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1
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0019481695
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Postembryonic production and aging in inner ear hair cells in sharks
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Corwin JT. Postembryonic production and aging in inner ear hair cells in sharks. J Comp Neurol. 201:1981;541-553.
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(1981)
J Comp Neurol
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Corwin, J.T.1
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2
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0007901792
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Perpetual production of hair cells and maturational changes in hair cell ultrastructure accompany postembryonic growth in an amphibian ear
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Corwin JT. Perpetual production of hair cells and maturational changes in hair cell ultrastructure accompany postembryonic growth in an amphibian ear. Proc Natl Acad Sci USA. 82:1985;3911-3915.
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(1985)
Proc Natl Acad Sci USA
, vol.82
, pp. 3911-3915
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Corwin, J.T.1
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3
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0023571859
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Regeneration of hair cell stereociliary bundles following severe acoustic trauma
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Cotanche DA. Regeneration of hair cell stereociliary bundles following severe acoustic trauma. Hear Res. 30:1987;181-195.
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(1987)
Hear Res
, vol.30
, pp. 181-195
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Cotanche, D.A.1
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4
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0023600053
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Light microscopic evidence of hair cell regeneration after gentamicin toxicity in chick cochlea
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Cruz RM, Lambert PR, Rubel EW. Light microscopic evidence of hair cell regeneration after gentamicin toxicity in chick cochlea. Arch Otolaryngol Head Neck Surg. 113:1987;1058-1062.
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(1987)
Arch Otolaryngol Head Neck Surg
, vol.113
, pp. 1058-1062
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Cruz, R.M.1
Lambert, P.R.2
Rubel, E.W.3
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5
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0000597242
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The avian inner ear. Continuous production of hair cells in vestibular sensory organs, but not in the auditory papilla
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Jorgensen JM, Mathiesen C. The avian inner ear. Continuous production of hair cells in vestibular sensory organs, but not in the auditory papilla. Naturwissenschaften. 75:1988;319-320.
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(1988)
Naturwissenschaften
, vol.75
, pp. 319-320
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Jorgensen, J.M.1
Mathiesen, C.2
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6
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0024434431
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Recovery of auditory function following intense sound exposure in the neonatal chick
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McFadden EA, Saunders JC. Recovery of auditory function following intense sound exposure in the neonatal chick. Hear Res. 41:1989;205-215.
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(1989)
Hear Res
, vol.41
, pp. 205-215
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McFadden, E.A.1
Saunders, J.C.2
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7
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0030902783
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Hair cell regeneration in the avian cochlea
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(suppl)
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Cotanche DA. Hair cell regeneration in the avian cochlea. Ann Otol Rhinol Laryngol. 168:1997;9-15. (suppl).
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(1997)
Ann Otol Rhinol Laryngol
, vol.168
, pp. 9-15
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Cotanche, D.A.1
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8
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0027404833
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Ultrastructural evidence for hair cell regeneration in the mammalian inner ear
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Force A, Li L, Corwin JT, Nevill G. Ultrastructural evidence for hair cell regeneration in the mammalian inner ear. Science. 259:1993;1616-1619.
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(1993)
Science
, vol.259
, pp. 1616-1619
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Force, A.1
Li, L.2
Corwin, J.T.3
Nevill, G.4
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9
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0023918917
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Regeneration of sensory hair cells after acoustic trauma
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Corwin JT, Cotanche DA. Regeneration of sensory hair cells after acoustic trauma. Science. 240:1988;1772-1774.
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(1988)
Science
, vol.240
, pp. 1772-1774
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Corwin, J.T.1
Cotanche, D.A.2
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10
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0024295746
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Hair cell regeneration after acoustic trauma in adult Coturnix quail
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Ryals BM, Rubel EW. Hair cell regeneration after acoustic trauma in adult Coturnix quail. Science. 240:1988;1774-1776.
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(1988)
Science
, vol.240
, pp. 1774-1776
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Ryals, B.M.1
Rubel, E.W.2
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12
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0030040342
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Regeneration of sensory cells after laser ablation in the lateral line sytem: Hair cell lineage and macrophage behavior revealed by time lapse microscopy
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Jones JE, Corwin JT. Regeneration of sensory cells after laser ablation in the lateral line sytem: hair cell lineage and macrophage behavior revealed by time lapse microscopy. J Neurosci. 16:1996;649-662.
