Antimicrobial drug residues in milk and meat: Causes, concer ns, prevalence, regulations, tests, and test performance

Journal of Food Protection

Volumn 61, Issue 6, 1998, Pages 742-756

  Mitchell, J M ^a   Griffiths, M W ^a   McEwen, S A ^a   McNab, W B ^b   Yee, A J ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b FOOD AND RURAL AFFAIRS   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CANADA; FOOD PRESERVATIVE; FOOD SAFETY; MICROBIAL SENSITIVITY TEST;

ANIMALIA;

EID: 0032103291     PISSN: 0362028X     EISSN: None     Source Type: Journal    
DOI: 10.4315/0362-028X-61.6.742     Document Type: Review

References (173)

1. Andersen, K. L., W. A. Moats, J. E. Rushing, D. P. Wesen, and M. G. Papich. 1995. Potential for oxytetracycline administration by three routes to cause milk residues in lactating cows, as detected by radioimmunoassay (CHARM II) and high-performance liquid chromatography test methods. Am. J. Vet. Res. 56:70-77.
2. Anderson, K. L., W. A. Moats, J. E. Rushing, D. P. Wesen, and M. G. Papich. 1996. Ampicillin and amoxicillin residue detection in milk, using microbial receptor assay (CHARM II) and liquid Chromatographic methods, after extra-label administration of the drugs to lactating cows. Am. J. Vet. Res. 57:73-78.
3. Anonymous. 1992. FASTer residue test holds promise. J. Am. Vet. Med. Assoc. 200:886-887.
4. Bell, C., J. R. Rhoades, P. Neaves, and D. Scannella. 1995. An evaluation of the Indexx SNAP test for the detection of beta-lactam antibiotics in ex-farm raw milks. Neth. Milk Dairy J. 49:15-25.
5. Bell, C., and D. Scannella. 1994. An evaluation of the LacTek beta-lactam milk screening kit. J. Soc. Dairy Technol. 47(1):15-16.
6. Bielecka, M., J. D. Baldock, and A. W. Kotula. 1981. Determination of antibiotics in meat using Bacillus stearothermophilus spores. J. Food Prot. 44:194-200.
7. Blackburn, C. W. 1993. Rapid and alternative methods for the detection of salmonellas in foods. J. Appl. Bacteriol. 75:199-214.
8. Bogaerts, R., and F. Wolf. 1980. A standardized method for the detection of residues of anti-bacterial substances in fresh meat. Fleischwirtschaft 60:672-673.
9. Boison, J. O., G. O. Korsrud, M. G. Papich, and J. D. MacNeil. 1995. Comparison of four commercially available rapid test kits with liquid chromatography for detecting penicillin G residues in bovine plasma. J. AOAC Int. 78:1144-1152.
10. Booth, J. M. 1982. Antibiotic residues in milk. In Pract. 4:100-109.
11. Booth, N. H. 1988. Toxicology of drug and chemical residues, p. 1149-1205. In Booth, N. H., and L. E. McDonald (ed.), Veterinary pharmacology and therapeutics. Iowa State University Press, Ames, Iowa.
12. Brady, M. S., and S. E. Katz. 1988. Antibiotic/antimicrobial residues in milk. J. Food Prot. 51:8-11.
13. Brock, T. D., M. J. Madigan, J. M. Mortinko, and J. Parker. 1994. Growth and its control, p. 321-360. In Biology of microorganisms, 7th ed. Prentice-Hall of Canada Ltd., Toronto, Ontario.
14. Brynes, S. D., S. F. Sundlof, A. Vilim, G. Lambert, M. S. Yong, and S. Z. Fitzpatrick. 1996. International harmonization of maximum residue levels for veterinary drugs via dietary intake estimates. Proceedings of the EuroResidue III Conference, Veldhoven, The Netherlands, 6-8 May.
15. Brynes, S. D., and M. S. Yong. 1993. Harmonization of tolerances under the free trade agreement between the United States and Canada. Proceedings of the EuroResidue II conference, Veldhoven, The Netherlands, 3-5 May.
16. Bugyei, K., W. Black, S. McEwen, and A. H. Meek. 1994. Detecting oxytetracycline residues in chicken tissues using the Delvotest P system. J. Food Prot. 57:141-145.
