Involvement of phosphoinositide 5-kinase in regulation of adhesive activity of highly metastatic hepatoma cells

Journal of Biochemistry

Volumn 124, Issue 5, 1998, Pages 1020-1025

  Saeki, Yoshiko ^a   Seya, Tsukasa ^a   Hazeki, Kaoru ^b   Ui, Michio ^b   Hazeki, Osamu ^c   Akedo, Hitoshi ^a  

^a OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^c HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Hepatoma cells; Integrin; Lung metastasis; Tumor invasion; Wortmannin

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BENZO[A]PYRENE; FIBRONECTIN; PHOSPHATIDYLINOSITIDE; PHOSPHOTRANSFERASE; WORTMANNIN; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; ANDROSTANE DERIVATIVE; CHROMONE DERIVATIVE; ENZYME INHIBITOR; MORPHOLINE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; POLYPHOSPHOINOSITIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER TRANSPLANTATION; CELL ADHESION; CONTROLLED STUDY; EMBRYO; GENETIC TRANSFECTION; HEPATOMA CELL; LIVER CELL; LUNG METASTASIS; MOUSE; NONHUMAN; ANIMAL; BAGG ALBINO MOUSE; DRUG EFFECT; ENZYMOLOGY; HUMAN; LIVER TUMOR; METABOLISM; METASTASIS; PATHOLOGY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; CELL ADHESION; CHROMONES; ENZYME INHIBITORS; HUMANS; LIVER NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MORPHOLINES; NEOPLASM METASTASIS; PHOSPHATIDYLINOSITOL PHOSPHATES;

EID: 0032201585     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a022194     Document Type: Article

References (19)

1. Tanigaki, Y., Saeki, Y., Matsuhisa, T., Ishiguro, S., Mori, Y., Tanaka, H., and Akedo, H. (1995) Antiangiogenic substances in a tumor cell line with low metastatic potential originating from the BALB/c mouse liver. Invasion Metastasis 15, 70-80
2. Giacotti, F.G. and Ruoslahti, E. (1990) Elevated levels of the α5β31 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells. Cell 60, 849-859
3. Iwata, K., Seya, T., Ariga, H., and Nagasawa, S. (1994) Expression of a hybrid complement regulatory protein, membrane cofactor protein (MCP)-decay-accelerating factor (DAF) on Chinese hamster ovary cells; comparison of its regulatory effect with those of DAF and MCP. J. Immunol. 152, 3436-3444
4. Noto, K., Kato, K., Okumura, K., and Yagita, H. (1995) Identification and characterization of mouse CD29 with a mAb. Int. Immunol. 7, 835-842
5. Hara, K., Yonezawa, K., Sakaue, H., Ando, A., Kotani, K., Kitamura, T., Kitamura, Y., Ueda, H., Stephens, L., Jackson, T.R., Hawkins, P.T., Dhand, R., Clark, A.E., Holman, G.D., Waterfield, M.D., and Kasuga, M. (1994) 1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells. Proc. Natl. Acad. Sci. USA 91, 7415-7419
6. Teranova, V.P., Liotta, L.A., Russo, R.G., and Martin, G.R. (1982) Role of laminin in the attachment and metastasis of murine tumor cells. Cancer Res. 42, 2265-2269
7. Okada, T., Sakuma, L., Fukui, Y., Hazeki, O., and Ui, M. (1994) Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase. J. Biol. Chem. 269, 3563-3567
8. Traynor-Kaplan, A.E., Thompson, B.L., Harris, A.L., Taylor, P., Omann, G.M., and Sklar, L.A. (1989) Transient increase in phosphatidylinositol 3,4-biphosphate and phosphatidylinositol triphosphate during activation of human neutrophils. J. Biol. Chem. 264, 15668-15673
9. McCarthy, J.B. and Furcht, L.T. (1984) Laminin and fibronectin promote the haptotactic migration of B16 mouse melanoma cells in vitro. J. Cell Biol. 98, 1474-1480
10. Ui, M., Okada, T., Hazeki, K., and Hazeki, O. (1995) Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. Trends Biochem. Sci. 20, 303-307
11. Vlahos, C.J., Matter, W.F., Hui, K.Y., and Brown, R.F. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-l-benzopyran-4-one (LY294002). J. Biol. Chem. 269, 5241-5248
12. Hara, K., Yonezawa, K., Sakaue, H., Kotani, K., Kojima, A., Waterfield, M.D., and Kasuga, M. (1995) Normal activation of p70 S6 kinase by insulin in cells overexpressing dominant negative 85 kD subunit of phosphoinositide 3-kinase. Biochem. Biophys. Res. Commun. 208, 735-741
13. Keely, P.J., Westwick, J.K., Whitehead, I.P., Der, C.J., and Parise, L.V. (1997) Cdc42 and Racl induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature 390, 632-636
14. Shaw, L.M., Rabinovitz, I., Wang, H.H.-F., Toker, A., and Mercurio, A.M. (1997) Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion. Cell 91, 949-960
15. Williams, M.J., Hughes, P.E., O'Toole, T.E., and Ginsberg, M.H. (1994) Cell adhesive molecules and intracellular signalling. Trends Cell Biol. 4, 109-112
16. Zhang, Z., Vuori, K., Wang, H.-G., Reed, J.C., and Ruoslahti, E. (1996) Integrin activation by Ras. Cell 85, 61-69
17. Kurosu, H., Maehama, T., Okada, T., Yamamoto, T., Hoshino, S., Fukui, Y., Ui, M., Hazeki, O., and Katada, T. (1997) Heterodimeric phosphoinositide 3-OH kinase consisting of p85 and p110β is synergistically activated by the betagamma subunit of G proteins and phosphotyrosyl peptide. J. Biol. Chem. 272, 24252-24256
18. Rodriguez-Viciana, P., Warne, P.H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M.J., Waterfield, M.D., and Downward, J. (1994) Phosphoinositide 3-kinase as a direct target of Ras. Nature 370, 527-532
19. Rodriguez-Viciana, P., Warne, P.H., Vanhaesebroeck, B., Waterfield, M.D., and Downward, J. (1996) Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. EMBO J. 15, 2442-2452