Androgens and estrogens modulate 5-HT(1A) and 5-HT(1B) agonist effects on aggression

Physiology and Behavior

Volumn 65, Issue 4-5, 1998, Pages 823-828

  Cologer Clifford, Athena ^a   Simon, Neal G ^a   Richter, Martin L ^a   Smoluk, Stefanie A ^a   Lu, Shifang ^a  

^a LEHIGH UNIVERSITY   (United States)

Author keywords

8 OH DPAT; Aggression; Androgen; CGS12066B; Estrogen; Serotonin receptors

Indexed keywords

1 (3 TRIFLUOROMETHYLPHENYL)PIPERAZINE; 2 DIPROPYLAMINO 8 HYDROXY 1 METHYLTETRALIN; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 (4 METHYL 1 PIPERAZINYL) 7 TRIFLUOROMETHYLPYRROLO[1,2 A]QUINOXALINE; ANDROGEN; ANDROSTANOLONE; DIETHYLSTILBESTROL; ELTOPRAZINE; ESTROGEN; METRIBOLONE; SEROTONIN; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 1B AGONIST; SEROTONIN 1B RECEPTOR; SILASTIC; STEROID; TESTOSTERONE;

AGGRESSION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; GONADECTOMY; LOCOMOTION; MALE; MOUSE; NEUROENDOCRINE SYSTEM; NONHUMAN; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM;

EID: 0032458297     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9384(98)00240-6     Document Type: Article

References (52)