17. Burgat-Sacaze, V., R. Andre, and J. C. Panisset. 1986. Toxicological significance of bound residues, p. 1-31. In A. G. Rico (ed.), Drug residues in animals. Academic Press, Toronto, Ontario.
18. Busta, F. F. 1966. Milk component(s) inhibitory to Bacillus stearothermophilus. J. Dairy Sci. 49:751-756.
19. Canadian Animal Health Institute. 1995. Compendium of veterinary products, 4th ed. North American Compendiums Ltd., Hensall, Ontario, Canada.
20. Candlish, A. A. G. 1991. Immunological methods in food microbiology. Food Microbiol. 8:1-14.
21. Cantarero, L. A., J. E. Butler, and J. W. Osborne. 1980. The absorptive characteristics of proteins for polystyrene and their significance in solid-phase immunoassays. Anal. Biochem. 105:375-382.
22. Carlsson, A., and L. Bjorck. 1992. Liquid chromatography verification of tetracycline residues in milk and influence of milk fat lipolysis on the detection of antibiotic residues by microbial assays and the CHARM II test. J. Food Prot. 55:374-378.
23. Carlsson, A., L. Bjorck, and K. Persson. 1989. Lactoferrin and lysozyme in milk during acute mastitis and their inhibitory effect in Delvotest P. J. Dairy Sci. 72:3166-3175.
24. Charm, S. E. 1994. Determination of non actionable positives associated with antibiotic tests. Dairy Food Environ. Sanit. 14:151-154.
25. Charm, S. E., and R. Chi. 1982. Rapid screening assay for beta-lactam antibiotics in milk: collaborative study. J. Assoc. Off. Anal. Chem. 65:1186-1192.
26. Charm, S. E., and R. Chi. 1988. Microbial receptor assay for rapid detection and identification of seven families of antimicrobial drugs in milk: collaborative study. J. Assoc. Off. Anal. Chem. 71:304-316.
27. Chen, H. C., and T. C. Chang. 1994. Detection of penicillin G in milk using a conductimetric method. J. Dairy Sci. 77:1515-1520.
28. Clifford, M. N. 1985. The history of immunoassays in food analysis, p. 3-10. In Immunoassays in food analysis. Elsevier Applied Science Publishers, New York.
29. Code of Federal Regulations. 1994. 21 CFR 1, part 556 (1 April). U.S. Department of Health and Human Services, Food and Drug Administration.
30. Codex Alimentarius Commission. 1993. List of Codex MRLs for vet drugs. In Residues of vet drugs in foods, volume 3, section 1. FAO/WHO, Rome.
31. Collins-Thompson, D. L., D. S. Wood, and I. Q. Thompson. 1988. Detection of antibiotic residues in consumer milk supplies in North America using the Charm test II procedure. J. Food Prot. 51:632-633.
32. Croubels, S., L. Okerman, K. Vanoosthuyze, J. Van Hoof, and C. Van Peteghem. 1996. Confirmation of tetracycline residues by HPLC after microbiological and ELISA screening of kidney and meat tissue. Proceedings of the EuroResidue III Conference, Veldhoven, The Netherlands, 6-8 May.
33. Cullor, J. S. 1993. Antibiotic residue tests for mammary gland secretions. Vet. Clin. North Am. Food Anim. Pract. 9:609-619.
34. Cullor, J. S., and J. Chen. 1991. Evaluating two new OTC milk screening ELISAs: do they measure up? Vet. Med. August: 845-850.
35. De La Haye, R., R. Patel, and S. Porter. 1996. Monitoring for residues: a strategy for screening. Proceedings of the EuroResidue III Conference, Veldhoven, The Netherlands, 6-8 May.
36. De Saeger, S., and C. Van Peteghem. 1996. Dipstick enzyme immunoassay to detect Fusarium T-2 toxin in wheat. Appl. Environ. Microbiol. 62:1880-1884.
37. Dewdney, J. M., and R. G. Edwards. 1984. Penicillin hypersensitivity - is milk a significant hazard?: a review. J. R. Soc. Med. 77:866-877.
