Column switching achiral/chiral separation of the stereoisomers of 2-(S)-[3,5-bis(trifluoromethyl)benzyloxy]4-[(3-(5-oxo-1-H,4H-1,2,4 -triazolo)methyl]-3-(S)-phenylmorpholine in plasma

Enantiomer

Volumn 2, Issue 1, 1997, Pages 37-43

  Zagrobelny, J ^a   Matuszewski, B K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [3,5 BIS(TRIFLUOROMETHYL)BENZYLOXY] 4 (3 OXO 1,2,4 TRIAZOL 5 YLMETHYL) 3 PHENYLMORPHOLINE; 2 [3,5-BIS(TRIFLUOROMETHYL)BENZYLOXY] 4 [3 [5 OXO (1H,4H) 1,2,4 TRIAZOLO]METHYL] 3 PHENYLMORPHOLINE; SUBSTANCE P ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CHIRALITY; CONFERENCE PAPER; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; DRUG IDENTIFICATION; DRUG ISOLATION; ENANTIOMER; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; STEREOISOMERISM; TECHNIQUE; ULTRAVIOLET SPECTROPHOTOMETRY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; FEMALE; HYDROGEN-ION CONCENTRATION; INJECTIONS, INTRAVENOUS; MALE; MORPHOLINES; RECEPTORS, NEUROKININ-1; STEREOISOMERISM;

ANIMALIA; CANIS FAMILIARIS;

EID: 0030813916     PISSN: 10242430     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (21)

1. Simonyi, M., Fitos, I. and Visay, J. (1986). Trends Pharmacol. Sci., 7, 112.
2. Testa, B. (1986). Trends Pharmacol. Sci., 7, 60.
3. Drayer, D. E. D. (1986). Clin. Pharmacol. Ther., 40, 125.
4. Ariens, E. J. (1986). Trends Pharmacol. Sci., 5, 200.
5. Walle, T. and Walle, U. K. (1986). Trends Pharmacol. Sci., 7, 155.
6. Ariens, E. (1984). J. Eur. J. Clin. Pharmacol., 26, 663.
7. Matuszewski, B. K., Constanzer, M. L., Hessey II, G. A. and Bayne, W. F. (1990). Anal. Chem., 62, 1308.
8. Matuszewski, B. K., Constanzer, M. L., Hessey II, G. A. and Bayne, W. F. (1990). J. Chromatogr., 526, 461.
9. Matuszewski, B. K. and Constanzer, M. L. (1992). Chirality, 4, 515.
10. Matuszewski, B. K., Constanzer, M. L. and Kiganda, M. (1994). Pharm. Res., 11, 449.
11. Ferretti, R., Gallinella, B., Latorre, F. and Villani, C. (1995). J. Chromatogr. A., 704, 217.
12. Walbroehl, Y. and Wagner, J. (1994). J. Chromatogr. A, 680, 253.
13. Bazylak, G. (1994). J. Chromatogr. A, 668, 519.
14. Aboul-Enein, H. Y. and Serignese, V. (1994). Biomed. Chromatogr., 8, 22.
15. Wu, S. Y. and Casida, J. E. (1994). Chem. Res. Toxic., 7, 77.
16. Fieger, H., Iredale, J. and Wainer, I. W. (1993). Chirality, 5, 65.
17. Chosson, E., Uzan, S., Gimenez, F., Wainer, I. W. and Farinotti, R. (1993). Chirality, 5, 71.
18. Aubry, A. F. and Wainer, I. W. (1993). Chirality, 5, 84.
19. Fieger, H. and Wainer, I. W. (1993). J. Pharm. Biomed. Anal., 11, 1173.
20. Wainer, I. W. and Garnyille, C. P. (1993). Therap. Drug. Monitor., 15, 570.
21. Hale, J. J., Mills, S. G., MacCoss, M., Shah, S. K., Qi, H., Mathre, D. J., Cascieri, M. A., Sadowski, S., Strader, C. D., MacIntyre, D. E. and Metzger, J. M. (J. Med. Chem., submitted).