Understanding neurotransmitter receptors: Molecular biology-based strategies

Essays in Biochemistry

Volumn 33, Issue , 1998, Pages 15-27

  Wheatley, Mark ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; NEUROTRANSMITTER RECEPTOR; RECOMBINANT PROTEIN;

ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN CONFORMATION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; GENE EXPRESSION; GTP-BINDING PROTEINS; HUMANS; LIGANDS; MODELS, MOLECULAR; PROTEIN CONFORMATION; RECEPTORS, NEUROTRANSMITTER; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 0032234278     PISSN: 00711365     EISSN: None     Source Type: Journal    
DOI: 10.1042/bse0330015     Document Type: Article

References (21)

1. Hulme, E.C., Birdsall, N.J.M. & Buckley, N.J. (1990) Muscarinic receptor subtypes. Annu. Rev. Pharmacol. Toxicol. 30, 633-673
2. Levitan, E.S. (1988) Cloning of serotonin and substance K receptors by functional expression in frog oocytes. Trends Neurosci. 11, 41-43
3. Zgombic, J.M., Weinshank, R.L., Macchi, M., Schecter, L.E., Branchek, T.A. & Hartig, P.R. (1991) Expression and pharmacological characterisation of a canine 5-hydroxytryptamine receptor sub-type. Mol. Phormacol. 40, 1036-1042
4. Howl, J. & Wheatley, M. (1993) Hepatic vasopressin receptors (VPRs) exhibit species heterogeneity. Comp. Biochem. Physiol. 105C, 247-250
5. 4C1 pituitary cells. J. Biol. Chem. 269, 13880-13886
6. Bass, B.L. (1997) RNA editing and hypermutation by adenosine deamination. Trends Biochem. Sci. 22, 157-162
7. Burns, C.M., Chu, H., Rueter, S.M., Hutchinson, L.K., Canton, H., Sanders-Bush, E. & Emeson, R.B. (1997) Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature (London) 387, 303-308
8. 2-adrenergic receptor polymorphisms. Notes Physiol. Sci. 10, 265-273
9. Wahlestedt, C. (1994) Antisense oligonucleotide strategies in neuropharmacology. Trends Biochem. Sci. 15, 42-46
10. 2 bradykinin receptor gene in mice eliminates bradykinin action in smooth muscle and neurons. J. Biol. Chem. 270, 13706-13710
11. Albert, P.R. (1994) Heterologous expression of G-protein-linked receptors in pituitary and fibroblast cell-lines. Vitam. Horm. 48, 59-109
12. Milligan, G., Bond, R.A. & Lee, M. (1995) Inverse agonism: pharmacological curiosity or potential therapeutic strategy? Trends Pharmacol. Sci. 16, 10-13
13. 2-adrenoceptor. Nature (London) 374, 272-276
14. a) receptors in CHO cells to a cyclic AMP-responsive luciferase reporter gene. J. Neurochem. 69, 1278-1285
15. Stables, J., Green, A., Marshall, F., Fraser, N., Knight, E., Sautel, M., Milligan, G., Lee, M. & Rees, S. (1997) A bioluminescent assay for agonist activity at potentially any G-protein-coupled receptor. Anal. Biochem. 252, 115-126
16. Strader, C.D., Fong, T.M., Tota, M.R. & Underwood, D. (1994) Structure and function of G-protein-coupled receptors. Annu. Rev. Biochem. 63, 101-132
17. Curtis, C.A.M., Wheatley, M., Bansal, S., Birdsall, N.J.M., Eveleigh, P., Pedder, E.K., Poyner, D. & Hulme, E.C. (1989) Propylbenzilylcholine mustard labels an acidic residue in transmembrane helix three of the muscarinic receptor. J. Biol. Chem. 264, 489-495
18. B-adrenergic receptor by all amino acid substitutions at a single site - evidence for a region which constrains receptor activation. J. Biol. Chem. 267, 1430-1433
19. B-adrenergic receptor: role of highly conserved polar amino acids in receptor activation. EMBO J. 15, 3566-3578
20. Maggio, R., Vogel, Z. & Wess, J. (1993) Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular crosstalk between G-protein-linked receptors. Proc. Natl. Acad. Sci. U.S.A. 90, 3103-3107
21. 2-adrenergic receptor which exploits the domain structure of G-protein-coupled receptors. J. Med. Chem. 40, 3871-3886