Inhibition of R-[3H]-baclofen binding to rat brain synaptic membranes by a homologous series of phenyl alcohol amides anticonvulsants and their evaluation as GABA(B) receptor blockers

Arzneimittel-Forschung/Drug Research

Volumn 48, Issue 11, 1998, Pages 1051-1057

  Meza Toledo, Sergio E ^a   Martínez Muñoz, Dalila ^b   Carvajal Sandoval, Guillermo ^a  

^a INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Anticonvulsants; Antiepileptics; Baclofen; CAS 1134 37 0; GABA(B) receptor blockers; Phenyl alcohol amides, pharmacology

Indexed keywords

2 HYDROXYSACLOFEN; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; ALCOHOL DERIVATIVE; AMIDE; ANTICONVULSIVE AGENT; BACLOFEN; BOVINE SERUM ALBUMIN; MACROGOL 400; PENTETRAZOLE; TRITON X 100; TROMETAMOL; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN SYNAPTOSOME; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; RAT; RECEPTOR AFFINITY; SYNAPTIC MEMBRANE; ANIMAL; BRAIN; CHEMISTRY; DRUG EFFECT; IN VITRO STUDY; METABOLISM; STRUCTURE ACTIVITY RELATION; ULTRASTRUCTURE; WISTAR RAT;

AMIDES; ANIMALS; ANTICONVULSANTS; BACLOFEN; BRAIN; GABA AGONISTS; MALE; MICE; RATS; RATS, WISTAR; RECEPTORS, GABA-B; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTIC MEMBRANES;

EID: 0032196689     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Carvajal, G., Russek, M., Tapia, R. et al., Biochem. Pharmacol. 13, 1059 (1964)
2. Carvajal, G., Massieu, G., in: Neurobiologia, Symposium Internacional, M. Velasco-Suárez, F. Escobedo-Ríos (eds.), pp. 103-115, Progreso, México (1979)
3. Meza-Toledo, S. E., Zenteno-García, M. T., Juárez-Carvajal, E. et al., Arzneim.-Forsch./Drim Res. 40 (II), 1289 (1990)
4. Pérez de la Mora, M., Tapia, R., Biochem. Pharmacol. 22, 2635 (1973)
5. Martínez-Muñoz, D., in: Advances in Epileptology: XIth Epilepsy International Symposium, R. Canger, F. Angeleri, J. K. Penry (eds.), pp. 463-466, Raven Press, New York (1980)
6. Tapia, R., Drucker-Colín, R. R., Meza-Ruiz, G. et al., Epilepsia 20, 135 (1979)
7. Solís, H., Jurado, J. L., Fernández, G. A., in: Neurobiología, Symposium Internacional, M. Velasco-Suárez, F. Escobedo-Ríos (eds.), pp. 83-94, Progreso, México (1979)
8. Solís, H., Galindo-Morales, J. A., Bravo, J. et al., Arch. Neurocien. (Méx.) 1, 99 (1996)
9. Brailowsky, S., Montiel, T., Marescaux, C. et al., Epilepsy Res. 11, 167 (1992)
10. Carvajal-Sandoval, G., Juárez-Carvajal, E., Cruz-Peinado, C. et al., Arzneim.-Forsch./Drug Res. 48 (I), 349 (1998)
11. Meza-Toledo, S. E., Juárez-Carvajal, E., Carvajal-Sandoval, G., Arzneim.-Forsch./Drug Res. 48 (II), 797 (1998)
12. Liu, Z., Vergnes, M., Depaulis, A. et al., Neurosci 48, 87 (1992)
13. Marescaux, C., Liu, Z., Bernasconi, R. et al., Pharmacol. Commun. 2, 57 (1992)
14. Hosford, D. A., Clark, S., Cao, Z. et al., Science 257, 398 (1992)
15. Hosford, D. A., Wang, Y., Che-Liu, C. et al., J. Pharm. Exp. Ther. 274, 1399 (1995)
16. Snead, O. C., Eur. J. Pharmacol. 213, 343 (1992)
17. Snead, O. C., Pharmacol. Commun. 2, 63 (1992)
18. Froestl, W., Mickel, S. J., Von-Sprecher, G. et al., J. Med. Chem. 38, 3313 (1995)
19. Bowery, N. G., Ann. Rev. Pharmacol. Toxicol. 33, 109 (1993)
20. Meza-Toledo, S. E., Ortega-González, C., Juárez-Carvajal, E. et al., Arzneim.-Forsch./Drug Res. 45 (II), 756 (1995)
21. Joseph-Nathan, P., Massieu, G., Carvajal, G. et al., Rev. Latinoamer. Quím. 9, 90 (1978)
22. Bowery, N. G., Hill, D. R., Hudson, A. L., Br. J. Pharmacol. 78, 191 (1983)
23. Hill, D. R., Bowery, N. G., Nature 290, 149 (1981)
24. Lowry, O. H., Rosebrough, N. J., Farr, A. L. et al., J. Biol. Chem. 193, 265 (1959)
25. Scatchard, G., Ann. N. Y. Acad. Sci. 51, 660 (1949)
26. Cheng, Y. C., Prusoff, W. H., Biochem. Pharmacol. 22, 3099 (1973)
27. Berthelot, P., Vaccher, C., Musadad, A. et al., J. Med. Chem. 30, 743 (1987)
28. Drew, C. A., Johnston, G. A. R., Kerr, D. I. B. et al., Neurosci. Lett 113, 107 (1990)
29. Bowery, N. G., TIPS 3, 400 (1982)
30. Bowery, N. G., TIPS 10, 401 (1989)
31. Froestl, W., Mickel, S. J., Hall, R. G. et al., J. Med. Chem. 38, 3297 (1995)
32. Kerr, D. I. B., Ong, J. Med. Res. Rev. 12, 593 (1992)
33. Bonanno, G., Raiteri, M., TIPS 14, 259 (1993)
34. Kaupmann, K., Huggel, K., Heid, J. et al., Nature 386, 239 (1997)
35. Chávez-Juárez, J. L., Martínez-Muñoz, D., Arch. Neurosci. (Méx.) 1, 173 (1996)
36. Oscós-Alvarado, A., Martínez-Muñoz, D., Psychopharmacol. 74, 93 (1981)
37. Pineda, A. G., Gutiérrez, V. M., Flores, A. M. et al., Arch. Neurocien. (Méx.) 1, 189 (1996)
38. Bittiger, H., Froestl, W., Mickel, S. J. et al., TIPS 14, 391 (1993)