The α2-adrenoceptor agonists xylazine and guanfacine exert different central nervous system, but comparable peripheral effects in calves

Journal of Veterinary Pharmacology and Therapeutics

Volumn 21, Issue 6, 1998, Pages 477-484

  Scholtysik, G ^a   Regli, F ^b   Bruckmaier, R M ^b   Blum, J W ^b  

^a UNIVERSITY OF BERN   (Switzerland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; FATTY ACID; GROWTH HORMONE; GUANFACINE; INSULIN; NORADRENALIN; XYLAZINE; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; CATECHOLAMINE;

ADRENALIN BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; CATTLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; HEART RATE; INSULIN BLOOD LEVEL; INTRAVENOUS DRUG ADMINISTRATION; LUNG GAS EXCHANGE; MALE; NONHUMAN; NORADRENALIN BLOOD LEVEL; OXYGEN CONSUMPTION; PHARMACODYNAMICS; PRIORITY JOURNAL; SEDATION; ANIMAL; BLOOD; BREATHING; CROSSOVER PROCEDURE; DRUG EFFECT; GLUCOSE BLOOD LEVEL; PERIPHERAL NERVOUS SYSTEM; PHYSIOLOGY;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; BLOOD GLUCOSE; CATECHOLAMINES; CATTLE; CENTRAL NERVOUS SYSTEM; CROSS-OVER STUDIES; FATTY ACIDS, NONESTERIFIED; GROWTH HORMONE; GUANFACINE; HEART RATE; INJECTIONS, INTRAVENOUS; INSULIN; MALE; OXYGEN CONSUMPTION; PERIPHERAL NERVOUS SYSTEM; PULMONARY GAS EXCHANGE; RESPIRATION; XYLAZINE;

EID: 0032217164     PISSN: 01407783     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2885.1998.00166.x     Document Type: Article

References (53)

