Regulation of rat hepatic low density lipoprotein receptors: In vivo stimulation by growth hormone is not mediated by insulin-like growth factor

Journal of Clinical Investigation

Volumn 97, Issue 2, 1996, Pages 292-299

  Rudling, Mats ^a   Olivecrona, Hans ^a   Eggertsen, Gösta ^a   Angelin, Bo ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

apo B editing; Hypophysectomy; IGF I; LDL receptor; Somatotropin

Indexed keywords

APOLIPOPROTEIN B100; APOLIPOPROTEIN B48; CHOLESTEROL; CORN OIL; DEXAMETHASONE; ETHINYLESTRADIOL; HUMAN GROWTH HORMONE; INTERMEDIATE DENSITY LIPOPROTEIN; LEVOTHYROXINE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; RECOMBINANT SOMATOMEDIN C; TRIACYLGLYCEROL;

ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL INTAKE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HORMONE SUBSTITUTION; HYPOPHYSECTOMY; LIPOPROTEIN BLOOD LEVEL; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; RNA EDITING; SUBCUTANEOUS DRUG ADMINISTRATION; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; CHOLESTEROL, DIETARY; DEXAMETHASONE; ESTRADIOL CONGENERS; ETHINYL ESTRADIOL; GLUCOCORTICOIDS; GROWTH HORMONE; INSULIN-LIKE GROWTH FACTOR I; LIPOPROTEINS; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LDL; THYROXINE;

EID: 0030070447     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118415     Document Type: Article

References (48)

