Anti-L-selectin oligonucleotide ligands recognize CD62L-positive leukocytes: Binding affinity and specificity of univalent and bivalent ligands

Cytometry

Volumn 33, Issue 4, 1998, Pages 394-405

  Ringquist, Steven ^a,b   Parma, David ^a  

^a GILEAD SCIENCES   (United States)

^b SIDNEY KIMMEL CANCER CENTER   (United States)

Author keywords

Adhesion molecules; Cell to cell interactions; FACS staining; Inflammation

Indexed keywords

HYBRID PROTEIN; L SELECTIN; L SELECTIN ANTIBODY; MONOCLONAL ANTIBODY CD 20; MONOCLONAL ANTIBODY CD 62; MONOCLONAL ANTIBODY CD11B; OKT 4; OKT 8; PADGEM PROTEIN; SELECTIN ANTAGONIST; UNCLASSIFIED DRUG;

ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DISSOCIATION CONSTANT; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; LEUKOCYTE ADHERENCE; LIGAND BINDING; LYMPHOCYTE SUBPOPULATION; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL;

BASE SEQUENCE; CELL ADHESION; HUMANS; KINETICS; L-SELECTIN; LEUKOCYTES; LIGANDS; LYMPHOCYTES; MOLECULAR SEQUENCE DATA; NEUTROPHILS; OLIGONUCLEOTIDES; SOLUBILITY; STAINING AND LABELING;

EID: 0032400827     PISSN: 01964763     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0320(19981201)33:4<394::AID-CYTO2>3.0.CO;2-0     Document Type: Article

References (81)

