Molecular analysis of the cyclin-dependent kinase inhibitor genes, p15, p16, p18 and p19 in the myelodysplastic syndromes

Leukemia Research

Volumn 21, Issue 3, 1997, Pages 235-240

  Nakamaki, Tsuyoshi ^a   Bartram, Claus ^b   Seriu, Taku ^b   Kahan, Jerry ^a   Fukuchi, Kunihiko ^c   Tsuruoka, Nobuyoshi ^c   Janssen, Johannes W G ^b   Miller, Carl W ^a   Koeffler, H Phillip ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

CDKIs (p15, p16, p18, p19); MDS

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; DNA; PROTEIN P16;

ARTICLE; CHRONIC MYELOMONOCYTIC LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; DNA SEQUENCE; GENE; HUMAN; HUMAN TISSUE; MYELODYSPLASTIC SYNDROME; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REFRACTORY ANEMIA; SINGLE STRAND CONFORMATION POLYMORPHISM; SOUTHERN BLOTTING; TUMOR SUPPRESSOR GENE;

EID: 0030946787     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(96)00115-4     Document Type: Article

References (47)

1. Boultwood J. & Fidler C. (1995) Chromosomal deletions in myelodysplasia. Leukemia Lymphoma 17, 1-2, 71.
2. Watte E., Preudhomme C., Hecquet B., Vanrumbeke M., Quesnel B., Dervite I., Morel P. & Fenaux P. (1994) p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies. Blood 84, 3148.
3. Adamson D. J., Dawson A. A., Bennett B., King D. J. & Haites N. E. (1995) p53 mutation in the myelodysplastic syndromes. Br. J. Haematol. 89, 1, 61.
4. Mori N., Hidai H., Yokota J., Okada M., Motoji T., Oshimi K. & Mizoguchi H. (1995) Mutations of the p53 gene in myelodysplastic syndrome and overt leukemia. Leukemia Res. 19, 11, 869.
5. Preudhomme C., Vachee A., Lepelley P., Vanrumbeke M., Zandecki M., Quesnel B., Cosson A. & Fenaux P. (1994) Inactivation of the retinoblastoma gene appears to be very uncommon in myelodysplastic syndrome. Br. J. Haematol. 87, 61.
6. Boultwood J., Fidler C., Lewis S., MacCarthy A., Sheridan H.. Kelly S., Oscier D., Buckle V. J. & Wainscoat J. S. (1993) Allelic loss of IRF1 in myclodysplasia and acute myeloid leukemia: retention of IRF1 on the 5q-chromosome in some patients with the 5q-syndrome. Blood 82, 2611.
7. Miyake K., Inokuchi K. & Nomura T. (1994) Expression of the DCC gene in human hematological malignancies. Leukemia Lymphoma 16, 13.
8. Jacobs A. (1992) Gene mutations in myelodysplasia. Leukemia Res. 16, 47.
9. Hutchinson R. M., Pringle J. H., Knight S. C., Lauder I., Potter A. & Jagger C. (1992) Oncogene expression in primary myelodysplasia: Correlation with haematological karyotypic, and clinical progression. J. Clin. Pathol. 45, 339.
10. Lyons J., Janssen J. W., Bartram C., Layton M. & Mufti G. J. (1988) Mutation of Ki-ras and N-ras oncogenes in myelodysplastic syndromes. Blood 71, 1707.
11. Hunter T. & Pines J. (1994) Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. Cell 79, 573.
12. Sheaff R. J. & Roberts J. M. (1995) Tumor suppression. Lessons in p16 from phylum Falxconium. Curr. Biol. 5, 28.
13. Serrano M., Hannon G. J. & Beach D. (1993) A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366, 704.
14. INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature 371, 257.
15. INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Devel. 8, 2939.
16. Chan F. K., Zhang J., Cheng L., Shapiro D. N. & Winoto A. (1995) Identification of human and mouse p 19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. Mol. Cell Biol. 15, 2682.
17. Hirai H., Roussel M. F., Kato J. Y., Ashmun R. A. & Sherr C. J. (1995) Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependcnt kinases CDK4 and CDK6. Mol. Cell Biol. 15, 2672.
18. Kamb A., Gruis N. A., Weaver-Feldhaus J., Liu Q., Harshman K., Tavtigian S. V., Stockert E., Day R. S., Johnson B. E. & Skolnick M. H. (1994) A cell cycle regulator potentially involved in genesis of many tumor types. Science 264, 436.
19. Nobori T., Miura K., Wu D. J., Lois A., Takabayashi K. & Carson A. D. (1994) Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 368, 753.
20. Hirama T. & Koeffler H. P. (1995) Role of the cyclin-dependent kinase inhibitors in the development of cancer. Blood 86, 841.
21. Ogawa S., Hirano N., Sato N., Takahashi T., Hangaishi A., Tanaka K., Kurokawa M., Tanaka T., Mitani K., Yazaki Y. & Hirai H. (1994) Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias. Blood 84(8), 2431.
22. Takeuchi S., Bartram C. R., Seriu T., Miller C. W., Tobler A., Janssen J. W., Reiter A., Ludwig W. D., Zimmermann M., Schwaller J., Lee F., Miyoshi I. & Koeffler H. P. (1995) Analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A, and p18 genes in acute lymphoblastic leukemia of childhood. Blood 86, 755.
