Reversal of hypocalcemia and decreased afterload in sepsis: Effect on myocardial systolic and diastolic function

American Journal of Respiratory and Critical Care Medicine

Volumn 158, Issue 6, 1998, Pages 1990-1998

  Kovacs, Attila ^a   Courtois, Michael R ^a   Barzilai, Benico ^a   Karl, Irene E ^a   Ludbrook, Philip A ^a   Hotchkiss, Richard S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIASTOLE; HEART AFTERLOAD; HEART MUSCLE CONTRACTILITY; HYPOCALCEMIA; NONHUMAN; PRIORITY JOURNAL; RAT; SEPSIS; SYSTOLE;

EID: 0032416949     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.158.6.9804114     Document Type: Article

References (38)

1. Dellinger, R. P., S. M. Opal, D. Rotrosen, R. A. Goldstein, S. Hurd, and J. L. Vincent. 1997. From the bench to the bedside: the future of sepsis research. Chest 111:744-753.
2. Bone, R. C. 1996. Immunologic dissonance: a continuing evolution in our understanding of the systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS). Ann. Intern. Med. 125:680-687.
3. Parrillo, J. E. 1993. Pathogenetic mechanisms of septic shock. N. Engl. J. Med. 328:1471-1477.
4. Lapinsky, S. E., J. Gold, and R. F. Grossman. 1994. Acute reversible cardiomyopathy associated with the systemic inflammatory response syndrome. Chest 105:298-301.
5. Parrillo, J. E. 1990. Septic shock in humans: advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy. Ann. Intern. Med. 113:227-242.
6. Abel, F. L. 1989. Myocardial function in sepsis and endotoxin shock. Am. J. Physiol. 257:R1265-R1281.
7. Parker, J. L., R. A. Keller, L. L. Behm, and H. R. Adams. 1990. Left ventricular dysfunction in early E. coli endotoxemia: effects of naloxone. Am. J. Physiol. 259:H504-H511.
8. McDonough, K. H., C. H. Lang, and J. J. Spitzer. 1985. The effect of hyperdynamic sepsis on myocardial performance. Circ. Shock 15:247-259.
9. Archer, L. T. 1985. Myocardial dysfunction in endotoxin- and E. coli-induced shock: pathophysiological mechanisms. Circ. Shock 15:261-280.
10. Soloman, M. A., R. Correa, H. R. Alexander, L. A. Koev, J. P. Cobb, D. K. Kim, W. C. Roberts, Z. M. N. Quezado, T. D. Scholz, R. E. Cunnion, W. D. Hoffman, J. Bacher, I. Yatsiv, R. L. Danner, S. M. Banks, V. J. Ferrans, R. S. Balaban, and C. Natanson. 1994. Myocardial energy metabolism and morphology in a canine model of sepsis. Am. J. Physiol. 266:H757-H768.
11. Hotchkiss, R. S., S. K. Song, J. J. Neil, R. D. Chen, J. K. Manchester, I. E. Karl, O. H. Lowry, and J. J. H. Ackerman. 1991. Sepsis does not impair tricarboxylic acid cycle in the heart. Am. J. Physiol. 260:C50-C57.
12. Dhainaut, J. F., M. F. Huyghebaert, J. F. Monsallier, G. Lefevre, J. Dall'Ava-Santucci, F. Brunet, D. Villemant, A. Carli, and D. Raichvarg. 1987. Coronary hemodynamics and myocardial metabolism of lactate, free fatty acids, glucose, and ketones in patients with septic shock. Circulation 75:533-541.
13. Zaloga, G. P. 1992. Hypocalcemia in critically ill patients. Crit. Care Med. 20:251-262.
14. Hotchkiss, R. S., and I. E. Karl. 1996. Calcium: a regulator of the inflammatory response in endotoxemia and sepsis. New Horiz. 4:58-71.
15. Wichterman, K. A., A. E. Baue, and I. H. Chandry. 1980. Sepsis and septic shock: a review of laboratory models and a proposal. J. Surg. Res. 29:189-201.
16. Courtois, M., C. J. Mechem, B. Barzilai, F. Gutierrez, and P. A. Ludbrook. 1994. Delineation of determinants of left ventricular early filling: saline versus blood. Circulation 90:2041-2050.
17. Courtois, M., B. Barzilai, A. F. Hall, and P. A. Ludbrook. 1997. Postextrasystolic left ventricular isovolumic pressure decay is not monoexponential. Cardiovas. Res. 35:206-216.
18. Mirsky, I. 1984. Assessment of diastolic function: suggested methods and future considerations. Circulation 69:836-841.