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(1996)
J Neurosci
, vol.16
, pp. 649-662
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Jones, J.E.1
Corwin, J.T.2
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13
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0030066169
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New hair cells arise from supporting cell conversion in the acoustically damaged chick inner ear
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Adler H, Raphael Y. New hair cells arise from supporting cell conversion in the acoustically damaged chick inner ear. Neurosci Lett. 205:1996;17-20.
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(1996)
Neurosci Lett
, vol.205
, pp. 17-20
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Adler, H.1
Raphael, Y.2
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14
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0030873162
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Further evidence for supporting cell conversion in the damaged avian basilar papilla
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Adler H. Further evidence for supporting cell conversion in the damaged avian basilar papilla. Int J Dev Neurosci. 15:1997;375-385.
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(1997)
Int J Dev Neurosci
, vol.15
, pp. 375-385
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Adler, H.1
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15
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0029984988
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Light microscopic evidence that direct transdifferentiation gives rise to new hair cells in regenerating avian auditory epithelium
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Roberson D. Light microscopic evidence that direct transdifferentiation gives rise to new hair cells in regenerating avian auditory epithelium. Auditory Neurosci. 2:1996;195-205.
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(1996)
Auditory Neurosci
, vol.2
, pp. 195-205
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Roberson, D.1
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16
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0027531639
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Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans
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Warchol ME, Lambert PR, Goldstein BJ, Forge A, Corwin JT. Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans. Science. 259:1993;1619-1622.
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(1993)
Science
, vol.259
, pp. 1619-1622
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Warchol, M.E.1
Lambert, P.R.2
Goldstein, B.J.3
Forge, A.4
Corwin, J.T.5
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17
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0343416372
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Morphological evidence for supporting cell to hair cell conversion in the mammalian utricular macula
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Li L, Forge A. Morphological evidence for supporting cell to hair cell conversion in the mammalian utricular macula. Int J Dev Neurosci. 15:1997;433-446.
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(1997)
Int J Dev Neurosci
, vol.15
, pp. 433-446
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Li, L.1
Forge, A.2
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18
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0029868518
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Post traumatic survival and recovery of the auditory sensory cells in culture
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Sobkowicz HM, August BK, Slapnick SM. Post traumatic survival and recovery of the auditory sensory cells in culture. Acta Otolaryngol (Stockh). 16:1996;257-262.
-
(1996)
Acta Otolaryngol (Stockh)
, vol.16
, pp. 257-262
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Sobkowicz, H.M.1
August, B.K.2
Slapnick, S.M.3
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19
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0030807182
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Cellular interaction as a response to injury in the organ of Corti in culture
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of special interest. This study suggests that the repair of injured hair cells is more dependent on the extent of injury than on how it occurs. The author suggest that injured hair cells may respond in a number of different ways, and they make the novel suggestion that the supporting cells provide both protective and trophic support to the injured cells during the repair and recovery process.
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Sobkowicz HM, August BK, Slapnick SM. Cellular interaction as a response to injury in the organ of Corti in culture. of special interest Int J Dev Neurosci. 15:1997;463-485 This study suggests that the repair of injured hair cells is more dependent on the extent of injury than on how it occurs. The author suggest that injured hair cells may respond in a number of different ways, and they make the novel suggestion that the supporting cells provide both protective and trophic support to the injured cells during the repair and recovery process.
-
(1997)
Int J Dev Neurosci
, vol.15
, pp. 463-485
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Sobkowicz, H.M.1
August, B.K.2
Slapnick, S.M.3
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20
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0030736634
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Organization of cell junctions and cytoskeleton in the reticular lamina in normal and ototoxically damaged organ of Corti
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Leonova EV, Raphael Y. Organization of cell junctions and cytoskeleton in the reticular lamina in normal and ototoxically damaged organ of Corti. Hear Res. 113:1997;14-28.
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(1997)
Hear Res
, vol.113
, pp. 14-28
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Leonova, E.V.1
Raphael, Y.2
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21
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0028905618
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Replacement of hair cells after laser microbeam irradiation in cultured organs of Corti from embryonic and neonatal mice
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Kelly MW, Talreja D, Corwin JT. Replacement of hair cells after laser microbeam irradiation in cultured organs of Corti from embryonic and neonatal mice. J Neurosci. 15:1995;3013-3026.
