63. Cunningham M.L., Matthews H.B. Cell proliferation as a determining factor for the carcinogenicity of chemicals: studies with mutagenic carcinogens and mutagenic noncarcinogens. Toxicol. Lett. 82/83:1995;9-14.