The sixth international conference on Alzheimer's disease, Amsterdam, the Netherlands, July 1998. The amyloid cascade hypothesis debate: Emerging consensus on the role of Aβ and amyloid in Alzheimer's disease

Amyloid

Volumn 5, Issue 4, 1998, Pages 301-304

  Small, David H ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Alzheimer's disease; Amyloid cascade hypothesis; A ; A PP

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; CONFERENCE PAPER; CONSENSUS DEVELOPMENT; HUMAN; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ALZHEIMER DISEASE; AMYLOID; AMYLOID BETA-PROTEIN; HUMANS;

EID: 0032235398     PISSN: 13506129     EISSN: None     Source Type: Journal    
DOI: 10.3109/13506129809007304     Document Type: Conference Paper

References (16)

1. Glenner GG and Wong CW (1984). Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120, 885-890
2. Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL and Beyreuther K (1985). Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA 82, 4245-4249
3. Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K and Müller-Hill B (1987). The precursor of Alzheimer's disease A4 protein resembles a cell surface receptor. Nature 325, 733-736
4. Terry RD (1963). The fine structure of neurofibrillary tangles in Alzheimer's disease. J Neuropathol Exp Neurol 22, 629-642
5. Kisilevsky R (1994). Amyloidosis. In Rubin E and Farber JL (eds). Pathology, pp. 1163-1174. (Philadelphia: JB Lippincott)
6. Yankner BA, Dawes LR, Fisher S, Villa-Komaroff L, Ostergranite ML and Neve RL (1989). Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 245, 417-420
7. Geula C, Wu CK, Saroff D, Lorenzo A, Yuan M and Yankner BA (1998). Aging renders the brain vulnerable to amyloid β-protein neurotoxicity. Nature Med 4, 827-831
8. Hardy JA and Higgins GA (1992). Alzheimer's disease: the amyloid cascade hypothesis. Science 256, 184-185
9. Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D and Younkin S (1996). Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and AβPP mutations linked to familial Alzheimer's disease. Nature Med 2, 864-870
10. Arriagada PV, Growdon JH, Hedley-Whyte ET and Hyman, BT (1992). Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42, 631-639
11. Holcomb L, Gordon MN, Mcgowan E, Yu X, Benkovic S, Jantzen P, Wright KK, Saad I, Mueller R, Morgan D, Sanders S, Zehr C, Ocampo K, Hardy J, Prada CM, Eckman C, Younkin S, Hsiao K and Duff K. (1998). Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nature Med 4, 97-100
12. Bales KR, Verina T, Dodel RC, Du YS, Altstiel L, Bender M, Hyslop P, Johnstone EM, Little SP, Cummins DJ, Piccardo P, Ghetti B and Paul SM (1997). Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition. Nature Genet 17, 263-264
13. Crook R, Verkkoniemi A, Perez-Tur J, Mehta N, Baker M, Houlden H, Farrer M, Hutton M, Lincoln S, Hardy J, Gwinn K, Somer M, Paetau A, Kalimo H, Ylikoski R, Pöyhönen M, Kucera S and Haltia M (1998). A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1. Nature Med 4, 452-455
14. Kuo YM, Emmerling MR, Vigo-Pelfrey V, Kasunic TC, Kirkpatrick JB, Murdoch GH, Ball M J and Roher AE (1996). Water-soluble Aβ (N-40, N-42) oligomers in normal and Alzheimer disease brains. J Biol Chem 271, 4077-4081
15. 1-42 are potent central nervous system neurotoxins. Proc Natl AcadSci USA 95, 6448-6453
16. Wang R, Sweeney D, Gandy SE and Sisodia SS (1996). The profile of soluble amyloid β protein in cultured cell media - detection and quantification of amyloid β protein and variants by immunoprecipitation mass spectrometry. J Biol Chem 271, 31894-31902