1. Berlan, M., Lafontan, M. & Tran, LD. (1980) La lipolyse adrénergique du tissu adipeux humain: propriétés et rôle physiologique des alpha récepteurs. Journal of Physiology, 76, 133-146.
2. Blum, J.W. (1984) Insulin suppressive effects of aminotetralin analogs and of dopamine. European Journal of Pharmacology, 105, 239-244.
3. Blum, J.W. & Flueckiger, N. (1988) Early metabolic and endocrine effects of perorally administered β-adrenoceptor agonists in calves. European Journal of Pharmacology, 151, 177-187.
4. Blum, J.W., Froehli, D. & Kunz, P. (1982) Effects of catecholamines on plasma free fatty acids in fed and fasted cattle. Endocrinology, 110, 452-456.
5. Blum, J.W., Guillebeau, A., Binswanger, U., Kunz, P., Da Prada, M. & Fischer, J.A. (1978) Effects of alpha-adrenergic stimulation and blockade on plasma parathyroid hormone concentrations in cows. Acta Endocrinologica (Kbh), 88, 555-545.
6. Brown, M.J., Struthers, A.D., Silvio, L.D., Yeo, T., Ghatei, M. & Burrin, J. (1985) Metabolic and haemodynamic effects of alpha-2-adrenoceptor stimulation and antagonism in man. Clinical Sciences, 68, 137S-139S.
7. Bruckmaier, R.M. & Blum, J.W. (1992) Responses of calves to treadmill exercise during beta-adrenergic agonist administration. Journal of Animal Science. 70, 2809-2821.
8. 2-adrenergic receptors in the antihypertensive responses evoked by central administration of clonidine analogs in conscious spontaneously hypertensive rats. The Journal of Pharmacology and Experimental Therapeutics, 273, 1162-1171.
9. Bylund, D.B., Eikenberg, D.C., Hieble, J.P., Langer, S.Z., Lefkowitz, R.J., Minneman, K.P., Molinoff, P.B., Ruffolo, R.R. Jr & Trendelenburg, A.U. (1994) IV international union of pharmacology nomenclature of adrenoceptors. Pharmacological Reviews, 46, 121-136.
10. Bylund, D.B., Hass, N.A., Cerutis, D.R. & Blaxall, H.S. (1995) Characterization of alpha-2 adrenergic receptor subtypes. Pharmacological Research Communications, 6, 87-90.
11. Bylund, D.B., Iversen, L.J., Matulka, W.J. & Chacko, U.M. (1997) Characterization of alpha-2D adrenergic receptor subtypes in bovine ocular tissue homogenates. The Journal of Pharmacology and Experimental Therapeutics, 281, 1171-1177.
12. Chilliard, Y. & Flechet, J. (1988) Effets de la clonidine (alpha-2 agoniste) sur la lipolyse du tissu adipeux de bovin adulte, in vitro. Reproduction. Nutrition et Développement, 28, 195-196.
13. Cryer, P.E. (1982) Clinical syndromes of autonomie failure. Cardiovascular Research, 16, 370-376.
14. Fain, J.N. & Garcia-Sainz, J.A. (1983) Adrenergic regulation of adipocyle metabolism. Journal of Lipid Research, 24, 945-966.
15. Ganhao, M.F., Hatting, J., Hurwitz, M.L. & Pitts, N.I. (1991) Evaluation of a simple plasma catecholamine extraction procedure prior to high-performance liquid chromatography and electrochemical detection. Journal of Chromatography, 564, 55-56.
16. 2-adrenoceptor-mediated effects on resting energy expenditure. International Journal of Obesity, 17, 657-641.
17. 2-adrenoceptor agonist, guanfacin, on energy expenditure, intake and deposition in rats. Comparative Biochemistry and Physiology, 112C, 29-34.
18. Gazzola, C., Magner, T., Berger, K.T. & Hunter, R.A. (1993) Effects of guanfacin and nitroprusside on the haemodynamics and oxygen consumption of Brahman steers. Comparative Biochemistry and Physiology, 106C, 443-448.
19. Gazzola, C., Magner, T., Lisle, A.T. & Hunter, R.A. (1995) Effects of α-adrenoceptor agonists and antagonists on metabolic rate in cattle. Comparative Biochemistry and Physiology. 111A, 73-77.
20. Gerlo, E. & Malfait, R. (1985) HPLC-Assay of free norepinephrine, epinephrine, dopamine, vanillylmandelic acid and homovanilic acid. Journal of Chromatography, 343, 9-20.
21. 2-adrenoceptors. Trends in Pharmacological Sciences, 12, 62-67.
22. 2-adrenoceptors. Progress in Drug Research, 47, 81-123.
23. Hill, C.E., Powis. D.A. & Hendry, I.A. (1993) Involvement of pertussis toxin-sensitive and -insensitive mechanisms in α-adrenoceptor modulation of noradrenaline release from rat sympathetic neurones in tissue culture. British Journal of Pharmacology, 110, 281-288.
24. Horvai, G. & Pungor, E. (1989) Electrochemical detectors in HPLC and ion chromatography. CRC Critical Reviews in Analytical Chemistry, 21, 1-28.