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(1995)
J Neurosci
, vol.15
, pp. 3013-3026
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Kelly, M.W.1
Talreja, D.2
Corwin, J.T.3
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22
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0030690437
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Macrophage activity in organ cultures of the avian cochlea: Demonstration of a resident population and recruitment to sites of hair cell lesions
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of special interest. This study explores the role of macrophages in response to injury of the basilar papilla in the chick. The author demonstrates recruitment of macrophages to the site of the hair-cell lesion and suggests that macrophages have a role (i.e. they are a source of growth factors) in the initiation of the basilar papilla's hair-cell regeneration response.
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Warchol ME. Macrophage activity in organ cultures of the avian cochlea: demonstration of a resident population and recruitment to sites of hair cell lesions. of special interest J Neurobiol. 33:1997;724-734 This study explores the role of macrophages in response to injury of the basilar papilla in the chick. The author demonstrates recruitment of macrophages to the site of the hair-cell lesion and suggests that macrophages have a role (i.e. they are a source of growth factors) in the initiation of the basilar papilla's hair-cell regeneration response.
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(1997)
J Neurobiol
, vol.33
, pp. 724-734
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Warchol, M.E.1
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23
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0029827693
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Regenerative proliferation in organ cultures of the avian cochlea: Identification of the initial progenitors and determination of the latency of the proliferation response
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Warchol ME, Corwin JT. Regenerative proliferation in organ cultures of the avian cochlea: identification of the initial progenitors and determination of the latency of the proliferation response. J Neurosci. 16:1996;5466-5477.
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(1996)
J Neurosci
, vol.16
, pp. 5466-5477
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Warchol, M.E.1
Corwin, J.T.2
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24
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0029060615
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Supporting cells in isolated sensory epithelia of avian utricles proliferate in serum free culture
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Warchol ME. Supporting cells in isolated sensory epithelia of avian utricles proliferate in serum free culture. Neuroreport. 6:1995;981-984.
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(1995)
Neuroreport
, vol.6
, pp. 981-984
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Warchol, M.E.1
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25
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0029788282
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Hair cell differentiation in chick cochlear epithelium after aminoglycoside toxicity; In vivo and in vitro observations
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Stone JS, Leanao SG, Baker LP, Rubel EW. Hair cell differentiation in chick cochlear epithelium after aminoglycoside toxicity; in vivo and in vitro observations. J Neurosci. 16:1996;6157-6174.
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(1996)
J Neurosci
, vol.16
, pp. 6157-6174
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Stone, J.S.1
Leanao, S.G.2
Baker, L.P.3
Rubel, E.W.4
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26
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0028868751
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Fimbrin expression in the developing rat cochlea
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Zine A, Hafidi A, Romand R. Fimbrin expression in the developing rat cochlea. Hear Res. 87:1995;165-169.
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(1995)
Hear Res
, vol.87
, pp. 165-169
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Zine, A.1
Hafidi, A.2
Romand, R.3
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27
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0029677830
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Localization of the hair cell specific protein fimbrin during regeneration in the chicken cochlea
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Lee KH, Cotanche DA. Localization of the hair cell specific protein fimbrin during regeneration in the chicken cochlea. Audiol Neurotol. 1:1996;41-53.
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(1996)
Audiol Neurotol
, vol.1
, pp. 41-53
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Lee, K.H.1
Cotanche, D.A.2
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28
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0027983034
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Diffusable factors regulate hair cell regeneration in the avian inner ear
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Tsue T, Oesterle EC, Rubel EW. Diffusable factors regulate hair cell regeneration in the avian inner ear. Proc Natl Acad Sci USA. 91:1994;1584-1588.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 1584-1588
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Tsue, T.1
Oesterle, E.C.2
Rubel, E.W.3
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29
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0030977880
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Induction of cell proliferation in avian inner ear sensory epithelia by insulin like growth factor 1 and insulin
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of special interest. This study convincingly demonstrates that both insulin and insulin-like growth factor type I can evoke a cell proliferation response from normal mature vestibular sensory epithelium explanted from 8- to 18-day-old chicks. This paper has an excellent discussion of the differences between growth-factor-elicited cell proliferation responses by avian and mammalian vestibular sensory epithelia.