38. Domagk, G. 1935. Ein Beitrag zur Chemotherapie der bakteriellen Infektionen. Dtsch. Med. Wochenschr. pp 250-255.
39. Engvall, E., and P. Perlman. 1971. Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. Immunochemistry. 8:871-874.
40. EU-Regulation 2377/90. 1990. Off. J. Eur. Communities L 224:1-8.
41. Fabiansson, S., and A. Rutegard. 1979. A modified method for the detection of antibiotic residues in slaughter animals. Acta Vet. Scand. 20:477-491.
42. Fitzpatrick, S. C., A. Vilim, G. Lambert, M. S. Yong, and S. D. Brynes. 1996. Dietary intake estimates as a means to the harmonization of maximum residue levels for veterinary drugs. Reg. Toxicol. Pharmacol. 24:177-183.
43. Fleming, A. 1929. On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae. Br. J. Exp. Pathol. 10:226-236.
44. Flint, S. H., and N. J. Hartley. 1993. Evaluation of the TECRA immunocapture ELISA for the detection of Salmonella typhimurium in foods. Lett. Appl. Microbiol. 17:4-6.
45. Foley, E. G., S. W. Lee, and G. A. Epstein. 1946. The effect of penicillin on staphylococci and streptococci commonly associated with bovine mastitis. J. Milk Food Technol. 8:129-133.
46. Foster, J. W., and H. B. Woodruff. 1943. Microbiological aspects of penicillin. J. Bacteriol. 46:187-202.
47. Franco, D. A., J. Webb, and C. E. Taylor. 1990. Antibiotic and sulfonamide residues in meat: implications for human health. J. Food Prot. 53:178-185.
48. Freeman, T. R. 1952. Milk quality. J. Milk Food Technol. 15:162-166.
49. Friedmann, R., and C. Epstein. 1951. The assay of the antibiotic nisin by means of a reductase test (resazurin) test. J. Gen. Microbiol. 5:830-839.
50. Fukal, L. 1991. Modern immunoassays in meat-product analysis. Nahrung 35:431-448.
51. Fukal, L., and J. Kas. 1989. The advantages of immunoassay in food analysis. Trends Anal. Chem. 8:112-116.
52. Gardner, I. A., J. S. Cullor, F. D. Galey, W. Sischo, M. Salman, B. Slenning, H. N. Erb, and J. W. Tyler. 1996. Alternatives for the validation of diagnostic assays used to detect antibiotic residues in milk. J. Am. Vet. Med. Assoc. 209:46-52.
53. Garrod, L. P. 1964. Hazards of antibiotics in milk and other food products. Proc. R. Soc. Med. 57:1087-1088.
54. Gildow, E. M., D. L. Fourt, and O. D. Shaw. 1938. Sulfanilamide in the treatment of streptococcic mastitis. J. Dairy Sci. 21:759-766.
55. Ginn, R. E., S. Tatini, and V. S. Packard, Jr. 1978. Comparative evaluation of the Difco disc assay method for detecting penicillin in milk and milk products. J. Food Prot. 41:361-363.
56. Golden, C. A. 1992. Understanding enzyme immunoassays and their application in drug residue detection. Agri-Practice 13(10):5-11.
57. Government of Canada. 1994. Food and Drugs Act and Regulations, Supply and Services Canada.
58. Gudding, R. 1976. An improved bacteriological method for the detection of sulfonamide residues in food. Acta Vet. Scand. 17:458-464.
59. Halbert, L. W., R. J. Frskine, P. C. Bartlett, and G. L. Johnson. 1996. Incidence of false-positive results for assays used to detect antibiotics in milk. J. Food Prot. 59:886-888.
60. Hapoja, A., and H. Korkeala. 1984. Antimicrobial residues in milk. Comparison of different agar diffusion methods. Acta Vet. Scand. 25:250-259.
61. Harik-Khan, R., and W. A. Moats. 1995. Identification and measurement of β-lactam antibiotic residues in milk: integration of screening kits with liquid chromatography. J. AOAC Int. 78:978-986.
62. Hawronsky, J. M., M. R. Adams, and A. L. Kyriakides. 1993. Rapid detection of antibiotics in raw milk by ATP bioluminescence. J. Soc. Dairy Technol. 46(1):31-33.
63. Health and Welfare Canada. 1991. Preparation of veterinary new drug submissions. Health Protection Branch.
64. Heeschen, W. H., and G. Suhren. 1996. Principles of and practical experiences with an integrated system for the detection of antimicrobials in milk. Milchwissenschaft 51:154-160.
