Enhanced expression of amyloid precursor protein in response to dibutyryl cyclic AMP is not mediated by the transcription factor AP-2

Journal of Neurochemistry

Volumn 68, Issue 3, 1997, Pages 909-916

  Bourbonnière, Martin ^a   Shekarabi, Masoud ^a   Nalbantoglu, Josephine ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Amyloid precursor protein; AP 2; Cyclic AMP; Expression; Regulation; Transcription

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BUCLADESINE; TRANSCRIPTION FACTOR AP 2;

ARTICLE; CELL STRAIN HEPG2; CONSENSUS SEQUENCE; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; ELECTROPHORETIC MOBILITY; GLIOMA CELL; HELA CELL; HUMAN; HUMAN CELL; HYBRID CELL; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE; TRANSCRIPTION REGULATION;

EID: 0031032434     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.68030909.x     Document Type: Article

References (78)

1. Arias J., Alberts A. S., Brindle P., Claret F. X., Smeal T., Karin M., Feramisco J., and Montminy M. (1994) Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature 370, 226-229.
2. Ausubel F. M., Brent R., Kingston R. E., Moore D. D., Seidman J. G., Smith J. A., and Struhl K., eds (1992) Short Protocols in Molecular Biology, 2nd edit., pp. 9-5. John Wiley & Sons, New York.
3. Berkowitz L. A., Riabowol K. T., and Gilman M. Z. (1989) Multiple sequence elements of a single functional class are required for cyclic AMP responsiveness of the mouse c-fos promoter. Mol. Cell. Biol. 9, 4272-4281.
4. Boshart M., Klüppel M., Schmidt A., Schütz G., and Luckow B. (1992) Reporter constructs with low background activity utilizing the cat gene. Gene 110, 129-130.
5. Bourbonnière M. and Nalbantoglu J. (1996) The helix-loop-helix transcription factor USF interacts with the basal promoter of human amyloid precursor protein. Mol. Brain Res. 35, 304-308.
6. Bravo R., Neuberg M., Burckhardt J., Almendral J., Wallich R., and Muller R. (1987) Involvement of common and cell type-specific pathways in c-fos gene control: stable induction by cAMP in macrophages. Cell 48, 251-260.
7. Buxbaum J. D., Gandy S. E., Cicchetti P., Ehrlich M. E., Czernik A. J., Fracasso R. P., Ramabhadran T. V., Unterbeck A. J., and Greengard P. (1990) Processing of Alzheimer β/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proc. Natl. Acad. Sci. USA 87, 6003-6006.
8. Buxbaum J. D., Koo E. H., and Greengard P. (1993) Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide. Proc. Natl. Acad. Sci. USA 90, 9195-9198.
9. Cai X. D., Golde T. E., and Younkin S. G. (1993) Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. Science 259, 514-516.
10. Chartier-Harlin M. C., Crawford F., Houlden H., Warren A., Hughes D., Fidani L., Goate A., Rossor M., Roques P., Hardy J., and Mullan M. (1991) Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene. Nature 353, 844-846.
11. Chernak J. M. (1993) Structural features of the 5′ upstream regulatory region of the gene encoding rat amyloid precursor protein. Gene 133, 255-260.
12. ++ channel activity in area CA1 of hippocampus. Proc. Natl. Acad. Sci. USA 88, 6467-6471.
13. Chrivia J. C., Kwok R. P., Lamb N., Hagiwara M., Montminy M. R., and Goodman R. H. (1993) Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365, 855-859.
14. Citron M., Oltersdorf T., Haass C., McConlogue L., Hung A. Y., Seubert P., Vigo-Pelfrey C., Lieberburg I., and Selkoe D. J. (1992) Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature 360, 672-674.
15. deGroot R. P. and Sassone-Corsi P. (1992) Activation of Jun/AP-1 by protein kinase A. Oncogene 7, 2281-2286.
16. Descheemaeker K. A., Wyns S., Nelles L., Auwer J., Ny T., and Collen D. (1992) Interaction of AP-1, AP-2, and Sp1-like proteins with two distinct sites in the upstream regulatory region of the plasminogen activator inhibitor-1 gene mediates the phorbol 12-myristate 13-acetate response. J. Biol. Chem. 267, 15086-15091.
