Blockage by terfenadine of the adenosine triphosphate (ATP)-sensitive K+ current in rabbit ventricular myocytes

Journal of Pharmacology and Experimental Therapeutics

Volumn 287, Issue 1, 1998, Pages 293-300

  Nishio, Manabu ^a   Habuchi, Yoshizumi ^a   Tanaka, Hideo ^a   Morikawa, Junichiro ^a   Yamamoto, Taku ^a   Kashima, Kei ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; ADENOSINE TRIPHOSPHATE; ANTIHISTAMINIC AGENT; CROMAKALIM; POTASSIUM CHANNEL; POTASSIUM ION; SODIUM CYANIDE; TERFENADINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; HEART ARRHYTHMIA; HEART DEPOLARIZATION; HEART MUSCLE ISCHEMIA; LIPID MEMBRANE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RABBIT;

ACTION POTENTIALS; ADENOSINE TRIPHOSPHATE; ANIMALS; HEART VENTRICLES; HISTAMINE H1 ANTAGONISTS; POTASSIUM CHANNEL BLOCKERS; RABBITS; TERFENADINE;

EID: 0032468952     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Antzelevitch C, Sicouri S, Litovsky SH, Lukas A, Krishnan SC, Di Diego JM, Gintant GA and Liu DW (1991) Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells. Circ Res 69:1427-1450.
2. Berul CI and Morad M (1995) Regulation of potassium channels by nonsedating antihistamines. Circulation 91:2220-2225.
3. Brown MW, Maldonado AL, Meredith CG and Speeg JR. KV (1985) Effect of ketokonazole on hepatic oxidative metabolism. Clin Pharmacol Ther 37:290-297.
4. Carlsson L, Abrahamsson C, Drews L and Duker G (1992) Antiarrhythmic effects of potassium channel openers in rhythm abnormalities related to delayed repolarization. Circulation 85:1491-1500.
5. Coquhoun D and Sigworth FJ (1983) Fitting and statistical analysis of single-channel records, in Single Channel Recording (Sakmann B and Neher E eds) pp 191-263, Plenum Press, New York, NY.
6. Coutant JE, Westmark PA, Nardella PA, Walter SM and Okerholm RA (1991) Determination of terfenadine and terfenadine acid metabolite in plasma using solid-phase extraction and high-performance liquid chromatography with fluorescence detection. J Chromatogr 570:139-148.
7. Crumb JR WJ, Wible B, Arnold DJ, Payne JP and Brown AM (1995) Blockade of multiple human cardiac potassium currents by the antihistamine terfenadine: Possible mechanism for terfenadine-associated cardiotoxicity. Mol Pharmacol 47: 181-190.
8. Fedida D and Giles WR (1991) Regional variations in action potentials and transient outward current in myocytes isolated from rabbit left ventricle. J Physiol (Lond) 422:191-209.
9. Giles WR and Imaizumi Y (1988) Comparison of potassium currents in rabbit atrial and ventricular cells. J Physiol (Lond) 405:123-145.
10. Habuchi Y, Yamamoto T, Nishio M, Tanaka H, Morikawa J and Yoshimura M (1996) Modulation of L-type Ca current by denopamine, a nonparenteral partial β1 stimulant, in rabbit ventricular cells. Naunyn-Schmiedeberg Arch Pharmacol 354: 437-443.
11. Hamill OP, Marty A, Neher E, Sakmann B and Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 391:85-100.
12. Horie M, Irisawa H and Noma A (1987) Voltage-dependent magnesium block of adenosine-triphosphate-sensitive potassium channel in guinea-pig ventricular cells. J Physiol (Lond) 387:251-272.
13. Horie M, Hayashi S, Yuzuki Y and Sasayama S (1992) Comparative studies of ATP sensitive potassium channels in heart and pancreatic β cells using Vaugham-Williams class Ia antiarrhythmics. Cardiovasc Res 26:1087-1094.
14. Jackman WM, Clark M, Friday KJ, Aliot EM, Anderson J and Lazzara R (1984) Ventricular tachyarrhythmias in the long QT syndrome. Med Clin North Am 68(5):1079-1109.
