메뉴 건너뛰기




Volumn 42, Issue 9, 1996, Pages 1426-1432

Tacrolimus (FK506) metabolite patterns in blood from liver and kidney transplant patients

Author keywords

high performance liquid chromatography; immunosuppressants; macrolides; mass spectrometry; metabolism; microparticle enzyme immunoassay; organ transplantation; therapeutic drug monitoring

Indexed keywords

DRUG METABOLITE; TACROLIMUS;

EID: 0029783338     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinchem/42.9.1426     Document Type: Article
Times cited : (77)

References (32)
  • 2
    • 0027485716 scopus 로고
    • Tacrolimus: A review of its pharmacology, and therapeutic potential in hepatic and renal transplantation
    • Peters DH, Fitton A, Plosker GL, Faulds D. Tacrolimus: a review of its pharmacology, and therapeutic potential in hepatic and renal transplantation. Drugs 1993;46:746-94.
    • (1993) Drugs , vol.46 , pp. 746-794
    • Peters, D.H.1    Fitton, A.2    Plosker, G.L.3    Faulds, D.4
  • 4
    • 0027994850 scopus 로고
    • A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression in liver transplantation
    • The US Multicenter FK506 Liver Study Group. A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression in liver transplantation. N Engl J Med 1994;331:1110-5.
    • (1994) N Engl J Med , vol.331 , pp. 1110-1115
  • 5
    • 0028124324 scopus 로고
    • Randomised trial comparing tacrolimus (FK 506) and cyclosporin in prevention of liver allograft rejection
    • European FK506 Multicentre Liver Study Group. Randomised trial comparing tacrolimus (FK 506) and cyclosporin in prevention of liver allograft rejection. Lancet 1994;344:423-8.
    • (1994) Lancet , vol.344 , pp. 423-428
  • 7
    • 0028676511 scopus 로고
    • Renal complications and development of hypertension in the European study of FK 506 and cyclosporin in primary liver transplant recipients
    • Devlin J, Williams R, Neuhaus P, McMaster P, Calne R, Pichlmayr R, et al. Renal complications and development of hypertension in the European study of FK 506 and cyclosporin in primary liver transplant recipients. Transplant Int 1994;7(Suppl 1):22-6.
    • (1994) Transplant Int , vol.7 , Issue.1 SUPPL. , pp. 22-26
    • Devlin, J.1    Williams, R.2    Neuhaus, P.3    McMaster, P.4    Calne, R.5    Pichlmayr, R.6
  • 8
    • 0028676652 scopus 로고
    • Neurological complications in the European multicentre study of FK506 and cyclosporin in primary liver transplantation
    • Neuhaus P, McMaster P, Calne R, Pichlmayr R, Otto G, Williams R, et al. Neurological complications in the European multicentre study of FK506 and cyclosporin in primary liver transplantation. Transplant Int 1994;7(Suppl 1):27-31.
    • (1994) Transplant Int , vol.7 , Issue.1 SUPPL. , pp. 27-31
    • Neuhaus, P.1    McMaster, P.2    Calne, R.3    Pichlmayr, R.4    Otto, G.5    Williams, R.6
  • 9
    • 0028676540 scopus 로고
    • Glucose metabolism in liver transplant recipients treated with FK506 or cyclosporin in the European multicentre study
    • Ericzon B, Groth C, Bismuth H, Calne R, McMaster P, Neuhaus P, et al. Glucose metabolism in liver transplant recipients treated with FK506 or cyclosporin in the European multicentre study. Transplant Int 1994;7(Suppl 1):11-4.
    • (1994) Transplant Int , vol.7 , Issue.1 SUPPL. , pp. 11-14
    • Ericzon, B.1    Groth, C.2    Bismuth, H.3    Calne, R.4    McMaster, P.5    Neuhaus, P.6
  • 11
    • 0028295725 scopus 로고
    • Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450 3A enzymes in rat, dog and human liver microsomes
    • Shiraga T, Matsuda H, Nagase K, Iwasaki K, Noda K, Yamazaki H, et al. Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450 3A enzymes in rat, dog and human liver microsomes. Biochem Pharmacol 1994;47:727-35.
