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Volumn 22, Issue 1-2, 1998, Pages 173-179

XXII. Evaluation of drug efficacy by using animal models or in vitro systems

Author keywords

Co infection model; Corticosteroid treated rat; Metabolism; Nude rat; Pneumocystis drug assay; Radiolabeled precursor

Indexed keywords

ANTIINFECTIVE AGENT; CLARITHROMYCIN; CORTICOSTEROID; COTRIMOXAZOLE; DEFEROXAMINE; EFLORNITHINE; PENTAMIDINE; PNEUMOCANDIN DERIVATIVE; SULFAMETHOXAZOLE; TRIMETHOPRIM; ANTIFUNGAL AGENT;

EID: 0032148383     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-8244(98)00076-5     Document Type: Conference Paper
Times cited : (6)

References (55)
  • 2
    • 0030017184 scopus 로고    scopus 로고
    • Genetic diversity at the internal transcribed spacer regions of the ribosomal RNA operon among isolates of Pneumocystis carinii from AIDS patients with recurrent pneumonia
    • Tsolaki, A.G., Miller, R.F., Underwood, A.P., Banerji, S. and Wakefield, A.E. (1996) Genetic diversity at the internal transcribed spacer regions of the ribosomal RNA operon among isolates of Pneumocystis carinii from AIDS patients with recurrent pneumonia. J. Infect. Dis. 174, 141-156.
    • (1996) J. Infect. Dis. , vol.174 , pp. 141-156
    • Tsolaki, A.G.1    Miller, R.F.2    Underwood, A.P.3    Banerji, S.4    Wakefield, A.E.5
  • 3
    • 0027433631 scopus 로고
    • Genetic stability and diversity of Pneumocystis carinii infecting rat colonies
    • Cushion, M.T., Kaselis, S.L., Stringer, S.L. and Stringer, J.R. (1993) Genetic stability and diversity of Pneumocystis carinii infecting rat colonies. Infect. Immun. 61, 4801-4813.
    • (1993) Infect. Immun. , vol.61 , pp. 4801-4813
    • Cushion, M.T.1    Kaselis, S.L.2    Stringer, S.L.3    Stringer, J.R.4
  • 7
    • 0024374998 scopus 로고
    • Comparison of tissular disposition of pentamidine mesylate in the rat after aerosol parenteral administration
    • Farinotti, R., Brun-Pascaud, M., Girard, P.M., Guillot, E., Certain, A. and Trouvin, J.H. (1989) Comparison of tissular disposition of pentamidine mesylate in the rat after aerosol parenteral administration. J. Infect. Dis. 160, 507-512.
    • (1989) J. Infect. Dis. , vol.160 , pp. 507-512
    • Farinotti, R.1    Brun-Pascaud, M.2    Girard, P.M.3    Guillot, E.4    Certain, A.5    Trouvin, J.H.6
  • 13
    • 0025094037 scopus 로고
    • Enhanced treatment of Pneumocystis carinii pneumonia in rats with Interferon-gamma and reduced doses of Trimethoprim/Sulfamethoxazole
    • Shear, H.L., Valladares, G. and Narachi, M.A. (1990) Enhanced treatment of Pneumocystis carinii pneumonia in rats with Interferon-gamma and reduced doses of Trimethoprim/Sulfamethoxazole. J. Acquired Immune Defic. Syndr. 3, 943-948.
    • (1990) J. Acquired Immune Defic. Syndr. , vol.3 , pp. 943-948
    • Shear, H.L.1    Valladares, G.2    Narachi, M.A.3
  • 14
    • 0029035636 scopus 로고
    • Response of rat model of Pneumocystis carinii pneumonia to continuous infusion of Deferoxamine
    • Merali, S., Chin, K., Grady, R.W., Weissberger, L. and Clarkson, A.B. (1995) Response of rat model of Pneumocystis carinii pneumonia to continuous infusion of Deferoxamine. Antimicrob. Agents Chemother. 39, 1442-1444.
