Decreased expression of GABA(A) receptor α6 and β3 subunits in stargazer mutant mice: A possible role for brain-derived neurotrophic factor in the regulation of cerebellar GABA(A) receptor expression?

Molecular Brain Research

Volumn 60, Issue 2, 1998, Pages 282-290

  Thompson, Christopher L ^a   Tehrani, Mohammad H Jalilian ^b   Barnes Jr , Eugene M ^b   Stephenson, F Anne ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Aminobutyric acid; Development; Immunoblotting; Mutant mice; Receptor regulation

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; AZIDE; BENZODIAZEPINE DERIVATIVE; TRITIUM;

ANIMAL TISSUE; ARTICLE; CEREBELLUM; GRANULE CELL; IMMUNOBLOTTING; MOUSE; MOUSE MUTANT; NERVE CELL DIFFERENTIATION; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; AFFINITY LABELING; ANIMAL; C57BL MOUSE; CELL MEMBRANE; GENE EXPRESSION REGULATION; GENETICS; MACROMOLECULE; METABOLISM; NERVE CELL; PHYSIOLOGY; RADIOASSAY; RECESSIVE GENE;

AFFINITY LABELS; ANIMALS; AZIDES; BENZODIAZEPINES; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL MEMBRANE; CEREBELLUM; GENE EXPRESSION REGULATION; GENES, RECESSIVE; MACROMOLECULAR SUBSTANCES; MICE; MICE, INBRED C57BL; MICE, NEUROLOGIC MUTANTS; NEURONS; RADIOLIGAND ASSAY; RECEPTORS, GABA-A; TRITIUM;

EID: 0032190557     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(98)00205-8     Document Type: Article

References (36)