65. Helton-Groce, S. L., T. D. Thompson, and R. S. Readnour. 1993. A study of tilmicosin residues in milk following subcutaneous administration to lactating dairy cows. Can. Vet. J. 34:619-621.
66. Huber, W. G. 1971. The impact of antibiotic drugs and their residues. Adv. Vet. Sci. Comp. Med. 15:101-132.
67. Huber, W. G. 1986. Allergenicity of antibacterial drug residues, p. 33-49. In A. G. Rico (ed.), Drug residues in animals. Academic Press, Toronto, Ontario.
68. Huis In't Veld, J., B. Hartog, and H. Hofstra. 1988. Changing perspectives in food microbiology: implementation of rapid microbiological analyses in modern food processing. Food Rev. Int. 4:271-329.
69. Hunter, G. J. E. 1949. The effect of penicillin in milk on the manufacture of cheddar cheese. J. Dairy Res. 16:235-241.
70. Hunter, G. J. E. 1949. A note on the effect of penicillin in the reductase test for milk quality. J. Dairy Res. 16:149-151.
71. Ibrahim, G. F. 1986. A review of immunoassays and their application to salmonellae detection in foods. J. Food Prot. 49:299-310.
72. Igarishi, R. T., R. W. Baughman, F. E. Nelson, and P. A. Hartman. 1961. Rapid antibiotic assay using Bacillus stearothermophilus. J. Milk Food Technol. 24:143-146.
73. Jackson, B. J., A. M. Brookins, D. Tetrreault, and K. Costello. 1993. Detection of Listeria in food and environmental samples by immunomagnetic bead capture and by cultural methods. J. Rapid Methods and Autom. Microbiol. 2:39-54.
74. Johnston, R. W., R. H. Reamer, E. W. Harris, H. G. Fugate, and B. Schwab. 1981. A new screening method for the detection of antibiotic residues in meat and poultry tissues. J. Food Prot. 44:828-831.
75. Jukes, T. H., and W. L. Williams. 1953. Nutritional effects of antibiotics. Pharmacol. Rev. 5:381-420.
76. Kampelmacher, E. H., P. A. M. Guinee, and L. M. Van Noorle Jansen. 1962. Simple determination of antibiotics in slaughter animals which had therapeutic antibiotic treatment during life. Tijdschr. Diergeneesk. 87:16-29.
77. Katz, S. E., and M. Siewierski. 1995. Bacillus stearothermophilus disc assay: a review. J. AOAC Int. 78:1408-1415.
78. Kaufman, B. M. 1995. Immunoassay of pesticides: an update. J. AOAC Int. 78:1079-1090.
79. Kaufmann, O. W. 1977. A practical sensitive test to detect penicillin in milk. J. Food Prot. 40:250-251.
80. Kersey, R. C., and F. V. Leghorn. 1953. A microbiological assay of penicillin in animal feeds. Appl. Microbiol. 1:150-152.
81. Kimbrell, W. 1990. Milk on trial. Dairy Foods 1990 (March):12-25.
82. Kindred, T. P., and W. T. Hubbert. 1993. Residue prevention strategies in the United States. J. Am. Vet. Med. Assoc. 202:46-49.
83. Knight, A. H., N. Shapton, and G. A. Prentice. 1987. Collaborative trial of the Penzyme assay: a rapid method for the detection of β-lactam antibiotics in milk. J. Soc. Dairy Technol. 40(2):30-33.
84. Kohler, G., and C. Milstein. 1975. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature (London) 256: 495-497.
85. Korkeala, H., O. Sorvettula, O. Maki-Petays, and J. Hirn. 1983. Comparison of different agar diffusion methods for the detection of residues in the kidneys of pigs treated with antimicrobial drugs. Meat Sci. 9:291-304.
86. Korsrud, G. O., and J. D. MacNeil. 1988. Evaluation of the swab test on premises, the calf antibiotic sulfa test, and a microbial inhibitor test with standard solutions of 22 antibiotics. J. Food Prot. 51:43-46.
