Epidermal expression of collagenase delays wound-healing in transgenic mice

Journal of Investigative Dermatology

Volumn 111, Issue 6, 1998, Pages 1029-1033

  Di Colandrea, Teresa ^a,d   Wang, Lisy ^b,e   Wille, John ^b,f   D'Armiento, Jeanine ^c   Chada, Kiran K ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c The New York Presbyterian Hospital   (United States)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^e Bristol Meyers Squibb   (United States)

^f Bioderm Technologies Inc   (United States)

Author keywords

MMP 1; Re epithelialization; Skin

Indexed keywords

COLLAGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPIDERMIS; EPITHELIZATION; HISTOPATHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE; WOUND CLOSURE; WOUND HEALING;

EID: 0032448427     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.1998.00457.x     Document Type: Article

References (20)

1. Albertson S, Hummel RP, Breeden M, Greenhalgh DG: PDGF and FGF reverse healing impairment in protein-malnourished diabetic mice. Surgery 114:368-373, 1993
2. Argen MS, Taplin CJ, Woessner F, Eagstein WH, Mertz PM: Collagenase in wound healing: effect of wound age and type. J Invest Dermatol 99:709-714, 1992
3. Brown RM, Middleton CA: Morphology and locomotion of individual epithelial cells in culture. J Cell Sci 78:105-115, 1985
4. D'Armiento J, Dalal SS, Okada Y, Berg RA, Chada K: Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema. Cell 71:955-961, 1992
5. D'Armiento J, DiColandrea T, Dalal SS, Okada Y, Huang M-T, Conney AH, Chada K: Collagenase expression in transgenic mouse skin causes hyperkeratosis and acanthosis and increases susceptibility to tumorigenesis. Mol Cell Biol 15:5732-5739, 1995
6. Greenhalgh DG, Sprugel KH, Murray MJ, Ross R: PDGF and FGF stimulate wound healing in the genetically diabetic mouse. Am J Pathol 136:1235-1246, 1990
7. Inoue M, Kratz G, Haegerstrand A, Stahle-Backdahl M: Collagenase expression is rapidly induced in wound-edge keratinocytes after acute injury in human skin, persists during healing and stops at re-epithelializarion. J Invest Dermatol 104:470-483, 1995
8. Janssen H, Rooman R, Robertson JIS: Wound Healing. Wrightson Biomedical Publishing, 1987, pp. 38-55; 61-69; 71-80
9. Martin P: Wound healing - aiming for perfect skin regeneration. Science 276:75-81, 1997
10. Martin P, Hopkinson-Woolley J, McCluskey J: Growth factors and cutaneous wound repair. Prog Growth Factor Res 4:25-44, 1992
11. Middleton CA: The effects of cell-cell contact on the spreading of pigmented retina epithelial cells in culture. Exp Cell Res 109:349-359, 1977
12. Nagase H: Activation mechanisms of matrix metalloproteinases. Biol Chem 378:151-160, 1997
13. Oakley C, Brunette DM: Response of single, pairs and clusters of epithelial cells to substratum topography. Biochem Cell Biol 73:473-489, 1995
14. Saarialho-Kere UK, Kovacs O, Pentland AP, Olerud JE, Welgus HG, Parks WC: Distinct localization of collagenase and TIMP expression in wound healing associated with ulcerative pyogenic granuloma. J Clin Invest 90:1952-1957, 1992
15. Stricklin GP, Nanney LD: Immunolocalization of collagenase and TIMP in healing human burn wounds. J Invest Dermatol 103:488-492, 1994
16. Stricklin GP, Li L, Jancic W, Wenczak BA, Nanney LD: Localization of mRNAs representing collagenase and TIMP in sections of healing human burn wounds. Am J Pathol 143:1657-1666, 1993
17. Uitto J, Perejda AJ (eds). Connective Tissue Disease: Molecular Pathology of the Extracellular Matrix. New York: Marcel Dekker, 1987, pp. 3-28, 29-54, 423-454
18. Vaalamo M, Weckroth M, Puolakkainen P, Kere J, Saarinen P, Lauharanta J, Saarialho-Kere UK: Patterns of matrix metalloproteinase and TIMP-1 expression in chronic and normally healing human cutaneous wounds. Br J Dermatol 135:52-59, 1996
19. Weckroth M, Vaheri A, Lauharanta J, Sorsa T, Konttinen YT: Matrix metalloproteinases, gelatinase and collagenase, in chronic leg ulcers. J Invest Dermatol 196:1119-1124, 1996
20. Yager DR, Zhang YL, Liang HX, Diegelmann RF, Cohen IK: Wound fluids from human pressure ulcers contain elevated matrix metalloproteinase levels and activity compared to surgical wound fluids. J Invest Dermatol 107:743-748, 1996