The effects of apolipoprotein E deficiency on brain cholinergic neurons

International Journal of Developmental Neuroscience

Volumn 16, Issue 7-8, 1998, Pages 755-762

  Kleifeld, Oded ^a   Diebler, Marie Francoise ^b   Chapman, Shira ^a   Oron, Lea ^a   Michaelson, Daniel M ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b CNRS   (France)

Author keywords

Alzheimer's disease; Apolipoprotein E; Cholinergic; VAChT; Vesamicol

Indexed keywords

APOLIPOPROTEIN E; VESICULAR ACETYLCHOLINE TRANSPORTER;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CHOLINERGIC ACTIVITY; CHOLINERGIC NERVE; CHOLINERGIC NERVE CELL; CHOLINERGIC SYNAPSE; CONTROLLED STUDY; FOREBRAIN; HYPERLIPOPROTEINEMIA TYPE 3; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ACETYLCHOLINE; ANIMALS; APOLIPOPROTEINS E; BRAIN; CELLS, CULTURED; CEREBRAL CORTEX; MALE; MICE; MICE, KNOCKOUT; NEURONS; PROSENCEPHALON;

ANIMALIA;

EID: 0032462948     PISSN: 07365748     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0736-5748(98)00084-7     Document Type: Article

References (32)

1. Allen, S. J., MacGowan, S. H., Tyler, S., Wilcox, G. K., Robertson, A. G., Holden, P. H., Smith, S. K. and Dawbarn, D., Reduced cholinergic function in normal and Alzheimer's disease brain is associated with apolipoprotein E4 genotype. Neurosci. Lett., 1997, 239, 33-36.
2. 3H]-piperidino) cyclohexanol. Proc. Natl. Acad. Sci. U.S.A., 1986, 83, 2267-2270.
3. Beffert, U. and Poirier, J., Apolipoprotein E, plaques, tangles and cholinergic disfunction in Alzheimer's disease. Ann. N.Y. Acad. Sci., 1996, 778, 166-184.
4. Bellosta, S., Nathan, B. R., Orth, M., Dong, L. M., Mahley, R. D. and Pitas, R. E., Stable expression and secretion of apolipoprotein E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth. J. Biol. Chem., 1995, 270, 27,063-27,071.
5. Bradford, M. M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 1976, 72, 248-254.
6. Chapman, S. and Michaelson, D. M., Specific neurochemical derangements of brain projecting neurons in apolipoprotein E-deficient mice. J. Neurochem., 1998, 70, 708-714.
7. Erickson, J. D., Varoqui, H., Schafter, M. K. -H., Modi, W., Diebler, M. -F., Weihe, E., Rand, J. B., Eiden, L. E., Bonner, T. I. and Usdin, T. B., Functional identification of a vesicular acetylcholine transporter and its expression from a "cholinergic" gene locus. J. Biol. Chem., 1994, 35, 21,929-21,932.
8. Farlow, M. R., Lahiri, D. K., Poirier, J., Davignon, J. and Hui, S., Apolipoprotein E genotype and gender influence response to tacrine therapy. Ann. NY Acad. Sci., 1996, 802, 101-110.
9. 1 muscarinic agonist treatment reverses cognitive and cholinergic impairments of apolipoprotein E-deficient mice. J. Neurochem., 1998, 70.
10. Francis, P. T., Gross, A. J. and Bowen, D. M., Neurotransmitters and neuropeptides. In Alzheimer's Disease, ed. R. D. Terry, R. Katzman and K. L. Birk. Raven Press, New York, 1994, pp. 247-262.
11. Genis, I., Gordon, I., Sehayek, E. and Michaelson, D. M., Phosphorylation of tau in apolipoprotein E-deficient mice. Neuroscience Lett., 1995, 199, 5-8.
12. Genis, I. and Michaelson, D. M., Hyperphosphorylation of tau in apolipoprotein E-deficient mice. In Progress in Alzheimer's and Parkinson's Disease, ed. A. Fisher, N. Yoshida and I. Hanin. Plenum Press, 1998 (in press).
13. Gilmore, M. L., Nash, N. R., Roghani, A., Edwards, R. H., Yi, H., Hersch, S. M. and Levey, A. I., Expression of the putative vesicular acetylcholine transporter in rat brain and localization in cholinergic synaptic vesicles. J. Neurosci., 1996, 76, 2179-2190.
14. Gordon, I., Grauer, E., Genis, I., Sehayek, E. and Michaelson, D. M., Memory deficits and cholinergic impairment in apolipoprotein E-deficient mice. Neurosci. Lett., 1995, 199, 1-4.