87. Korsrud, G. O., C. D. C. Salisbury, A. C. E. Fesser, and J. D. MacNeil. 1992. Evaluation and testing of Charm Test II receptor assays for the detection of antimicrobial residues in meat, p. 75-79. In A. K. Agarwal (ed.), Analysis of antibiotic residues in food products of animal origin. Plenum Press, New York.
88. Korsrud, G. O., C. D. C. Salisbury, A. C. E. Fesser, and J. D. MacNeil. 1995. Laboratory evaluation of the Charm Farm test for antimicrobial residues in meat. J. Food Prot. 58:1129-1132.
89. Kosikowsky, F. V. 1963. Induced and natural inhibitory behavior of milk and significance to antibiotic disk assay testing. J. Dairy Sci. 46:96-101.
90. Kraack, J., and A. Tolle. 1967. Brilliantschwarz-reduktionstest mit Bac. stearothermophilus vor. calidolactis zum Nachweis von Hemmstoffen in der Milch. Milchwissenschaft 22:669-673.
91. Kuby, J. 1992. Overview of the immune system, p. 2-19. In Immunology. W. H. Freeman and Company, New York.
92. Larocque, L., G. Carignan, and S. Sved. 1990. Sulfamethazine (sulfadimidine) residues in Canadian consumer milk. J. Assoc. Off. Anal. Chem. 73:365-367.
93. Lassiter, C. A. 1955. Antibiotics as growth stimulants for dairy cattle: a review. J. Dairy Sci. 38:1102-1138.
94. Lehotay, S. J., and R. W. Miller. 1994. Evaluation of commercial immunoassays for the detection of alachlor in milk, eggs and liver. J. Environ. Sci. Health Part B Pestic. Food Contain. Agric. Wastes B29:395-414.
95. Lindsay, S. 1992. History and basic principles, p. 1-7. In J. Barnes (ed.), High performance liquid chromatography. John Wiley and Sons, Toronto, Ontario.
96. Lloyd, D. N., and D. van der Merwe. 1987. The use of a diffusion test for the detection of antibiotics in the tissues of slaughter stock. J. S. Afr. Vet. Med. Assoc. 58:183-186.
97. Loo, Y. H., H. M. Thornberry, J. Ehrlich, J. M. McGuire, G. M. Savage, and J. C. Sylvester. 1945. Assay of streptomycin by the paper-disk method. J. Bacteriol. 50:701-709.
98. MacNeil, J. D., G. O. Korsrud, J. O. Boison, M. G. Papich, and W. D. G. Yates. 1991. Performance of five screening tests for the detection of penicillin G residues in experimentally injected calves. J. Food Prot. 54:37-40.
99. Martin, S. W., A. H. Meek, and P. Willeberg. 1987. Measurement of disease frequency and production, p. 48-76. In Veterinary epidemiology. Iowa State University Press, Ames.
100. McEwen, S. A., A. H. Meek, and W. D. Black. 1991. A dairy farm survey of antibiotic treatment practices, residue control methods and associations with inhibitors in milk. J. Food Prot. 54:454-459.
101. McGrane, P., J. Early, and M. T. Rowe. 1994. Modified Delvotest P for the quantitative estimation of penicillin in raw milk. Milchwissenschaft. 49:507-510.
102. McGrane, P., M. T. Rowe, and S. Anger. 1996. Evaluation of Delvotest SP and Charm AIM-96 for the detection of a range of antibiotics in milk. Milchwissenschaft 51:330-332.
103. McKean, J. D. 1987. A veterinary approach to residue testing. Large Anim. Vet. 1987(September/October):38-42.
104. Medina, M. B., R. A. Barford, M. S. Palumbo, and L. D. Rowe. 1992. Evaluation of commercial immunochemical assays for detection of sulfamethazine in milk. J. Food Prot. 55:284-290.
105. Mercer, H. D. 1975. Antibiotic drugs in food-producing animals: control mechanisms of governmental agencies. Vet. Clin. N. Am. 5:3-34.
106. Messer, J. E. Leslie, G. A. Houghtby, J. T. Peeler, and J. E. Barnett. 1982. Bacillus stearothermophilus disc assay for detection of inhibitors in milk: collaborative study. J. Assoc. Off. Anal Chem. 65:1208-1214.