    • (1995) Antimicrob. Agents Chemother. , vol.39 , pp. 1442-1444
    • Merali, S.1    Chin, K.2    Grady, R.W.3    Weissberger, L.4    Clarkson, A.B.5
  • 15
    • 0029102054 scopus 로고
    • Clinically achievable plasma deferoxamine concentrations are therapeutic in a rat model of Pneumocystis carinii pneumonia
    • Merali, S., Chin, K., Der Angel, L., Grady, R.W., Armstrong, M. and Clarkson, A.B. (1995) Clinically achievable plasma deferoxamine concentrations are therapeutic in a rat model of Pneumocystis carinii pneumonia. Antimicrob. Agents Chemother. 39, 2023-2026.
    • (1995) Antimicrob. Agents Chemother. , vol.39 , pp. 2023-2026
    • Merali, S.1    Chin, K.2    Der Angel, L.3    Grady, R.W.4    Armstrong, M.5    Clarkson, A.B.6
  • 16
    • 0023722304 scopus 로고
    • Efficacy of DL-α-difluoromethylornithine in a rat model of Pneumocystis carinii pneumonia
    • Clarkson, A.B., Williams, D.E. and Rosemberg, C. (1988) Efficacy of DL-α-difluoromethylornithine in a rat model of Pneumocystis carinii pneumonia. Antimicrob. Agents Chemother. 32, 1158-1163.
    • (1988) Antimicrob. Agents Chemother. , vol.32 , pp. 1158-1163
    • Clarkson, A.B.1    Williams, D.E.2    Rosemberg, C.3
  • 17
    • 0025108249 scopus 로고
    • Deferoxamine and eflornithine (DL-α-difluoromethylornithine) in a rat model of Pneumocystis carinii pneumonia
    • Clarkson, A., Saric, M. and Grady, R. (1990) Deferoxamine and eflornithine (DL-α-difluoromethylornithine) in a rat model of Pneumocystis carinii pneumonia. Antimicrob. Agents Chemother. 34, 1833-1835.
    • (1990) Antimicrob. Agents Chemother. , vol.34 , pp. 1833-1835
    • Clarkson, A.1    Saric, M.2    Grady, R.3
  • 18
    • 0029820317 scopus 로고    scopus 로고
    • Continuous infusion of DL-α-difluoromethylornithine and improved efficacy against a rat model of Pneumocystis carinii pneumonia
    • Chin, K., Merali, S., Saric, M. and Clarkson, A.B. (1996) Continuous infusion of DL-α-difluoromethylornithine and improved efficacy against a rat model of Pneumocystis carinii pneumonia. Antimicrob. Agents Chemother. 40, 2318-2320.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 2318-2320
    • Chin, K.1    Merali, S.2    Saric, M.3    Clarkson, A.B.4
  • 19
    • 0025191262 scopus 로고
    • Pneumocystis carinii: Improved models to study efficacy of drugs for treatment or prophylaxis of Pneumocystis carinii pneumonia in the rat (Rattus spp.)
    • Bartlett, M.S., Fishman, J.A., Durkin, M.M., Queener, S.F. and Smith, J.W. (1990) Pneumocystis carinii: improved models to study efficacy of drugs for treatment or prophylaxis of Pneumocystis carinii pneumonia in the rat (Rattus spp.). Exp. Parasitol. 70, 100-106.
    • (1990) Exp. Parasitol. , vol.70 , pp. 100-106
    • Bartlett, M.S.1    Fishman, J.A.2    Durkin, M.M.3    Queener, S.F.4    Smith, J.W.5
  • 20
    • 0020507484 scopus 로고
    • Intermittent chemoprophylaxis for Pneumocystis carinii pneumonia
    • Hughes, W.T. and Smith, B.L. (1983) Intermittent chemoprophylaxis for Pneumocystis carinii pneumonia. Antimicrob. Agents Chemother. 24, 300-301.
    • (1983) Antimicrob. Agents Chemother. , vol.24 , pp. 300-301
    • Hughes, W.T.1    Smith, B.L.2
  • 21
    • 0028040787 scopus 로고
    • Relative potency of 10 drugs with anti-Pneumocystis carinii activity in animal model
    • Hughes, W.T., Killmar, J.T. and Oz, H.S. (1994) Relative potency of 10 drugs with anti-Pneumocystis carinii activity in animal model. J. Infect. Dis. 170, 906-911.
