DNA aptamers block L-selectin function in vivo: Inhibition of human lymphocyte trafficking in SCID mice

Journal of Clinical Investigation

Volumn 98, Issue 12, 1996, Pages 2688-2692

  Hicke, Brian J ^a   Watson, Susan R ^a   Koenig, Andrea ^b   Lynott, C Kate ^a   Bargatze, Robert F ^c   Chang, Ying Fon ^a   Ringquist, Steven ^a   Moon McDermott, Lotus ^a   Jennings, Susan ^a   Fitzwater, Tim ^a   Han, Hui Ling ^b   Varki, Nissi ^b   Albinana, Irma ^a   Willis, Michael C ^a   Varki, Ajit ^b   Parma, David ^a  

^a GILEAD SCIENCES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Montana Immuno Tech   (United States)

Author keywords

Cell adhesion; Inflammation; Oligonucleotide; SELEX; Therapeutics

Indexed keywords

APTAMER; DNA; L SELECTIN; LIGAND; OLIGODEOXYNUCLEOTIDE; SIALOPROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; INHIBITION KINETICS; INTRACELLULAR TRANSPORT; LECTIN BINDING; LIGAND BINDING; LYMPHOCYTE MIGRATION; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; SEQUENCE ANALYSIS; TECHNOLOGY;

ANIMALS; ANTIGENS, CD15; BINDING SITES; CALCIUM; CELL ADHESION; CLONING, MOLECULAR; DEOXYRIBONUCLEOTIDES; DNA-BINDING PROTEINS; FLOW CYTOMETRY; L-SELECTIN; LIGANDS; LYMPHOCYTES; MICE; MICE, SCID; PROTEIN BINDING; SPECTROMETRY, FLUORESCENCE;

EID: 0030478841     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119092     Document Type: Article

References (30)