107. Miller, D. J. S. 1993. Present state and trends in the use of veterinary drugs. Proceedings of the EuroResidue II conference, Veldhoven, The Netherlands, 3-5 May.
108. Mitchell, J. M. 1992. Keeping inhibitor tests accurate. Ontario Milk Producer 1992 (September).
109. Mitchell, J. M., and A. J. Yee. 1995. Antibiotic use and transfer of drug resistance: does it mean we should stop treating animals with these drugs? Dairy Food Environ. Sanit. 15:484-487.
110. Mitchell, M., B. Bodkin, and J. Martin. 1995. Detection of beta-lactam antibiotics in bulk tank milk. J. Food Prot. 58:577-578.
111. Miuro, T., H. Kouno, and T. Kitagawa. 1981. Detection of residual penicillin in milk by sensitive EIA. J. Pharmacobio-Dynamics. 4:706-710.
112. Moats, W. A. 1983. Detection and semiquantitative estimation of penicillin G and cloxacillin in milk by thin-layer chromatography. J. Agric. Food Chem. 31:1348-1350.
113. Moats, W. A. 1984. Determination of penicillin G and cloxacillin residues in beef and pork tissue by high-performance liquid chromatography. J. Chromatogr. 317:311-318.
114. Moats, W. A. 1985. Physiochemical methods for identifying antibiotic residues in foods. Proceedings of the 190th Meeting of the American Chemical Society, Chicago, 8-13 September.
115. Moats, W. A. 1990. Liquid Chromatographic approaches to antibiotic residue analysis. J. Assoc. Off. Anal. Chem. 73:343-346.
116. Neal, C. E., and H. E. Calbert. 1955. The use of 2,3,5-triphenyltetrazolium chloride as a test for antibiotic substances in milk. J. Dairy Sci. 38:629-633.
117. Newsome, W. H. 1986. Potential and advantages of immunochemical methods in foods. J. Assoc. Off. Anal. Chem. 69:919-923.
118. Notermans, S., and K. Wernars. 1989. Immunological methods for detection of foodborne microorganisms and their toxins. Int. J. Food Microbiol. 12:91-102.
119. Nouws, J. F. M., N. J. G. Broex, J. M. P. Hartog, and F. Driessens. 1988. The new Dutch kidney test. Arch. Lebensmittelhyg. 39:135-138.
120. Nouws, J. F. M., G. Loeffen, J. Schouten, H. Van Egmond, H. Keukens, and H. Stegeman. 1996. Improvement of the tube diffusion test with respect to detection of antibiotic residues and sulphonamides in raw milk. Arch. Lebensmittelhyg. 46:125-148.
121. O'Rangers, J. J. 1993. Utilization of new screening tests for animal drug residue detection. Proceedings of the EuroResidue II Conference, Veldhoven, The Netherlands, 3-5 May.
122. Ormerod, A. D., T. M. S. Reid, and R. A. Main. 1987. Penicillin in milk - its importance in urticaria. Clin. Allergy 17:229-234.
123. Ostermaier, S., E. Schneider, E. Usleber, E. Martlbauer, and G. Terplan. 1995. Rapid enzyme immunoassays for the detection of three sulphonamides in milk. Food Agric. Immunol. 7:253-258.
124. Paige, J. C. 1994. Analysis of tissue residues. FDA Vet. 9(6):4-6.
125. Park, C. E., D. Warburton, P. J. Laffey, and collaborators. 1996. A collaborative study on the detection of staphylococcal enterotoxins with and enzyme immunoassay kit (TECRA). J. Food Prot. 59:390-397.
126. Patterson, J. R., C. D. C. Salisbury, J. D. MacNeil, J. O. K. Boison, G. O. Korsrud, and W. Chan. 1994. Test strategy for monitoring antimicrobial residues in meat. Proceedings of the VIth Congress of the International Society for Animal Clinical Biochemistry, Guelph, Ontario, Canada, 2-6 August.
127. Pitre, J. 1963. Gel diffusion test for antibiotics in meat and organs of slaughtered animals. Bull. Acad. Vet. Fr. 36:175-182.
128. Place, A. R. 1990. Animal drug residues in milk, the problem and the response. Dairy Food Environ. Sanit. 10:662-664.
