Concentrations of Leptin and Neuropeptide Y in Maternal Plasma, Umbilical Cord Blood and in Amniotic Fluid in Pregnant Women with EPH-Gestosis

Archivum Immunologiae et Therapiae Experimentalis

Volumn 46, Issue 5, 1998, Pages 311-316

  Kokot, Franciszek ^a   Ulman, Izabela ^a   Wiecek, Andrzej ^a   Irzyniec, Tomasz ^a   Ulman, Józef ^b  

^a UNIVERSITY OF SILESIA   (Poland)

^b Municipal Hospital   (Poland)

Author keywords

Amniotic fluid; EPH gestosis; Leptin; Neuropeptide Y; Normal pregnancy; Umbilical cord blood

Indexed keywords

LEPTIN; NEUROPEPTIDE Y; PROTEIN;

ADULT; AMNION FLUID; ARTICLE; BLOOD; FEMALE; FETOMATERNAL TRANSFUSION; FETUS BLOOD; HUMAN; METABOLISM; PREECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATION;

ADULT; AMNIOTIC FLUID; FEMALE; FETAL BLOOD; HUMANS; LEPTIN; MATERNAL-FETAL EXCHANGE; NEUROPEPTIDE Y; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATIONS, CARDIOVASCULAR; PROTEINS;

EID: 0032253429     PISSN: 0004069X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. CARO J. F., KOLACZYŃSKI J. W., NYCE M. R., OHANNESIAN J. P., OPENTANOVA I., GOLDMAN W. H., LYNN R. B., ZHANG P. L., SINHA M. K. and CONSIDINE R. V. (1996): Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a posible mechanism for leptin resistance. Lancet, 348, 159 - 161.
2. CHUA S. C., CHUNG W. K., WU-PENG X. S., ZHANG Y., LIU S., FARTAGLIA L. and LEIBEL R. L. (1996): Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor Science, 271, 994 - 996.
3. COMPFIELD L. A., SMITH F. J., GUISEZ Y., DEVOS R. and BURN P. (1995): Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural network. Science, 269, 546-549.
4. CONSIDINE R. V., SINHA M. K., HEIMAN M. I., KRAUCIUNAS A. STEPHENS T. W., NYCE M. R., OHANNESIAN J. P., MARCO C. C., MCKEE L. J., BAUER T. L. and CARO J. F. (1996): Serum leptin concentrations in normal weight and obese humans. N. Engl. J. Med., 334, 292 - 295.
5. GAINSFORD T., WILLSON T. A., METCOLF D., HANDMAN E., MCFARLANE C., NG A., NICOLA N. A., ALEXANDER W. S. and HILTON D. J. (1996): Leptin can induce proliferation, differentiation and functional activation of hemopoietic cells. Proc. Natl Acad. Sci. USA, 93, 14564 - 14568.
6. HARTMANN B. W., WAGENBICHLER P. and SÖREGI G. (1997): Maternal and umbilical-cord serum leptin concentrations in normal, full-term pregnancies. N. Engl. J. Med., 337, 863.
7. HASSINK S. G., DE LANCEY E., SHESLOW D. V., SMITH-KIRWIN S. M., O'CONNOR D. M., CONSIDINE R. V., OPENTANOVA I., DOSTAL K., SPEAR M. L., LEEF K., ASH M., SPITZER A. R. and FUNANAGE V. L. (1997): Placental leptin. An important new growth factor in intrauterine and neonatal development? Pediatrics, 100, el (electronic pages).
8. HUGHES E. C. (1972): Obstetric-gynecologic terminology. Davies, Philadelphia, 422 - 423.
9. MASUZAKI H., OGAWA Y., ISSE N., SATOH N., OKAZAKI T., SHIGEMOTO M., MORI K., TAMURA N., HOSADA K., YOSHIMASA Y., JINGAMI H., KAWADA T. and NAKAO K. (1995): Human obese gene expression: adipocyte-specific expression and regional differences in the adipose tissue. Diabetes, 44, 855 - 858.
10. MATSUDA J., YOKOTA I., IIDA M., MURAKAMI T., NAITO E., ITO M., SHIMO K. and KURODA Y. (1997): Serum leptin concentration in cord blood: relationship to birth weight and gender. J. Clin. Endocrinol. Metab., 82, 1642 - 1644.
11. PELLEYMOUNTER M. A., CULLEN M. J., BAKER M. B., HECHT R., WINTERS D., BOONE T. and COLLINS F. (1995): Effects of the obese gene product on body weight regulation in ob/ob mice. Science, 269, 540 - 543.
12. SCHUBRING C., KIESS W., ENGLARO P., RASCHER W., DÖTSCH J., HAMITSCH S., ATTANASIO A. and BLUM W. F. (1997): Levels of leptin in maternal serum amniotic fluid, and arterial and venous cord blood: relation to neonatal and placental weight. J. Clin. Endocrinol. Metab., 82, 1480-1483.
13. STEPHENS T. W., BASHINSKI M., BRISTOW P. K., BUE-VALLESKY J. M., BURGETTI S. G., CRAFT L., PRATER J., HOFFMAN J., HUANG H. M., KRIAUNUNAS A., MACKELTAR W., ROSTACH P. R., ZHANG X. Y. and METMAN M. (1995): The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature, 377, 530 - 534.
14. TARTAGLIA L. A., DEMBSKI M., WENG X., DENG N., CULPEPPER J., DEVOS R., RICHARDS G. J., CAMPFIELD L. A., CLARK F. T., DEEDS J., MUIR C., SANKER S., MORIARTY A., MOORE K. J., SMUTKO J. S., MAYS G. G., WOLF E. A., MONROE C. A. and TEPPER R. J. (1995): Identification and expression cloning of a leptin receptor, OB-R. Cell, 83, 1263 - 1271.
15. WILDING J. P. H., GILBEY S. G., BAILEY C. J., BATT R. A. L., WILLIAMS G., GHATEI M. A. and BLOOD S. R. (1993): Increased neuropeptide Y - messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse. Endocrinology, 132, 1939 - 1944.
16. ZHANG Y., PROENCA R., MAFFEI M., BARONE M., LEOPOLD L. and FRIEDMAN J. M. (1994): Positional cloning of the mouse obese gene and its humans homologue. Nature, 372, 425 - 432.