1. Bevilacqua, M.P., and R.M. Nelson. 1993. Selectins. J. Clin. Invest. 91: 379-387.
2. Rosen, S.D., and C.R. Bertozzi. 1994. The selectins and their ligands. Curr. Opin. Cell. Biol. 6:663-673.
3. McEver, R.P., K.L. Moore, and R.D. Cummings. 1995. Leukocyte trafficking mediated by selectin-carbohydrate interactions. J. Biol. Chem. 270: 11025-11028.
4. Picker, L.J., and E.C. Butcher. 1992. Physiological and molecular mechanisms of lymphocyte homing. Ann. Rev. Immunol. 10:561-591.
5. Springer, T.A. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 76:301-314.
6. Lasky, L.A. 1995. Selectin-carbohydrate interactions and the initiation of the inflammatory response. Ann. Rev. Biochem. 64:113-139.
7. Carlos, T.M., and J.M. Harlan. 1994. Leukocyte-endothelial adhesion molecules. Blood. 84:2068-2101.
8. Bradley, L.M., G.G. Atkins, and S.L. Swain. 1992. Long-term CD4+ memory T cells from the spleen lack MEL-14, the lymph node homing receptor. J. Immunol. 148:324-331.
9. Berg, E.L., M.K. Robinson, O. Mansson, E.C. Butcher, and J.L. Magnani. 1991. A carbohydrate domain common to both sialyl Le(a) and sialyl Le(X) is recognized by the endothelial cell leukocyte adhesion molecule ELAM-1. J. Biol. Chem. 266:14869-14872.
10. Foxall, C., S.R. Watson, D. Dowbenko, C. Fennie, L.A. Lasky, M. Kiso, A. Hasegawa, D. Asa, and B.K. Brandley. 1992. The three members of the selectin receptor family recognize a common carbohydrate epitope, the sialyl Lewis(x)oligosaccharide. J. Cell Biol. 117:895-902.
11. Nelson, R.M., S. Dolich, A. Aruffo, O. Cecconi, and M.P. Bevilacqua. 1993. Higher-affinity oligosaccharide ligands for E-selectin. J. Clin. Invest. 91: 1157-1166.
12. Varki, A. 1994. Selectin ligands. Proc. Natl. Acad. Sci. USA. 91:7390-7397.
13. Lasky, L.A., M.S. Singer, D. Dowbenko, Y. Imai, W.J. Henzel, C. Grimley, C. Fennie, N. Gillett, S.R. Watson, and S.D. Rosen. 1992. An endothelial ligand for L-selectin is a novel mucin-like molecule. Cell. 69:927-938.
14. Baumhueter, S., M.S. Singer, W. Henzel, S. Hemmerich, M. Renz, S.D. Rosen, and L.A. Lasky. 1993. Binding of L-selectin to the vascular sialomucin CD34. Science (Wash. DC). 262:436-438.
15. Sako, D., X.-J. Chang, K.M. Barone, G. Vachino, H.M. White, G. Shaw, G.M. Veldman, K.M. Bean, T.J. Ahern, B. Furie, et al. 1993. Expression cloning of a functional glycoprotein ligand for P-selectin. Cell. 75:1179-1180.
16. Norgard, K.E., K.L. Moore, S. Diaz, N.L. Stults, S. Ushiyama, R.P. McEver, R.D. Cummings, and A. Varki. 1993. Characterization of a specific ligand for P-selectin on myeloid cells. A minor glycoprotein with sialylated O-linked oligosaccharides. J. Biol. Chem. 268:12764-12774.
17. Albelda, S.M., C.W. Smith, and P.A. Ward. 1994. Adhesion molecules and inflammatory injury. FASEB (Fed. Am. Soc. Exp. Biol.) J. 8:504-512.
18. Bevilacqua, M.P., R.M. Nelson, G. Mannori, and O. Cecconi. 1994. Endothelial-leukocyte adhesion molecules in human disease. Ann. Rev. Med. 45: 361-378.
19. Lefer, A.M., A.S. Weyrich, and M. Buerke. 1994. The role of selectins, a new family of adhesion molecules, in ischemia-reperfusion injury. Cardiovasc. Res. 28:289-294.
20. Tuerk, C., and L. Gold. 1990. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science (Wash. DC). 249:505-510.
21. Gold, L. 1995. Oligonucleotides as research, diagnostic, and therapeutic agents. J. Biol. Chem. 270:13581-13584.
22. Gold, L., B. Polisky, O. Uhlenbeck, and M. Yarus. 1995. Diversity of oligonucleotide functions. Ann. Rev. Biochem. 64:763-797.
23. O'Connell, D., A. Koenig, S. Jennings, B. Hicke, H.-L. Han, T. Fitzwater, Y.-F. Chang, N. Varki, D. Parma, and A. Varki. 1996. Calcium-dependent oligonucleotide antagonists specific for L-selectin. Proc. Natl. Acad. Sci. USA. 93:5883-5887.
24. Bargatze, R.F., S. Kurk, G. Watts, T.K. Kishimoto, C.A. Speer, and M.A. Jutila. 1994. In vivo and in vitro functional examination of a conserved epitope of L- and E-selectin crucial for leukocyte-endothelial cell interactions. J. Immunol. 152:5814-5825.
25. Geng, J.-G., K.L. Moore, A.E. Johnson, and R.P. McEver. 1991. Neutrophil recognition requires a Ca(2+)-induced conformational change in the lectin domain of GMP-140. J. Biol. Chem. 266:22313-22318.
26. Erbe, D.V., B.A. Wolitzky, L.G. Presta, C.R. Norton, R.J. Ramos, D.K. Burns, J.M. Rumberger, B.N. Rao, C. Foxall, B.K. Brandley, and L.A. Lasky. 1992. Identification of an E-selectin region critical for carbohydrate recognition and cell adhesion. J. Cell Biol. 119:215-227.
27. Erbe, D.V., S.R. Watson, L.G. Presta, B.A. Wolitzky, C. Foxall, B.K. Brandley, and L.A. Lasky. 1993. P- and E-selectin use common sites for carbohydrate ligand recognition and cell adhesion. J. Cell Biol. 120:1227-1235.
28. Sgroi, D., A. Varki, S. Braesch-Andersen, and I. Stamenkovic. 1993. CD22, a B cell-specific immunoglobulin superfamily member, is a sialic acid-binding lectin. J. Biol. Chem. 268:7011-7018.
29. Kishimoto, T.K., M.A. Jutila, and E.C. Butcher. 1990. Identification of a human peripheral lymph node homing receptor: a rapidly down-regulated adhesion molecule. Proc. Natl. Acad. Sci. USA. 87:2244-2248.
30. Gallatin, W.M., I.L. Weissman, and E.C. Butcher. 1983. A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature (Lond.), 304:30-34.