    • (1994) J. Infect. Dis. , vol.170 , pp. 906-911
    • Hughes, W.T.1    Killmar, J.T.2    Oz, H.S.3
  • 22
    • 0029868005 scopus 로고    scopus 로고
    • Monodrug efficacies of sulfonamides in prophylaxis for Pneumocystis carinii pneumonia
    • Hughes, W.T. and Killmar, J. (1996) Monodrug efficacies of sulfonamides in prophylaxis for Pneumocystis carinii pneumonia. Antimicrob. Agents Chemother. 40, 962-965.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 962-965
    • Hughes, W.T.1    Killmar, J.2
  • 24
    • 0031029910 scopus 로고    scopus 로고
    • Efficacy of lasalocid against murine Pneumocystis carinii pneumonitis
    • Oz, H.S., Hughes, W.T. and Rehg, J.E. (1997) Efficacy of lasalocid against murine Pneumocystis carinii pneumonitis. Antimicrob. Agents Chemother. 41, 191-192.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 191-192
    • Oz, H.S.1    Hughes, W.T.2    Rehg, J.E.3
  • 25
    • 0026026899 scopus 로고
    • Furazolidone and nitrofurantoin in the treatment of experimental Pneumocystis carinii pneumonia
    • Walzer, P.D., Kim, C.K., Foy, J.M. and Zhang, J. (1991) Furazolidone and nitrofurantoin in the treatment of experimental Pneumocystis carinii pneumonia. Antimicrob. Agents Chemother. 35, 158-163.
    • (1991) Antimicrob. Agents Chemother. , vol.35 , pp. 158-163
    • Walzer, P.D.1    Kim, C.K.2    Foy, J.M.3    Zhang, J.4
  • 26
    • 0026699703 scopus 로고
    • Treatment of experimental pneumocystosis: Review of 7 years of experience and development of a new system for classifying antimicrobial drugs
    • Walzer, P.D., Foy, J., Steele, P. and White, M. (1992) Treatment of experimental pneumocystosis: review of 7 years of experience and development of a new system for classifying antimicrobial drugs. Antimicrob. Agents Chemother. 36, 1943-1950.
    • (1992) Antimicrob. Agents Chemother. , vol.36 , pp. 1943-1950
    • Walzer, P.D.1    Foy, J.2    Steele, P.3    White, M.4
  • 28
    • 0031053882 scopus 로고    scopus 로고
    • Clinically used antimicrobial drugs against experimental pneumocystosis, singly and in combination: Analysis of drug interactions and efficacies
    • Walzer, P.D., Runck, J., Orr, S., Foy, J., Steele, P. and White, M. (1997) Clinically used antimicrobial drugs against experimental pneumocystosis, singly and in combination: analysis of drug interactions and efficacies. Antimicrob. Agents Chemother. 41, 242-250.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 242-250
    • Walzer, P.D.1    Runck, J.2    Orr, S.3    Foy, J.4    Steele, P.5    White, M.6
  • 29
    • 0026647832 scopus 로고
    • Efficacy of intermittent dosage of 8-aminoquinolines for therapy or prophylaxis of Pneumocystis pneumonia in rats
    • Queener, S., Dean, R., Bartlett, M.S., Milhous, W., Berman, J. and Ellis, W. (1992) Efficacy of intermittent dosage of 8-aminoquinolines for therapy or prophylaxis of Pneumocystis pneumonia in rats. J. Infect. Dis. 165, 764-768.
    • (1992) J. Infect. Dis. , vol.165 , pp. 764-768
    • Queener, S.1    Dean, R.2    Bartlett, M.S.3    Milhous, W.4    Berman, J.5    Ellis, W.6
  • 30
    • 0026081818 scopus 로고
    • 8-Aminoquinolines from Walter Reed Army Institute for Research for treatment and prophylaxis of Pneumocystosis pneumonia in rat models
    • Bartlett, M.S., Queener, S.F., Tidwell, R.R., Milhous, W.K., Berman, J.D., Ellis, W.Y. and Smith, J.W. (1991) 8-Aminoquinolines from Walter Reed Army Institute for Research for treatment and prophylaxis of Pneumocystosis pneumonia in rat models. Antimicrob. Agents Chemother. 35, 277-282.