15. Kakei M, Noma A and Shibasaki T (1985) Properties of adenosine-triphosphate-regulated potassium channels in guinea-pig ventricular cells. J Physiol (Lond) 363:441-462.
16. Lang DG, Wang CM and Wenger TL (1993) Terfenadine alters action potentials in isolated canine purkinje fibers more than acrivastine. J Cardiovasc Pharmacol 22:438-442.
17. 2+ current in rat ventricular myocytes by terfenadine. Circ Res 81:202-210.
18. + channels in guinea pig ventricular myocytes. J Cardiol Pharmacol 26:761-769.
19. Monaham BP, Ferguson CL, Killeavy ES, Lloyd BK, Troy J and Cantilena JR. LR (1990) Torsade de pointes occurring in association with terfenadine use. JAMA 264:2788-2790.
20. Nichols CG and Lederer WJ (1991) Adenosine triphosphate-sensitive potassium channels in the cardiovascular system. Am J Physiol 261:H1675-1686.
21. + channels in cardiac muscle. Nature 305:147-148.
22. Parret JR (1994) Protection of the heart by ischaemic preconditioning: mechanisms and possibilities for pharmacological exploitation. Trends Pharmacol Sci 15:19-25.
23. ATP channel in ischaemic preconditioning. Cardiovasc Res 28:783-787.
24. Pinney SP, Koller BS, Franz MR and Woosley RL (1995) Terfenadine increases the QT interval in isolated guinea pig heart. J Cardiovasc Pharmacol 25:30-34.
25. Rampe D, Wible B, Brown AM and Dage RC (1993) Effects of terfenadine and its metabolites on a delayed rectifier K channel cloned from human heart. Mol Pharmacol 44:1240-1245.
26. 1-receptors and sedative properties of antihistamines: assessment in the case of terfenadine. Drug Res 32:1171-1173.
27. Roy ML, Dumaine RD and Brown AM (1996) HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine. Circulation 94:817-823.
28. Salata JJ, Jurkiewicz NK, Wallace AA, Stupienski III. RF, Guinosso JR. PJ and Lynch JR. JJ (1995) Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine. Circ Res 76:110-119.
29. 1-receptor-antagonist drugs. N Engl J Med 330:1663-1670.
30. + current activated by pinacidil. Circ Res 68:1127-1137.
31. Takahashi N, Ito M, Saikawa T and Arita M (1991) Nicorandil suppresses early afterdepolarisation and ventricular arrhythmias induced by caesium chloride in rabbits in vivo. Cardiovasc Res 25:445-452.
32. Veldkamp MW, Van Ginneken ACG and Bouman LN (1993) Single delayed rectifier channels in the membrane of rabbit ventricular myocytes. Circ Res 72:865-878.
33. 1-receptors in vivo determined by receptor binding techniques. Drug Res 32:1167-1170.
34. Wilde AAM and Janse MJ (1994) Electrophysiological effects of ATP sensitive potassium channel modulation: implications for arrhythmogenesis. Cardiovasc Res 28:16-24.
35. Woodhull AM (1973) Ionic blockage of sodium channels in nerve. J Gen Physiol 61:687-708.
36. Woosley RL, Chen Y, Freiman JP and Gillis RA (1993) Mechanism of the cardiotoxic actions of terfenadine. JAMA 269:1532-1536.
37. Wu B, Sato T, Kiyosue T and Arita M (1992) Blockage of 2,4-dinitrophenol induced ATP sensitive potassium current in guinea pig ventricular myocytes by class I antiarrhythmic drugs. Cardiovasc Res 26:1095-1101.
38. Yang T, Prakash C, Roden DM and Snyders DJ (1995) Mechanism of block of a human cardiac potassium channel by terfenadine racemate and enantiomers. Br J Pharmacol 115:267-274.
39. Zilberter Yu, Burnashev N, Papin A, Portnov V and Khodorov B (1988) Gating kinetics of ATP-sensitive single potassium channels in myocardial cells depends on electromotive force. Pflügers Arch 411:584-589.