Modulation of L-type Ca current by denopamine, a nonparenteral partial β1 stimulant, in rabbit ventricular cells

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 354, Issue 4, 1996, Pages 437-443

  Habuchi, Yoshizumi ^a   Yamamoto, Taku ^a   Nishio, Manabu ^a   Tanaka, Hideo ^a   Morikawa, Junichiro ^a   Yoshimura, Manabu ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Ca current; Denopamine; Spare receptor theory; 1 Partial agonist

Indexed keywords

ATENOLOL; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BISOPROLOL; CYCLIC AMP; DENOPAMINE; FORSKOLIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); ISOPRENALINE; PERTUSSIS TOXIN; PRAZOSIN;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; HEART MUSCLE CELL; HEART VENTRICLE; IN VITRO STUDY; INOTROPISM; NONHUMAN; RABBIT;

EID: 0029820037     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00168434     Document Type: Article

References (28)

1. Arad H, Levitzki A (1979) The mechanism of partial agonism in the beta -receptor dependent adenylate cyclase of turkey erythrocytes. Mol Pharmacol 16:749-756
2. Bahinski A, Nairn AC, Greengard P, Gadsby DC (1989) Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes. Nature 340:718-721
3. 1- and β-adrenergic interactions on L-type calcium current in cardiac myocytes. Pflügers Arch 421:397-399
4. 2+ current in sinoatrial node cells of rabbits. Am J Physiol 268:H 1053-H 1060
5. Harvey RD, Hume JR (1989) Autonomie regulation of a chloride current in heart. Science 244:983-985
6. Hedberg A, Carlsson E, Fellenius E, Lundgren B (1982) Cardiostimulatory effects of prenalterol, a beta-1 adrenoceptor partial agonist, in vivo and in vitro: correlation between physiological effects and adenylate cyclase activity. Naunyn-Schmiedeberg's Arch Pharmacol 318:185-191
7. Hescheler J, Kameyama M, Trautwein W (1986) On the mechanism of muscarinic inhibition of the cardiac Ca current. Pflügers Arch 407:182-189
8. 1-adrenergic selectivity of the new cardiotonic agent denopamine in its stimulating effects on adenylate cyclase. Biochem Pharmacol 36:1947-1954
9. Isenberg G, Klockner U (1982) Calcium tolerant ventricular myocytes prepared by preincubation in a "KB medium". Pflügers Arch 395:6-18
10. Katz AM (1986) The sarcoplasmic reticulum. In: Fozzard HA, Haber E, Jennings RB, Katz AM, Morgan HE (eds) The heart and cardiovascular system. Raven Press, New York, pp 731-746
11. Kaumann AJ (1978) On spare β-adrenoceptors for inotropic effects of catecholamines in kitten ventricle. Naunyn-Schmiedeberg's Arch Pharmacol 305:97-102
12. Kaumann AJ, Lemoine H, Schwederski-Menke U, Ehle B (1989) Relations between β-adrenoceptor occupancy and increases of contractile force and adenylate cyclase activity induced by catecholamines in human ventricular myocardium: acute desensitization and comparison with feline ventricle. Naunyn-Schmiedeberg's Arch Pharmacol 339:99-112
13. Kenakin TP (1982) Organ selectivity of drugs: alternatives to receptor selectivity. Trends Pharmacol Sci 3:153-156
14. Kenakin TP, Beek D (1980) Is prenalterol (H 133/80) really a selective beta 1 adrenoceptor agonist? Tissue selectivity resulting from differences in stimulus-response relationships. J Pharmacol Exp Ther 213:406-413
15. 1-adrenoceptor. J Clin Invest 85:950-954
16. Kino M, Hirota Y, Yamamoto S, Sawada K, Moriguchi M, Kotaka M, Kubo S, Kawamura K (1983) Cardiovascular effects of a newly synthesized cardiotonic agent (TA-064) on normal and diseased hearts. Am J Cardiol 51:802-810
17. ++ transients. J Pharmacol Exp Ther 265:1292-1300
18. 1-specific and non-adrenergic stimulant effects of denopamine. Naunyn-Schmiedeberg's Arch Pharmacol 339:113-128
19. Levitzki A (1988) From epinephrine to cyclic AMP. Science 241:800-806
20. Naito K, Nagao T, Otsuka M, Harigaya S, Nakajima H (1985) Studies on the affinity and selectivity of dopamine (TA-064), a new cardiotonic agent, for β-adrenergic receptors. Jpn J Pharmacol 38:235-241
21. Ono K, Tsujimoto G, Sakamoto A, Eto K, Masaki T, Ozaki Y, Satake M (1994) Endothelin-A receptor mediates cardiac inhibition by regulating calcium and potassium currents. Nature 370:301-304
22. Sasaki Y, Yabana H, Nagao T, Takeyama S (1988) Effect of denopamine on the phosphorylation of cardiac muscle proteins in the perfused guinea-pig heart: comparison with isoproterenol. Biochem Pharmacol 37:679-686
23. Satoh Y, Taniguchi K, Koike A, Adachi H, Yajima T, lizumi T, Shiigai T, Hiroe M, Marumo F (1993) Short-term effects of denopamine on anaerobic threshold and related parameters in patients with chronic heart failure: a double-blind crossover study. Clin Pharmacol Ther 53:562-569
24. Suzuki T, Nantel F, Bonin H, Valiquette M, Bouvier M (1993) Cellular characterization of the pharmacological selectivity and tachyphylactic properties of denopamine for the human beta adrenergic receptors. J Pharmacol Exp Ther 267:785-790
25. Venter JC (1979) High efficacy coupling between beta-adrenergic receptors and cardiac contractility: direct evidence for "spare" beta-adrenergic receptors. Mol Pharmacol 16:429-440
26. Winegrad S (1986) Membrane control of force generation. In: Fozzard HA, Haber E, Jennings RB, Katz AM, Morgan HE (eds) The heart and cardiovascular system. Raven Press, New York, pp 703-730
27. 1-receptors. J Cardiovasc Pharmacol 12:323-331
28. Zygmunt AC, Gibbons WR (1991) Calcium-activated chloride current in rabbit ventricular myocytes. Circ Res 68:424-437