Tumour necrosis factor-alpha and lymphotoxin-alpha in the pathology of experimental autoimmune encephalomyelitis: Is either one responsible or is there another ligand-mediating disease?

Research in Immunology

Volumn 149, Issue 9, 1998, Pages

  Willenborg, D O ^a   Fordham, S A ^b   O'Brien, N C ^a   Cowden, W B ^b   Ramshaw, I A ^b  

^a CANBERRA HOSPITAL   (Australia)

^b Biology and Environment   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; LYMPHOTOXIN; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ASTROCYTE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEMYELINATING DISEASE; HELPER CELL; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW;

EID: 0032209161     PISSN: 09232494     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-2494(99)80008-X     Document Type: Article

References (41)

1. Ando, D.G., Clayton, J., Kono, D., Urban, J.L. & Sercarz, E.E. (1989), Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine type. Cell. Immunol. 124, 132-143.
2. Baker, D., O'Neil, J.K. & Turk, J.K. (1991), Cytokines in the central nervous system of mice during chronic relapsing experimental allergic encephalomyelitis. Cell. Immunol., 134, 505-510.
3. Barbara, J.A.J., Van Ostade, X. & Lopez, A. (1996), Tumour necrosis factor-alpha (TNFα): the good, the bad and potentially very effective. Immunol. Cell Biol., 74, 434-443.
4. Bazzoni, F. & Beutler, B. (1996), Tumour necrosis factor ligand and receptor families. N. Engl. J. Med., 334, 1717-1725.
5. Becher, B., Dodelet, V., Fedorowicz, V. & Antel, J.P. (1996), Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro. J. Clin. Invest., 98, 1539-1543.
6. Brocke, S.K., Gijbels, K., Allegretta, M., Ferber, I., Piercy, C., Blankenstein, T., Martin, R., Utz, U., Karin, N., Mitchell, D., Veroma, T., Waisman, A., Gaur, A., Conlon, P., Ling, N., Fairchild, P.J., Wraith, D.C., O'Garra, A., Fathman, C.G. & Steinman, L. (1996), Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature, 379, 343-345.
7. Chung, I.Y. & Benveniste, E.N. (1990), Tumor necrosis factor production by astrocytes : Induction by lipopolysaccharide, interferon γ and interleukin-1. J. Immunol., 144, 2999-3007.
8. DeTongi, P., Goellner, J., Ruddle, N.H., Streeter, P.R., Pick, A., Mariathasan, S., Smith, S.C., Carlson, R., Shornick, L.P., Strauss-Schoenberger, J., Russell, J.H., Karr, R. & Chaplin, D.D. (1994), Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science, 264, 703-707.
9. Fiorentino, D.F., Bond, M.W. & Mossman, T.R. (1989), Two types of mouse helper T cell : Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med., 170, 2081-2095.
10. Frei, K., Eugster, H.-P., Bopst, M., Constantinescu, C.S., Lavi, E. & Fontana, A. (1997), Tumour necrosis factor α and lymphotoxin a are not required for induction of autoimmune encephalomyelitis. J. Exp. Med., 185(12), 2177-2182.
11. Hayder, H., Blanden, R.V., Korner, H., Rimminton, D.S., Sedgwick, J.D. & Mullbacher, A. (1998), Adenovirus-induced liver pathology is mediated through TNF receptors I and II but is independent of TNF or lymphotoxin. J. Exp. Med. (in press).
12. Held, H., Myermann, R., Qin, Y. & Mueller, C. (1993), Perforin and tumour necrosis factor a in the pathogenesis of experimental allergic encephalomyelitis: comparison of autoantigen induced and transferred disease in Lewis rats. J. Autoimmunity, 6, 311-322.
13. Karin, N.D., Mitchell, D., Ling, N., Brocke, S. & Steinman (1994), Reversal of experimental autoimmune encephalomyelitis by a soluble variant of myelin basic protein epitope: T cell receptor antagonism and reduction of interferon-γ and TNFα production. J. Exp. Med., 180, 2227-2237.
14. Kennedy, M.K., Torrance, D.S., Picha, K.S. & Mohler, K.M. (1992), Analysis of cytokine mRNA expression in the central nervous system of mice with experimental allergic encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol., 149, 2496-2505.
15. Klinkert, W.E.F., Kojima, K., Lesslaur, W., Rinnwer, W., Lassman, H., & Wekerle, H. (1997), TNFα receptor fusion protein prevents experimental autoimmune encephalomyelitis and demyelination in Lewis rats: an overview. J. Neuroimmunol., 72, 163-168.
16. Korner, H., Riminton, D.S., Strickland, D.H., Lemckert, F.A., Pollard, J.D. & Sedgwick, J.D. (1997), Critical points of tumour necrosis factor action in central nervous system autoimmune inflammation defined by gene targeting. J. Exp. Med., 186(9), 1585-1590.
17. Lafaille, J.J., Van de Keere, F., Hsu, A.L., Baron, J.L., Mass, W., Raine, C.S. & Tonegawa, S. (1997), Myelin basic protein -specific T helper (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from disease. J. Exp. Med., 186, 307-312.
18. Liu, J., Marino, M.W., Wong, G., Grail, D., Dunn, A., Bettadapura, J., Slavin, A.J., Old, L. & Bernard, C.C.A. (1998), TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination. Nature Med., 4, 78-82.