1. Arbones ML, Ord DC, Ley K, Ratech H, Maynard-Curry C, Otten G, Capon DJ, Tedder TF: Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin deficient mice. Immunity 1: 247-260, 1994.
2. Bertozzi CR, Fukuda S, Rosen SD: Sulfated disaccharide inhibitors of L-selectin: Deriving structural leads from a physiological selectin ligand. Biochemistry 34: 14271-14278, 1995.
3. Bradley LM, Watson SR, Swain SL: Entry of naive CD4 cells into peripheral lymph nodes requires L-selectin. J Exp Med 180: 2401-2406, 1994.
4. Brown D, Gold L: Template recognition by an RNA-dependent RNA polymerase: identification and characterization of two RNA binding sites on Q beta replicase. Biochemistry 34: 14765-14774, 1995.
5. Brown D, Gold L: Selection and characterization of RNAs replicated by Q beta replicase. Biochemistry 34: 14775-14782, 1995.
6. Brown D, Gold L: RNA replication by Q beta replicase: A working model. Proc Natl Acad Sci USA 93: 11558-11562, 1996.
7. Butcher EC, Picker LJ: Lymphocyte homing and homeostasis. Science 272: 60-66, 1996.
8. 2+. RNA 1: 538-550, 1995.
9. Connell GJ, Illangasekare M, Yarus M: Three small ribooligonucleotides with specific arginine sites. Biochemistry 32: 5497-5502, 1993
10. Connell GJ, Yarus M: RNAs with dual specificity and dual RNAs with similar specificity. Science 264: 1137-1141, 1994.
11. Crothers DM, Metzger H: The influence of polyvalency on the binding properties of antibodies. Immunochemistry 9: 341-357, 1972.
12. Dailey MO, Fathman CG, Butcher EC, Pillemer E, Weissman IL: Abnormal migration of T lymphocyte Clones. J Immunol 128: 2134-2136, 1982.
13. Davis KA, Abrams B, Lin Y, Jayasena SD: Use of a high affinity DNA ligand in flow cytometry. Nucl Acids Res 24: 702-706, 1996.
14. DeLisi C: The biophysics of ligand-receptor interactions. Q Rev Biophys 13: 201-230, 1980.
15. DeLisi C: The effect of cell size and receptor density on ligand-receptor reaction rate constants. Mol Immunol 18: 507-511, 1981.
16. Dower SK, DeLisi C, Titus JA, Segal DM: Mechanism of binding of multivalent immune complexes to Fc receptors: 1. Equilibrium binding. Biochemistry 20: 6326-6334, 1981.
17. Ellington AD, Szostak JW: In vitro selection of RNA molecules that bind specific ligands. Nature 346: 818-822, 1990.
18. Gallatin WM, Weissman IL, Butcher EC: A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature 304: 30-34, 1983.
19. 2+ ions. J. Biol. Chem. 267: 19846-19853, 1992.
20. Geoffroy JS, Rosen SD: Demonstration that a lectin-like receptor (gp90MEL) directly mediates adhesion of lymphocytes to high endothelial venules of lymph nodes. J Cell Biol 198: 2463-2469, 1989.
21. Gold L: Oligonucleotides as research, diagnostic, and therapeutic agents. J. Biol. Chem. 270: 13581-13584, 1995.
22. Gold L, Polisky B, Uhlenbeck O, Yarus M: Diversity of oligonucleotide functions. Annu Rev Biochem 64: 763-797, 1995.
23. Hale SP, Schimmel P: Protein synthesis editing by a DNA aptamer. Proc Natl Acad Sci USA 93: 2755-2758, 1996.
24. Hallmann R, Jutila MA, Smith CW, Anderson DC, Kishimoto TK, Butcher EC: The peripheral lymph node homing receptor, LECAM-1, is involved in CD18-independent adhesion of human neutrophils to endothelium. Biochem Biophys Res Commun 174: 236-243, 1991.
25. Hicke B, Watson SR, Koenig A, Lynott CK, Bargatze RF, Chang Y-F, Ringquist S, Moon-McDermott L, Jennings S, Fitzwater TF, Han H-L, Varki N, Albinana I, Willis MC, Varki A, Parma D: DNA aptamers block L-selectin function in vivo. J Clin Invest 98: 2688-2692, 1996.
26. Hou S, Hyland L, Bradley LM, Watson SR, Doherty PC: Subverting lymph node trafficking by treatment with the Mel-14 monoclonal antibody to L-selectin does not prevent an effective host response to Sendai virus. J Immunol 155: 252-258, 1995.
27. Illangasekare M, Sanchez G, Nickles T, Yarus M: Aminoacyl-RNA synthesis catalyzed by an RNA. Science 267: 643-647, 1995.
28. Irvine D, Tuerk C, Gold, L: SELEXION: Systematic evolution of ligands by exponential enrichment with integrated optimization by nonlinear analysis. J Mol Biol 222: 739-761, 1991.
29. Jayasena VK, Brown D, Shatland T, Gold L: In vitro selection of RNA specifically cleaved by bacteriophage T4 RegB endonuclease. Biochemistry 7: 2349-2356, 1996.
30. Jenison RD, Gill SC, Pardi A, Polisky B: High-resolution molecular discrimination by RNA. Science 263: 1425-1429, 1994.
31. Jung TM, Gallatin WM, Weissman IL, Dailey MO: Down-regulation of homing receptors after T cell activation. J Immunol 141:4110-4117, 1988.