17. Dewji N. N. and Do C. (1996) Heat shock factor-1 mediates the transcriptional activation of Alzheimer's β-amyloid precursor protein gene in response to stress. Mol. Brain Res. 35, 325-328.
18. Esch F., Keim P. S., Beattie E. C., Blacher R. W., Culwell A. R., Oltersdorf T., McClure D., and Ward P. J. (1990) Cleavage of amyloid β peptide during constitutive processing of its precursor. Science 248, 1122-1124.
19. Estus S., Golde T. E., Kunishita T., Blades D., Lowery D., Eisen M., Usiak M., Qu X. M., Tabira T., and Greenberg B. D. (1992) Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor. Science 255, 726-728.
20. Glenner G. G. and Wong C. W. (1984) Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 120, 885-890.
21. Goate A., Chartier Harlin M. C., Mullan M., Brown J., Crawford F., Fidani L., Giuffra L., Haynes A., Irving N., and James L. (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349, 704-706.
22. Golde T. E., Estus S., Younkin L. H., Selkoe D. J., and Younkin S. G. (1992) Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science 255, 728-730.
23. Goldgaber M., Lerman M. I., McBride O. W., Saffiotti U., and Gajdusek D. C. (1987) Characterization and chromosomal localization of a DNA encoding brain amyloid of Alzheimer's disease. Science 235, 877-880.
24. Goldgaber D., Harris H. W., Hla T., Maciag T., Donnelly R. J., Jacobsen J. S., Vitek M. P., and Gajdusek D. C. (1989) Interleukin 1 regulates synthesis of amyloid β-protein precursor mRNA in human endothelial cells. Proc. Natl. Acad Sci. USA 86, 7606-7610.
25. Gonzalez G. A. and Montminy M. R. (1989) Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59, 675-680.
26. Gray C. W. and Patel A. J. (1993a) Regulation of beta-amyloid precursor protein isoform mRNAs by transforming growth factor-beta 1 and interleukin-1 beta in astrocytes. Mol. Brain Res. 19, 251-256.
27. Gray C. W. and Patel A. J. (1993b) Induction of beta-amyloid precursor protein isoform mRNAs by bFGF in astrocytes. Neuroreport 4, 811-814.
28. Greco D., Zellmer E., Zhang Z., and Lewis E. (1995) Transcription factor AP-2 regulates expression of the dopamine β-hydroxylase gene. J. Neurochem. 65, 510-516.
29. Grummt I. (1981) Specific transcription of mouse ribosomal DNA in a cell-free system that mimics control in vivo. Proc. Natl. Acad. Sci. USA 78, 727-731.
30. Haass C., Koo E. H., Mellon A., Hung A. Y., and Selkoe D. J. (1992a) Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature 357, 500-503.
31. Haass C., Schlossmacher M. G., Hung A. Y., Vigo-Pelfrey C., Mellon A., Ostaszewski B. L., Lieberburg I., Koo E. H., Schenk D., and Teplow D. B. (1992b) Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature 359, 322-325.
32. Hoffman P. W. and Chernak J. M. (1995) DNA binding and regulatory effects of transcription factors Sp1 and USF at the rat amyloid precursor protein gene promoter. Nucleic Acids Res. 23, 2229-2235.
33. Hung A. Y., Haass C., Nitsch R. M., Qiu W. Q., Citron M., Wurtman R. J., Growdon J. H., and Selkoe D. J. (1993) Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. J. Biol. Chem. 268, 22959-22962.
34. Imagawa M., Chiu R., and Karin M. (1987) Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP. Cell 51, 251-260.
35. Imataka H., Sogawa K., Yasumoto K., Kikuchi Y., Sasano K., Kobayashi A., Hayami M., and Fujii-Kuriyama Y. (1992) Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene. EMBO J. 11, 3663-3670.
36. Izumi R., Yamada T., Yoshikai S., Sasaki H., Hattori M., and Sakaki Y. (1992) Positive and negative regulatory elements for the expression of the Alzheimer's disease amyloid precursor-encoding gene in mouse. Gene 112, 189-195.