1. Gordon, T., W. B, Kannel. W. P. Castelli, and T. R. Dawber. 1981. Lipoproteins. cardiovascular disease, and death. The Framingham study Arch Intern Med. 141.1128-1131.
2. Steinberg. D. 1988. Metabolism of lipoproteins and their role in the pathogenesis of atherosclerosis. Athernscler Rev. 18:1-23.
3. Lipid Research Clinics Program. 1984 The Lipid Research Clinics coronary primary prevention trial results. 1. Reduction in incidence of coronary heart disease. JAMA (J Am Med. Assoc ). 251:351-364.
4. Frick. M. H . O. Elo, K. Haapa, O. P Hemonen, P. Heinsalmi, P. Helo. J. K. Huttunen, P Kaitamemi, P Koskmen. V. Manninen, et al. 1987. Helsinki heart study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of tieatment, changes in risk factors, and incidence of coronary heart disease N Engl. J Med 317:1237-1245.
5. Brown. G , J. J. Albers, L. D. Fisher, S. M. Schaefer, J. T. Lin, C Kaplan. X Q. Zhao, B. D. Bisson. V. F. Fitzpatrick, and H T. Dodge. 1990. Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B. N. Engl J Med. 323:1289-1298
6. Buchwald. H.. R. L. Varco, J. P. Matts, J. M. Long, L. L. Fitch, G. S. Campbell, M. B. Pearce, A. E Yellin, W. A. Edmiston, R. J. Smink, et al. 1990 Effect of partial ileal bypass surgery on mortality and morbidity from coronary heart disease in patients with hypercholesterolemia. Report of the Program on the Surgical Control of the Hyperlipidemias (POSCH). N. Engl J Med. 323: 946-955.
7. Scandinavian Simvastatm Survival Study Group. 1994. Randomized trial of cholesterol lowering in 4444 patients, with coronary heart disease, the Scandinavian Simvastatin Survival Study (4S). Lancet 334.1383-1389.
8. Brown, M S . and J L. Goldstein. 1986. A receptor-mediated pathway for cholesterol homeostasis Science (Wash. DC). 232:34-47.
9. Myant, N. B. 1990 Cholesterol Metabolism, LDL. and the LDL Receptor Academic Press Inc., Orlando. FL 465 pp.
10. Dietschy.J M., S. D Turley, and D. K. Spady. 1993. Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans. J. Lipid Res 34.1637-1659
11. Angelin, B. 1995. Studies on the regulation of hepatic cholesterol metabolism in humans. Eur, J. Clin Invest. 25:215-224
12. Kovanen, P. T., D W Bilheimer, J. L. Goldstein. J. J. Jaramillo, and M. S. Brown. 1981. Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog. Proc. Natl. Acad. Sci. USA. 78 1194-1198
13. Rudling. M. J.. E. Reihnér, K. Einarsson, S. Ewerth. and B. Angelin. 1990. Low density lipoprotein receptor-binding activity in human tissues quantitative importance of hepatic receptors and evidence for regulation of their expression in vivo. Proc Natl. Acad. Sci USA. 87:3469-3473.
14. Reihnér, E., M Rudling, D. Ståhlberg, L. Berglund, S. Ewerth. I. Bjorkhem, K. Einarsson, and B. Angelin. 1990. Influence of pravastatin. a specific inhibitor of HMG-CoA reductase, on hepatic metabolism of cholesterol. N Engl J. Med. 323:224-228.
15. Åkerlund, J. E.. E. Rcihnér, B. Angelin, M. Rudling, S. Ewerth, I. Björkhem, and K. Einarsson. 1991. Hepatic metabolism of cholesterol in Crohn's disease Effect of partial resection of ileum. Gastroenterology. 100: 1046-1053.
16. Goldstein, J. L., and M. S. Brown. 1990. Regulation of the mevalonate pathway. Nature (Lond ) 343.425-430.
17. Brindley, D. N., and A. M Salter. 1991. Hormonal regulation of the hepatic low density lipoprotein receptor and the catabolism of low density lipoproteins: relationship with the secretion of very low density lipoproteins. Prog. Lipid Res. 30:349-360
18. Kovanen, P. T, M. S. Brown, and J. L. Goldstern. 1979 Increased hinding of low density lipoprotein to liver membranes from rats treated with 17alpha-ethinyl estradiol. J. Biol Chem 254:11367-11373.
19. Angelin, B., H. Olivecrona, E Reihnér, M Rudling. D. Ståhlberg, M. Eriksson. S. Ewerth, P. Henriksson, and K. Einarsson. 1992. Hepatic cholesterol metabolism in estrogen-treated men. Gastroenterology 103:1657-1663.
20. Rudling, M.. G. Norstedt, H. Olivecrona, E. Reihnér, J.-Å Guslafsson. and B. Angelin. 1992. Importance of growth hormone for the induction of hepatic low density lipoprotein receptors. Proc Natl Acad. Sci. USA. 89:6983-6987.
21. Salter. A. M.. R. Hayashi, S. M. Al-Seeni. N. F. Brown, J Bruce, O Sorensen, E. A. Atkinson, B Middleton. R. C. Bleackley, and D. N. Brindley. 1991 Effects of hypothyroidism and high-fat feeding on mRNA concentrations for the low-density-lipoprotein receptor and on acyl-CoA:cholesterol acyltransferase activities in rat liver. Biochem J. 276.825-832.
22. Wade, D P., B. L. Knight, and A. K. Soutar. 1989 Regulation of low-density-lipoprotein-receptor mRNA by insulin in human hepatoma Hep G2 cells. Eur. J. Biochem. 181:727-731
23. Rudling, M., and B. Angelin. 1993. Stimulation of rat hepatic low density lipoprotein receptors by glucagon. Evidence of a novel regulatory mechanism in vivo. J. Clin. Invest. 91:2796-2805
24. Rudling, M.. and B. Angelin. 1993. Loss of resistance to dietary cholesterol in the rat following hypophysectomy: importance of growth hormone for the expression of hepatic low density lipoprotein receptors. Proc. Natl. Acad Sci USA 90.8851-8855.