    • (1994) Biochem Pharmacol , vol.47 , pp. 727-735
    • Shiraga, T.1    Matsuda, H.2    Nagase, K.3    Iwasaki, K.4    Noda, K.5    Yamazaki, H.6
  • 12
    • 0026662551 scopus 로고
    • Cytochrome P450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat
    • Sattler M, Guengerich F, Yun CH, Christians U, Sewing KF. Cytochrome P450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat. Drug Metab Dispos 1992;20:753-61.
    • (1992) Drug Metab Dispos , vol.20 , pp. 753-761
    • Sattler, M.1    Guengerich, F.2    Yun, C.H.3    Christians, U.4    Sewing, K.F.5
  • 13
    • 0026681640 scopus 로고
    • In vitro metabolism of FK506 in rat, rabbit, and human liver microsomes: Identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism
    • Vincent S, Karanam B, Painter S, Chiu SHL. In vitro metabolism of FK506 in rat, rabbit, and human liver microsomes: identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism. Arch Biochem Biophys 1992;294:454-60.
    • (1992) Arch Biochem Biophys , vol.294 , pp. 454-460
    • Vincent, S.1    Karanam, B.2    Painter, S.3    Chiu, S.H.L.4
  • 15
    • 0026343345 scopus 로고
    • High performance liquid chromatography/mass spectrometry of FK506 and its metabolites in blood, bile and urine of liver grafted patients
    • Christians U, Braun F, Kosian N, Schmidt M, Schiebel HM, Ernst L, et al. High performance liquid chromatography/mass spectrometry of FK506 and its metabolites in blood, bile and urine of liver grafted patients. Transplant Proc 1991;23:2741-4.
    • (1991) Transplant Proc , vol.23 , pp. 2741-2744
    • Christians, U.1    Braun, F.2    Kosian, N.3    Schmidt, M.4    Schiebel, H.M.5    Ernst, L.6
  • 16
    • 0026447470 scopus 로고
    • Specific and sensitive measurement of FK506 and its metabolites in blood and urine of liver-graft recipients
    • Christians U, Braun F, Schmidt M, Kosian N, Schiebel HM, Ernst L, et al. Specific and sensitive measurement of FK506 and its metabolites in blood and urine of liver-graft recipients. Clin Chem 1992;38:2025-32.
    • (1992) Clin Chem , vol.38 , pp. 2025-2032
    • Christians, U.1    Braun, F.2    Schmidt, M.3    Kosian, N.4    Schiebel, H.M.5    Ernst, L.6
  • 20
    • 0027518214 scopus 로고
    • Isolation, identification, and biological activities of oxidative metabolites of FK506, a potent immunosuppressive macrolide lactone
    • Iwasaki K, Shiraga T, Nagase K, Tozuka Z, Noda K, Sakuma S, et al. Isolation, identification, and biological activities of oxidative metabolites of FK506, a potent immunosuppressive macrolide lactone. Drug Metab Dispos 1993;21:971-7.
    • (1993) Drug Metab Dispos , vol.21 , pp. 971-977
    • Iwasaki, K.1    Shiraga, T.2    Nagase, K.3    Tozuka, Z.4    Noda, K.5    Sakuma, S.6
  • 21
    • 0028893714 scopus 로고
    • Further metabolism of FK506 (tacrolimus). Identification and biological activities of the metabolites oxidized at multiple sites of FK506
    • Iwasaki K, Shiraga T, Matsuda H, Nagase K, Tokuma Y, Hata T, et al. Further metabolism of FK506 (tacrolimus). Identification and biological activities of the metabolites oxidized at multiple sites of FK506. Drug Metab Dispos 1995;23:28-34.
    • (1995) Drug Metab Dispos , vol.23 , pp. 28-34
    • Iwasaki, K.1    Shiraga, T.2    Matsuda, H.3    Nagase, K.4    Tokuma, Y.5    Hata, T.6
  • 22
    • 0029156771 scopus 로고
    • Simplified high-performance liquid chromatography-mass spectrometry assay for measurement of tacrolimus and its metabolites and cross-validation with microparticle enzyme immunoassay
    • Gonschior AK, Christians U, Winkler M, Schiebel HM, Linck A, Sewing KF. Simplified high-performance liquid chromatography-mass spectrometry assay for measurement of tacrolimus and its metabolites and cross-validation with microparticle enzyme immunoassay. Ther Drug Monit 1995;17:504-10.
