Growth hormone deficiency and cardiovascular risk

Bailliere's Clinical Endocrinology and Metabolism

Volumn 12, Issue 2, 1998, Pages 199-216

  Hew, F L ^a   O'Neil, D ^a   Kamarudin, N ^a   Alford, F P ^a   Best, J D ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Adults; Atherosclerosis; Dyslipidaemia; Growth hormone deficiency; Growth hormone therapy; Hypertension; Hypopituitarism; Insulin resistance; Insulinaemia; Obesity

Indexed keywords

CHOLESTEROL; HUMAN GROWTH HORMONE; INSULIN; LIPOPROTEIN A;

BLOOD CLOTTING DISORDER; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; DYSLIPIDEMIA; FOLLOW UP; GROWTH HORMONE DEFICIENCY; HORMONE SUBSTITUTION; HUMAN; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; OBESITY; PSYCHOLOGICAL ASPECT; REVIEW; WELLBEING;

EID: 0032406718     PISSN: 0950351X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0950-351X(98)80018-9     Document Type: Article

References (70)

1. Al-Shoumer KAS Cox KH Hughes CL Fasting and postprandial lipid abnormalities in hypopituitary women receiving conventional replacement therapy Journal of Clinical Endocrinology and Metabolism 82 1997 2653 2659
2. Angelin B Rudling M Growth hormone and lipoprotein metabolism Endocrinology and Metabolism 2 supplement B 1995 25 28
3. Attanasio AF Lamberts SWJ Matranga AMC Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment Journal of Clinical Endocrinology and Metabolism 82 1997 82 88
4. Austin MA Breslow JL Hennekens CH Low density lipoprotein subclass patterns and risk of myocardial infarction Journal of the American Medical Association 260 1988 1917 1921
5. Bengtsson BA Eden S Lonn L Treatment of adults with growth hormone (GH) deficiency with recombinant human GH Journal of Clinical Endocrinology and Metabolism 76 1993 309 317
6. Beshyah SA Henderson A Niththyananthan R Metabolic abnormalities in growth hormone deficient adults II, carbohydrate tolerance and lipid metabolism Endocrinology and Metabolism 1 1994 173 180
7. Beshyah SA Rutherford OM Thomas E Assessment of regional body composition by dual energy X-Ray absorptiometry in hypopituitary adults before and during growth hormone treatment Endocrinology and Metabolism 2 1995 147 155
8. Beshyah SA Henderson A Niththyananthan R The effects of short and long term growth hormone replacement therapy in hypopituitary adults on lipid metabolism and carbohydrate tolerance Journal of Clinical Endocrinology and Metabolism 80 1995 356 363
9. Beshyah SA Henderson A Baynes C Post-heparin plasma lipase activity in hypopituitary adults Hormone Research 442 1995 69 74
10. Binnerts A Swart GR Wilson PJH The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body composition Clinical Endocrinology 37 1992 79 87
11. Bjorntorp P Metabolic implications of body fat distribution Diabetes Care 14 1991 1132 1143
12. de Boer H Blok GJ Voerman HJ Body composition in adult growth hormone deficient men, assessed by anthropometry and bioimpedence analysis Journal of Clinical Endocrinology and Metabolism 75 1992 833 837
13. de Boer H Blok GJ Voerman HJ Serum lipid levels in growth hormone deficient men Metabolism 43 1994 199 203
14. de Boer H Blok GJ van der Veen EA Clinical aspects of growth hormone deficiency in adults Endocrinology Review 16 1995 63 86
15. Burman P Johansson AG Siegbahn A Growth hormone (GH)-deficient men are more responsive to GH replacement therapy than women Journal of Clinical Endocrinology and Metabolism 82 1997 550 555
16. Caidahl K Eden S Bengtsson BA Cardiovascular and renal effects of growth hormone Clinical Endocrinology 40 1994 393 400
17. Chen Y-DI Facchini F Landau C Plasma post-heparin lipoprotein lipase activity is decreased in normal individuals who are resistant to insulin-mediated glucose uptake Endocrinology and Metabolism 1 1994 153 158
18. Christopher M Hew FL Oakley M Defects of insulin action and skeletal muscle glucose metabolism in growth hormone-deficient (GHD) adults persists following 24 months recombinant growth hormone (rhGH) therapy Journal of Clinical Endocrinology and Metabolism 83 1998 1668 1681
19. Cuneo RC Salomon F McGauley GA Sonksen PH The growth hormone deficiency syndrome in adults Clinical Endocrinology 37 1992 387 397
20. Cuneo RC Salomon F Wilmshurst P Cardiovascular effects of growth hormone treatment in growth hormone-deficient adults: Stimulation of the renin-aldosterone system Clinical Science 81 1991 587 592
21. Cuneo R Salomon F Watts GF Growth hormone treatment improves serum lipids and lipoproteins in adults with growth hormone deficiency Metabolism 42 1993 1519 1523
22. Cuneo RC Judd S Wallace JD The Australian multi-centre trial of growth hormone deficent adults Journal of Clinical Endocrinology and Metabolism 83 1998 107 116
