Longitudinal HIV-1 RNA levels in a cohort of homosexual men

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

Volumn 18, Issue 2, 1998, Pages 155-161

  O'Brien, Thomas R ^a   Rosenberg, Philip S ^a   Yellin, Frances ^b   Goedert, James J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b National Cancer Institute ^*  (United States)

Author keywords

AIDS; Epidemiology; Homosexual men; Longitudinal HIV 1; RNA levels

Indexed keywords

VIRUS RNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; HOMOSEXUALITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEROCONVERSION; VIREMIA;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0032102082     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042560-199806010-00007     Document Type: Article

References (22)

1. Daar ES, Moudgil T, Meyer RD, Ho DD. Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection. N Engl J Med 1991;324:961-4.
2. Henrard DR, Phillips JF, Muenz LR, et al. Natural history of HIV-1 cell-free viremia. JAMA 1995;274:554-8.
3. O'Brien TR, Blattner WA, Waters D, et al. Serum HIV-1 RNA levels and time to development of AIDS in the Multicenter Hemophilia Cohort Study. JAMA 1996;276:105-10.
4. Mellors JW, Kingsley LA, Rinaldo CR, et al. Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversion. Ann Intern Med 1995;122:573-9.
5. Mellors JW, Rinaldo CR Jr, Gupta P, White RM, Todd JA, Kingsley LA. Prognosis in HIV-1 infection predicted by quantity of virus in plasma. Science 1996;272:1167-70.
6. Ho DD, Neuman AU, Perelson AS, Chen W, Leonard JM, Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995;373:123-6.
7. Wei X, Ghosh SK, Taylor ME, et al. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 1995;373:117-22.
8. Piatak Jr. M, Saag MS, Yang LC, et al. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science 1993;259:1749-54.
9. Goedert JJ, Biggar RJ, Melbye M, et al. Effect of T 4 count and cofactors on the incidence of AIDS in homosexual men infected with human immunodeficiency virus. JAMA 1987;257:331-4.
10. Mulder J, McKinney N, Christopherson C, Sninsky J, Greenfield L, Kwok S. Rapid and simple PCR assay for quantitation of human immunodeficiency virus type I RNA in plasma: application to acute retroviral infection. J Clin Microbiol 1994;32:292-300.
11. Tollerud DJ, Brown LM, Clark JW, et al. Cryopreservation and long-term liquid nitrogen storage of peripheral blood mononuclear cells for flow cytometry analysis: effects on cell subset proportions and fluorescence intensity. J Clin Lab Anal 1991;5:255-61.
12. Fletcher MA, Baron GC, Ashman MR, Fischl MA, Klimas NG. Use of whole blood methods in assessment of immune parameters in immunodeficiency states. Diagn Clin Immunol 1987;5:69-81.
13. SAS Institute Inc. SAS users guide: statistics, V.5. Cary, NC: SAS Institute, 1985:420-2.
14. Armitage P. Statistical methods in medical research. Oxford: Blackwell Scientific Publications, 1971:397-8.
15. Centers for Disease Control and Prevention. Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. MMWR Morbid Mortal Wkly Rep 1987;36(Suppl 1S):1S-15S.
16. Cox DR. Regression models and life-tables [with discussion]. J Royal Stat Soc, Series B. 1972;34:187-230.
17. SAS Institute. SAS/STAT software: the PHREG procedure. Cary, NC: SAS Institute, 1991.
18. SAS Institute. SAS technical report P-229: SAS/STAT software: changes and enhancements, Release 6.07. Cary, NC: SAS Institute, 1992.
19. Feinberg MB, McLean AR. AIDS: decline and fall of immune surveillance. Curr Biol 1997;7:R136-40.
20. Perelson AS, Neumann AU, Markowitz M, Leonard JM, Ho DD. HIV-1 dynamics in vivo: virion clearance rate, infected cell lifespan, and viral generation time. Science 1996;271:1582-6.
21. + lymphocytes as prognostic markers of HIV-1 infection. Ann Intern Med 1997;126:946-54.
22. Katzenstein DA, Hammer SM, Hughes MD, et al. The relation of virologic and immunologic markers to clinical outcomes after nucleoside therapy in HIV-infected adults with 200 to 500 CD4 cells per cubic millimeter. N Engl J Med 1996;335:1091-8.