    • (1995) Ther Drug Monit , vol.17 , pp. 504-510
    • Gonschior, A.K.1    Christians, U.2    Winkler, M.3    Schiebel, H.M.4    Linck, A.5    Sewing, K.F.6
  • 23
    • 0025134337 scopus 로고
    • Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes
    • Pichard L, Fabre I, Fabre G, Domergue J, Saint Aubert B, Mourad G, Maurel P. Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes. Drug Metab Dispos 1990;18:595-606.
    • (1990) Drug Metab Dispos , vol.18 , pp. 595-606
    • Pichard, L.1    Fabre, I.2    Fabre, G.3    Domergue, J.4    Saint Aubert, B.5    Mourad, G.6    Maurel, P.7
  • 24
    • 0026457407 scopus 로고
    • Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction
    • Hebert M, Roberts J, Prueksaritanont T, Benet L. Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction. Clin Pharmacol Ther 1992;52:453-7.
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 453-457
    • Hebert, M.1    Roberts, J.2    Prueksaritanont, T.3    Benet, L.4
  • 25
    • 0006055331 scopus 로고
    • Biochemical tests for liver disease
    • Zakim D, Boyer TD, eds. Philadelphia: WB Saunders Co
    • Stolz A, Kaplowitz N. Biochemical tests for liver disease. In: Zakim D, Boyer TD, eds. Hepatology, a textbook of liver disease. Philadelphia: WB Saunders Co, 1990:637-67.
    • (1990) Hepatology, a Textbook of Liver Disease , pp. 637-667
    • Stolz, A.1    Kaplowitz, N.2
  • 29
    • 0028284542 scopus 로고
    • Comparison of different assays for the quantitation of FK506 levels in blood or plasma
    • Winkler M, Christians U, Stoll K, Baumann J, Pichlmayr R. Comparison of different assays for the quantitation of FK506 levels in blood or plasma. Ther Drug Monit 1994;16:281-6.
    • (1994) Ther Drug Monit , vol.16 , pp. 281-286
    • Winkler, M.1    Christians, U.2    Stoll, K.3    Baumann, J.4    Pichlmayr, R.5
  • 30
    • 0025879435 scopus 로고
    • The effect of graft function on FK506 plasma levels, dosages, and renal function, with particular reference to the liver
    • Abu-Elmagd K, Fung J, Alessiani M, Jain A, Venkataramanan R, Warty V, et al. The effect of graft function on FK506 plasma levels, dosages, and renal function, with particular reference to the liver. Transplantation 1991;52:71-7.
    • (1991) Transplantation , vol.52 , pp. 71-77
    • Abu-Elmagd, K.1    Fung, J.2    Alessiani, M.3    Jain, A.4    Venkataramanan, R.5    Warty, V.6
  • 31
    • 0344041213 scopus 로고
    • Evaluation of the new Pro-TracR tacrolimus monoclonal whole blood ELISA for monitoring of tacrolimus levels in patients after kidney, heart and liver transplantation
    • Winkler M, Christians U, Gonschior AK, Baumann J, Kattner A, Wonigeit K. Evaluation of the new Pro-TracR tacrolimus monoclonal whole blood ELISA for monitoring of tacrolimus levels in patients after kidney, heart and liver transplantation [abstract]. Ther Drug Monit 1995;17:430.
    • (1995) Ther Drug Monit , vol.17 , pp. 430
    • Winkler, M.1    Christians, U.2    Gonschior, A.K.3    Baumann, J.4    Kattner, A.5    Wonigeit, K.6
  • 32
    • 0025879435 scopus 로고
    • The effect of graft function on FK506 plasma levels, dosages, and renal function, with particular reference to the liver
    • Abu-Elmagd K, Fung J, Alessiani M, Jain A, Venkataramanan R, Warty V, et al. The effect of graft function on FK506 plasma levels, dosages, and renal function, with particular reference to the liver. Transplantation 1991;52:71-7.
    • (1991) Transplantation , vol.52 , pp. 71-77
    • Abu-Elmagd, K.1    Fung, J.2    Alessiani, M.3    Jain, A.4    Venkataramanan, R.5    Warty, V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.