Synthesis and pharmacological evaluation of a new homologous series of (±)-p-fluoro-phenyl alcohol amide anticonvulsants

Arzneimittel-Forschung/Drug Research

Volumn 48, Issue 4, 1998, Pages 349-352

  Carvajal Sandoval, Guillermo ^a,b   Juárez Carvajal, Enedina ^a   Cruz Peinado, Claudia ^a   Meza Toledo, Sergio Enrique ^a,b  

^a INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^b IPN

Author keywords

Anticonvulsants; Antiepileptics; Fluoro phenyl alcohol amides, pharmacology, synthesis

Indexed keywords

2 HYDROXY 2 (4' FLUOROPHENYL)BUTYRAMIDE; 3 HYDROXY 3 (4' FLUOROPHENYL)PENTANAMIDE; 4 HYDROXY 4 (4' FLUOROPHENYL)HEXANAMIDE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; GABAERGIC SYSTEM; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; POLYMERIZATION; SEIZURE; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; ANTICONVULSANTS; BUTYRIC ACIDS; CONVULSANTS; HEXANOIC ACIDS; INJECTIONS, INTRAPERITONEAL; MALE; MICE; PENTANOIC ACIDS; PENTYLENETETRAZOLE; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031979040     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Carvajal, G., Russek, M., Tapia, R. et al., Biochem. Pharmacol. 13, 1059 (1964)
2. Carvajal, G., Massieu, G., in: Neurobiología, Symposium Internacional, M. Velasco-Suárez, F. Escobedo-Rios (eds.), pp. 103-115, Progreso, México (1979)
3. Meza-Toledo, S. E., Zenteno-Garcia, M. T., Juárez-Carvajal, E. et al., Arzneim.-Forsch./Drug Res. 40 (II), 1289 (1990)
4. Pérez de la Mora, M., Tapia, R., Biochem. Pharmacol. 22, 2635 (1973)
5. Tapia, R., Drucker-Colín, R. R., Meza-Ruíz, G. et al., Epilepsia 20, 135 (1979)
6. Solís, H., Jurado, J. L., Fernández, G. A., in: Neurobiologia, Symposium International, M. Velasco-Suárez, F. Escobedo-Ríos (eds.), pp. 83-94, Progreso, México (1979)
7. Solís, H., Galindo-Morales, J. A., Bravo, J. et al., Arch. Neurocien. (Méx) 1, 99 (1996)
8. Brailowsky, S., Montiel, T., Marescaux, C. et al., Epilepsy Res. 11, 167 (1992)
9. Johnson, W. S., Daub, G. H., in: Organic Reactions, Vol. 6, R. Adams, H. Adkins, A. H. Blatt et al. (eds.), pp. 1-73, John Wiley & Sons, New York (1951)
10. Meza-Toledo, S. E., Ortega-González, C., Juárez-Carvajal, E. et al., Arzneim.-Forsch./Drug Res. 45 (II), 756 (1995)
11. Joseph-Nathan, P., Massieu, G., Carvajal, G. et al., Rev. Latinoamer. Quím. 9, 90 (1978)
12. Hauser, C. R., Swamer, F. W., Adams, J. T., in: Organic Reactions, Vol. 8, R. Adams, A. H. Blatt, A. C. Cope et al. (eds.), p. 122, John Wiley & Sons, New York (1954)
13. Swinyard, E. A., J. Am. Pharm. Assoc. 38, 201 (1949)
14. Swinyard, E. A., in: International Encyclopedia of Pharmacology and Therapeutics, Vol. 1, J. Mercier (ed.), pp. 47-65, Pergamon Press, Oxford (1973)
15. Krall, R. L., Penry, J. K., White, B. G. et al., Epilepsia 19, 409 (1978)
16. Litchfield, J. T., Wilcoxon, F., J. Pharmacol. Exp. Ther. 96, 99 (1949)
17. Gómez, L. E., Cueva-Rolón, R., Lehmann, F. P. A., Biopharm. Drug Disp. 16, 77 (1995)