Frequent Expression of the c-kit Proto-Oncogene in Canine Malignant Mammary Tumor

Journal of Veterinary Medical Science

Volumn 60, Issue 12, 1998, Pages 1335-1340

  Kubo, Kihei ^a   Matsuyama, Satoshi ^a   Katayama, Kumiko ^a   Tsutsumi, Chizu ^a   Yonezawa, Kumiko ^a   Shimada, Terumasa ^a   Kotani, Takeo ^a   Sakuma, Sadashige ^a   Ohashi, Fumihito ^a   Takamori, Yasuhiko ^a  

^a Osaka Prefecture University   (Japan)

Author keywords

c kit; Canine; Mammary tumor; RT PCR; Tumor marker

Indexed keywords

CANIS FAMILIARIS; FELIDAE; MAMMALIA;

DNA; MESSENGER RNA; STEM CELL FACTOR RECEPTOR;

ANIMAL; ANIMAL DISEASE; ARTICLE; BIOSYNTHESIS; CAT; CHEMISTRY; DOG; DOG DISEASE; EXPERIMENTAL NEOPLASM; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MOUSE; POLYMERASE CHAIN REACTION; RAT; SEQUENCE HOMOLOGY;

ANIMALS; CATS; DNA, NEOPLASM; DOG DISEASES; DOGS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MAMMARY NEOPLASMS, ANIMAL; MICE; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-KIT; RATS; RNA, MESSENGER; SEQUENCE HOMOLOGY, NUCLEIC ACID;

EID: 0032252057     PISSN: 09167250     EISSN: None     Source Type: Journal    
DOI: 10.1292/jvms.60.1335     Document Type: Article

References (29)

