Note: Caution in use of empirical equations for pharmacodynamic indirect response models

Journal of Pharmacokinetics and Biopharmaceutics

Volumn 26, Issue 6, 1998, Pages 735-741

  Krzyzanski, Wojciech ^a   Jusko, William J ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A1 RECEPTOR AGONIST;

ANIMAL EXPERIMENT; ARTICLE; DRUG DISTRIBUTION; DRUG EFFECT; DRUG MONITORING; INTRAVENOUS DRUG ADMINISTRATION; MATHEMATICAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0032457218     PISSN: 0090466X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020707208521     Document Type: Article

References (5)

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3. W. Krzyzanski and W. J. Jusko. Mathematical formalism for the properties of four basic models of indirect pharmacodynamic responses. J. Pharmacokin. Biopharm. 25:107-123 (1997).
4. D. Z. D'Argenio and A. Schumitzky. A program package for simulation and parameter estimation in pharmacokinetics. Comput. Meth. Prog. Biomed. 9:115-134 (1979).
5. A. N. Kong, E. A. Ludwig, R. L. Slaughter, P. N. DiStefano, E. Middleton, and W. J. Jusko. Pharmacokinetics and pharmacodynamic modeling of direct suppression effects of methylprednisolone on serum cortisol and blood histamine in human subjects. Clin. Pharmacol. Ther. 46:616-628 (1989).