Effects of the 5-HT1A antagonist (+)-WAY-100135 on murine social and agonistic behavior

Pharmacology Biochemistry and Behavior

Volumn 54, Issue 1, 1996, Pages 159-167

  Bell, Robert ^a   Mitchell, Paul J ^b,c   Hobson, Helen ^d  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b PFIZER INC   (United States)

^c University of Bath   (United Kingdom)

^d NONE

Author keywords

(+) WAY 100135; Agonistic behavior 5 HT1A antagonist; Ethological analysis; Social behavior

Indexed keywords

MURINAE;

N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; SEROTONIN 1A ANTAGONIST; PIPERAZINE DERIVATIVE; SEROTONIN ANTAGONIST;

AGGRESSION; ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; DEFENSIVE BEHAVIOR; ETHOLOGY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOCIAL BEHAVIOR; SUBCUTANEOUS DRUG ADMINISTRATION; ANIMAL; ARTICLE; DRUG EFFECT; MOUSE STRAIN; SOCIAL ISOLATION;

AGONISTIC BEHAVIOR; ANIMALS; MALE; MICE; MICE, INBRED STRAINS; PIPERAZINES; SEROTONIN ANTAGONISTS; SOCIAL BEHAVIOR; SOCIAL ISOLATION;

EID: 0029666429     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/0091-3057(95)02168-X     Document Type: Article

References (37)

1. Bell, R.; Hepper, P. Catecholamines and aggression in animals. Behav. Brain Res. 23:1-21; 1987.
2. 1A antagonist, on social and agonistic behavior in male albino mice. Pharmacol. Biochem. Behav. 46:67-72; 1993.
3. Bell, R.; Hobson, H. The effects of (-)-pindolol and SDZ 216-525 on social and agonistic behavior in mice. Pharmacol. Biochem. Behav. 46:883-880; 1993.
4. 1A receptor influences on rodent social and agonistic behavior: A review and empirical study. Neurosci. Biobehav. Rev. 18:325-338; 1994.
5. Bell, R.; Donaldson, C.; Gracey, D. Differential effects of CGS 12066B and CP-94,253 on murine social and agonistic behavior. Pharmacol. Biochem. Behav. 52:7-16; 1995.
6. 1A receptor antagonists (+)-WAY-100135 and WAY-100635. Neuropharmacology 34:805-811; 1995.
7. 1A receptor ligands in the mouse. Br. J. Pharmacol. 151P; 1994.
8. 2-adrenergic heteroreceptors in the rat hypothalamus. J. Pharmacol. Exp. Therapeut. 254:236-244; 1990.
9. 1A receptor ligands on a safety signal withdrawal procedure of conflict in the rat. Pharmacol. Biochem. Behav. 48:281-289; 1994.
10. 1A ligands on the agonistic behavior of rats. J. Psychopharmacol. Abstracts Abst. 24; 1994.
11. Cutler, M. G.; Dixon, A. K. Effect of ipsapirone on the behaviour of mice during social encounters. Neuropharmacology 27: 1039-1044; 1988.
12. 1A receptor antagonist. Soc. Neurosci. Abstr. 17:92; 1991.
13. 1A receptors. Eur. J. Pharmacol. 237:283-291; 1993.
14. Fornal, C. A.; Metzler, C. W.; Veasey, S. C.; McCreary, A. C.; Dourish, C. T. Single-unit recordings from freely moving animals provide evidence that WAY-100635, but not (S)-WAY-100135, blocks the action of endogenous serotonin at the 5-HT autoreceptor. Br. J. Pharmacol. 112:92P; 1994.
15. 1A receptors. Br. J. Pharmacol. 86:601P; 1985.
16. 1A receptor antagonist and an SSRI in vivo: Effects of 5-HT cell firing and extracellular 5-HT. Br. J. Pharmacol. (in press).
17. 1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Eur. J. Pharmacol. 154:339-341; 1988.
18. Hendrie, C. A.; Rodgers, R. J. Microcomputer-based data logging and analysis in psychopharmacology. In: West, R.; Christie, M.; Weinman, J., eds. Computers, psychology and medicine. Chichester: Wiley; 1990:187-201.
19. 1A receptors: Behavioural and in vivo brain microdialysis studies. Life Sci. 46:955-963; 1990.
20. 1A receptor antagonist. Soc. Neurosci. Abstr. 17:91; 1991.
21. Krsiak, M. Effects of drugs on the behaviour of aggressive mice. Br. J. Pharmacol. 65:525-533; 1979.
22. 1A receptor ligands (+)-WAY-100135 and SDZ 216-525. Eur. J. Pharmacol. 249:25-35; 1993.
23. 1A agonist-like effects of NAN-190. Soc. Neurosci. Abstr. 16:1034; 1990.
24. Middlemiss, D. N.; Tricklebank, M. D. Centrally active 5-HT receptor agonists and antagonists. Neurosci. Biobehav. Rev. 16: 75-82; 1992.
25. 1A receptor mediated activity in the rat: A pharmacological characterisation of the actions of novel agonists and antagonists. J. Pharmacol. Exp. Ther. 264:1364-1376; 1993.
26. Mitchell, P. J.; Forster, E. A. Gepirone exhibits antidepressant-like activity on the social/agonistic behavior of resident rats. J. Psychopharmacol. Abstracts Abst. 335; 1992.
27. 1A antagonists WAY-100135 and SDZ 216-525 on 5-HT neuronal firing in the guinea-pig dorsal raphe nucleus. Neuropharmacology 33:61-66; 1994.
28. Olivier, B.; Mos, J. Rodent models of aggressive behaviour and serotonergic drugs. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 16:847-870; 1992.
29. 3 antagonists and benzodiazepines: Their comparative behavioural pharmacology. Chichester: Wiley; 1991:195-231.
30. Rodgers, R. J.; Waters, A. J. Benzodiazepines and their antagonists: A pharmacoethological analysis with particular reference to effects on aggression. Neurosci. Biobehav. Rev. 9:21-35; 1985.
31. 1A receptor antagonist, in the murine elevated plusmaze. Eur. J. Pharmacol. 261:321-325; 1994.
32. 1A antagonist WAY-100135: An in vivo microdialysis study. Eur. J. Pharmacol. 239:195-202; 1993.
33. Sanchez, C.; Arnt, J.; Hyttel, J.; Moltzen, E. K. The role of serotonergic mechanisms in inhibition of isolation-induced aggression in mice. Psychopharmacol. 110:53-59; 1993.
34. 1A antagonists, BMY7378. Eur. J. Pharmacol. 176:331; 1990.
35. 1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)-tetralin in the rat. Eur. J. Pharmacol. 106:271-282; 1984.
36. 1A receptors in the rat dorsal raphe nucleus. Soc. Neurosci. Abrast. 13:1649; 1987.
37. 1A receptor in rate and guinea-pig hippocampal membranes. Eur. J. Pharmacol. 137:293-294; 1987.