19. Schiller, N. B., P. M. Shah, M. Crawford, A. DeMaria, R. Devereux, H. Feigenbaum, H. Gutgesell, N. Reichek, D. Sahn, I. Schnittger, N. H. Silverman, and A. J. Tajik. 1989. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. ASE Committee on Standards. J. Am. Soc. Echocardiogr. 2:358-367.
20. Grossman, W., E. Braunwald, T. Mann, L. P. McLaurin, and L. H. Green. 1997. Contractile state of the left ventricle in man as evaluated from the end-systolic pressure-volume relation. Circulation 56:845-852.
21. Colan, S. D., K. M. Borow, and A. Neumann. 1984. The left ventricular end-systolic wall stress-velocity of fiber shortening relation: a load independent index of myocardial contractility. J. Am. Coll. Cardiol. 4: 715-724.
22. Hoit, B. D., Z. U. Khan, C. M. Pawloski-Dahm, and R. A. Walsh. 1997. In vivo determination of left ventricular wall stress-shortening relationship in normal mice. Am. J. Physiol. 272:H1047-H1052.
23. Fentzke, R. C., C. E. Korcarz, S. G. Shroff, H. Lin, J. Sandelski, J. M. Leiden, and R. M. Lang. 1997. Evaluation of ventricular and arterial hemodynamics in anesthetized closed-chest mice. J. Am. Soc. Echocardiogr. 10:915-925.
24. Hotchkiss, R. S., S. K. Song, C. S. Ling, S. Cliff, J. J. Ackerman, and I. E. Karl. 1990. Sepsis does not alter red blood cell glucose metabolism or Na+ concentration: a 2H-, 23Na-NMR study. Am. J. Physiol. 258: R21-R31.
25. Natanson, C., P. F. Mitchell, H. K. Ballantyne, T. MacVittie, J. J. Conklin, and J. E. Parillo. 1986. Gram-negative bacteremia produces both severe systolic and diastolic cardiac dysfunction in a canine model that simulates human septic shock. J. Clin. Invest. 78:259-270.
26. Hung, J., and Y. W. Lew Wilbur. 1993. Cellular mechanisms of endotoxin-induced myocardial depression in rabbits. Circ. Res. 73:125-134.
27. Parker, J. L., L. Janet, and H. R. Adams. 1981. Contractile dysfunction of atrial myocardium from endotoxin-shocked guinea pigs. Am. J. Physiol. 240:H954-H962.
28. i and contractility in isolated adult rabbit ventricular myocytes. Am. J. Physiol. 271:H1449-H1455.
29. Deitch, E. A. 1998. Animal models of sepsis and shock: a review and lessons learned. Shock 9:1-11.
30. Hotchkiss, R. S., and I. E. Karl. 1994. Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in mouse model of endotoxemia. Proc. Natl. Acad. Sci. U.S.A. 91:3039-3043.
31. Song, S. K., I. E. Karl, J. J. H. Ackerman, and R. S. Hotchkiss. 1993. Increased intracellular Ca2+: a critical link in the pathophysiology of sepsis? Proc. Natl. Acad. Sci. U.S.A. 90:3933-3937.
32. 2+ regulation or signaling. Am. J. Physiol. 259:G56-G61.
33. Piper, R. D., F. Y. Li, M. L. Myers, and W. J. Sibbald. 1997. Structure-function relationships in the septic rat heart. Am. J. Respir. Crit. Care Med. 156:1473-1482.
34. Schnornack, P. A., S. Sheng-Kwei, R. S. Hotchkiss, and J. J. H. Ackerman. 1997. Inhibition of ion transport in septic rat heart: 133Cs+ as an NMR active K+ analog. Am. J. Physiol. 272:C1635-C1641.
35. Colbert, M. C., D. G. Hall, T. R. Kimball, S. A. Witt, J. N. Lorenz, M. L. Kirby, T. E. Hewett, R. Klevitsky, and J. Robbins. 1997. Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice. J. Clin. Invest. 100:1958-1968.
36. Osnes, J.-B., H. Refsum, T. Skomedal, and I. Oye. 1978. Qualitative differences between β-adrenergic and α-adrenergic inotropic effects in rat heart muscle. Acta. Pharmacol. Toxicol. 42:235-247.
37. Carabello, B. A., L. H. Green, W. Grossman, L. H. Cohn, J. K. Koster, and J. J. Collins. 1980. Hemodynamic determinants of prognosis of aortic valve replacement in critical aortic stenosis and advanced congestive heart failure. Circulation 62:42-48.
38. Hoit, B. D., Y. Shao, M. Gabel, R. A. Walsh. 1995. Disparate effects of early pressure overload hypertrophy on velocity-dependent and force-dependent indices of ventricular performance in the conscious baboon. Circulation 91:1213-1220.