1. A receptor expression. Soc. Neurosci. Abstr. 23:1997;48.9.
2. Benke D., Fritschy J.-M., Trzeciak A., Bannwarth W., Mohler H. Distribution, prevalence and drug binding profile of γ-aminobutyric acid type A receptor subtypes differing in the α-subunit variant. J. Biol. Chem. 269(43):1994;27100-27107.
3. Cook S.J., McCormick F. Inhibition by cAMP of Ras-dependent activation of Raf. Science. 262:1993;1069-1072.
4. A-receptor subtypes during postnatal development: an immunohistochemical study. J. Neurosci. 14(9):1994;5302-5324.
5. Ghosh A., Carnahan J., Greenberg M.E. Requirement for BDNF in activity-dependent survival of cortical neurons. Science. 263:1994;1618-1623.
6. Gao W.-Q., Zheng J.L., Karihaloo M. Neurotrophin-4/5 (NT-4/5) and brain-derived neurotrophic factor (BDNF) act at later stages of cerebellar granule cell differentiation. J. Neurosci. 15(4):1995;2656-2667.
7. Hatten M.E., Heinz N. Mechanisms of neural patterning and specification in the developing cerebellum. Ann. Rev. Neurosci. 18:1995;385-408.
8. Homanics G.E., DeLorey T.M., Firestone L.L., Quinlan J.J., Handforth A., Harrison N.L., Krasowski M.D., Rick C.E.M., Korpi E.R., Makela R., Brilliant M.H., Hagiwara N., Ferguson C., Snyder K., Olsen R.W. Mice devoid of γ-aminobutyric acid type A receptor β3 subunit have epilepsy, cleft palate and hypersensitive behavior. Proc. Natl. Acad. Sci. USA. 94:1997;4143-4148.
9. A receptor α6 subunit gene inactivation inhibits δ subunit expression. J. Neurosci. 17(4):1997;1350-1362.
10. A receptor α subunit is expressed only in cerebellar granule cells. J. Mol. Biol. 214:1990;619-624.
11. A receptor. Nature. 361:1993;356-359.
12. 3H ]Ro15-4513 binding sites Neuroscience. 53(2):1993;483-488.
13. Kuno H., Kihara H.K. Simple microassay of protein with membrane filter. Nature. 215:1967;974-976.
14. Kurino M., Fukunaga K., Ushio Y., Miyamoto E. Cyclic AMP inhibits activation of mitogen-activated protein kinase and cell proliferation in response to growth factors in cultured rat cortical astrocytes. J. Neurochem. 67:1996;2246-2255.
15. A receptor mRNAs in the rat brain: III. Embryonic and postnatal development. J. Neurosci. 12:1992;4151-4172.
16. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurements with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
17. Maisonpierre P.C., Belluscio L., Friedman B., Alderson R.F., Wiegand S.J., Furth M.E., Lindsay R.M., Yancopoulos G.D. NT-3, BDNF and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression. Neuron. 5:1990;501-509.
18. Munson P.J., Rodbard D. LIGAND: a versatile computer approach for characterization of ligand binding systems. Anal. Biochem. 107:1980;220-239.
19. Noebels J.L., Qiao X., Bronson R.T., Spencer C., Davisson M.T. Stargazer, a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures. Epilepsy Res. 7:1990;129-135.
20. A receptor antibodies. Biochem. Soc. Trans. 25:1997;547S.
21. Pollard S., Thompson C.L., Stephenson F.A. Quantitative characterisation of α6 and α1α6 subunit-containing native γ-aminobutyric acid receptors of adult rat cerebellum demonstrates two α subunits per receptor oligomer. J. Biol. Chem. 270:1995;21285-21290.
22. Qiao X., Hefti F., Knusel B., Noebels J.L. Selective failure of brain-derived neurotrophic factor mRNA expression in the cerebellum of stargazer, a mutant mouse with ataxia. J. Neurosci. 16(2):1996;640-648.
23. Quirk K., Gillard N.P., Ragan C.I., Whiting P.J., McKernan R.M. Model of subunit composition of γ-aminobutyric acid receptor subtypes expressed in rat cerebellum with respect to their α and γ/δ subunits. J. Biol. Chem. 269(23):1994;16020-16028.
24. Segal R.A., Takahashi H., McKay R.D.G. Changes in neurotrophin responsiveness during the development of cerebellar granule cells. Neuron. 9:1992;1041-1052.
25. A receptors in the cerebellum of the rat, cat and monkey using monoclonal antibodies. J. Neurosci. 9(6):1989;2197-2209.
26. A receptors. Biochem. J. 310:1995;1-9.
27. A receptor, in: E.C. Hulme (Ed.), Receptor Biochemistry: A Practical Approach, IRL Press, Oxford, UK, 1990, pp. 177-201.
28. A receptor subtypes expressed in cerebellar granule cells: a developmental study. J. Neurochem. 62:1994;2037-2044.
29. A receptor α5 and α6 subunit-like immunoreactivity in rat brain. Neurosci. Lett. 144:1992;53-56.
30. A receptor α1 and α6 subunit expression by a cyclic AMP-mediated signalling mechanism in cerebellar granule cells in primary culture. J. Neurochem. 67(1):1996;434-437.
31. A receptor α6 subunit. J. Neurosci. 16(11):1996;3630-3640.
32. A receptor subtype that is insensitive to diazepam. J. Pharmacol. Exp. Ther. 257(3):1991;1236-1242.
33. 3H ]Ro15-4513 J. Neurochem. 59:1992;568-574.
34. Wright E.M., Vogel K.S., Davies A.M. Neurotrophic factors promote the maturation of developing sensory neurons before they become dependent on these factors for survival. Neuron. 9:1992;139-150.
35. A receptor subunit mRNA occurs only after cerebellar granule cell migration. Dev. Brain Res. 75:1993;91-104.
36. Zheng T.M., Zhu W.J., Puia G., Vicini S., Grayson D.R., Costa E., Caruncho H.J. Changes in γ-aminobutyric acid type-A receptor subunit mRNAs, translation product expression, and receptor function during neuronal maturation in vitro. Proc. Natl. Acad. Sci. USA. 91:1994;10952-10956.