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Treatment of B-cell lymphomas with anti-idiotype antibodies alone and in combination with alpha interferon
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The anti-tumor effect of monoclonal anti-CD20 antibody (mAb) therapy includes direct anti-proliferative activity and induction of apoptosis in CD20 positive non-Hodgkin's lymphoma (NHL) cell lines
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Maloney DG, Smith B, Appelbaum FR: The anti-tumor effect of monoclonal anti-CD20 antibody (mAb) therapy includes direct anti-proliferative activity and induction of apoptosis in CD20 positive non-Hodgkin's lymphoma (NHL) cell lines. Blood 1996, 88:637a.
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Phase I clinical trial using escalating single-dose infusion of chimeric anti-CD20 monoclonal antibody (IDEC-C2B8) in patients with recurrent B-cell lymphoma
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IDEC-C2B8 (rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma
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Maloney DG, Grillo-Lopez AJ, White CA, Bodkin D, Schilder RJ, Neidhart •• JA, et al.: IDEC-C2B8 (rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma. Blood 1997, 90:2188-2195. This article describes the treatment of 37 patients using rituxan at 375 mg/m2. Thirty-four of these patients had low-grade or follicular NHL, and there was a 50% response rate, with a 10.4 months median-duration time to progression. Minimal infusional symptoms were noted. Peripheral blood B cells were depleted, but there was no increase in infections. Patients with a follicular histology had a higher response rate. Responses were observed even in patients with bulky disease.
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Pawson R, Dyer MJ, Barge R, Matutes E, Thornton PD, Emmett E, Kluin-• Nelemans JC, Fibbe WE, Willemze R, Catovsky D: Treatment of T-cell prolymphocytic leukemia with human CD52 antibody. J Clin Oncol 1997, 15:2667-2672. Although a rare disease, this illustrates the activity of Campath-1H mAb. Overall, 11 of 15 patients responded to the mAb and nine had a CR. Complications included marrow aplasia in two patients. However, this is a dramatic effect in patients with a usually rapidly fatal disease. Two patients went on to successful autografts while in remission using stem cells collected during first CR.
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Osterborg A, Dyer MJ, Bunjes D, Pangalis GA, Bastion Y, Catovsky D, •• Mellstedt H: Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia: European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia. J Clin Oncol 1997, 15:1567-1574. The response rate in previously treated chronic lymphocytic leukemia was 42%, however 28 of 29 patients cleared the peripheral blood of chronic lymphocytic leukemia cells, but only 36% cleared the bone marrow. Minimal effects were observed in lymph nodes. First infusion symptoms were moderate and six patients developed serious infections from the resulting immunodeficiency.
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A multicenter phase II study of iodine-131 anti-B1 antibody (Bexxar) in patients with chemotherapy-relapsed/refractory low-grad or transformed low grade B cell non-Hodgkin's lymphoma
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Kaminski MS, Vose J, Saleh M, Lister A, Knox S, Crowther D, et al.: A multicenter phase II study of iodine-131 anti-B1 antibody (Bexxar) in patients with chemotherapy-relapsed/refractory low-grad or transformed low grade B cell non-Hodgkin's lymphoma [abstract]. Blood 1997, 90:509a.
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Matthews DC, Appelbaum FR, Eary JF, Fisher DR, Durack LD, Bush SA, Hui TE, Martin PJ, Mitchell D, Press OW, et al.: Development of a marrow transplant regimen for acute leukemia using targeted hematopoietic irradiation delivered by 131I-labeled anti-CD45 antibody, combined with cyclophosphamide and total body irradiation. Blood 1995, 85:1122-1131.
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Serotherapy of B-cell neoplasms with anti-B4-blocked ricin: A phase I trial of daily bolus infusion
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A phase I study of bolus versus continuous infusion of the anti-CD19 immunotoxin, IgG-HD37-dgA, in patients with B-cell lymphoma
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Stone MJ, Sausville EA, Fay JW, Headlee D, Collins RH, Figg WD, et al.: A phase I study of bolus versus continuous infusion of the anti-CD19 immunotoxin, IgG-HD37-dgA, in patients with B-cell lymphoma. Blood 1996, 88:1188-1197.
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Sievers EL, Appelbaum FA, Spielberger RT, Forman SJ, Flowers DA, Berger MS, Shannon-Dorcy K, Bernstein ID: Selective ablation of acute myeloid leukemia using an anti-CD33 chlicheamicin immunoconjugate. Blood 1997, 90:504a.
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LeMaistre CF, Saleh MN, Kuzel TM, Foss F, Platanias LC, Schwartz G, •• Ratain M, Rook A, Freytes CO, Craig F, Reuben J, Nichols JC: Phase I trial of a ligand fusion-protein (DAB389IL-2) in lymphomas expressing the receptor for interleukin-2. Blood 1998, 91:399-405. This is a large trial of the DAB389IL-2 fusion toxin in patients with CD25 positive malignancies. Activity was observed in patients with cutaneous T-cell lymphoma (13 of 35), NHL (3 of 17), but no responses were observed in 21 patients with Hodgkin's disease.
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Pivotal phase III trial of two dose levels of DAB 389IL-2 (Ontaka) for the treatment of mycosis fungoides
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Kuzel T, Olsen E, Martin A, Kim Y, Duvic M, Frankel A, et al.: Pivotal phase III trial of two dose levels of DAB 389IL-2 (Ontaka) for the treatment of mycosis fungoides. Blood 1997, 90:586a.
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Donor leukocyte infusions are effective in relapsed multiple myeloma after allogeneic bone marrow transplantation
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Lokhorst HM, Schattenberg A, Cornelissen JJ, Thomas LL, Verdonck LF: • Donor leukocyte infusions are effective in relapsed multiple myeloma after allogeneic bone marrow transplantation. Blood 1997, 90:4206-4211. This article describes donor lymphocyte infusions in 13 patients with relapsed myeloma following allografting. Eight of 13 patients responded, and seven of these developed acute graft-versus-host disease. Higher T-cell doses induced greater graft-versus-host disease and a higher response rate. (See Bonini et al., Science 1997, 276:1719-1724 for a means to control graft-versus-host disease).
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Blood
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Lokhorst, H.M.1
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Lokhorst HM, Schattenberg A, Cornelissen JJ, Thomas LL, Verdonck LF: • Donor leukocyte infusions are effective in relapsed multiple myeloma after allogeneic bone marrow transplantation. Blood 1997, 90:4206-4211. This article describes donor lymphocyte infusions in 13 patients with relapsed myeloma following allografting. Eight of 13 patients responded, and seven of these developed acute graft-versus-host disease. Higher T-cell doses induced greater graft-versus-host disease and a higher response rate. (See Bonini et al., Science 1997, 276:1719-1724 for a means to control graft-versus-host disease).
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Science
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Bonini, C.1
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