129. Prescott, J. F., and J. D. Baggot. 1988. Antibiotic residues, p. 341-346. In Antimicrobial therapy in veterinary medicine. Black-well Scientific Publications, Inc., Boston.
130. Read, R. B. Jr., J. G. Bradshaw, A. A. Swartzentruber, and A. R. Brazis. 1971. Detection of sulfa drugs and antibiotics in milk. Appl. Microbiol. 21:806-808.
131. Roach, V. Z., M. R. Plaunt, L. F. Strenkoski, and R. Firstenberg-Eden. 1995. Evaluation of Difco's Bacillus stearothermophilus disk assay for detection of amoxicillin, ampicillin, cephapirin and penicillin in raw commingled bulk milk. AOAC Annual Meeting, Nashville, Tenn., September.
132. Samarajeewa, U., C. I. Wei, T. S. Huang, and M. R. Marshall. 1991. Application of immunoassays in the food industry. Crit. Rev. Food Sci. Nutr. 29:403-434.
133. Schipper, I. A., and W. E. Petersen. 1951. Assay of aureomycin in milk by use of methylene blue. Vet. Med. 46:222-224.
134. Schloter, M., B. Abmus, and A. Hartmann. 1995. The use of immunological methods to detect and identify bacteria in the environment. Biotechnol. Adv. 13:75-90.
135. Shaikh, B. 1993. Liquid Chromatographic analysis of antibacterial drug residues in food products of animal origin. J. Chromatogr. 643:369-378.
136. Silverman, C. J., and F. V. Kosikowsky. 1952. Systematic testing of inhibitory substances in milk. J. Milk Food Technol. 15:120-124.
137. Sischo, W. M. 1996. Quality milk and tests for antibiotic residues. J. Dairy Sci. 79:1065-1073.
138. Skerritt, J. H. 1995. Analytical aspects of immunoassays of agrochemicals, p. 1-16. In D. A. Kurtz, J. H. Skerritt, and L. Stankar (ed.), New frontiers in agrochemical immunoassay. AOAC International, Arlington, Va.
139. Smither, R. 1978. Bacterial growth inhibitors formed during the adventitious growth of micro-organisms in chicken liver and pig kidney. J. Appl. Bacteriol. 45:267-277.
140. Spencer, G. R. 1950. Recent progress in mastitis control. J. Milk Food Technol. 13:44-49.
141. Stephany, R. W. 1990. Quality criteria in veterinary drug residue analysis. Proceedings of the EuroResidue Conference, Noordwijkerhout, The Netherlands, 21-23 May.
142. Stoltz, E. I., and D. J. Hankinson. 1953. Antibiotics and lactic acid starter cultures. Appl. Microbiol. 1:21-29.
143. Suhren, G., and W. Heeschen. 1996. Detection of inhibitors in milk by microbial tests: a review. Nahrung 40:1-7.
144. Suhren, G., and W. Heeschen. 1993. Detection of tetracyclines in milk by a Bacillus cereus microtitre test with indicator. Milchwissenschaft 48:259-263.
145. Suhren, G., A. Hoffmeister, J. Reichmuth, and W. Heeschen. 1990. Incidence of inhibitory substances in milk for consumption from various European countries. Milchwissenschaft 45:485-490.
146. Suhren, G., J. Reichmuth, and H. G. Walte. 1996. Detection of β-lactam antibiotics in milk by the Penzyme test. Milchwissenschaft 51:269-273.
147. Sundlof, S. F. 1989. Drug and chemical residues in livestock. Vet. Clin. N. Am. Food Anim. Pract. 5:411-449.
148. Sundlof, S. F. 1990. Residue detection: a survey of available technology. Bovine Pract. 25:15-17.
149. Sundlof, S. F., J. B. Kaneene, and R. Miller. 1995. National survey on veterinarian-initiated drug use in lactating dairy cows. J. Am. Vet. Med. Assoc. 207:347-352.
150. Szekacs, A. 1994. Development of enzyme-linked immunosorbent assay (ELISA) systems for environmental monitoring. Acta Biol. Hung. 45:77-80.
151. Takacs, J., and S. Kovacs. 1969. Demonstration of antibiotic residues in the meat of slaughtered animals. Acta Vet. Acad. Sci. Hung. 19:11-19.