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Oesterle EC, Tsue TT, Rubel EW. Induction of cell proliferation in avian inner ear sensory epithelia by insulin like growth factor 1 and insulin. of special interest J Comp Neurol. 380:1997;262-274 This study convincingly demonstrates that both insulin and insulin-like growth factor type I can evoke a cell proliferation response from normal mature vestibular sensory epithelium explanted from 8- to 18-day-old chicks. This paper has an excellent discussion of the differences between growth-factor-elicited cell proliferation responses by avian and mammalian vestibular sensory epithelia.
-
(1997)
J Comp Neurol
, vol.380
, pp. 262-274
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Oesterle, E.C.1
Tsue, T.T.2
Rubel, E.W.3
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30
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0029794227
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Proliferation in the auditory receptor epithelium mediated by a cyclic AMP dependent signaling pathway
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Navaratnam DS, Su HS, Scott SP, Oberholtzer JC. Proliferation in the auditory receptor epithelium mediated by a cyclic AMP dependent signaling pathway. Nat Med. 2:1996;1136-1139.
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(1996)
Nat Med
, vol.2
, pp. 1136-1139
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Navaratnam, D.S.1
Su, H.S.2
Scott, S.P.3
Oberholtzer, J.C.4
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31
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0027222954
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Retinoic acid stimulates regeneration of mammalian auditory hair cells
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Lefebvre P, Malgrange B, Staecker H, Moonen G, Van De Water TR. Retinoic acid stimulates regeneration of mammalian auditory hair cells. Science. 260:1993;692-695.
-
(1993)
Science
, vol.260
, pp. 692-695
-
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Lefebvre, P.1
Malgrange, B.2
Staecker, H.3
Moonen, G.4
Van De Water, T.R.5
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32
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0028856478
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Histological evidence for hair cell regeneration after ototoxic cell destruction with local application of gentamicin in the chinchilla crista ampullaris
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Tanyeri H, Lopez I, Honrubia V. Histological evidence for hair cell regeneration after ototoxic cell destruction with local application of gentamicin in the chinchilla crista ampullaris. Hear Res. 89:1995;194-202.
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(1995)
Hear Res
, vol.89
, pp. 194-202
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-
Tanyeri, H.1
Lopez, I.2
Honrubia, V.3
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33
-
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0030837815
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Quantification of the process of hair cell loss and recovery in the chinchilla crista ampullaris after gentamicin treatment
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Lopez I, Honrubia V, Lee SC, Schoeman G, Beykirch K. Quantification of the process of hair cell loss and recovery in the chinchilla crista ampullaris after gentamicin treatment. Int J Dev Neurosci. 15:1997;447-461.
-
(1997)
Int J Dev Neurosci
, vol.15
, pp. 447-461
-
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Lopez, I.1
Honrubia, V.2
Lee, S.C.3
Schoeman, G.4
Beykirch, K.5
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34
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0030760532
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Analysis of small hair bundles in the utricles of mature guinea pigs
-
Analysis of variations in the maturity of stereociliary bundle morphology in the utricles of mature guinea pigs formed the basis for these authors to put forth the intriguing hypothesis that there is a low level of ongoing hair-cell proliferation to replace hair cells lost to normal processes. This phenomena has been demonstrated in the vestibule of adult birds but until now has not been thought to occur actively in the vestibule of mammals. This is a potentially important observation that needs confirmation by other methodologies.
-
Lambert PR, Gu R, Corwin JT. Analysis of small hair bundles in the utricles of mature guinea pigs. Am J Otol. 18:1997;637-643 Analysis of variations in the maturity of stereociliary bundle morphology in the utricles of mature guinea pigs formed the basis for these authors to put forth the intriguing hypothesis that there is a low level of ongoing hair-cell proliferation to replace hair cells lost to normal processes. This phenomena has been demonstrated in the vestibule of adult birds but until now has not been thought to occur actively in the vestibule of mammals. This is a potentially important observation that needs confirmation by other methodologies.
-
(1997)
Am J Otol
, vol.18
, pp. 637-643
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Lambert, P.R.1
Gu, R.2
Corwin, J.T.3
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35
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0028291216
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Inner ear hair cell regeneration in a mammal: Identification of a trigger factor
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Lambert PR. Inner ear hair cell regeneration in a mammal: identification of a trigger factor. Laryngoscope. 104:1994;701-718.