23. Eden S Wiklund O Oscarsson J Growth hormone treatment of growth hormone-deficient adults results in a marked increase in Lp(a) and HDL-cholesterol concentrations Arteriosclerosis and Thrombosis 13 1993 296 301
24. Erfurth EM Bulow B Mikozy Z Increased cardiovascular mortality in patients with hypopituitarism Endocrinology and Metabolism 3 supplement A 1996 121
25. Fedou C Brun J-F Raynaud E Insulin sensitivity and glucose effectiveness measured with the minimal model in adults with GH deficiency Endocrinology and Metabolism 3 1996 99 104
26. Fowelin J Attvall S Lager I Bengtsson BA Effects of treatment with recombinant human growth hormone on insulin sensitivity and glucose metabolism in adults with growth hormone deficiency Metabolism 42 1993 1443 1447
27. Garry P Collins P Devlin JG An open 36-month study of lipid changes with growth hormone in adults: lipid changes following replacement of growth hormone in adult acquired growth hormone deficiency European Journal of Endocrinology 134 1996 51 56
28. Haffner SM Paidi M Mykkanen L Greater effect of diabetes on LDL size in women than in men Diabetes Care 17 1994 1164 1171
29. Heiss G Tamir I Davies CE Lipoprotein cholesterol distributions in selected North America populations: the Lipid Research Clinics Program Prevalence Study Circulation 61 1980 302 315
30. Hew FL, Christopher MC & Alford F (in press) Growth hormone deficiency in adults and glucose metabolism. In Jorgensen JOL (ed.) Growth Hormone in Adults . Cambridge: Cambridge University Press.
31. Hew FL Koschmann M Christopher M Insulin resistance in growth hormone-deficient adults: defects in glucose utilization and glycogen synthase activity Journal of Clinical Endocrinology and Metabolism 81 1996 555 564
32. Hew FL Alford F Christopher M Effects of growth hormone deficiency and replacement in adults on skeletal muscle glucose metabolism, lipid profiles and regional body composition Endocrinology and Metabolism 3 supplement A 1996 55 60
33. Hussain MA Schmitz O Mengel A Comparison of the effects of growth hormone and insulin-like growth factor I on substrate oxidation and on insulin sensitivity in growth hormone-deficient humans Journal of Clinical Investigation 94 1994 1126 1133
34. Hwu C-M Kwok CF Lai T-Y Growth hormone (GH) replacement reduces total body fat and normalizes insulin sensitivity in GH-deficient adults: a report of one-year clinical experience Journal of Clinical Endocrinology and Metabolism 82 1997 3285 3292
35. Johannsson G Bengtsson B-A Andersson B Long-term cardiovascular effects of growth hormone treatment in GH-deficient adults. Preliminary data in a small group of patients Clinical Endocrinology 45 1996 305 314
36. Johansson J-O Landin K Tengborn L High fibrinogen and plasminogen activator inhibitor activity in growth hormone deficient adults Arteriosclerosis and Thrombosis 14 1994 434 437
37. Johansson JO Fowelin J Landin K Growth hormone-deficient adults are insulin resistant Metabolism 44 1995 1126 1129
38. Johansson JO Landin K Johannsson G Long term treatment with growth hormone decreases plasminogen activator inhibitor-1 and tissue plasminogen activator in growth hormone-deficient adults Thrombosis and Haemostasis 76 1996 422 428
39. Johansson JO Oscarsson J Bjarnason R Bengtsson BA Two weeks of daily injections and continuous infusion of growth hormone (GH) in GH-deficient adults: I. Effects on insulin-like growth factor-1 (IGF-1), GH, IGF binding proteins, and glucose homeostasis Metabolism 45 3 1996 362 369
40. Kahn SE Prigeon RL McCulloch DK Quantitation of the relationship between insulin sensitivity and B cell function in human subjects: evidence for a hyperbolic function Diabetes 42 1993 1663 1672
41. Kannell WB Gordon T Castelli WP Role of lipids and lipoprotein fractions in assessing atherogenesis. The Framingham Study Progress in Lipid Research 20 1981 339 348
42. Landin K Tengvory L Smith U Elevated fibrinogen and plasminogen activator (PAI-1) in hypertension are related to metabolic risk factors for cardiovascular disease Journal of Internal Medicine 227 1990 273 278
43. Libber SM Plotnick LP Johanson AJ Long-term follow-up of hypopituitary patients treated with human growth hormone Medicine 69 1990 46 55
44. Markussis V Beshyah SA Fisher C Abnormal carotid arterial wall dynamics in symptom-free hypopituitary adults European Journal of Endocrinology 136 1997 157 164
45. Milner RDG Russell-Fraser T Brook CGD Experience with growth hormone in Great Britain: the report of the MRC working party Clinical Endocrinology 11 1979 15 38