    • (1991) Antimicrob. Agents Chemother. , vol.35 , pp. 277-282
    • Bartlett, M.S.1    Queener, S.F.2    Tidwell, R.R.3    Milhous, W.K.4    Berman, J.D.5    Ellis, W.Y.6    Smith, J.W.7
  • 33
    • 0027964497 scopus 로고
    • Experimental evaluation of combined prophylaxis against murine pneumocystosis and toxoplasmosis
    • Brun-Pascaud, M., Chau, F., Simonpoli, A.M., Girard, P.M., Derouin, F. and Pocidalo, J.J. (1994) Experimental evaluation of combined prophylaxis against murine pneumocystosis and toxoplasmosis. J. Infect. Dis. 170, 653-658.
    • (1994) J. Infect. Dis. , vol.170 , pp. 653-658
    • Brun-Pascaud, M.1    Chau, F.2    Simonpoli, A.M.3    Girard, P.M.4    Derouin, F.5    Pocidalo, J.J.6
  • 34
    • 0030249415 scopus 로고    scopus 로고
    • Evaluation of the activities of rifabutin combined with atovaquone or low-dose of cotrimoxazole for prevention of pneumocystosis and toxoplasmosis in a dual infection rat model
    • Brun-Pascaud, M., Chau, F., Derouin, F. and Girard, P.M. (1996) Evaluation of the activities of rifabutin combined with atovaquone or low-dose of cotrimoxazole for prevention of pneumocystosis and toxoplasmosis in a dual infection rat model. J. Eukaryotic Microbiol. 43, 14-15S.
    • (1996) J. Eukaryotic Microbiol. , vol.43
    • Brun-Pascaud, M.1    Chau, F.2    Derouin, F.3    Girard, P.M.4
  • 35
    • 0029818730 scopus 로고    scopus 로고
    • Combination of PS-15, epiroprim, or pyrimethamine with dapsone in prophylaxis of Toxoplasma gondii and Pneumocystis carinii dual infections in a rat model
    • Brun-Pascaud, M., Chau, F., Garry, L., Jacobus, D., Derouin, F. and Girard, P.M. (1996) Combination of PS-15, epiroprim, or pyrimethamine with dapsone in prophylaxis of Toxoplasma gondii and Pneumocystis carinii dual infections in a rat model. Antimicrob. Agents Chemother. 40, 2067-2070.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 2067-2070
    • Brun-Pascaud, M.1    Chau, F.2    Garry, L.3    Jacobus, D.4    Derouin, F.5    Girard, P.M.6
  • 36
    • 0029959303 scopus 로고    scopus 로고
    • Altered trimethoprim/sulfamethoxazole ratios for prophylaxis and treatment of Toxoplasma gondii and Pneumocystis carinii dual infections in rat model
    • Brun-Pascaud, M., Chau, F., Derouin, F. and Girard, P.M. (1996) Altered trimethoprim/sulfamethoxazole ratios for prophylaxis and treatment of Toxoplasma gondii and Pneumocystis carinii dual infections in rat model. J. Acquired Immune Defic. Syndr. 13, 201-207.
    • (1996) J. Acquired Immune Defic. Syndr. , vol.13 , pp. 201-207
    • Brun-Pascaud, M.1    Chau, F.2    Derouin, F.3    Girard, P.M.4
  • 37
    • 0010259997 scopus 로고    scopus 로고
    • Experimental evaluation of roxithromycin combined with dapsone or sulfamethoxazole on pneumocystosis and toxoplasmosis dual infections in rat model
    • in press
    • Brun-Pascaud, M., Chau, F., Derouin, F. and Girard, P.M. (1997) Experimental evaluation of roxithromycin combined with dapsone or sulfamethoxazole on pneumocystosis and toxoplasmosis dual infections in rat model. J. Antimicrob. Chemother., in press.