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(1994)
Laryngoscope
, vol.104
, pp. 701-718
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Lambert, P.R.1
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36
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0010265303
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TGF alpha with insulin induce proliferation in rat vestibular epithelia
-
in press
-
Kuntz AL, Oesterle EC. TGF alpha with insulin induce proliferation in rat vestibular epithelia. Arch Otolaryngol Head Neck Surg. 1998;. in press.
-
(1998)
Arch Otolaryngol Head Neck Surg
-
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Kuntz, A.L.1
Oesterle, E.C.2
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37
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0028932793
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Induction of cell proliferation in mammalian inner ear sensory epithelia by transforming growth factor alpha and epidermal growth factor
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Yamashita H, Oesterle EC. Induction of cell proliferation in mammalian inner ear sensory epithelia by transforming growth factor alpha and epidermal growth factor. Proc Natl Acad Sci USA. 92:1995;3152-3155.
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(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 3152-3155
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Yamashita, H.1
Oesterle, E.C.2
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38
-
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0031032087
-
Induction of cell proliferation by fibroblast and insulin like growth factors in pure rat inner ear epithelial cell cultures
-
of outstanding interest. This novel approach used partially dissociated sheets of early postnatal rat utricular epithelium to screen a large number of different growth factors for their ability to initiate a cell proliferation response. Several growth factors from different families were identified as mitogens for utricular sensory epithelium in this system, with some growth factor combinations demonstrating an additive effect on the cell proliferation response of this tissue. This is a well designed and executed experimental series using blocking antibodies to confirm the growth factor effects on mitogenesis in vitro.
-
Zheng JL, Helbig C, Gao WQ. Induction of cell proliferation by fibroblast and insulin like growth factors in pure rat inner ear epithelial cell cultures. of outstanding interest J Neurosci. 17:1997;216-226 This novel approach used partially dissociated sheets of early postnatal rat utricular epithelium to screen a large number of different growth factors for their ability to initiate a cell proliferation response. Several growth factors from different families were identified as mitogens for utricular sensory epithelium in this system, with some growth factor combinations demonstrating an additive effect on the cell proliferation response of this tissue. This is a well designed and executed experimental series using blocking antibodies to confirm the growth factor effects on mitogenesis in vitro.
-
(1997)
J Neurosci
, vol.17
, pp. 216-226
-
-
Zheng, J.L.1
Helbig, C.2
Gao, W.Q.3
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39
-
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0030739832
-
Triggers of hair cell regeneration in the avian inner ear
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Yamane H, Nakagawa T, Iguchi H, Shibata S, Takayama M, Sunami K, Nakai Y. Triggers of hair cell regeneration in the avian inner ear. Auris Nasus Larynx. 24:1997;221-225.
-
(1997)
Auris Nasus Larynx
, vol.24
, pp. 221-225
-
-
Yamane, H.1
Nakagawa, T.2
Iguchi, H.3
Shibata, S.4
Takayama, M.5
Sunami, K.6
Nakai, Y.7
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40
-
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0001024646
-
Response to: Regeneration and mammalian auditory hair cells: Technical comment
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Staecker H, Lefebvre P, Malgrange B, Moonen G, Van De Water TR. Response to: Regeneration and mammalian auditory hair cells: technical comment. Science. 267:1995;709-711.
-
(1995)
Science
, vol.267
, pp. 709-711
-
-
Staecker, H.1
Lefebvre, P.2
Malgrange, B.3
Moonen, G.4
Van De Water, T.R.5
-
41
-
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0028903919
-
Regeneration and mammalian auditory hair cells: Technical comment
-
Chardin S, Romand R. Regeneration and mammalian auditory hair cells: technical comment. Science. 267:1995;707-709.
-
(1995)
Science
, vol.267
, pp. 707-709
-
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Chardin, S.1
Romand, R.2
-
42
-
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0032567792
-
Replacement of mammalian auditory hair cells
-
This paper provides a convincing demonstration of hair-cell renewal in early postnatal rat organ of Corti explants following aminoglycoside damage to the auditory hair cells. The results suggest that the EGF receptor plays a role in the hair-cell renewal response by the damage organ of Corti, as either TGFα or EGF can initiate this hair-cell renewal response in the aminoglycoside-damaged explants. The results suggest that the damaged hair-cell population is renewed via transdifferentiation of either supporting cells or latent hair-cell precursors and/or repair of damaged hair cells, as none of the renewed hair-cell population labeled for thymidine incorporation.
