Bidirectional regulation of GABAA receptor α1 and α6 subunit expression by a cyclic AMP-mediated signalling mechanism in cerebellar granule cells in primary culture

Journal of Neurochemistry

Volumn 67, Issue 1, 1996, Pages 434-437

  Thompson, Christopher L ^a   Pollard, Simon ^a   Stephenson, F Anne ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Benzodiazepine; Cyclic AMP; Forskolin; GABA; GABAA receptor

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; AZIDE; BENZODIAZEPINE DERIVATIVE; BUCLADESINE; CYCLIC AMP; FORSKOLIN; ISOBUTYLMETHYLXANTHINE; PHOSPHODIESTERASE INHIBITOR; TRITIUM; 4 AMINOBUTYRIC ACID RECEPTOR; RECEPTOR SUBTYPE; RECEPTOR SUBUNIT;

AFFINITY LABELING; ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CEREBELLUM; CHEMISTRY; CYTOLOGY; DRUG EFFECT; METABOLISM; NERVE CELL; PHYSIOLOGY; RADIOASSAY; RAT; SIGNAL TRANSDUCTION; WISTAR RAT; ANIMAL CELL; CELL POPULATION; DRUG BINDING SITE; DRUG RECEPTOR BINDING; GENE EXPRESSION; GRANULE CELL; IMMUNOBLOTTING; IN SITU HYBRIDIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; RECEPTOR GENE; TRANSCRIPTION REGULATION;

1-METHYL-3-ISOBUTYLXANTHINE; AFFINITY LABELS; ANIMALS; AZIDES; BENZODIAZEPINES; BUCLADESINE; CELLS, CULTURED; CEREBELLUM; CYCLIC AMP; FORSKOLIN; NEURONS; PHOSPHODIESTERASE INHIBITORS; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, GABA-A; SIGNAL TRANSDUCTION; TRITIUM;

EID: 0029666439     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.67010434.x     Document Type: Article

References (15)

1. Angelotti T. P., Uhler M. D., and Macdonald R. L. (1993) Enhancement of recombinant γ-aminobutyric acid type A receptor currents by chronic activation of cAMP-dependent protein kinase. Mol. Pharmacol. 44, 1202-1210.
2. A receptor channel: a mechanism for interaction with a multitude of central nervous system functions, in The Challenge of Neuropharmacology (Mohler H. and Da Prada M., eds), pp. 15-39. Editiones Roche, Basel.
3. A receptor function by protein kinase C phosphorylation. Neuron 12, 1081-1094.
4. A receptor subunit mRNAs in the rat brain. III. Embryonic and post-natal development. J. Neurosci. 12, 4151-4172.
5. Lowry O. H., Rosebrough N. J., Farr A. L., and Randall R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
6. A receptor channels. Annu. Rev. Neurosci. 17, 569-602.
7. A receptors by cAMP-dependent protein phosphorylation. Science 257, 661-665.
8. A receptor α1 subunit. J. Neurochem. 61 (Suppl.), S256B.
9. A receptors of adult rat cerebellum demonstrates two α subunits per receptor oligomer. J. Biol. Chem. 270, 21285-21290.
10. A receptor subtypes expressed in rat cerebellum with respect to their a and γ/δ-subunits. J. Biol. Chem. 269, 16020-16028.
11. Ross A. F., Green W. N., Hartman D. S., and Claudio T. (1991) Efficiency of acetylcholine receptor subunit assembly and its regulation by cAMP. J. Cell Biol. 113, 623-636.
12. A receptors. Biochem. J. 310, 1-9.
13. A receptor subtypes expressed in cerebellar granule cells: a developmental study. J. Neurochem. 62, 2037-2044.
14. A receptor α4 subunit. FEBS Lett. 289, 227-230.
15. Wroblewska B., Wroblewski J. T., Saab O. H., and Neale J. H. (1993) N-Acetylaspartylglutamate inhibits forskolin-stimulated cyclic AMP levels via a metabotropic glutamate receptor in cultured cerebellar granule cells. J. Neurochem. 61, 943-948.