    • (1997) J. Antimicrob. Chemother.
    • Brun-Pascaud, M.1    Chau, F.2    Derouin, F.3    Girard, P.M.4
  • 38
    • 0025764873 scopus 로고
    • Morphological evaluation of Pneumocystis carinii after extraction from infected lung
    • Soulez, B., (1991) Morphological evaluation of Pneumocystis carinii after extraction from infected lung. J. Parasitol. 77, 449-453.
    • (1991) J. Parasitol. , vol.77 , pp. 449-453
    • Soulez, B.1
  • 39
    • 0013959578 scopus 로고
    • Latent pneumocystis infection in rats, relapse and chemotherapy
    • Frenkel, J.K., Good, J.T. and Schultz, J.A. (1966) Latent pneumocystis infection in rats, relapse and chemotherapy. Lab. Invest. 15, 1559-1577.
    • (1966) Lab. Invest. , vol.15 , pp. 1559-1577
    • Frenkel, J.K.1    Good, J.T.2    Schultz, J.A.3
  • 41
    • 0026073466 scopus 로고
    • Remarkable in vitro and in vivo activities of the hydroxynaphthoquinone 566C80 against tachyzoites and tissue cysts of Toxoplasma gondii
    • Araujo, F.G., Huskinson, J. and Remington, J.S. (1991) Remarkable in vitro and in vivo activities of the hydroxynaphthoquinone 566C80 against tachyzoites and tissue cysts of Toxoplasma gondii. Antimicrob. Agents Chemother. 35, 293-299.
    • (1991) Antimicrob. Agents Chemother. , vol.35 , pp. 293-299
    • Araujo, F.G.1    Huskinson, J.2    Remington, J.S.3
  • 43
    • 0026463755 scopus 로고
    • Sparfloxacin, ethambutol, and cortisol receptor inhibitor RU-40 555 treatment for disseminated Mycobacterium avium complex infection of normal C57BL/6 mice
    • Perronne, C., Cohen, Y., Truffot-Pernot, C., Grosset, J., Vildé, J.L. and Pocidalo, J.J. (1992) Sparfloxacin, ethambutol, and cortisol receptor inhibitor RU-40 555 treatment for disseminated Mycobacterium avium complex infection of normal C57BL/6 mice. Antimicrob. Agents Chemother. 36, 2408-2412.
    • (1992) Antimicrob. Agents Chemother. , vol.36 , pp. 2408-2412
    • Perronne, C.1    Cohen, Y.2    Truffot-Pernot, C.3    Grosset, J.4    Vildé, J.L.5    Pocidalo, J.J.6
  • 44
    • 0029134721 scopus 로고
    • Beige mouse model for Mycobacterium avium complex disease
    • Gangadharam, P.R. (1995) Beige mouse model for Mycobacterium avium complex disease. Antimicrob. Agents Chemother. 39, 1647-1654.
    • (1995) Antimicrob. Agents Chemother. , vol.39 , pp. 1647-1654
    • Gangadharam, P.R.1
  • 45
    • 0027964497 scopus 로고
    • Experimental evaluation of combined prophylaxis against murine pneumocystosis and toxoplasmosis
    • Brun-Pascaud, M., Chau, F., Simonpoli, A.M., Girard, P.M., Derouin, F. and Pocidalo, J.J. (1994) Experimental evaluation of combined prophylaxis against murine pneumocystosis and toxoplasmosis. J. Infect. Dis. 170, 653-658.
    • (1994) J. Infect. Dis. , vol.170 , pp. 653-658
    • Brun-Pascaud, M.1    Chau, F.2    Simonpoli, A.M.3    Girard, P.M.4    Derouin, F.5    Pocidalo, J.J.6
  • 47
    • 0019823902 scopus 로고
    • Metabolic and synthetic activities of Pneumocystis carinii in vitro
    • Pesanti, E.L. and Cox, C. (1981) Metabolic and synthetic activities of Pneumocystis carinii in vitro. Infect. Immun. 34, 908-914.
