Antitumor activity of 7-[2-(N-Isopropylamino)ethyl]-(20S)-camptothecin, CKD602, as a potent DNA topoisomerase I inhibitor

Archives of Pharmacal Research

Volumn 21, Issue 5, 1998, Pages 581-590

  Lee, Jun Hee ^a   Lee, Ju Mong ^a   Kim, Joon Kyum ^a   Ahn, Soon Kil ^a   Lee, Sang Joon ^a   Kim, Mie Young ^b   Jew, Sang Sup ^c   Park, Jae Gab ^c   Hong, Chung Il ^a  

^a Chong Kun Dang Research Institute   (South Korea)

^b Chung Ang University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Antitumor; Camptothecin; CKD602; Ex vivo pharmacodyanmics; Topoisomerase I; Xenograft

Indexed keywords

7 (2 (N ISOPROPYLAMINO)ETHYL)CAMPTOTHECIN; 7-(2-(N-ISOPROPYLAMINO)ETHYL)CAMPTOTHECIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DNA TOPOISOMERASE; DRUG DERIVATIVE; ENZYME INHIBITOR;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CELL SURVIVAL; DOG; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; MOUSE; NUDE MOUSE;

ANIMALS; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CELL SURVIVAL; DNA TOPOISOMERASES, TYPE I; DOGS; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION;

EID: 0032174937     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02975379     Document Type: Article

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