25. Hostettler-Allen, R.L., Tappy, L. & Blum, J.W. (1994) Insulin resistance, hyperglycemia, and glucosuria in intensively milk-fed calves. Journal of Animal Science, 72, 160-173.
26. 2-adrenergic agonist, guanfacin. on the energy metabolism of steers fed on low-quality-roughage diets. British Journal of Nutrition, 67, 337-343.
27. Hunter, R.A., Sillence, M.N., Gazzola, C. & Spiers, W.G. (1993) Increasing annual growth rates of cattle by reducing maintenance energy requirements. Australian Journal of Agricultural Research, 44, 579-595.
28. Kleinlogel, H., Scholtysik, G. & Sayers, A.C. (1975) Effects of clonidine and BS 100-141 on the ECG sleep pattern in rats. European Journal of Pharmacology, 33, 156-163.
29. Kroneberg, G., Oberdorf, A., Hoffmeister, F. & Wirth, W. (1967) Zur Pharmakologie von 2-(2,6-Dimethylphenylamino)-4H-5,6-dehydro1,3-thiazin (Bayer 1470). eines Hemmstoffes adrenergischer und cholinergisher Neurone. Naunyn - Schmiedeberg's Archives of Pharamcology, 256, 257-280.
30. 2-Sympathomimetika beim Rind. Vet. 9, 6-15.
31. 2-adrenoceptor agonist, xylazine in sheep. British Journal of Pharmacology, 108, 907-913.
32. 2-adrenoceptor-subtype function. Trends in Pharmacological Sciences, 18, 211-214.
33. 2-adrenoceptors: implications for receptor classification. British Journal of Pharmacology, 106, 1011-1018.
34. 2A subtype. British Journal of Pharmacology, 121, 1721-1729.
35. 2A-adrenoceptors stimulate growth hormone release in the rat. Europian Journal of Pharmacology, 287, 45-48.
36. 2-adrenoceptor agonist guanfacine on heat production of steers in different thermal environments. Proceedings of the Society of Nutrition Physiology, 3, 313.
37. Nami, R., Bianchini, C., Fiorella, G., Chierichetti, S.M. & Gennari, C. (1985) Comparison of effects of guanfacine and clonidine on blood pressure, heart rate, urinary catecholamines, and cyclic nucleotides during and after administration to patients with mild to moderate hypertension. Journal of Cardiovascular Pharmacology, 5, 546-551.
38. Roming, L.G.P. (1984) Tolazolin als Xylazin-Antagonist beim Rind. Deutsche Tierärztliche Wochenschrift, 91, 154-157.
39. 2-adrenoceptor subtypes. Annual Review of Pharmacology and Toxicology, 32, 243-279.
40. 2-Adrenoceptor activation inhibits noradrenaline release in human and rabbit isolated renal arteries. European Journal of Pharmacology, 196, 277-285.
41. SAS (1989) SAS user's guide: statistics. SAS Inst. Inc., Cary, NC.
42. 2-adrenoceptor agonists. In Progress in Hypertension. Vol. 2. Eds Saito, H., Minami, M. & Parvez, S.H. pp. 257-268. VSP, Utrecht, The Netherlands.
43. Schwartz, D.D. (1997) Activation of alpha-2 adrenergic receptors inhibits norepinephrine release by a pertussis toxin-insensitive pathway independent of changes in cytosolic calcium in cultured rat sympathetic neurons. The Journal of Pharmacology and Experimental Therapeutics, 282, 248-255.
44. 2-adrenoceptor agonist guanfacine on growth and thermogenesis in mice. Journal of Animal Science, 70, 5429-5454.
45. 2D-adrenergic receptors in bovine pineal gland. Molecular Pharmacology, 40, 255-241.
46. 2-adrenoceptor mediating prejunctional inhibition of cardioacceleration in the pithed rat heart. British Journal of Pharmacology, 115, 316-320.
47. 2-agonist-induced effects on growth in rats. Proceedings of the Nutrition Society of Australia, 15, 172.
48. 1-imidazoline receptors. British Journal of Pharmacology, 120, 1575-1581.
49. Thomas, G.B., Scott, C.J., Cummins, J.T. & Clarke, I.J. (1994) Adrenergic regulation of growth hormone secretion in the ewe. Domestic Animal Endocrinology, 11, 187-195.
50. 2A in the rabbit. Naunyn-Schmiedeberg's Archives of Pharmacology, 348, 55-45.
51. 2D-adrenoceptors. Naunyn-Schmiedeberg's Archives of Pharmacology, 353, 245-249.
52. 2-adrenergic receptor regulation. Domestic Animal Endocrinology, 14, 334-348.
53. Zimmerli, U.V. & Blum, J.W. (1990) Acute and longterm metabolic, endocrine, respiratory, cardiac and skeletal muscle activity changes in response to perorally administered β-adrenoceptor agonists in calves. Journal of Animal Physiology and Animal Nutrition, 63, 157-172.