    • (1981) Infect. Immun. , vol.34 , pp. 908-914
    • Pesanti, E.L.1    Cox, C.2
  • 48
    • 0025329935 scopus 로고
    • Growth and metabolism of Pneumocystis carinii in axenic culture
    • Cushion, M.T. and Ebbets, D. (1991) Growth and metabolism of Pneumocystis carinii in axenic culture. J. Clin. Microbiol. 28, 1385-1394.
    • (1991) J. Clin. Microbiol. , vol.28 , pp. 1385-1394
    • Cushion, M.T.1    Ebbets, D.2
  • 49
    • 0024375123 scopus 로고
    • Characterization of de novo folate synthesis in Pneumocystis carinii and Toxoplasma gondii. Potential for screening therapeutic agents
    • Kovacs, J.A., Allegra, C.J., Beaver, J., Boarman, D., Lewis, M., Parillo, J.E., Chabner, B. and Masur, H. (1989) Characterization of de novo folate synthesis in Pneumocystis carinii and Toxoplasma gondii. Potential for screening therapeutic agents. J. Infect. Dis. 160, 312-320.
    • (1989) J. Infect. Dis. , vol.160 , pp. 312-320
    • Kovacs, J.A.1    Allegra, C.J.2    Beaver, J.3    Boarman, D.4    Lewis, M.5    Parillo, J.E.6    Chabner, B.7    Masur, H.8
  • 50
    • 0025951346 scopus 로고
    • Microculture screening assay for primary in vitro evaluation of drugs against Pneumocystis carinii
    • Comley, J.C.W., Mullin, R.J., Wolfe, L.A., Hanlon, M.H. and Ferone, R. (1991) Microculture screening assay for primary in vitro evaluation of drugs against Pneumocystis carinii. Antimicrob. Agents Chemother. 35, 1965-1974.
    • (1991) Antimicrob. Agents Chemother. , vol.35 , pp. 1965-1974
    • Comley, J.C.W.1    Mullin, R.J.2    Wolfe, L.A.3    Hanlon, M.H.4    Ferone, R.5
  • 51
    • 0027279944 scopus 로고
    • Development and characterization of a rapid screening assay for identifying antipneumocystis agents
    • Martinez, A. and Kovacs, J.A. (1993) Development and characterization of a rapid screening assay for identifying antipneumocystis agents. Antimicrob. Agents Chemother. 37, 1674-1678.
    • (1993) Antimicrob. Agents Chemother. , vol.37 , pp. 1674-1678
    • Martinez, A.1    Kovacs, J.A.2
  • 52
    • 0028512360 scopus 로고
    • Measurement of protein biosynthesis in Pneumocystis carinii to investigate the effects of translation-specific inhibitors
    • Bishop, R.L., Jackson, H.C. and Warhurst, D.C. (1994) Measurement of protein biosynthesis in Pneumocystis carinii to investigate the effects of translation-specific inhibitors. J. Eukaryotic Microbiol. 41, 76S-78S.
    • (1994) J. Eukaryotic Microbiol. , vol.41
    • Bishop, R.L.1    Jackson, H.C.2    Warhurst, D.C.3
  • 54
    • 0022409732 scopus 로고
    • Method of testing the susceptibility of Pneumocystis carinii to antimicrobial agents in vitro
    • Cushion, M.T., Stanforth, D., Linke, M.J. and Walzer, P.D. (1985) Method of testing the susceptibility of Pneumocystis carinii to antimicrobial agents in vitro. Antimicrob. Agents Chemother. 28, 796-801.
    • (1985) Antimicrob. Agents Chemother. , vol.28 , pp. 796-801
    • Cushion, M.T.1    Stanforth, D.2    Linke, M.J.3    Walzer, P.D.4
  • 55
    • 0031039940 scopus 로고    scopus 로고
    • A cytotoxicity assay for evaluation of candidate anti-Pneumocystis carinii agents
    • Cushion, M.T., Chen, F. and Kloepfer, N. (1997) A cytotoxicity assay for evaluation of candidate anti-Pneumocystis carinii agents. Antimicrob. Agents Chemother. 41, 379-384.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 379-384
    • Cushion, M.T.1    Chen, F.2    Kloepfer, N.3


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