Regulation of cytokine gene expression in experimental autoimmune encephalomyelitis

Journal of Neuroscience Research

Volumn 46, Issue 4, 1996, Pages 438-444

  Zitron, Ian M ^b   Reddy, B Praveen ^a   Gould, Karen E ^a   Stepaniak, Jolie A ^a   Swanborg, Robert H ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WILLIAM BEAUMONT HOSPITAL   (United States)

Author keywords

CFA; MBP; suppressor T cells

Indexed keywords

GAMMA INTERFERON;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CELL ACTIVITY; CELL CULTURE; ENCEPHALOMYELITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; SUPPRESSOR CELL;

ACUTE DISEASE; ANIMALS; CELLS, CULTURED; CONVALESCENCE; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GENE EXPRESSION REGULATION; INTERFERON TYPE II; LYMPHOCYTE ACTIVATION; POLYMERASE CHAIN REACTION; RATS; RATS, INBRED LEW; RNA, MESSENGER; SPLEEN; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 0029829471     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19961115)46:4<438::AID-JNR5>3.0.CO;2-H     Document Type: Article

References (27)

1. Chomczynski P, Sacchi N (1987): Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chlorofom extraction. Anal Biochem 162:156-159.
2. Dore-Duffy P, Balabanov R, Washington R, Swanborg RH (1994): Transforming growth factor betal inhibits cytokine-induced CNS endothelial cell activation. Mol Chem Neuropathol 22: 161-175.
3. Dore-Duffy P, Balabanov R, Rafols J, Swanborg RH (1996): Recovery phase of acute experimental autoimmune encephalomyelitis in rats corresponds to development of endothelial cell unresponsiveness to interferon gamma activation. J Neurosci Res 44:223-234.
4. Issazadeh S, Mustafa M, Ljungdahl A, Hojeberg B, Dagerlind A, Elde R, Olsson T (1995): Interferon gamma, interleukin 4 and transforming growth factor beta in experimental autoimmune encephalomyelitis in Lewis rats: dynamics of cellular mRNA expression in the central nervous system and lymphoid cells. J Neurosci Res 40:579-590.
5. Johns LD, Flanders KC, Ranges GE, Sriram S (1991): Successful treatment of experimental allergic encephalomyelitis with transforming growth factor-betal. J Immunol 147:1792-1796.
6. Karpus WJ, Swanborg RH (1989): CD4 + suppressor cells differentially affect the production of IFN-gamma by effector cells of experimental autoimmune encephalomyelitis. J Immunol 143: 3492-3497.
7. Karpus WJ, Swanborg RH (1991): CD4 + suppressor cells inhibit the function of effector cells of experimental autoimmune encephalomyelitis through a mechanism involving transforming growth factor-beta. J Immunol 146:1163-1168.
8. Kiefer R, Funa K, Schweitzr T, Jung S. Bourde O, Toyka KV, Hartung H-P (1996): Transforming growth factor-betal in experimental autoimmune neuritis: cellular localization and time course. Am J Pathol 148:211-223.
9. Kuruvilla AP, Shah R, Hochwald GM, Liggitt HD, Palladino MA, Thorbecke GJ (1991): Protective effect of transforming growth factor betal on experimental autoimmune diseases in mice. Proc Natl Acad Sci USA 88:2918-2921.
10. Lider O, Santos LMB, Lee CSV, Higgins PJ, Weiner HL (1989): Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. II. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8 + T lymphocytes. J Immunol 142:748-752.
11. McDonald AH, Swanborg RH (1988): Antigen-specific inhibition of immune interferon production by suppressor cells of autoimmune encephalomyelitis. J Immunol 140:1132-1138.
12. Miller A, Lider O, Roberts AB, Sporn MB, Weiner HL (1992): Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. Proc Natl Acad Sci USA 89:421-425.
13. Mustafa MI, Diener P, Höjeberg B, Van der Meide P, Olsson T (1991): T cell immunity and interferon-gamma secretion during experimental allergic encephalomyelitis in Lewis rats. J Neuroimmunol 31:165-177.
14. Paterson PY, Swanborg RH (1988): Demyelinating diseases of the central and peripheral nervous systems. In Samter M, Talmage DW, Frank MM, Austen KF, Claman HN (eds): "Immunological Diseases." Boston: Little, Brown and Company, pp 1877-1916.
15. Powell MB, Mitchell D, Lederman J, et al. (1990): Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity. Int Immunol 2:539-554.
16. Qian SW, Kondaiah P, Roberts AB, Sporn MB (1990): cDNA cloning by PCR of rat transforming growth factor-beta 1. Nucleic Acids Res 18:3059.
17. Racke MK, Dhib-Jalbut S, Cannella B, Albert PS, Raine CS, McFarlin DE (1991): Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-betal. J Immunol 146:3012-3017.
18. Ruddle NH, Bergman CM, McGrath KM, et al. (1990): An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis. J Exp Med 172:1193-1200.
19. Santambrogio L, Hochwald GM, Saxena B, Leu C-H, Martz JE, Carlino JA, Ruddle NH, Palladino MA, Gold LI, Thorbecke GJ (1994): Studies on the mechanisms by which transforming growth factor-beta protects against allergic encephalomyelitis. J Immunol 151:1116-1127.
20. Schluesener HJ, Lider O (1989): Transforming growth factors betal and beta2: cytokines with identical immunosuppressive effects and potential role in the regulation of autoimmune T cell function. J Neuroimmunol 24:249-258.
21. Stevens DB, Gould KE, Swanborg RH (1994): Transforming growth factor-betal inhibits tumor necrosis factor-alpha/lymphotoxin production and adoptive transfer of disease by effector cells of autoimmune encephalomyelitis. J Neuroimmunol 51:77-83.
22. Stoll G, Muller S, Schmidt B, et al. (1993): Localization of interferon-gamma and Ia-antigen in T cell line-mediated experimental autoimmune encephalomyelitis. Am J Pathol 142:1866-1875.
23. Swanborg RH (1988): Experimental allergic encephalomyelitis. Methods Enzymol 162:413-421.
24. Swierkosz JE, Swanborg RH (1975): Suppressor cell control of unresponsiveness to experimental allergic encephalomyelitis. J Immunol 115:631-633.
25. Vandenbark AA, Vainiene M, Celnik B, Hashim GA, Buenafe A, Offner H (1994): Definition of encephalitogenic and immunodominant epitopes of guinea pig myelin basic protein (Gp-BP) in Lewis rats tolerized neonatally with Gp-BP or Gp-BP peptides. J Immunol 153:852-861.
26. Welch AM, Holda JH, Swanborg RH (1980): Regulation of experimental allergic encephalomyelitis. II Appearance of suppressor cells during the remission phase of the disease. J Immunol 125:186-189.
27. Willenborg DO (1979): Experimental allergic encephalomyelitis in the Lewis rat: studies on the mechanism of recovery from disease and acquired resistance to reinduction. J Immunol 123:1145-1150.