-
Zine A, de Ribaupierre F. Replacement of mammalian auditory hair cells. Neuroreport. 9:1998;263-268 This paper provides a convincing demonstration of hair-cell renewal in early postnatal rat organ of Corti explants following aminoglycoside damage to the auditory hair cells. The results suggest that the EGF receptor plays a role in the hair-cell renewal response by the damage organ of Corti, as either TGFα or EGF can initiate this hair-cell renewal response in the aminoglycoside-damaged explants. The results suggest that the damaged hair-cell population is renewed via transdifferentiation of either supporting cells or latent hair-cell precursors and/or repair of damaged hair cells, as none of the renewed hair-cell population labeled for thymidine incorporation.
-
(1998)
Neuroreport
, vol.9
, pp. 263-268
-
-
Zine, A.1
De Ribaupierre, F.2
-
43
-
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0029936479
-
Morphological indications of hair cell neodifferentiation in the organ of Corti of amikacin treated rat pups
-
of outstanding interest
-
of outstanding interest Lenoir M, Vago P. Morphological indications of hair cell neodifferentiation in the organ of Corti of amikacin treated rat pups. C R Acad Sci (Paris). 319:1996;269-276.
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(1996)
C R Acad Sci (Paris)
, vol.319
, pp. 269-276
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Lenoir, M.1
Vago, P.2
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44
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0030858915
-
Does the organ of Corti attempt to differentiate new hair cells after antibiotic intoxication in rat pups?
-
of special interest. This study characterizes a transient attempt at hair-cell renewal in situ at the level of the outer hair cells in the aminoglycoside-damaged cochleae of young rats. Atypical cells that have similarities in surface morphology to developing hair cells appear and then disappear at the junction between damaged and undamaged hair cells within the organ of Corti. These results may represent an unsuccessful attempt at repair or unsuccessful attempt at repair or unsuccessful hair-cell neodifferentiation, as suggested by the authors. Their observation is important because it is the first evidence of an attempt at hair-cell renewal in situ in the mammalian cochlea.
-
Lenoir M, Vago P. Does the organ of Corti attempt to differentiate new hair cells after antibiotic intoxication in rat pups? of special interest Int J Dev Neurosci. 15:1997;487-495 This study characterizes a transient attempt at hair-cell renewal in situ at the level of the outer hair cells in the aminoglycoside-damaged cochleae of young rats. Atypical cells that have similarities in surface morphology to developing hair cells appear and then disappear at the junction between damaged and undamaged hair cells within the organ of Corti. These results may represent an unsuccessful attempt at repair or unsuccessful attempt at repair or unsuccessful hair-cell neodifferentiation, as suggested by the authors. Their observation is important because it is the first evidence of an attempt at hair-cell renewal in situ in the mammalian cochlea.
-
(1997)
Int J Dev Neurosci
, vol.15
, pp. 487-495
-
-
Lenoir, M.1
Vago, P.2
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45
-
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0030728956
-
Analysis of rat vestibular hair cell development and regeneration using calretinin as an early marker
-
This study confirms calretinin's usefulness as an early marker of hair-cell differentiation and its application to mammalian vestibular hair-cell regeneration research. The authors used antibodies raised against calretinin to track damaged vestibular hair cells that were no longer identifiable by their characteristic morphology following ototoxic damage, and the consequent loss of their identifying sensory hair bundles. This type of approach may prove to be useful for sorting out the relative contributions of transdifferentiation and repair to the hair-cell renewal process.
-
Zheng JL, Gao WQ. Analysis of rat vestibular hair cell development and regeneration using calretinin as an early marker. J Neurosci. 17:1997;8270-8282 This study confirms calretinin's usefulness as an early marker of hair-cell differentiation and its application to mammalian vestibular hair-cell regeneration research. The authors used antibodies raised against calretinin to track damaged vestibular hair cells that were no longer identifiable by their characteristic morphology following ototoxic damage, and the consequent loss of their identifying sensory hair bundles. This type of approach may prove to be useful for sorting out the relative contributions of transdifferentiation and repair to the hair-cell renewal process.
-
(1997)
J Neurosci
, vol.17
, pp. 8270-8282
-
-
Zheng, J.L.1
Gao, W.Q.2
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46
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0031916949
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Establishment of conditionally immortalized rat utricular epithelial cell lines using a retrovirus mediated gene transfer technique
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of special interest
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