Baseline K+ channels as targets of general anesthetics: Studies of the action of volatile anesthetics on TOK1

Toxicology Letters

Volumn 100-101, Issue , 1998, Pages 293-300

  Yost, C Spencer ^a   Gray, Andrew T ^a   Winegar, Bruce D ^a   Leonoudakis, Dmitri ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

General anesthetic; K+ channels; TOK1; Volatile anesthetic

Indexed keywords

ANESTHETIC AGENT; DESFLURANE; HALOTHANE; INHALATION ANESTHETIC AGENT; ISOFLURANE; POTASSIUM CHANNEL;

ANIMAL CELL; APLYSIA; CONFERENCE PAPER; CONTROLLED STUDY; GRANULE CELL; NONHUMAN; OOCYTE; PRIORITY JOURNAL; XENOPUS;

ANESTHETICS, GENERAL; ANIMALS; HUMANS; NEURONS; POTASSIUM CHANNELS; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 0032445162     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(98)00198-2     Document Type: Conference Paper

References (21)

1. Blumenthal, T., Spieth, J., 1996. Gene structure and organization in Caenorhabditis elegans. Curr. Opin. Genet. Dev. 6, 692-698.
2. + channel. EMBO J. 15, 6854-6862.
3. Franks, N.P., Lieb, W.R., 1994. Molecular and cellular mechanisms of general anaesthesia. Nature 367, 607-614.
4. Goldstein, S.A., Price, L.A., Rosenthal, D.N., Pausch, M.H., 1996. ORK1, a potassium-selective leak channel with two pore domains cloned from Drosophila melanogaster by expression in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 93, 13256-13261.
5. Hille, B., 1992. Ionic channels of excitable membranes, 2nd Edition. Sinauer, Sunderland, MA, p. 74.
6. Hodgkin, A.L., Huxley, A.F., 1952. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physio. (Lond.) 117, 500-544.
7. Kandel, E.R., 1979. Behavioral Biology of Aplysia. W.H. Freeman, San Francisco, CA.
8. Ketchum, K.A., Joiner, W.J., Sellers, A.J., Kaczmarek, L.K., Goldstein, S.A., 1995. A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem. Nature 376, 690-695.
9. Koblin, D.D., Chortkoff, B.S., Laster, M.J., Eger, E.I., Halsey, M.J., Ionescu, P., 1994. Polyhalogenated and perfluorinated compounds that disobey the Meyer-Overton hypothesis. Anesth. Analg. 79, 1043-1048.
10. + channel with two pore domains and novel gating properties. J. Biol. Chem. 271, 4183-4187.
11. + channel with a novel structure. EMBO J. 15, 1004-1011.
12. + channel. FEBS Lett. 402, 28-32.
13. Lysko, G.S., Robinson, J.L., Castro, R., Ferrone, R.H., 1994. The stereospecific effects of isoflurane isomers in vivo. Eur. J. Pharm. 263, 25-29.
14. Mayeri, E., Rothman, B.S., Brownell, P.H., Branton, W.D., Padgett, L., 1985. Nonsynaptic characteristics of neurotransmission mediated by egg-laying hormone in the abdominal ganglion of Aplysia. J. Neurosci. 5, 2060-2077.
15. Mori, H., Palmer, R.E., Sternberg, P.W., 1994. The identification of a Caenorhabditis elegans homolog of p34cdc2 kinase. Mol. Gen. Genet. 245, 781-786.
16. Rogalski, T.M., Williams, B.D., Mullen, G.P., Moerman, D.G., 1993. Products of the unc-52 gene in Caenorhabditis elegans are homologous to the core protein of the mammalian basement membrane heparan sulfate proteoglycan. Genes Dev. 7, 1471-1484.
17. + channels in Aplysia sensory neurones. Nature 299, 413-417.
18. Wei, A., Jegla, T., Salkoff, L., 1996. Eight potassium channel families revealed by the C. elegans genome project. Neuropharmacol 35, 805-829.
19. Winegar, B.D., Owens, D.F., Yost, C.S., Forsayeth, J.R., Mayeri, E., 1996. Volatile general anesthetics produce hyperpolarization of Aplysia neurons by activation of a discrete population of baseline potassium channels. Anesthesiology 85, 889-900.
20. Winegar, B.D., Yost, C.S., 1997. Halothane directly activates potassium channels in Aplysia neurons. Anesth. Analg. Abstr. 84, S567.
21. Yoon, C.H., Lee, J., Jongeward, G.D., Sternberg, P.W., 1995. Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene ccbl. Science 269, 1102-1105.