Mechanism of action of β2-glycoprotein I-dependent lupus anticoagulants

Lupus

Volumn 7, Issue SUPPL. 2, 1998, Pages

  Arnout, J ^a   Vermylen, J ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Affinity for phospholipid; Beta 2 glycoprotein I; Bivalent antibody interaction; Lupus anticoagulant activity

Indexed keywords

BETA2 GLYCOPROTEIN 1; CARDIOLIPIN ANTIBODY; LUPUS ANTICOAGULANT; PHOSPHOLIPID; PROTHROMBIN; ANION; AUTOANTIGEN; EPITOPE; GLYCOPROTEIN; IMMUNOGLOBULIN F(AB) FRAGMENT;

ANTIPHOSPHOLIPID SYNDROME; BINDING AFFINITY; CONFERENCE PAPER; HUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; THROMBOSIS; ANIMAL; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY REACTION; AUTOIMMUNE DISEASE; BIOLOGICAL MODEL; CHEMISTRY; IMMUNOLOGY; MACROMOLECULE; MAMMAL; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION; REVIEW;

ANIMALS; ANIONS; ANTIBODIES, ANTICARDIOLIPIN; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIGEN-ANTIBODY REACTIONS; ANTIPHOSPHOLIPID SYNDROME; AUTOANTIGENS; AUTOIMMUNE DISEASES; BETA 2-GLYCOPROTEIN I; EPITOPES; GLYCOPROTEINS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; LUPUS COAGULATION INHIBITOR; MACROMOLECULAR SUBSTANCES; MAMMALS; MODELS, IMMUNOLOGICAL; PHOSPHOLIPIDS; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 0032246781     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (64)