19. Ludowyk, P.A., Hughes, W., Hugh, A., Willenborg, D.O., Rockett, K.A. & Parish, C.R. (1993), Astrocytic hypertrophy: an important pathological feature of chronic experimental autoimmune encephalomyelitis in aged rats. J. Neuroimmunol., 48, 121-134.
20. Mariathasan, S., Matsumoto, M., Baranyay, F., Nahm, M.H., Kanagawa, O. & Chaplin, D.D. (1995), Absence of lymph nodes in lymphotoxin-alpha (LTα)-deficient mice is due to abnormal organ development, not defective lymphocyte migration. J. Inflamm., 45, 72-78.
21. Mauri, D.N., Ebner, R., Montgomery, R.I., Kochel, K.D., Cheung, T.C., Yu, G.-L., Ruben, S., Murphy, M., Eisenberg, R.J., Cohem, G.H., Spear, P.G. & Ware, C.F. (1998), LIGHT, a new mwmber of the TNF superfamily, and lymphotoxin α are ligands fo Herpesvirus entry mediator. Immunity, 8, 21-30.
22. Miossec, P., Cavender, D. & Ziff, M. (1986), Production of interleukin 1 by human endothelial cells. J. Immunol., 136, 2486-2489.
23. Olsson, T. (1995), Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis. Imm. Rev., 144, 245-268.
24. Pakala, S.V., Kurrer, M.O. & Katz, J.D. (1997), T helper (Th2) cells induce pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice. J. Exp. Med., 186, 299-306.
25. Powell, M.B., Mitchell, D., Lederman, J., Buckmeier, J., Zamvil, S.S., Graham, M., Ruddle, N.H. & Steinman. (1990), Lymphotoxin and tumour necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity. Intern. Immunol., 2, 539-544.
26. Raine, C.S., Barnett, L.B., Brown, A., & McFarlin, D.E. (1980), Neuropathology of experimental allergic encephalomyelitis in inbred strains of mice. Lab Invest., 43, 150-157.
27. Renno, T., Krakowski, M., Piccirillo, C., Lin, J. & Owens, T. (1995), TNFα expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimentel allergic encephalomyelitis. J. Immunol., 154, 944-953.
28. Riminton, D.S., Korner, H., Strickland, D.H., Lemckert, F.A., Pollard, J.D. & Sedgwick, J.D. (1998), Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient mice, but not tumour necrosis factor-deficient, mice. J. Exp. Med., 187, 1517-1528.
29. Rothe, J., Lesslaur, W., Lorscher, H., Lang, P., Koebel, P., Kontgen, F., Althage, R., Zinkernagel, R., Steinmetz, M. & Bluethmann, H. (1993), Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated cytotoxicity but highly susceptible to infection with Listeria monocytogenes. Nature, 364, 798-802.
30. Ruddle, N.H., Bergman, C.M., McGrath, K.M., Lingenheld, E.G., Grunnet, M.L., Padula, S.J. & Clark, R.B. (1990), An antibody to lymphotoxin and tumour necrosis factor prevents transfer of experimental allergic encephalomyelitis. J. Exp. Med. 172, 1193-1200.
31. Ruuls, S.R & Sedgewick, J.D. (1998), Cytokine-directed therapies in multiple sclerosis and experimental autoimmune encephalomyelitis. Immunol. Cell Biol., 76, 65-73.
32. Selmaj, K., Paplerz, W., Glabinski, A., & Kono, T. (1995), Prevention of chronic relapsing experimental autoimmune encephalomyelitis by soluble tumour necrosis factor receptor 1. J. Neuroimmunol., 56, 135-141.
33. Selmaj, K., Raine, C.S. & Cross, A.H. (1991), Antitumour necrosis factor therapy abrogates autoimmune demyelination. Ann. Neurol., 30, 694-700.
34. Sharief, M.K. & Hentges, R. (1991), Association between tumour necrosis factor-a and disease progression in patients with multiple sclerosis. N. Engl. J. Med., 7, 467-472.
35. Sironi, M., Breviario, F., Proserpio, P., Biondi, A., Vecchi, A., Van Dame, J., Dejana, E. & Mantovani, A. 1989), IL-1 stimulates 1L-6 production in endothelial cells. J. Immunol., 142, 549-553.
36. Sommers, N., Loschmann, P.A., Northoff, G.H., Weller, M., Steinbracher, A., Steinbach, J.P., Lichtenfels, R. Meyermann, R., Reitmuller, A., Fontana, A., Dichgans, J. & Martin, R. (1995), The anti-depressant Rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis. Nat. Med., 1, 244-248.
37. Suen, W.E., Bergman, C.M., Hjelstrom, P. & Ruddle, N.H. (1997), A critical role for lymphotoxin in experimental allergic encephalomyelitis. J. Exp. Med., 186(8), 1233-1240.
38. Waldor, M.K., Sriram, S., Hardy, R., Herzenberg, L.A., Herzenberg, L.A., Lanier, L., Lim, M. & Steinman, L. (1985), Reversal of experimental allergic encephalomyelitis with monoclonal antibody to a T-cell subset marker. Science, 227, 415-417.
39. Willenborg, D.O., Fordham, S.A., Cowden, W.B., & Ramshaw, I.A. (1995), Cytokines and murine autoimmune encephalomyelitis: inhibition or enhancement of disease with antibodies to select cytokines, or by delivery of exogeneous cytokines using a recombinant vaccinia virus system. Scand. J. Immunol., 41, 31-41.
40. Zamvil, S.S & Steinman, L. (1990), The T lymphocyte in experimental allergic encephalomyelitis. Ann. Rev. Immunol., 8, 579-621.
41. Zheng, L., Fisher, G., Miller, R.E., Peschon, J., Lynch, D.H. & Lenardo, M.J. (1995), Induction of apoptosis in mature T cells by tumour necrosis factor. Nature, 377, 348-351.