152. Takahashi, Y., Y. S. Endoh, S. Hamamoto, Y. Ishihara, M. Nishikawa, and H. Nogawa. 1994. Enzyme immunoassay of sulfamethoxazole in chicken tissues: interlaboratory study. J. Vet. Med. Sci. 56:1207-1208.
153. Telling, G. M. 1990. Control of veterinary drug residues in food. Proceedings of the EuroResidue Conference, Noordwijkerhout, The Netherlands, 21-23 May.
154. Thorogood, S. A., and A. Ray. 1984. An evaluation of the Penzym® assay: a rapid method for the detection of β-lactam antibiotics in milk. J. Soc. Dairy Technol. 37(2):38-40.
155. Tittiger, F., B. Kingscote, B. Meldrum, and M. Prior. 1975. Survey of antibiotic residues in Canadian slaughter animals. Can. J. Comp. Med. 39:178-182.
156. Toon, E. R., and G. L. Ellis. 1973. Special feature: chromatography, p. 78-80. In Foundations of chemistry. Holt, Rinehart and Winston, Inc., Toronto.
157. Tyler, J. W., J. S. Cullor, R. J. Erskine, W. L. Smith, J. Dellinger, and K. McClure. 1992. Milk antimicrobial drug residue assay results in cattle with experimental, endotoxin-induced mastitis. J. Am. Vet. Med. Assoc. 201:1378-1384.
158. Van Houweling, C. D. 1969. Use of antibiotics in food animals: a review and status report. FDA Pap. 3:21-25.
159. Van Os, J. L., A. Lameris, J. Doodeward, and J. G. Oostendorp. 1975. Diffusion test for the determination of antibiotic residues in milk. Neth. Milk Dairy J. 29:16-34.
160. Van Schothorst, M. 1965. Study about the occurrence of antibioticresidues in normal slaughter animals. Tijdschr. Diergeneesk. 90:579-582.
161. Van Schothorst, M., and G. Peelen-Knol. 1970. Detection and identification of some antibiotics in slaughter animals. Neth. J. Vet. Sci. 3(2):85-93.
162. Vasavada, P. C. 1993. Rapid methods and automation in dairy microbiology. J. Dairy Sci. 76:3101-3113.
163. Vermunt, A. E. M., J. Stadhouders, G. F. M. Loeffen, and R. Bakker. 1993. Improvements of the tube diffusion method for detection of antibiotics and sulfonamides in raw milk. Neth. Milk Dairy J. 47:31-41.
164. Vickers, H. R. 1964. Dermatological hazards of the presence of penicillin in milk. Proc. R. Soc. Med. 57:1091-1092.
165. Wal. J. M., G. F. Bones, S. Mamas, and F. Dray. 1975. Radioimmunoassay of penicilloyl groups in biological fluids (including milk). FEBS Lett. 57:9-13.
166. Welsh, M., P. H. Langer, R. L. Burkhart, and C. R. Schroeder. 1948. Penicillin blood and milk concentrations in the normal cow following parenteral administration. Science 108:185-187.
167. Wemimont, G. T. 1985. The measurement process, p. 6-10. In W. Spendley (ed.), Use of statistics to develop and evaluate analytical methods. Association of Official Analytical Chemists, Arlington, Va.
168. Whitehead, H. R., and G. A. Cox. 1956. The detection of penicillin in milk. J. Appl. Bacteriol. 19:247-249.
169. Wilkowske, H. H., and W. A. Krienke. 1951. Influence of penicillin on the lactic acid production of certain lactobacilli. J. Dairy Sci. 34:1030-1033.
170. Wilson, C. D. 1964. The use of antibiotics in the control of mastitis. Proc. R. Soc. Med. 57:1088-1090.
171. Wyatt, G. M. 1995. Antibody-based detection of microbial analytes in food: aspects of development. Food Agric. Immunol. 7:55-65.
172. Yalow, R. S., and S. A. Berson. 1959. Assay of plasma insulin in human subjects by immunological methods. Nature (London) 184: 1648-1649.
173. Yong, M. S. 1994. Fundamental approaches to hazard evaluation and risk assessment of drug residues the current situation in Canada. Proceedings of the International Conference on Risk Assessment and Risk Management in the Regulatory Evaluation of Veterinary Medicinal Products, Brussels, Belgium, 17-18 March.