1. Hughes GRV, Harris EN, Gharavi AE The anticardiolipin syndrome J Rheumatol 1986; 13: 486-489.
2. Vermylen J et al. Thrombosis as an immune phenomenon. Baillière's Clinical Immunology and Allergy 1987, 1: 619-641.
3. Love PE, Santoro SA. Antiphospholipid antibodies: Anticardiolipin and the lupus anticoagulant m systemic lupus erythematosus (SLE) and in non-SLE disorders, Ann Intern Med 1990; 112: 682-698.
4. Exner T, Triplett DA, Taberner D, Machin SJ. Guidelines for testing and revised criteria for lupus anticoagulants. Thromb Haemost 1991; 65: 320-322.
5. Brandt JT, Triplett DA, Alving B, Scharrer I. Criteria for the diagnosis of lupus anticoagulants an update. Thromb Haemost 1995; 74: 1185-1190
6. Harris EN et al. Anticardiolipin antibodies, detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus Lancer 1983; 11. 1211-1214.
7. Loizou S et al. Measurement of anticardiolipin antibodies by an enzyme-linked immunosorbent assay (ELISA): standardization and quantitation of results Clin Exp Immunol. 1985, 62: 738-745
8. McNeil HP, Simpson RJ, Chesterman CN, Krilis SA. Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta-2-glycoprotein I (apolipo-protein H). Proc Natl Acad Sci USA 1990; 87: 4120-4124
9. Galli M et al. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. Lancet 1990; 335: 1544-1547.
10. Matsuura E et al Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease. Lancet 1990; 336: 177-178
11. Vermylen J, Arnout J Is the antiphospholipid syndrome caused by antibodies directed against physiologically relevant phospholipidprotein complexes? J Lab Clin Med 1992: 120. 10-12.
12. Hunt JE et al A phospholipid-beta 2-glycoprotein I complex is an antigen for anticardiolipin antibodies occurring in autoimmune disease but not with infection. Lupus 1992. 1. 75-81.
13. Bevers EM et al. Lupus anticoagulant IgGs (LA) are not directed to phospholipids only, but to a complex of lipid-bound human prothrombin Thromb Haemost 1991; 66: 629-632.
14. Oosting JD et al. Lupus anticoagulant activity is frequently dependent on the presence of beta 2-glycoprotein I Thromb Haemost 1992; 67: 499-502
15. Roubey RA, Pratt CW, Buyon JP, Winfield JB. Lupus anticoagulant activity of autoimmune antiphospholipid antibodies is dependent upon beta 2-glycoprotein I. J Clin Invest 1992; 90. 1100-1104
16. Galli M et al. Anticoagulant activity of beta 2-glycoprotein I is potentiated by a distinct subgroup of anticardiolipin antibodies. Thromb Haemost 1992; 68: 297-300.
17. Horbach DA, van Oort E, Derksen RHWM, de Groot PhG. The contribution of anti-prothrombin-antibodies to lupus anticoagulant activity. Discrimination between functional and non-functional anti-prothrombin antibodies. Thromb Haemost 1998; 79: 790-795.
18. McIntyre JA, Wagenknecht DR, Sugi T Phospholipid binding plasma proteins required for antiphospholipid antibody detection-an overview. Am J Reprod Immunol 1997, 37: 101-110.
19. Martinuzzo ME, Forastiero RR, Carreras LO. Anti beta 2 glycoprotein I antibodies: detection and association with thrombosis Br J Haematol 1995. 89, 397-402
20. Ginsburg KS et al. Anticardiolipin antibodies and the risk for ischemic stroke and venous thrombosis Ann Intern Med 1992, 117 997-1002
21. Ginsberg JS et al. Antiphospholipid antibodies and venous thromboembolism. Blood 1995, 86: 3685-3691.
22. Branch DW et al. Immunoglobulin G fractions from patients with antiphospholipid antibodies cause fetal death in BALB/c mice: a model for autoimmune fetal loss Am J Obstet Gynecol 1990; 163: 210-216.
23. Blank M, Cohen J, Toder V, Shoenfeld Y Induction of antiphospholipid syndrome in naive mice with mouse lupus monoclonal and human polyclonal anti-cardiolipin antibodies. Proc Natl Acad Sci USA 1991, 88. 3069-3073.
24. Bakimer R et al. Induction of primary antiphospholipid syndrome in mice by immunization with a human monoclonal anticardiolipin antibody (H-3). J Clin Invest 1992; 89: 1558-1563.
25. 2-glycoprotein I (apolipoprotein H) J Clin Invest 1992, 90: 1105-1109.
26. Blank M et al. Immunization with anticardiolipin cofactor (beta-2-glycoprotein I) induces experimental antiphospholipid syndrome in naive mice. J Autotmmun 1994; 7: 441-455
27. 2-Glycoprotein I and human immunoglobulin G antiphospholipid antibodies. Circulation 1996; 94: 1746-1751
28. Horbach DA et al Lupus anticoagulant is the strongest risk factor for both venous and arterial thrombosis in patients with systemic lupus erythematosus. Comparison between different assays for the detection of antiphospholipid antibodies Thromb Haemost 1996: 76: 916-924
29. 2-glycoprotein I, antiprothrombin anibodies, and lupus anticoagulants in patients with systemic lupus erythematosus with a history of thrombosis. J Rheumatol 1997; 24: 1710-1715
