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Volumn 8, Issue 4, 1998, Pages 480-487

Factors controlling hair-cell regeneration/repair in the inner ear

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; GROWTH FACTOR; INSULIN; SOMATOMEDIN; SOMATOMEDIN B; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 0032143824     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(98)80035-4     Document Type: Article
Times cited : (58)

References (52)
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    • Analysis of small hair bundles in the utricles of mature guinea pigs
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    • in press
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    • of outstanding interest. This novel approach used partially dissociated sheets of early postnatal rat utricular epithelium to screen a large number of different growth factors for their ability to initiate a cell proliferation response. Several growth factors from different families were identified as mitogens for utricular sensory epithelium in this system, with some growth factor combinations demonstrating an additive effect on the cell proliferation response of this tissue. This is a well designed and executed experimental series using blocking antibodies to confirm the growth factor effects on mitogenesis in vitro.
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    • Replacement of mammalian auditory hair cells
    • This paper provides a convincing demonstration of hair-cell renewal in early postnatal rat organ of Corti explants following aminoglycoside damage to the auditory hair cells. The results suggest that the EGF receptor plays a role in the hair-cell renewal response by the damage organ of Corti, as either TGFα or EGF can initiate this hair-cell renewal response in the aminoglycoside-damaged explants. The results suggest that the damaged hair-cell population is renewed via transdifferentiation of either supporting cells or latent hair-cell precursors and/or repair of damaged hair cells, as none of the renewed hair-cell population labeled for thymidine incorporation.
    • Zine A, de Ribaupierre F. Replacement of mammalian auditory hair cells. Neuroreport. 9:1998;263-268 This paper provides a convincing demonstration of hair-cell renewal in early postnatal rat organ of Corti explants following aminoglycoside damage to the auditory hair cells. The results suggest that the EGF receptor plays a role in the hair-cell renewal response by the damage organ of Corti, as either TGFα or EGF can initiate this hair-cell renewal response in the aminoglycoside-damaged explants. The results suggest that the damaged hair-cell population is renewed via transdifferentiation of either supporting cells or latent hair-cell precursors and/or repair of damaged hair cells, as none of the renewed hair-cell population labeled for thymidine incorporation.
    • (1998) Neuroreport , vol.9 , pp. 263-268
    • Zine, A.1    De Ribaupierre, F.2
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    • Morphological indications of hair cell neodifferentiation in the organ of Corti of amikacin treated rat pups
    • of outstanding interest
    • of outstanding interest Lenoir M, Vago P. Morphological indications of hair cell neodifferentiation in the organ of Corti of amikacin treated rat pups. C R Acad Sci (Paris). 319:1996;269-276.
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    • Lenoir, M.1    Vago, P.2
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    • Does the organ of Corti attempt to differentiate new hair cells after antibiotic intoxication in rat pups?
    • of special interest. This study characterizes a transient attempt at hair-cell renewal in situ at the level of the outer hair cells in the aminoglycoside-damaged cochleae of young rats. Atypical cells that have similarities in surface morphology to developing hair cells appear and then disappear at the junction between damaged and undamaged hair cells within the organ of Corti. These results may represent an unsuccessful attempt at repair or unsuccessful attempt at repair or unsuccessful hair-cell neodifferentiation, as suggested by the authors. Their observation is important because it is the first evidence of an attempt at hair-cell renewal in situ in the mammalian cochlea.
    • Lenoir M, Vago P. Does the organ of Corti attempt to differentiate new hair cells after antibiotic intoxication in rat pups? of special interest Int J Dev Neurosci. 15:1997;487-495 This study characterizes a transient attempt at hair-cell renewal in situ at the level of the outer hair cells in the aminoglycoside-damaged cochleae of young rats. Atypical cells that have similarities in surface morphology to developing hair cells appear and then disappear at the junction between damaged and undamaged hair cells within the organ of Corti. These results may represent an unsuccessful attempt at repair or unsuccessful attempt at repair or unsuccessful hair-cell neodifferentiation, as suggested by the authors. Their observation is important because it is the first evidence of an attempt at hair-cell renewal in situ in the mammalian cochlea.
    • (1997) Int J Dev Neurosci , vol.15 , pp. 487-495
    • Lenoir, M.1    Vago, P.2
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    • Analysis of rat vestibular hair cell development and regeneration using calretinin as an early marker
    • This study confirms calretinin's usefulness as an early marker of hair-cell differentiation and its application to mammalian vestibular hair-cell regeneration research. The authors used antibodies raised against calretinin to track damaged vestibular hair cells that were no longer identifiable by their characteristic morphology following ototoxic damage, and the consequent loss of their identifying sensory hair bundles. This type of approach may prove to be useful for sorting out the relative contributions of transdifferentiation and repair to the hair-cell renewal process.
    • Zheng JL, Gao WQ. Analysis of rat vestibular hair cell development and regeneration using calretinin as an early marker. J Neurosci. 17:1997;8270-8282 This study confirms calretinin's usefulness as an early marker of hair-cell differentiation and its application to mammalian vestibular hair-cell regeneration research. The authors used antibodies raised against calretinin to track damaged vestibular hair cells that were no longer identifiable by their characteristic morphology following ototoxic damage, and the consequent loss of their identifying sensory hair bundles. This type of approach may prove to be useful for sorting out the relative contributions of transdifferentiation and repair to the hair-cell renewal process.
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    • Zheng, J.L.1    Gao, W.Q.2
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    • Establishment of conditionally immortalized rat utricular epithelial cell lines using a retrovirus mediated gene transfer technique
    • of special interest
    • of special interest Zheng JL, Lewis A, Gao WQ. Establishment of conditionally immortalized rat utricular epithelial cell lines using a retrovirus mediated gene transfer technique. Hear Res. 117:1998;13-23.
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    • Zheng, J.L.1    Lewis, A.2    Gao, W.Q.3
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    • Conditional immotalization of hair cells from the inner ear
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    • Holey, M.C.1    Nishida, Y.2    Grix, N.3
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    • Potential role of bFGF and retinoic acid in the regeneration of chicken cochlear hair cells
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.