Analysis of relaxation and repolarization mechanisms of nicorandil in rat mesenteric artery

British Journal of Pharmacology

Volumn 119, Issue 8, 1996, Pages 1549-1556

  Fujiwara, Toshimasa ^a   Angus, James A ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Cromakalim; K+(ATP) channel; Levcromakalim; Membrane potential; Mesenteric artery; Nicorandil; Nifedipine; Nitric oxide donor

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ADENOSINE TRIPHOSPHATE; CALCIUM CHANNEL; CALCIUM ION; CROMAKALIM; CYCLIC GMP; GLIBENCLAMIDE; GUANYLATE CYCLASE; LEMAKALIM; METHYLENE BLUE; NICORANDIL; NIFEDIPINE; NITRIC OXIDE DONOR; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; POTASSIUM CHLORIDE;

ANIMAL TISSUE; ARTERY MUSCLE; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DEPOLARIZATION; DISSOCIATION; ENZYME ACTIVATION; FORCE; HYPERPOLARIZATION; MALE; MEMBRANE POTENTIAL; MESENTERIC ARTERY; MYOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RAT; REPOLARIZATION; SMOOTH MUSCLE RELAXATION;

EID: 0030475841     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb16071.x     Document Type: Article

References (18)

1. ANGUS, M.J., BROUGHTON, S. & MULVANY, M.J. (1988). Role of α-adrenoceptors in constrictor responses of rat, guinea-pig and rabbit small arteries to neural activation. J. Physiol., 403, 495-510.
2. +-channel opening and guanylate cyclase stimulation to its vasorelaxation effects on various endothelin-1-contracted arterial preparations. Comparison to aprikalim (RP 52891) and nitroglycerin. J. Pharmacol. Exp. Ther., 259, 526-534.
3. CAVERO, I., MONDOT, S. & MESTRE, M. (1988). Vasodilating effects of cromakalim in rats are mediated by glibenclamide-sensitive potassium channels. J. Pharmacol. Exp. Ther., 248, 1261-1268.
4. 2+ channel antagonists and inhibition but not depolarisation to 5-hydroxytryptamine in the rabbit basilar artery. Eur. J. Pharmacol., 235, 113-116.
5. ENDOH, M. & TAIRA, N. (1983). Relationship between relaxation and cyclic GMP formation caused by nicorandil in canine mesenteric artery. Naunyn-Schmiedeberg's Arch Pharmacol., 322, 319-321.
6. FURUKAWA, K., ITOH, T., KAJIWARA, M., KITAMURA, K., SUZUKI, H., ITO, Y. & KURIYAMA, H. (1981). Vasodilating actions of 2-nicotinamidoethyl nitrate on porcine and guinea-pig coronary arteries. J. Pharmacol. Exp. Ther., 218, 248-259.
7. GARLAND, C.J. & MCPHERSON, G.A. (1992). Evidence that nitric oxide does not mediate the hyperpolarisation and relaxation to acetylcholine in the rat small mesenteric artery. Br. J. Pharmacol., 105, 429-435.
8. GREENBERG, S.S., CANTOR, E., HO, E. & WALEGA, M. (1991). Comparison of nicorandil-induced relaxation, elevations of cyclic guanosine monophosphate and stimulation of guanylate cyclase with organic nitrate esters. J. Pharmacol. Exp. Ther., 258, 1061-1071.
9. HOLZMANN, S. (1983). Cyclic GMP as a possible mediator of coronary arterial relaxation by nicorandil (SG-75). J. Cardiovasc. Pharmacol., 5, 364-370.
10. KSOLL, E., PARSONS, A.A., MACKERT, J.R.L., SCHILLING, L. & WAHL, M. (1991). Analysis of cromakalim-, pinacidil-, and nicorandil-induced relaxation of the 5-hydroxytryptamine precontracted rat isolated basilar artery. Naunyn-Schmiedeberg's Arch Pharmacol. 343, 377-383.
11. LEW, M.J. (1995). Extended concentration-response curves used to reflect full agonist efficacies and receptor occupancy-response coupling ranges. Br. J. Pharmacol., 115, 745-752.
12. +-channel opening to nicorandil-induced vasorelaxation depends on the conduit vessel and on the nature of the spasmogen. J. Pharmacol. Exp. Ther., 268, 1411-1418.
13. +-channel-dependent and cyclic GMP-dependent components in a single vascular preparation. J. Cardiovasc. Pharmacol., 17, 903-912.
14. MULVANY, M.J. & HALPERN, W. (1977). Contractile properties of small arterial resistance vessels in spontaneous hypertensive rats. Circ Res., 41, 19-26.
15. MULVANY, M.J. & WARSHAW, D.M. (1979). The active tension-length curve of vascular smooth muscle related to its cellular component. J. Gen. Pharmacol., 74, 85-104.
16. NELSON, M.T. & QUAYLE, J.M. (1995). Physiological roles and properties of potassium channels in arterial smooth muscle (Review). Am. J. Physiol., 34, C799-C822.
17. TAIRA, N. (1987). Similarity and dissimilarity in the mode and mechanism of action between nicorandil and classical nitrates: an overview. J. Cardiovasc. Pharmacol., 10, (Suppl 8), S1-S9.
18. TAIRA, N. (1989). Nicorandil as a hybrid between nitrates and potassium channel activators. Am. J. Cardiol., 63, 18J-24J.