Isolation of partially purified P450 2D18 and characterization of activity toward the tricyclic antidepressants imipramine and desipramine

Archives of Biochemistry and Biophysics

Volumn 359, Issue 1, 1998, Pages 115-121

  Thompson, Chad M ^a   Kawashima, Hidenori ^b   Strobel, Henry W ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Baculovirus; Brain drug metabolism; CYP2D18; CYP2D4; CYP2D6; Cytochrome P450; Desipramine; Enzyme purification; GBR 12935; Imipramine; Protein expression; Tricyclic antidepressants

Indexed keywords

1 [2 (BENZHYDRYLOXY)ETHYL] 4 (3 PHENYLPROPYL)PIPERAZINE; CYTOCHROME P450; CYTOCHROME P450 2D18; DESIPRAMINE; IMIPRAMINE; KETOCONAZOLE; QUINIDINE; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN MICROSOME; CONCENTRATION RESPONSE; DEPRESSION; DRUG BINDING; DRUG MECHANISM; ENZYME PURIFICATION; GENE OVEREXPRESSION; HYDROXYLATION; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA; UNIDENTIFIED BACULOVIRUS;

EID: 0032211208     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.1998.0892     Document Type: Article

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