32. Jutila MA, Rott L, Berg EL, Butcher EC: Function and regulation of the neutrophil MEL-14 antigen in vivo: Comparison with LFA-1 and Mac-1. J Immunol 143: 3318-3324, 1989.
33. Kanof ME, James SP: Leu-8 antigen expression is diminished during cell activation but does not correlate with effector function of activated T lymphocytes. J Immunol 140: 3701-3706, 1988.
34. Kansas GS, Wood GS, Fishwild DM, Engleman EG: Functional characterization of human T lymphocyte subsets distinguished by monoclonal anti-Leu-8. J. Immunol 134: 2995-3002, 1985.
35. Kansas GS, Ley K, Munro JM, Tedder TF: Regulation of leukocyte rolling and adhesion to HEV through the cytoplasmic domain of L-selectin. J Exp Med 177: 833-838, 1993.
36. Kaufman EN, Jain RK: Effect of bivalent interaction upon apparent antibody affinity: Experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays. Cancer Res 52: 4157-4167, 1992.
37. Kishimoto TK, Jutila MA, Berg EL, Butcher EC: Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors. Science 245: 1238-1241, 1989.
38. Kishimoto TK, Jutila MA, Butcher EC: Identification of a human peripheral lymph node homing receptor: a rapidly down-regulated adhesion molecule. Proc Natl Acad Sci USA 87: 2244-2248, 1990.
39. Kishimoto TK, Warnock PA, Jutila MA: Antibodies against human neutrophil LECAM-1 (LAM-1/LEU-8/DREG-56 antigen) and endothelial cell ELAM-1 inhibit a common CD18-independent adhesion pathway in vitro. Blood 78: 805-811, 1991.
40. Klotz IM: Ligand-receptor interactions: Facts and fantasies. Q Rev Biophys 18: 227-259, 1985.
41. Lewinsohn DM, Bargatze RF, Butcher EC: Leukocyte-endothelial cell recognition: Evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes. J Immunol 138: 4313-4321, 1987.
42. Ley K, Gaehtegens P, Fennie C, Singer MS, Lasky LA, Rosen SD: Lectin-like adhesion molecule-1 mediates leukocyte rolling in mesenteric venules in vivo. Blood 77: 2553-2555, 1991.
43. Ley K, Tedder TF, Kansas GS: L-selectin can mediate rolling independent of E-and P-selectin in mesenteric venules in vivo. Blood 82: 1632-1638, 1993.
44. Ley K, Tedder TF: Leukocyte interactions with vascular endothelium: new insights into selectin-mediated attachment and rolling. J Immunol 155: 525-528, 1995.
45. Ley K, Bullard DC, Arbones ML, Bosse R, Vestweber D, Tedder TF, Beaudet AL: Sequential contribution of L-and P-selectin to leukocyte rolling in vivo. J Exp Med 181: 669-675, 1995.
46. Lipkin EW, Teller DC, de Haen C: Equilibrium binding of insulin to rat white fat cells at 15 C. J Biol Chem 261: 1702-1711, 1986.
47. Luscinskas FW, Kansas GS, Ding H, Pizcueta P, Schlieffenbaum B, Tedder TF, Gimbrone MA: Monocyte rolling, arrest and spreading on IF-4 activated vascular endothelium under flow is mediated via sequential action of L-selectin, B1 and B2 integrin. J Cell Biol 125: 1417-1427, 1994.
48. Ma X-L, Weyrich AS, Lefer DJ, Buerke M, Albertine KH, Kishimoto TK, Lefer AM: Monoclonal antibody to L-selectin attenuates neutrophil accumulation and protects ischemic reperfused cat myocardium. Circulation 88: 649-658, 1993
49. Mayo KH, Nunez M, Burke C, Starbuck C, Lauffenburger D, Savage CR Jr: Epidermal growth factor receptor binding is not a simple one-step process. J Biol Chem 264: 17838-17844, 1989.
50. Mihelcic D, Schlieffenbaum B, Tedder TF, HarlanJM, Winn RK: Inhibition of leukocyte L-selectin function with a monoclonal antibody attenuates reperfusion injury to the rabbit ear. Blood 84: 2322-2328, 1994.
51. Mulligan MS, Varani J, Dame MK, Lane CL, Smith CW, Anderson DC, Ward PA: Role of endothelial-leukocyte adhesion molecule 1 (ELAM-1) in neutrophil-mediated lung injury in rats. J Clin Invest 88: 1396-1406, 1991.
52. Mulligan MS, Watson SR, Fennie C, Ward PA: Protective effects of selectin chimeras in neutrophil-mediated lung injury. J Immunol 151: 6410-6417, 1993.
53. Mulligan MS, Miyasaka M, Tamatani T, Jones ML, Ward PA: Requirements for L-selectin in neutrophil-mediated lung injury in rats. J Immunol 152: 832-840, 1994.
54. Navarro RF, Jalkanen ST, Hsu M, Soenderstrup-Hansen G, Goronzy J, Weyand C, Fathman CG, Clayberger C, Krensky AM, Butcher EC: Human T cell clones express functional homing receptors required for normal lymphocyte trafficking. J Exp Med 162: 1075-1080, 1985.
55. Nieuwlandt D, Wecker M, Gold L: In vitro selection of RNA ligands to substance P. Biochemistry 34: 5651-5659, 1995.
56. Norgard KE, Han H, Powell L, Kriegler M, Varki A, Varki NM: Enhanced interaction of L-selectin with the high endothelial venule ligand via selectively oxidized sialic acids. Proc Natl Acad Sci USA 90: 1068-1072, 1993.