23. Haidar M. A., Cao X. B., Manshouri T., Chan L. L., Glassman A., Kantarjian H. M., Keating M. J., Beran M. S. & Albitar M. (1995) p16INK4A and p15INK4B gene deletions in primary leukemias. Blood 86, 311.
24. Quesnel B., Preudhomme C., Philippe N., Vanrumbeke M., Dervite I., Lai J. L., Bauters F., Wattel E. & Fenaux P. (1995) p16 gene homozygous deletion in acute lymphoblastic leukemia. Blood 85, 657.
25. Fizzotti M., Cimino G., Pisegna S., Alimena G., Quartarone C., Mandelli F., Pelicci P. G. & Lo Coco F. (1995) Detection of homozygous deletions of the cyclin-dependent kinase 4-inhibitor (P16) gene in acute lymphoblastic leukemia and association with adverse prognostic features. Blood 85, 2685.
26. Ogawa S., Hangaishi A., Miyawaki S., Hirosawa S., Miura Y., Takeyama K., Kamada N., Ohtake S., Uike N., Shimazaki C. & Hirai H. (1995) Loss of the cyclin-dependent kinase 4-inhibitor (p16; MTS1) gene is frequent in and highly specific to lymphoid tumors in primary human hematopoietic malignancies. Blood 86(4), 1548.
27. Ohnishi H., Kawamura M., Ida K., Sheng X. M., Hanada R., Nobori T., Yamamori S. & Hayashi Y. (1995) Homozygous deletions of p16/MTS1 gene are frequent but mutations are infrequent in childhood T-cell acute lymphoblastic leukemia. Blood 86(4), 1269.
28. Hatta Y., Hirama T., Miller C. W., Yamada Y., Tomonaga M. & Koeffler H. P. (1995) Homozygous deletions of the p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia (ATL). Blood 85(10), 2699.
29. Nakamaki T., Kawamata N., Shwaller J., Tobler A., Fey M., Pakkala S., Lee Y. Y., Kim B. K., Fukuchi K., Tsuruoka N., Kahan J., Miller C. W. & Koeffler H. P. (1995) Structural integrity of the cyclin-dependent kinase inhibitor genes, p15, p16 and p18 in myeloid leukemia. Br. J. Haematol. 91, 139.
30. Sill H., Goldman J. M. & Cross N. C. (1995) Homozygous deletions of the p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia. Blood 85(8), 2013.
31. Uchida T., Watanabe T., Kinoshita T., Murate T., Saito H. & Hotta T. (1995) Mutational analysis of the CDKN2 (MTS1/p16INK4A) gene in primary B-cell lymphomas. Blood 86(7), 2724.
32. Sambrook J., Fritsch E. F. & Maniatis T. (1989) Molecular Cloning: A Laboratory Manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
33. Johnson K. R., Nousseef W. M., Care A., Wheelock M. J., Hudson S., Koeffler H. P., Selsted M., Miller C. & Rovera G. L. (1987) Characterization of cDNA clones for human MPO: predicted amino acid sequence and evidence for multiple mRNA species. Nucleic Acid Res. 15, 2012.
34. Orita M., Iwahana H., Kanazawa H., Hayashi K. & Sekiya T. (1989) Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc. Natl. Acad. Sci. U.S.A. 86, 2766.
35. Stone S., Dayananth P., Jiang P., Weaver Feldhaus J. M., Tavtigian S.V., Cannon Albright L. & Kamb A. (1995) Genomic structure, expression and mutational analysis of the P15(MTS2) gene. Oncogene 11, 987.
36. Okamoto A., Hussain S. P., Hagiwara K., Spillare E. A., Rusin M. R., Demetrick D. J., Serrano M., Hannon G. J., Shiseki M., Zariwala M., Xiong Y., Beach D. H., Yokota J. & Harris C. C. (1995) Mutations in the p16INK4/MTS1/ CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer. Cancer Res. 55, 1448.
37. INK4D in hematopoietic malignancies.
38. Spirin K. S., Simpson J. F., Miller C. W. & Koeffler H. P. Molecular analysis of INK4 genes in breast carcinomas. Submitted.
39. Tasaka T., Berenson J., Hirama T. & Koeffler H. P. Analysis of the INK4 family of genes in multiple myeloma. Br. J. Haematol. (in press).
40. Kawamato N., Miller C. W. & Koeffler H. P. (1996) Molecular analysis of a family of cyclin-dependent kinase inhibitors; P15/MTS2/INK4B and p18 genes in non-small lung cancers. Mol. Carcinogen. 14, 263.
41. Kawamata N., Seriu T., Koeffler H. P. & Bartram C. R. (1996) Molecular analysis of the cyclin-dependent kinase inhibitor family; p16(CDKN2/MTS1/INK4A), p18(INK4C) and p27(Kip1) genes in neuroblastomas. Cancer. 77, 570.
42. Park D. J., Wilczynski S. P., Pham E. Y., Miller C. W. & Koeffler H. P. Molecular analysis of the INK4 family of genes in prostate carcinomas. Submitted.
43. Johansson B., Mertens F. & Mitelman F. (1993) Cytogenetic deletion maps of hematologic neoplasms: circumstantial evidence for tumor suppressor loci. Genes Chromosomes Cancer 8, 205.
44. Hirama T. & Koeffler H. P. (1995) The role of cyclin-dependent kinase inhibitors in development of cancer. Blood 86, 841.
45. Cline M. J. (1994) The molecular basis of leukemia. New Eng. J. Med. 2(3), 328.
46. Lampkin B. C., Nagao T. & Mauer A. M. (1971) Synchronization and recruitment in acute leukemia. J. Clin. Invest. 50, 2204.
47. Schumacher H. R., McFeely A. E., Davis K. D. & Maugel T. K. (1971) The acute leukemia cell: IV. DNA synthesis in peripheral blood and bone. Am. J. Clin. Pathol. 56, 508.