Potassium channel activation and relaxation by nicorandil in rat small mesenteric arteries

British Journal of Pharmacology

Volumn 125, Issue 8, 1998, Pages 1715-1725

  Davie, C S ^a   Kubo, M ^a   Standen, N B ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Glibenclamide; K(ATP) channels; Mesenteric artery; Metabolic inhibition; Nicorandil; Potassium current

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 6 ANILINO 5,8 QUINOLINEQUINONE; BARIUM ION; CALCIUM CHANNEL; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; GLIBENCLAMIDE; GLUCOSE; GUANYLATE CYCLASE; IBERIOTOXIN; NICORANDIL; POTASSIUM CHANNEL; POTASSIUM ION;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; MALE; MESENTERIC ARTERY; METABOLIC INHIBITION; MYOGRAPHY; NONHUMAN; PATCH CLAMP; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; VASODILATATION;

AMINOQUINOLINES; ANIMALS; CALCIUM CHANNELS; CARBONYL CYANIDE M-CHLOROPHENYL HYDRAZONE; ELECTROPHYSIOLOGY; ENZYME INHIBITORS; GLYBURIDE; GUANYLATE CYCLASE; MALE; MEMBRANE POTENTIALS; MESENTERIC ARTERIES; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NICORANDIL; PATCH-CLAMP TECHNIQUES; PEPTIDES; POTASSIUM CHANNELS; RATS; RATS, WISTAR; UNCOUPLING AGENTS; VASODILATOR AGENTS;

EID: 0032406484     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702232     Document Type: Article

References (42)