30. 2-glycoprotein I and antiprothrombin antibodies on the anticoagulant activity of activated protein C Blood 1998; 91: 1999-2004.
31. 2-glycoprotein 1 cDNA. FEBS lett 1991; 289. 183-186.
32. 2-glycoprotein 1 Biochem J 1991, 277: 387-391
33. 2-glycoprotein I. Nucleic Acid Res 1989; 17: 6401.
34. 2-glycoprotein I and mapping of the gene to chromosome 11. Genomics 1992; 13: 1082-1087.
35. 2-glycoprotein I). Biochem Biophys Res Commun 1993: 191: 1288-1293.
36. 2-glycoprotein I: the presence of five sushi domains Biochemistry 1991; 30: 11687-11694.
37. 2-glycoprotein I. Febbs lett 1992; 313: 192-197.
38. Wurm H βeta 2-glycoprotein I (apolipoprotein H) interactions with phospholipid vesicles. Int J Biochem 1984; 16: 511-515.
39. 2-glycoprotein I in the rat: isolation from serum and demonstration in lipoprotein density fractions. J Biochem 1980; 11. 265-270
40. 2-glycoprotein I on the dextran sulfate and sulfatide activation of the contact system (Hageman factor system) m the blood coagulation Int J Biochem 1988, 20: 787-792.
41. 2-glycoprotein I contains a phospholipid binding site (Cys281-Cys288) and a region recognized by anticardiolipin antibodies. J Immunol 1994; 152: 653-659.
42. 2-GPl using synthetic peptides. Lupus 1995; 4: S7-S11
43. 2-glycoprotein I to cardiolipin Biochem J 1995; 310: 315-321.
44. 2-glycoprotein I identifies a cluster of lysine residues that are critical for phospholipid binding and anti-cardiolipin antibody activity. J Immunol 1996; 157. 3744-3751.
45. 2-glycoprotein I by cleaving domain V into a nicked form. Blood 1998, 91. 4173-4179.
46. 2-glycoprotein I) which affect phospholipid binding. Human Molec Genet 1997; 6: 311-316.
47. 2-glycoprotein I in its interaction with cardiolipin J Biochem 1995; 118: 129-136.
48. 2-glycoprotein I complexes to lipid membranes. Biochemistry 1996, 35: 13833-13842.
49. 2-glycoprotein I binding to phospholipid membranes Thromb Haemost 1998, in press.
50. 2GPI binding to phospholipids J Clin Invest 1997; 99: 2260-2268.
51. Arnout J et al. Beta-2-glycoprotein I dependent lupus anticoagulants form stable bivalent antibody-beta-2-glycoprotein I complexes on phospholipid surfaces. Thromb Haemost 1998; 79: 79-86.
52. Romans DG, Tilley CA, Dorrington KJ Monogamous bivalency of IgG antibodies I. Deficiency of branched ABHI-active oligosaccharide chains on red cells of infants causes the weak antiglobulin reactions in hemolytic disease of the newborn due to ABO incompatibility. J Immunol 1980; 124: 2807-2811.
53. Wagenknecht DR, McIntyre JA. Changes in beta 2-glycoprotein I antigenicity induced by phospholipid binding. Thromb Haemost 1993; 69: 361-365.
54. 2-Glycoprotein I reactivity of monoclonal anticardiolipin antibodies from patients with the antiphospholipid syndrome. Arthritis Rheum 1994, 37: 1453-1461
55. Pengo V, Biasiolo A, Fior MG. Autoimmune antiphospholipid antibodies arc directed against a cryptic epitope expressed when β2-glycoprotein I is bound to a suitable surface. Thromb Haemost 1995; 73: 29-34.
56. Arvieux J, Roussel B, Jacob MC, Colomb MG. Measurement of antiphospholipid antibodies by ELISA using beta 2-glycoprotein I as an antigen. J Immunol Methods 1991; 143: 223-229.
57. Matsuura E et al. Anticardiolipin antibodies recognize β2-Glycoprotein I structure altered by interaction with an oxygen modified solid phase surface. J Exp Med 1994; 179: 457-462.
58. Roubey RAS, Eisenberg RA, Harper MF, Winfield JB. 'Anticardiolipin' autoantibodies recognize β2-glycoprotein I in the absence of phospholipid. Importance of Ag density and bivalent binding J Immunol 1995; 154. 954-960.
59. Wang MX et al. Epitope specificity of monoclonal anti-β2-Glycoprotein I antibodies derived from patients with the antiphospholipid syndrome. J Immunol 1995, 155: 1629-1636.
60. George J et al Target recognition of β2-Glycoprotein I (β2-GPI)-Dependent anticardiolipin antibodies: evidence for involvement of the fourth domain of β2-GPI in antibody binding. J Immunol 1998; 160: 3917-3923.
61. Arnout J. The pathogenesis of the antiphospholipid syndrome: a hypothesis based on parallelisms with heparin-induced thrombocytopenia Thromb Haemost 1996; 75: 536-541.
62. Arvieux J, Roussel B, Pouzol P, Colomb MG. Platelet activating properties of murine monoclonal antibodies to beta 2-glycoprotein I Thromb Haemost 1993, 70: 336-341.
63. 2 glycoprotein I monoclonal antibodies via Fcy receptor II. J Leukoc Biol 1995; 57: 387-394.
64. Simantov R et al. Activation of cultured vascular endothelial cells by antiphospholipid antibodies. J Clin Invest 1995; 96: 2211-2219.