37. Kang J., Lemaire H.-G., Unterbeck A., Salbaum J. M., Masters C. L., Grzeschik K. H., Multhaup G., Beyreuther K., and Muller-Hill B. (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733-736.
38. Kovacs D. M., Wasco W., Witherby J., Felsenstein K. M., Brunel F., Roeder R. G., and Tanzi R. E. (1995) The upstream stimulatory factor functionally interacts with the Alzheimer amyloid β-protein precursor gene. Hum. Mol. Genet. 4, 1527-1533.
39. Krupinski J. (1991) The adenyl cyclase family. Mol. Cell. Biochem. 104, 73-79.
40. Kwok R. P. S., Lundblad J. R., Chrivia J. C., Richards J. P., Bachinger H. P., Brennan R. G., Roberts S. G. E., Green M. R., and Goodman R. H. (1994) Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 370, 223-226.
41. Lahiri D. K. and Nall C. (1995) Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1. Mol. Brain Res. 32, 233-240.
42. Lavrovsky Y., Abraham N. G., Levere R. D., Lavrovsky V., Schwartzman M. L., and Kappas A. (1994) Characterization of a 142-bp fragment of the murine c-fos oncogene promoter upstream of the SIF-binding element. Gene 142, 285-290.
43. Lillie J. W. and Green M. R. (1989) Transcription activation by the adenovirus E1a protein. Nature 338, 39-44.
44. Lüscher B., Mitchell P. J., Williams T., and Tjian R. (1989) Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers. Genes Dev. 3, 1507-1517.
45. MacGregor P. F., Abate C., and Curran T. (1990) Direct cloning of leucine zipper proteins: jun binds cooperatively to the CRE and CRE-BP1. Oncogene 5, 451-458.
46. Masters C. L., Simms G., Weinmann N. A., Multhaup G., McDonald B. L., and Beyreuther K. (1985) Amyloid plaque core protein in Alzheimer's disease and Down's syndrome. Proc. Natl. Acad. Sci. USA 82, 4245-4249.
47. McKnight G. S. (1991) Cyclic AMP second messenger systems. Curr. Opin. Cell Biol. 3, 213-217.
48. Medcalf R. L., Ruegg M., and Schleuning W.-D. (1990) A DNA motif related to the cAMP-responsive element and an exon-located activator protein-2 binding site in the human tissue-type plasminogen activator gene promoter cooperate in basal expression and convey activation by phorbol ester and cAMP. J. Biol. Chem. 265, 14618-14626.
49. Mitchell P. J., Wang C., and Tjian R. (1987) Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen. Cell 50, 847-861.
50. Mitchell P. J., Timmons P. M., Hébert J. M., Rigby P. W. J., and Tjian R. (1991) Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis. Genes Dev. 5, 105-119.
51. Mullan M., Crawford F., Axelman K., Houlden H., Lilius L., Winblad B., and Lannfelt L. (1992) A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nat. Genet. 1, 345-347.
52. Murrell J., Farlow M., Ghetti B., and Benson M. D. (1991) A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science 254, 97-99.
53. Nitsch R. M., Slack B. E., Wurtman R. J., and Growdon J. H. (1992) Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science 258, 304-307.
54. Park K. and Kim K.-H. (1993) The site of cAMP action in the insulin induction of gene expression of acetyl-CoA carboxylase is AP-2 J. Biol. Chem. 268, 17811-17819.
55. Quitschke W. W. and Goldgaber D. (1992) The amyloid beta-protein precursor promoter. A region essential for transcriptional activity contains a nuclear factor binding domain. J. Biol. Chem. 267, 17362-17368.
56. Refolo L. M., Salton S. R., Anderson J. P., Mehta P., and Robakis N. K. (1989) Nerve and epidermal growth factors induce the release of the Alzheimer amyloid precursor from PC 12 cell cultures. Biochem. Biophys. Res. Commun. 164, 664-670.
57. Robakis N. K., Ramakrishna N., Wolfe G., and Wisniewski H. M. (1987) Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. Proc. Natl. Acad. Sci. USA 84, 4190-4194.
58. Roberts S. B., Ripellino J. A., Ingalls K. M., Robakis N. K., and Felsenstein K. M. (1994) Non-amyloidogenic cleavage of the beta-amyloid precursor protein by an integral membrane metalloendopeptidase. J. Biol. Chem. 269, 3111-3116.