1. 1. Archer, J.: The influence of testosterone on human aggression. Br. J. Psychol. 82:1-28; 1991.
2. 1A receptor influences on rodent social and agonistic behavior: A review and empirical study. Neurosci. Biobehav. Rev. 18:325-338; 1994.
3. 1A antagonist (+)-WAY-100135 on murine social and agonistic behavior. Pharmacol. Biochem. Behav. 54:159-167; 1996.
4. 4. Berman, M. E.; Tracy, J. I.; Coccaro, E. F.: The scrotonin hypothesis of aggression revisited. Clin. Psychol. Rev. 17:651-665; 1997.
5. 5. Biegon, A.: Effects of steroid hormones on the serotonergic system. Ann. NY Acad. Sci. 600:427-434; 1990.
6. 6. Bitran, D.; Hull, E.: Pharmacological analysis of male rat sexual behavior. Neurosci. Biobehav. Rev, 11:365-389; 1987.
7. 7. Brain, P.; Haug, M.: Hormonal and neurochemical correlates of various forms of animal "aggression." Psychoneuroendocrinology 17:537-551; 1992.
8. 8. Brain, P. F.; Nowell, N. W.: Some observations on intermale aggression testing in albino mice. Commun. Behav. Biol. 5:7-17; 1970.
9. 9. Coccaro, E. F.: Neurotransmitter correlates of impulsive aggression in humans. Ann. NY Acad. Sci. 794:82-89; 1996.
10. 10. Coccaro, E. F.; Kavousi, R. J.: Fluoxetine and impulsive aggressive behavior in personality-disordered subjects. Arch. Gen. Psychiatry 54:1081-1088; 1997.
11. 11. Cologer-Clifford, A.; Simon, N.; Smoluk, S.: Serotonin agonist-induced decreases in intermale aggression are brain region and receptor subtype dependent. Pharmacol. Biochem. Behav. 58: 425-430; 1997.
12. 12. Denenberg, V. H.; Gaulin-Kremer, E.; Gandelman, R.; Zarrow, M. X.: The development of standard stimulus animals for mouse (Mus musculus) aggression testing by means of olfactory bulbectomy. Animal Behav. 21:590-598; 1973.
13. 13. Doering, C. H.; Leyra, P. T.: Methyltrienolone (R1881) is not aromatized by placental microsomes or rat hypothalamic homogenates. J. Ster. Biochem, 20:1157-1162; 1984.
14. 14. Dohanich, G.; Nock, B.; McEwen, B. S.: Steroid hormones, receptors and neurotransmitters. In: Moudgil, V. K., ed. Molecular mechanisms of steroid hormone action. Berlin: Walter de Gruyter; 1985:701-732.
15. 15. Fischette, C.; Biegon, A.; McEwen, B.: Sex differences in serotonin 1 receptor binding in rat brain. Science 222:333-335; 1983.
16. 1B receptors. Prog. Neuropsychopharmacol. Biol. Psychiatry 14:91-102; 1990.
17. 1B) agonists in the isolation-induced social behavioural deficit test. Neuropharmacology 30:623-627; 1991.
18. 1B agonist CGS12066B. Pharmacol. Biochem. Behav. 40:279-281; 1991.
19. 19. Frankfurt, M.; McKittrick, C.; Mendelson, S.; McEwen, B.: Effect of 5,7-dihydroxytryptamine, ovariectomy and gonadal steroids on serotonin receptor binding in rat brain. Neuroendocrinology 59:245-250; 1994.
20. 20. Gandelman, R.: Gonadal hormones and the induction of intraspecific fighting in mice. Neurosci. Biobehav, Rev. 4:133-140; 1980.
21. 21. Garattini, S.; Giacalone, E.; Valzelli, L.: Isolation, aggressiveness and brain 5-hydroxytryptamine turnover. J. Pharm. Pharmacol. 19:338-339; 1967.
22. 22. Hen, R.: Mean genes. Neuron 16:17-21; 1996.
23. 23. Jones, G. H.; Hernandez, T. D.; Kendall, D. A.; Marsden, C. A.; Robbins, T. W.: Dopaminergic and serotonergic function following isolation rearing in rats: Study of behavioural responses and postmortem in vivo neurochemistry. Pharmacol. Biochem. Behav. 43:17-35; 1992.
24. 24. Liebenauer, L. L.; Slotnick, B. M.: Social organization and aggression in a group of olfactory bulbectomized male mice. Physiol. Behav. 60:403-409; 1996.
25. 25. Lindgren, T.; Kantak, K. M.: Effects of serotonin receptor agonists and antagonists on offensive aggression in mice. Aggress. Behav. 13:87-96; 1987.
26. 26. Linnoila, M.; Virkunnen, M.: Aggression, suicidality, and serotonin. J. Clin. Psychiatry 53:46-51; 1992.
27. 27. McMillen, B.; DaVanzo, E.; Scott, S.; Song, A.: N-Akyl-substituted aryl-piperazine drugs: Relationship between affinity for serotonin receptors and inhibition of aggression. Drug Dev. Res. 12:53-62; 1988.
28. 28. Mehlman, P. T.; Highley, J.; Faucher, I.; Lilly, A.; Taub, D.; Vickers, J.; Suomi, S.; Linnoila, M.: Low CSF 5-HIAA concentrations and severe aggression and impulse control in nonhuman primates. Am. J. Psychiatry 151:1485-1491; 1994.
29. 1A receptors in the medial preoptic nucleus of the castrated male rat. Eur. J. Pharmacol. 181:329-331; 1990.
30. 3 receptors in the amygdala of the castrated male rat. Brain Res. 528:339-343; 1990.
31. 31. Miczek, K. A.; Weerts, E.; Haney, M.; Tidey, J.: Neurobiological mechanisms controlling aggression: Preclinical developments for pharmacotherapeutic interventions. Neurosci. Biobehav. Rev. 18: 97-110; 1994.
32. 32. Mos, J.; Olivier, B.; Poth, M.; van Aken, H.: The effects of intraventricular administration of eltoprazine, 1-(3-trifluoromethylphenyl) piperazine hydrochloride and 8-hydroxy-2-(di-n-propylamino) tetralin on resident intruder aggression in the rat. Eur. J. Pharmacol. 212:295-298; 1992.
33. 33. Mos, J.; Olivier, B.: A comparison of drug responses by male and female rats during aggression tests. In: Haug, M.; Whalen, R. E.; Aron, C.; Olsen, K. L., eds. The development of sex differences and similarities in behavior. The Netherlands: Kluwer Academic; 1993:205-225.
34. 34. Olivier, B.; Mos, J.; van der Heyden, J.; Hartog, J.: Serotonergic molulation of social interactions in isolated male mice. Psychopharmacology (Berlin) 97:154; 1989.
35. 35. Olivier, B.; Mos, J.: Serenics, serotonin and aggression. Prog. Clin. Biol. Res. 361:203-230; 1990.
36. 36. Olivier, B.; Mos, J.; Raghoebar, M.; de Koning, P.; Mak, M.: Serenics. Prog. Drug Res. 42:169-248; 1994.
37. 37. Olivier, B.; Mos, J.; van Oorschot, R.; Hen, R.: Serotonin receptors and animal models of aggressive behavior. Pharmacopsychiatry 28:80-90; 1995.
38. 1B receptor knock out -Behavioral consequences. Behav. Brain Res. 73:305-312; 1996.
39. 39. Rastegar, A.; Ciesielisk, L.; Simler, S.; Messripour M.; Mandel, P.: Brain monoamines following castration of aggressive muricidal rats. Neurochem. Res. 18:471-477; 1993.
40. 1A receptors. Eur. J. Pharmacol. 264:241-247; 1997.
41. 41. Sanchez, C.; Arnt, J.; Hyttel, J.; Moltzen, E. K.: The role of serotonergic mechanisms in inhibition of isolation-induced aggression in male mice. Psychopharmacology (Berlin) 110:53-59; 1993.
42. 1B receptor. Science 265:1875-1878; 1994.
43. 1B receptor subtypes in rat brain: Sensitivity to guanine nucleotides. Eur. J. Pharmacol. 187:209-223; 1990.
44. 1 receptors and offensive aggression in rats: A combined behavioral and autoradiographic study with eltoprazine. Pharmacol. Biochem. Behav. 38:447-458; 1991.
45. 45. Simon, N. G.; Gray, J. L.; Gandelman, R.: An empirically derived scoring system for intermale aggression in mice. Aggress. Behav. 9:157-166; 1983.
46. 46. Simon, N. G.; Lu, S. F.; McKenna, S. E.; Chen, X.; Clifford, A .C.: Sexual dimorphisms in regulatory systems for aggression. In: Haug, M.; Whalen, R. E.; Aron, C.; Olsen, K., eds. The development of sex differences and similarities in behavior. The Netherlands: Kluwer Academic Publishers; 1993:389-408.
47. 47. Simon, N. G.; Masters, D.: Activation of intermale aggression by testosterone but not its metabolites in C57BL/6J mice. Physiol. Behav. 41:405-407; 1987.
48. 48. Simon, N.; McKenna, S.; Lu, S.; Cologer-Clitford, A.: Development and expression of hormonal systems regulating aggression. Ann. NY Acad. Sci. 794:8-17; 1996.
49. 49. Simon, N.; Whalen, R.; Hormonal regulation of aggression: Evidence for a relationship among genotype, receptor binding, and behavioral sensitivity to androgen and estrogen. Aggress. Behav. 12:255-266; 1986.
50. 1B agonists. Int. Soc. Res. Agg., XII World Meeting, Strasbourg, 1996.
51. 51. Valzelli, L.; Garattini, S.: Behavioral changes and 5-hydroxytryptamine turnover in animals. Adv. Pharmacol. 66:249-260; 1968.
52. 52. White, S.; Kucharik, R.; Moyer, J.: Effects of serotonergic agents on isolation-induced aggression. Pharmacol. Biochem. Behav. 39:729-736; 1991.