46. Murai A Miyahara T Fujimoto M Lp(a) lipoprotein as a risk factor for coronary heart disease and cerebral infarction Atherosclerosis 38 1981 51 61
47. O'Halloran DJ Wieringa G Tsatsoulis A Shalet SM Increased serum lipoprotein(a) concentrations after growth hormone (GH) treatment in patients with isolated GH deficiency Annals of Clinical Biochemistry 33 1996 330 334
48. O'Neal DN Kalfas A Dunning PL The effects of 3 months of recombinant human growth hormone (GH) therapy on insulin and glucose-mediated glucose disposal and insulin secretion in GH-deficient adults: a minimal model analysis Journal of Clinical Endocrinology and Metabolism 79 1994 975 983
49. O'Neal DN Hew FL Sikaris K Low density lipoprotein particle size in hypopituitary adults on conventional hormone replacement therapy Journal of Clinical Endocrinology and Metabolism 81 1996 2448 2454
50. Oscarsson J Wiklund O Jakobsson K-E Serum lipoproteins in acromegaly before and 6–15 months after transpherroidal adenomectomy Clinical Endocrinology 41 1994 603 608
51. Oscarsson J Ottosson M Wiklund O Low dose continuous infused growth hormone results in increased lipoprotein (a) and decreased low density lipoprotein cholesterol concentrations in middle-aged men Clinical Endocrinology 41 1994 109 116
52. Parni P Angelin B Lobie PE Growth hormone specifically stimulates the expression of low density lipoprotein in human hepatoma cells Endocrinology 136 1995 3767 3773
53. Press M Growth hormone and metabolism Diabetes and Metabolism Review 4 1988 391 414
54. Reaven GM Banting Lecture. Role of insulin resistance in human disease Diabetes 37 1988 1595 1607
55. Richelsen B Pedersen SB Borglum JD Growth hormone treatment of obese women for 5 wk: effect on body composition and adipose tissue LPL activity American Journal of Physiology 266 1994 E211 E216
56. Rosen T Bengtsson B-A Premature mortality due to cardiovascular disease in hypopituitarism Lancet 336 1990 285 288
57. Rosen T Eden S Larsson G Cardiovascular risk factors in adult patients with growth hormone deficiency Acta Endocrinologica 129 1993 195 200
58. Rowe JW Young JB Minaker KI Effect of insulin and glucose infusions on sympathetic nervous system activity in normal man Diabetes 30 1981 219 225
59. Rudling M Parini P Angelin B Growth hormone and bile acid synthesis. Key role for the activity of hepatic microsomal cholesterol 7alpha-hydroxylase in the rat Journal of Clinical Investigation 99 1997 2239 2245
60. Rudling M Olivecrona H Eggertsen G Angelin B Regulation of rat hepatic low density lipoprotein receptors. In vivo stimulation by growth hormone is not mediated by insulin-like growth factor I Journal of Clinical Investigation 97 1996 292 299
61. Sacca L Cittadini A Fazio S Growth hormone and the heart Endocrinology Review 15 1994 555 573
62. Salomon F Cuneo RC Hesp R Sonksen P The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency New England Journal of Medicine 321 1989 1797 1803
63. Snel YEM Brummer RJM Doerga ME Adipose tissue assessed by magnetic resonance imaging in growth hormone-deficient adults: the effect of growth hormone replacement and a comparison with control subjects American Journal of Clinical Nutrition 61 1995 1290 1294
64. Snel YEM Doerga ME Brummer RJM Resting metabolic rate, body composition and related hormonal parameters in growth hormone-deficient adults before and after growth hormone replacement therapy European Journal of Endocrinology 133 1995 445 450
65. Sverrisdottir YB Johannsson G Bengtsson BA Elam M Adult patients with hypopituitarism and untreated GH deficiency have increased muscle sympathetic nerve activity Endocrinology and Metabolism 4 supplement A 1997 56
66. Utermann G The mysteries of lipoprotein(a) Science 246 1989 904 910
67. Weaver JU Monson JP Noonan K The effect of low dose recombinant human growth hormone replacement on regional fat distribution, insulin sensitivity, and cardiovascular risk factors in hypopituitary adults Journal of Clinical Endocrinology and Metabolism 80 1995 153 159
68. Webster JM Stewart M Al-Maskari M The effect of growth hormone replacement therapy for up to 12 months on lipoprotein composition and lipoprotein(a) in growth hormone-deficient adults Atherosclerosis 133 1997 115 121
69. Whitehead HM Boreham C Melirath EM Growth hormone treatment of adults with growth hormone deficiency: results of a 13-month placebo controlled cross-over study Clinical Endocrinology 36 1992 45 52
70. Wuster C Slenczka E Ziegler R Erhohte pravalenz von osteoporose und arteriosklerose bei konventionell substituierter hypophysenvorderlappeninsuffizienz: bedarf einer zusatzlichen wachstumshormonsubstitution? Klinische Wochenschrift 69 1991 769 773