25. Angelin, B., and M. Rudling 1994. Growth hormone and hepatic lipoprotein metabolism. Curr Opin. Lipidol 5.160-165
26. Elam, M. B., C. P. Simkevich, S. S. Solomon. H. G. Wilcox, and M. Heimberg 1988. Stimulation of in vitro triglyceride synthesis in the rat hepatocyte by growth hormone treatment in vivo. Endocrinology. 122:1397-1402.
27. Elam, M B., H. G. Wilcox, S. S. Solomon, and M. Heimberg. 1992. In vivo growth hormone treatment stimulates secretion of very low density lipoprotein by the isolated perfused rat liver. Endocrinology. 131 2717-2722
28. Sjoberg. A., J. Oscarsson. K. Bostrom. T. Innerarity, S. Edén, and S.-O. Olofsson. 1992. Effects of growth hormone on apolipoprotein B (apoB) messenger ribonucleic acid editing, and apoB-48 and apoB-100 synthesis and secretion in the rat liver. Endocrinology. 130 3356-3364.
29. Sparks, C E., and J B Marsh 1981. Metabolic heterogeneity of apolipoprotein B in the rat. J. Lipid Res. 22:519-527
30. Sjóberg, A., J. Oscarsson, S. Edén, and S.-O. Olofsson. 1994. Continuous but not intermittent administration of growth hormone to hypophysectomized rats increases apolipoprotein-E secretion from cultured hepatocytes. Endocrinology. 134:790-798.
31. Mahlcy, R. W. 1988. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science (Wash. DC). 240:622-630.
32. Vikman-Adolfsson, K., J. Oscarsson, P. Nilsson-Ehle, and S. Edén. 1994. Growth hormone but not gonadal steroids influence lipoprotein lipase and hepatic lipase activity in hypophysectomized rats. J Endocrinol. 140:203-209.
33. Veldhuis. J. D.. J. E. Nestler, and J. F. Strauss III. 1987. The msulin-like growth factor, somatomediti-C. modulates low density lipoprotein metabolism by swine granulosa cells. Endocrinology. 121 340-346.
34. Hochberg. Z. P. Hertz, G. Maor, J. Oiknine. and M. Aviram. 1992. Growth hormone and insulin-like growth factor-I increase macrophage uptake and degradation of low density lipoprotein. Endocrinology. 131:430-435.
35. Rudling, M 1992. Hepatic mRNA levels for the LDL receptor and HMG-CoA reductase show coordinate regulation in vivo. J. Lipid Res. 33:493-501.
36. Baum, C. L., B B. Teng, and N. O. Davidson. 1990. Apolipoprotein B messenger RNA editing in the rat liver. Modulation by fasting and refeeding a high carbohydrate diet. J. Biol. Chem. 265:19263-19270.
37. Daughaday, W. H., I. K. Mariz, and S. L. Blethen. 1980. Inhibition of access of bound somatomedin to membrane receptor and immunobindmg sites: a comparison of radioreceptor and radioimmunoassay of somatomedin in native and acid-ethanol-extracted serum. J. Clin, Endocrinol. & Metab. 51:781-788.
38. Snedecor. G. W.. and W. G. Cochran. 1980. Statistical Methods. 7th ed. The Iowa State University Press, Ames. IA. 507 pp.
39. Rudling. M. J. 1987. Role of the liver for the receptor-mediated catabolism of low-density lipoprotein in the 17 alpha-ethinylestradiol-treated rat. Biochim. Biophys Acta. 919:175-180.
40. Yoshiaki, I., F Giannoni. T. Funahashi, and N. O Davidson. 1994. REPR and complementation factor(s) interact to modulate rat apolipoprotein B mRNA editing in response to alterations in cellular cholesterol flux. J. Lipid Res. 35:1447-1489.
41. Srivastava. R A., J. Tang, D. Baumann, and G. Schonfeld 1992. Hormonal and nutritional stimuli modulate apolipoprotein B mRNA editing in mouse liver. Biochem. Bitophvs. Res Commun. 188:135-141.
42. Tamura, K., M. Kobayashi. Y. Ishii. T. Tamura. K. Hashimoto. S. Nakamura, M. Niwa, and J. Zapf. 1989. Primary structure of rat insulin-like growth factor-I and its biological activities J. Biol Chem. 264:5616-5621.
43. Sjóberg, A , J. Oscarsson, S.-O. Olofsson, and S. Eden. 1994. Insulin-like growth factor-I and growth hormone have different effects on serum lipoproieins and secretion of lipoproteins from cultured rat hepatocytes. Endocrinology. 135:1415-1421.
44. Zenobi, P. D., G. S. Jaeggi, W. F. Riesen, M. E. Roder, and E. R. Froesch. 1992. Insulin-like growth factor-I improves glucose and lipid metabolism in type 2 diabetes mellitus. J Clin Invest. 90:2234-2241.
45. Olivecrona, H., A. G. Johansson, E. Lindh, S. Ljunghall, L. Berglund, and B. Angelin. 1995. Hormonal regulation of serum lipoprotein (a) levels: contrasting effects of growth hormone and insulin-like growth factor-I Arterioscler. Thromb. Vasc. Biol. 15:847-849.
46. Parini. P., B. Angelin, P. E. Lobie, G. Norstedt, and M. Rudling. 1995. Growth hormone specifically stimulates the expression of low density lipoprotein receptors in human hepatoma cells. Endocrinology 136:3767-3773.
47. Caro, J F., J Poulos, O. Ittoop, W. J Pories. E. G. Flickinger. and M K Sinha. 1988. Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal liver. J Clin. Invest. 81.976-981
48. Ericsson, S., M. Eriksson. S. Vitols, K. Einarsson, L. Berglund, and B. Angelin. 1991. Influence of age on the metabolism of plasma low density lipoproteins in healthy males. J. Clin. Invest. 87.591-596