1. Chomczynski, P. and Sacchi, N. 1987. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159.
2. Chui, X., Egami, H., Yamashita, J., Kurizaki, T., Ohmachi, H., Yamamoto, S. and Ogawa, M. 1996. Immunohistochemical expression of the c-kit proto-oncogene product in human malignant and non-malignant breast tissues. Br. J. Cancer 73: 1233-1236.
3. Cohen, P. S., Chan, J. P., Lipkunskaya, M., Biedler, J. L. and Seeger, R. C. 1994. Expression of stem cell factor and c-kit in human neuroblastoma. The children's Cancer Group. Blood 84: 3465-3472.
4. Costa, J. J., Demetri, G. D., Harrist, T. J., Dvorak, A. M., Hayes, D. F., Merica, D. F., Menchaca, D. M., Gringeri, A. J., Schwartz, L. B. and Galli, S. J. 1996. Recombinant human stem cell factor (kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation. J. Exp. Med. 183: 2681-2686.
5. DiPaola, R. S., Kuczynski, W. I., Onodera, K., Ratajczak, M. Z., Hijima, N., Moore, J. and Gewiru, A. M. 1997. Evidence for a functional kit receptor in melanoma, breast and lung carcinoma cells. Cancer Gene Therapy 4: 176-182.
6. Herbst,R., Munemitsu,S. and Ullrich, A. 1995. Oncogenic activation of v-kit involves deletion of a putative tyrosinesubstrate interaction site. Oncogene 10: 369-379.
7. Hines, S. J., Organ, C., Kornstein, M. J. and Krystal, G. W. 1995. Coexpression of the c-kit and stem cell factor genes in breast carcinoma. Cell Growth Differ. 6: 769-779.
8. Hirota, S., Isozaki, K., Moriyama, Y., Hashimoto, K., Nishida, T., Ishiruro, S.,Kawano, K., Harada, M., Kurata, A., Takeda, M., Tunio, G. M., Matsuzawa, Y., Kanakura, Y., Shinomura, Y. and Kitamura, Y. 1998. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 279: 577-580.
9. Huang, S., Luca, M., McConkey, D. J., Langley, K. E., Lyman, S. D. and Bar-Eli, M. 1996. Enforced c-kit expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential. Oncngene 13: 2339-2347.
10. Furitsu, T., Tsujimura, T., Tono, T., Ikeda, H., Kitayama, H., Koshimizu, U., Sugahara, H.,Butterfield, J. H., Ashman, L. K. and Kanayama, Y. 1993. Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J. Clin. Invest. 92: 1736-1744.
11. Lammie, A., Drobnjak, M., Gerald, W., Saad, A., Cote, R. and Cordon-Cardo, C. 1994. Expression of c-kit and kit ligand proteins in normal human tissues. J. Histochem. Cytochem. 42: 1417-1425.
12. London, C. A., Kisseberth, W. C., Galli, S. J., Geissler, E. N. and Helfand, S. C. 1996. Expression of stem cell factor receptor (c-kit) by the malignant mast cells from spontaneous canine mast cell tumors. J. Comp. Pathol. 115: 399-414.
13. Matsuyama, S., Kubo, K. Ohashi, F. and Takamori, Y. 1997. Partial cloning of prohibitin cDNA from canine, feline, bovine, equine and rabbit liver mRNA by RT-PCR. J. Vet. Med. Sci. 59:201-203.
14. Montone, K. T., van Belle, P., Elenitsas, R. and Elder, D. E. 1997. Proto-oncogene c-kit expression in malignant melanoma: protein loss with tumor progression. Mod. Pathol. 10: 939-944.
15. Moulton, J. E. 1990. Mammary tumors of the dog. pp. 518-546. In: Tumors in Domestic Animals, 3rd ed. (Moulton, J. E ed.). University of California Press, Berkeley and Los Angeles, California.
16. Natali, P. G., Nicotra, M. R., Sures, I., Santoro, E., Btgotti, A.and Ullrich, A. 1992. Expression of c-kit receptor in normal and transformed human nonlymphoid tissues. Cancer Res. 52: 6139-6143.
17. Natali, P. G., Nicotra, M. R., Sures, I., Mottolese, M., Botti, C. and Ullrich, A. 1992. Breast cancer is associated with loss of the c-kit oncogene product. Int. J. Cancer 52: 713-717.
18. Natali, P. G., Berlingteri, M. T., Nicotra, M. R., Fusco, A., Santoro, E., Bigotti, A. and Vecchio, G. 1995. Transformation of thyroid epithelium is associated with loss of c-kit receptor. Cancer Res. 55: 1787-1791.
19. Nishida, K., Tsukamoto, T., Uchida, K., Takahashi, T., Takahashi, T. and Ueda, R. 1996. Introduction of the c-kit gene leads to growth suppression of a breast cancer cell line MCF-7. Anticancer Res. 16: 3397-3402.
20. Piesch, T., Nicotra, M. R., Fraioli, R., Wolf, H. K., Mottolese, M. and Natali, P. G. 1998. Expression of the c-Kit receptor and its ligand SCF in non-small-cell lung carcinomasz Int. J. Cancer 75: 171-175.
21. Qiu F., Ray P., Brown, K., Barker, P.E., Jhanwar, S., Ruddle F.H., Besmer, P. 1988. Primary structure of c-kit: relationship with the CSF-1 PDGF receptor kinase family-oncogenic activation of v-kit involves deletion of extracellular domain and C terminus. EMBO J. 7: 1003-1011.
22. Sanger, F., Nicklen, S. and Coulson, A. R. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad, Sci. U.S.A. 74: 5463-5467.
23. Sekido, Y., Ibata, Y., Ueda, R., Hida, T., Suyama, M., Shimokata, K., Ariyoshi, Y. and Takahashi, T. 1991. Preferential expression of c-kit protooncogene transcripts in small cell lung cancer. Cancer Res. 51: 2416-2419.
24. Takaoka, A., Toyota, M., Hinoda, Y., Itoh, F., Mita, H., Adachi, M. and Imai, K. 1997. Expression and identification of aberrant c-kit transcripts in human cancer cells. Cancer Lett. 115: 257-261.
25. Tsujimura, T., Hirota, S., Nomura, S., Niwa, Y., Yamazaki, M., Tono, T., Morii, E., Kim, H., Kondo, K., Nishimune, Y. and Kitamura, Y. 1991. Characterization of Ws mutant allele of rats: a 12-base deletion in tyrosine kinasc domain of c-kit gene. Blood 78: 1942-1946.
26. Tsujimura, T. 1996. Role of c-kit receptor tyrosine kinase in the developement, survival and neoplastic transformation of mast cells. Pathol. Int. 46: 933-938.
27. Tuura, Y., Hiraki, H., Watanabe, K., Igarashi, S., Shimamura, K., Fukuda, T., Suzuki, T. and Seito, T. 1994. Preferential localization of c-kit product in tissue mast cells, basal cells of skin, epithelial cells of breast, small cell lung carcinoma, and seminoma/dysgerminoma in human: immunohistochemical study on formalin-fixed, paraffin-embedded tissues. Virchows Arch. 424: 135-141.
28. Yarden, Y., Kuang, W.J., Yang-Feng, T., Coussens, L., Munemitsu, S., Dull, T.J., Chen, E., Schlessinger, J., Francke, U. and Ullrich A. 1987. Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J. 6: 3341-3351.
29. Zakut, R., Perlis, R., Eliyahu, S., Yarden, Y., Givol, D., Lyman, S. D. and Halaban, R. 1993. KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells. Oncogene 8: 2221-2229.