57. O'Connell D, Koenig A, Jennings S, Hicke B, Han H-L, Varki N, Fitzwater TF, Chang Y-F, Parma D, Varki A: Evolved RNA ligands specific for L-selectin. Proc Natl Acad Sci USA 93: 5883-5887, 1996.
58. Picker LJ, Treer JR, Ferguson-Darnell B, Collins PA, Buck D, Terstappen LWMM: Control of lymphocyte recirculation in man. I. Differential regulation of the peripheral lymph node homing receptor L-selection on T cells during the virgin to memory cell transition. J Immunol 150: 1105-1121, 1993.
59. Pollet RJ, Standaert ML, Haase BA: Insulin binding to the human lymphocyte receptor. J Biol Chem 252: 5828-5834, 1977.
60. Reichert RA, Gallatin WM, Weissman IL, Butcher EC: Germinal center B cells lack homing receptors necessary for normal lymphocyte recirculation. J Exp Med 157: 813-827, 1983.
61. Reynolds JA: Interaction of divalent antibody with cell surface antigens. Biochemistry 18: 264-269, 1979.
62. Riggs AD, Bourgeois S, Cohn M: The lac repressor-operator interaction: III kinetic studies. J Mol Biol 53: 401-417, 1970.
63. Ringquist S, MacDonald M, Gibson T, Gold L: Nature of the ribosomal mRNA track: Analysis of ribosome-binding sites containing different sequences and secondary structures. Biochemistry 32: 10254-10262, 1993.
64. Ringquist S, Jones T, Snyder EE, Gibson T, Boni I, Gold L: High-affinity RNA ligands to Escherichia coli ribosomes and ribosomal protein S1: Comparison of natural and unnatural binding sites. Biochemistry 34: 3640-3648, 1995.
65. Schneider D, Tuerk C, Gold L: Selection of high affinity RNA ligands to the bacteriophage R17 coat protein. J Mol Biol 228: 862-869, 1992.
66. Simon SI, Chambers JD, Sklar LA: Flow cytometric analysis and modeling of cell-cell adhesive interactions: The neutrophil as a model. J Cell Biol 111: 2747-2756, 1990.
67. Simon SI, Chambers JD, Butcher E, Sklar LA: Neutrophil aggregation is B2-integrin-and L-selectin-dependent in blood and isolated cells. J Immunol 149: 2765-2771, 1992.
68. Simon SI, Rochon YP, Lynam EB, Smith CW, Anderson DC, Sklar LA: B2-integrin and L-selectin are obligatory receptors in neutrophil aggregation. Blood 82: 1097-1106, 1993.
69. Spertini O, Freedman AS, Belvin MP, Penta AC, Griffin JD, Tedder TF: Regulation of leukocyte adhesion molecule-1 (TQ-1, Leu-8) expression and shedding by normal and malignant cells. Leukemia 5: 300-308, 1991.
70. Spertini O, Kansas GS, Munro M, Griffin JD, Tedder TF: Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin. Nature 349: 691-694, 1991.
71. Springer TA: Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu Rev Physiol 57: 827-872, 1995.
72. Tedder TF, Penta AC, Levine HB, Freedman AS: Expression of the human leukocyte adhesion molecule, LAM1: Identity with the TQ1 and Leu-8 differentiation antigens. J Immunol 144: 532-540, 1990.
73. Tedder TF, Steeber DA, Pizcueta P: L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites. J Exp Med 181: 2259-2264, 1995.
74. Tedder TF, Steeber DA, Chen A, Engel P: The selectins: vascular adhesion molecules. FASEB J 9: 866-873, 1995.
75. Tuerk C, Gold L: Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249: 505-510, 1990.
76. von Andrian UH, Chambers JD, McEvoy LM, Bargatze RF, Arfors K-E, Butcher EC: Two step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and leukocyte B-2 integrins in vivo. Proc Natl Acad Sci USA 87: 7538-7542, 1991.
77. von Andrian UH, Hansell P, Chambers JD, Berger E, Torres-Filho I, Butcher EC, Arfors K-E: L-selectin function is required for B2 integrin-mediated neutrophil adhesion at physiologic shear rates in vivo. Am J Physiol 263: H1034-H1044, 1992.
78. von Andrian UH, Berger EM, Ramezani L, Chambers JD, Ochs HD, Harlan JM, Paulson JC, Etzioni A, Arfors K-E: In vivo behavior of granulocytes from two patients with distinct inherited leukocyte adhesion deficiency syndromes. J Clin Invest 91: 2893-2897, 1993.
79. Watson SR, Fennie C, Lasky LA: Neutrophil influx into an inflammatory site inhibited by a soluble homing receptor-IgG chimera. Nature 349: 164-167, 1991.
80. Yarus M, Berg P: Recognition of tRNA by isoleucyl-tRNA synthetase: Effect of substrates on the dynamics of tRNA-enzyme interaction. J Mol Biol 42: 171-189, 1969.
81. Yednock TA, Butcher EC, Stoolman LM, Rosen SD: Receptors involved in lymphocyte homing: relationship between a carbohydrate-binding receptor and the MEL-14 antigen. J Cell Biol 104: 725-731, 1987.