1. AKAI, K., WANG, Y , SATO, K., SEKIGUCHl, N., SUGIMURA, A., KUMAGAI, T., KOMARU, T., KANATSUKA, H. & SHIRATO, K. (1995). Vasodilatory effect of nicorandil on coronary arterial microvessels: Its dependency on vessel size and the involvement of the ATP-sensitive potassium channels. J. Cardiovasc. Pharmacol., 26, 541-547.
2. CANDIA, S., GARCIA, M.L. & LATORRE, R. (1992) Mode of action of iberiotoxin, a potent blocker of calcium-activated potassium channel. Biophys. J., 63, 583-590.
3. CONWAY, M.A., NELSON, M.T. & BRAYDEN, J.E. (1993). 2-deoxyglucose-induced vasodilation and hyperpolarisation in rat coronary artery are reversed by glibenclamide. Am. J. Physiol., 266, H1322-H1326.
4. DART, C. & STANDEN, N.B. (1993). Adenosine-activated potassium current in smooth muscle cells isolated from pig coronary artery. J. Physiol., 471, 767-786.
5. DART, C. & STANDEN, N.B. (1995). Activation of ATP-dependent potassium channels by hypoxia in smooth muscle cells isolated from pig coronary artery. J. Physiol., 483, 29-39.
6. DAVIE, C.S., MILLAR, J.S. & STANDEN, N.B. (1997). Functional studies on the mechanism of action of nicorandil in the rat mesenteric artery and its potentiation during impaired metabolism. Br. J. Pharmacol., 120, P89.
7. DAVIE, C.S. & STANDEN, N.B. (1998). Enhancement of the vasorelaxant potency of nicorandil by metabolic inhibition and adenosine in the pig coronary artery. Cardiovasc. Res., 37, 791-798.
8. DAVIES, N.W. (1993). A suite of programs for acquisition and analysis of voltage- and patch-clamp data developed using the Axobasic library. J. Physiol., 459, 111P.
9. FRAMPTON, J., BUCKLEY, M.M. & FITTON, A. (1992). Nicorandil. A review of its pharmacology and therapeutic effects in angina pectoris. Drugs, 44, 625-655.
10. FUJIWARA, T. & ANGUS, J.A. (1996). Analysis of relaxation and repolarization mechanisms of nicorandil in rat mesenteric artery. Br. J. Pharmacol., 119, 1549-1556.
11. GARLAND, C.J. & MCPHERSON, G.A. (1992). Evidence that nitric oxide does not mediate the hyperpolarization and relaxation to acetylcholine in the rat small mesenteric artery. Br. J. Pharmacol., 105, 429-435.
12. GOLDSCHMIDT, M., LANDZBERG, B.R., FRISHMAN, W.H. (1996). Nicorandil: A potassium channel opening drug for treatment of ischaemic heart disease. J. Clin. Pharmacol., 36, 559-572.
13. KCa activator, NS1619, on rat cerebral a rtery smooth muscle. Br. J. Pharmacol., 117, 119-129.
14. HOLZMANN, S. (1983). cGMP as a possible mediator of coronary arterial relaxation by nicorandil (SG-75). J. Cardiovasc. Pharmacol., 5, 364-370.
15. HOLZMANN, S., KUKOVETZ, W.R., BRAIDA, C. & POCH, G (1992). Pharmacological interaction experiments differentiate between glibenclamide-sensitive potassium channels and cyclic GMP as components of vasodilation by nicorandil. Eur. J. Pharmacol., 215, 1-7.
16. + channel. J. Biol. Chem., 271, 24321-24324.
17. KAJIOKA, S., OIKE, M. & KITAMURA, K. (1990). Nicorandil opens a calcium-dependent potassium channel in smooth muscle cells of the rat portal vein. J. Pharmacol. Exp. Ther., 254, 905-913.
18. + channels by ATP and nucleotide diphosphate in rabbit portal vein. Am. J. Physiol., 266, H1687-H1698.
19. + channels in cultured vascular smooth muscle cells. Circ. Res., 74, 471-476.
20. KUKOVETZ, W.R., HOLZMANN, S., BRIADA, C. & POCH, G. (1991). Dual mechanism of the relaxing effect of nicorandil by stimulation of cGMP formation and by hyperpolarisation. J. Cardiovasc. Pharmacol., 17, 627-633.
21. +-channels and depolarises smooth muscle cells of porcine coronary artery. Circ. Res., 70, 612-616.
22. MÜLSCH, A., BUSSE, R., LIEBAU, S. & FORESTERMANN, U. (1988). LY 83583 interferes with the release of endothelium dependent relaxing factor and inhibits soluble guanylyl cyclase. J. Pharmacol. Exp. Ther., 247, 283-288.
23. MULVANY, M.J., AALKJAER, C. & CHRISTENSEN, J. (1980). Changes in noradrenaline sensitivity and morphology of arterial resistance vessels during development of high blood pressure in spontaneously hypertensive rats. Hypertension, 2, 664-671.
24. MULVANY, M.J. & HALPERN, W. (1976). Mechanical properties of vascular smooth muscle cells in situ. Nature, 260, 617-619.
25. MURPHY, M.E. & BRAYDEN, J.E. (1995). Nitric oxide hyperpolarises rabbit mesenteric arteries via ATP-sensitive potassium channels. J. Physiol., 486, 47-58.
26. NELSON, M.T., PATLAK, J.B., WORLEY, J.F. & STANDEN, N.B. (1990). Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle cell tone. Am. J. Physiol., 259, C3-C18.
27. NELSON, M.T. & QUAYLE, J.M. (1995). Physiological roles and properties of potassium channels in arterial smooth muscle. Am. J. Physiol., 268, C799-C822.
28. + channels. Trends Pharmacol. Sci., 10, 431-434.
29. QUAYLE, J.M., BONEV, A.D., BRAYDEN, J. & NELSON, M.T. (1995). Pharmacology of ATP-sensitive potassium currents in smooth muscle cells from rabbit mesenteric artery. Am. J. Physiol., 269, C1112-C1118.
30. QUAYLE, J.M., NELSON, M.T. & STANDEN, N.B (1997). ATP-sensitive and inwardly rectifying potassium channels in smooth muscle. Physiol. Rev., 77, 1165-1232.
31. RANDALL, M.D. & GRIFFITH, T.M. (1993). Modulation of vasodilatation to levcromakalim by hypoxia and EDRF in the rabbit isolated ear: a comparison with pinacidil, sodium nitroprusside and verapamil. Br. J. Pharmacol., 109, 386-393.
32. RANDALL, M.D., UJIIE, H. & GRIFFITH, T.M. (1994). Modulation of vasodilatation to levcromakalim by adenosine analogues in the rabbit ear: an explanation for hypoxic augmentation. Br. J. Pharmacol., 112, 49-54.
33. SCHMIDT, H.H.H.W., LOHMANN, S.M. & WALTER, U. (1993). The nitric oxide and cGMP signal transduction system: regulation and mechanism of action. Biochem. Biophys. Acta., 1178, 152-175.
34. + channels by pinacidil and nicorandil. Br. J. Pharmacol., 124, 985-991.
35. + channels in smooth muscle cells of pig proximal urethra. J. Pharmacol. Exp. Ther., 280, 483-491.
36. von BECKERATH, N., CYRYS, S., DISCHNER, A & DAUT, J. (1991). Hypoxic vasodilatation in isolated, perfused guinea pig heart: an analysis of the underlying mechanisms. J. Physiol., 42, 297-319.
37. +-channel activities of cultured smooth muscle cells from porcine coronary artery. Am J. Physiol., 263, H491-H496.
38. YAMAGISHI, T., YANAGISAWA, T., SATOH, K. & TGAIRA, N. (1994). Relaxant mechanisms of cyclic AMP-increasing agents in porcine coronary artery. Eur. J. Pharmacol., 251, 253-262.
39. + channel. J. Physiol., 499, 715-720.
40. + channels in porcine tracheal smooth muscle cells. Am. J. Physiol., 270, L338-L345.
41. YONEYAMA, G., SATOH, K. & TAIRA, N. (1990). Nicorandil increases coronary blood flow predominantly by a potassium-channel opening mechanism. Cardiovasc. Drugs Ther., 4, 1119-1126.
42. + channel in smooth muscle cells of rat mesenteric artery. Br. J. Pharmacol., 114, 662-672.