15. Hefli, T., Hartikka, J. and Sanches-Ramos, J., Dissociated cholinergic neurons of the basal forebrain in culture. In A Dissection and Tissue Culture Manual of the Neurons System. Alan R. Liss Inc., 1989, pp. 172-182.
16. Ichikawa, T., Ajiki, K., Matsuura, J. and Misawa, H., Localization of two cholinergic markers, choline acetyltransferase and vesicular acetylcholine transporter in the central nervous system of the rat: in situ hybridization histochemistry and immunohistochemistry. J. Chem. Neuroanat., 1997, 13, 23-39.
17. Karnovsky, M. J. and Roots, L. A., A direct cloning thio choline method for cholinesterase. J. Histochem. Cytochem., 1964, 121, 242-245.
18. Mahley, R. W., Apolipoprotein E cholesterol transport protein with expanding role in cell biology. Science, 1988, 240, 622-629.
19. Nathan, B. P., Bellosta, S., Sanan, D. A., Weisgraber, K. H., Mahley, R. W. and Pitas, R. E., Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science, 1994, 264, 850-852.
20. Nathan, B. P., Chang, K. C., Bellosta, S., Brisch, E., Ge, N., Mahley, R. W. and Pitas, R. E., The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization. J. Biol. Chem., 1995, 270, 19,791-19,799.
21. Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setala, K., Walsh, A., Vertsuytt, J. G., Rubin, E. M. and Breslaw, J. L., Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell, 1992, 16, 343-353.
22. Poirier, J., Apolipoprotein E animals of CNS injury and in Alzheimer's disease. Trends in Neuroscience, 1994, 17, 525-530.
23. Poirier, J., Delise, M. -C., Quirion, R., Auberta, I., Farlow, M., Lahiri, D., Hui, S., Bertrand, P., Nalbantoglu, J. and Grefix, B. M., Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A., 1995, 92, 12,260-12,264.
24. Riekkinen, P. Jr., Soininen, H., Partanen, J., Paakkonen, A., Helisami, S. and Riekkinen, P. Sr., The ability of THA treatment to increase cortical alpha waves is related to apolipoprotein E genotype of Alzheimer disease patients. Psychpharmacology-Berlin, 1997, 129, 285-288.
25. Roses, A. D., Apolipoprotein E is a gentic locus that affects the rate of Alzheimer's disease expression: β amyloid burden is a secondary consequence dependent on apoE genotype and duration of disease. J. Neuropathol. Exp. Neurol., 1994, 53, 429-437.
26. Roses, A. D., A model for susceptibility polymorphisms for complex diseases: apolipoprotein E and Alzheimer's disease. Neurogenetics, 1997, 1, 3-11.
27. Slotnick, B. M. and Leonard, C. M., A Stereotactic Atlas of the Albino Rat Forebrain. DHEW Publications, no. (ADM) 75-100. U.S. Department of Health, Education and Welfare, Washington, DC, 1975, p. 173.
28. Sofroniew, M. V., Campbell, P. E., Cuello, A.C. and Eckenstein, F., In The Rat Nervous System, ed. G. Paxinos. Academic Press, Australia, 1985, pp. 471-485.
29. Svensson, A. L., Warpman, U., Hellstrom-Lindahl, E., Bogdanovic, N., Lannfelt, L. and Nordberg, A., Nicotinic receptors, muscarinic receptors and choline acetyltransferase activity in the temporal cortex of Alzheimer patients with differing apolipoprotein E genotypes. Neurosci. Lett., 1997, 232, 37-40.
30. Varoqui, H., Diebler, M. -F., Meunier, F., Rand, J. B., Usdin, T. B., Bonner, T. I., Eiden, L. E. and Erickson, J. D., Cloning and expression of the vesamicol binding protein from the marine ray Torpedo: homology with the putative vesicular acetylcholine transporter UNC-17 from Caenorhabditis elegans. FEBS Lett., 1994, 342, 97-102.
31. Weihe, E., Tao-Cheng, J.-H., Schafer, M. K. -H., Erickson, J. D. and Eiden, L. E., Proc. Natl. Acad. Sci. U.S.A., 1996, 93, 3547-3552.
32. Whitehouse, P. J., Price, D. L., Struble, R. G., Clark, A. W., Coyle, J. R. and Delon, M. R., Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science, 1982, 215, 1237-1239.