59. Salbaum J. M., Weidemann A., Lemaire H.-G., Masters C. L., and Beyreuther K. (1988) The promoter of Alzheimer's disease amyloid A4 precursor gene. EMBO J. 7, 2807-2813.
60. Sambrook J., Fritsch E. F., and Maniatis T. (1989) Molecular Cloning. A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
61. Sassone-Corsi P., Ransone L. J., and Verma I. M. (1990) Cross-talk in signal transduction: TPA-inducible factor jun/AP-1 activates cAMP-responsive enhancer elements. Oncogene 5, 427-431.
62. Schilling K., Luk D., Morgan J. I., and Curran T. (1991) Regulation of a fos-lacZ fusion gene: a paradigm for quantitative analysis of stimulus-transcription coupling. Proc. Natl. Acad. Sci. USA 88, 5665-5669.
63. Schorle H., Meier P., Buchert M., Jaenisch R., and Mitchell P. J. (1996) Transcription factor AP-2 essential for cranial closure and craniofacial development. Nature 381, 235-238.
64. Seamon K. D. and Daly J. W. (1986) Forskolin: its biological and chemical properties. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1-150.
65. Selkoe D. J. (1994) Normal and abnormal biology of the β-amyloid precursor protein. Annu. Rev. Neurosci. 17, 489-517.
66. Seubert P., Vigo-Pelfrey C., Esch F., Lee M., Dovey H., Davis D., Sinha S., Schlossmacher M., Whaley J., and Swindlehurst C. (1992) Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids. Nature 359, 325-327.
67. Seubert P., Oltersdorf T., Lee M. G., Barbour R., Blomquist C., Davis D. L., Bryant K., Fritz L. C., Galasko D., and Thai L. J. (1993) Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide. Nature 361, 260-263.
68. Shoji M., Golde T. E., Ghiso J., Cheung T. T., Estus S., Shaffer L. M., Cai X. D., McKay D. M., Tintner R., and Frangione B. (1992) Production of the Alzheimer amyloid beta protein by normal proteolytic processing. Science 258, 126-129.
69. Slack B. E., Nitsch R. M., Livneh E., Kunz G. M. Jr., Breu J., Eldar H., and Wurtman R. J. (1993) Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 fibroblasts overexpressing protein kinase C alpha. J. Biol. Chem. 268, 21097-21101.
70. Tanzi R. E., Gusella J. F., Watkins P. C., Bruns G. A. P., St. George-Hyslop P., van Keuren M. L., Patterson D., Pagan S., Kurnit D. M., and Neve R. L. (1987) Amyloid β protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 235, 880-883.
71. Trejo J., Massamiri T., Deng T., Dewji N. N., Bayney R. M., and Brown J. H. (1994) A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's β-amyloid precursor protein gene. J. Biol. Chem. 269, 21682-21690.
72. Vostrov A. A., Quitschke W. W., Vidal F., Schwarzman A. L., and Goldgaber D. (1995) USF binds to the APBα sequence in the promoter of the amyloid β-protein precursor gene. Nucleic Acids Res. 23, 2734-2741.
73. Weidemann A., König G., Bunke D., Fischer P., Salbaum J. M., Masters C. L., and Beyreuther K. (1989) Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell 57, 115-126.
74. Williams T. and Tjian R. (1991a) Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins. Science 251, 1067-1071.
75. Williams T. and Tjian R. (1991b) Analysis of the DNA-binding and activation properties of the human transcription factor AP-2. Genes Dev. 5, 670-682.
76. Williams T., Admon A., Lüscher B., and Tjian R. (1988) Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements. Genes Dev. 2, 1557-1569.
77. Wolozin B., Lesch P., Lebovics R., and Sunderland T. (1993) Olfactory neuroblasts from Alzheimer donors: studies on APP processing and cell regulation. Biol. Psychiatry 34, 824-838.
78. Zhang J., Hagopian-Donaldson S., Serbedzija G., Elsemore J., Plehn-Dujowich D., McMahon A. P., Flavell R. A., and Williams T. (1996) Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature 381, 238-241.