Studies on the roles of ATP, adenosine and nitric oxide in mediating muscle vasodilatation induced in the rat by acute systemic hypoxia

Journal of Physiology

Volumn 495, Issue 2, 1996, Pages 553-560

  Skinner, Matthew R ^a,b   Marshall, Janice M ^a  

^a UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^b ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ALTHESIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NUCLEOTIDASE; THEOPHYLLINE;

ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; FEMORAL ARTERY; HYPOXIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; TAIL ARTERY; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASODILATATION;

EID: 0029740338     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.1996.sp021615     Document Type: Article

References (23)

1. BAKER, C. H. & SUTTON, E. T. (1993). Antagonism of acetykholine and adenosine rat cremaster vasodilation by combination of NO antagonists. International Journal of Microcirculation: Clinical and Experimental 12, 275-286.
2. DEUSSEN, A., MOSER, G. & SCHRADER, J. (1986). Contribution of endothelial cells to cardiac adenosine production. Pflügers Archiv 406, 608-614.
3. GARDINER, S. M., COMPTON, A. M., KEMP, P. A. & BENNETT, T. (1990). Regional and cardiac haemodynamic effects of L-NAME in conscious Long Evans rats. British Journal of Pharmacology 101, 625-631.
4. HEADRICK, J. P., MATHERNE, G. P. & BERNE, R. M. (1992). Myocardial adenosine formation during hypoxia: effects of ecto-5′-nucleotidase inhibition. Journal of Molecular and Cellular Cardiology 24, 295-303.
5. HOPWOOD, A. M., LINCOLN, J., KIRKPATRICK, K. A. & BURNSTOCK, G. (1989). Adenosine 5-triphosphate, adenosine and endothelium - derived relaxing factor in hypoxic vasodilatation of the heart. European Journal of Pharmacology 165, 323-326.
6. 2-purinoceptors mediate both vasodilation (via the endothelium) and vasoconstriction of the isolated rat femoral artery. European Journal of Pharmacology 107, 161-168.
7. LINCOLN, J., RALEVIC, V. & BURNSTOCK, G. (1991). Neurohumoral substances and the endothelium. In Cardiovascular Significance of Endothelium-Derived Vasoactive Factors, ed. RUBANYI, G. M., pp. 83-110. Futura Publishing Co. Inc., Mount Kisco, New York.
8. + channels, potassium and muscle vasodilatation in the rat in systemic hypoxia. Journal of Physiology 472, 1-9.
9. MEKUMYANTS, A. M., BALASHOV, S. A. & KHAYUTIN, V. M. (1995). Control of arterial lumen by shear-stress on endothelium. News in Physiological Sciences 10, 204-210.
10. MIAN, R. & MARSHALL, J. M. (1991). The role of adenosine in dilator responses induced in arterioles and venules of rat skeletal muscle during systemic hypoxia. Journal of Physiology 436, 499-511.
11. MIAN, R. & MARSHALL, J. M. (1995). The role of adenosine in mediating vasodilatation in mesenteric circulation of the rat in acute and chronic hypoxia. Journal of Physiology 489, 225-234.
12. 1-purinoceptors by ATP depends partly on its conversion to AMP and adenosine and partly on direct action. European Journal of Pharmacology 97, 47-54.
13. PADDLE, B. M. & BURNSTOCK, G, (1974). Release of ATP from perfused heart during coronary vasodilatation. Blood Vessels 11, 110.
14. POHL, U, DEZSI, L., SIMON, B. & BUSSE, R. (1987). Selective inhibition of endothelium-dependent dilation in resistance-sized vessels in vivo. American Journal of Physiology 253, H234-239.
15. ATP channels in vascular smooth muscle. Cardiovascular Research 28, 797-804.
16. RUBIO, R., BERNE, R. M. & DOBSON, J. G. (1973). Sites of adenosine production in cardiac and skeletal muscle. American Journal of Physiology 225, H195-205.
17. G-Methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo - a role for nitric oxide in the central regulation of sympathetic tone. Circulation Research 70, 607-611.
18. SEGAL, S. S. (1994). Invited editorial on 'Nitric oxide release is present from incubated skeletal muscle preparations'. Journal of Applied Physiology 77, 2517-2518.
19. SHEN, W., Xu, X., OCHOA, M., ZHAO, G., WOLIN, M. S. & HINTZE, T. H. (1994). Role of nitric oxide in the regulation of oxygen consumption in conscious dogs. Circulation Research 74, 1086-1095.
20. SKINNER, M. R. & MARSHALL, J. M. (1995). The role of nitric oxide in vasodilatation induced in skeletal muscle of the anaesthetized rat by acute systemic hypoxia. Journal of Physiology 487.P, 86-87P.
21. TAYLOR, E. M., PARSONS, M. E., WRIGHT, P. W., PIPKIN, M. A. & HOWSON, W. (1989). The effects of adenosine triphosphate and related purines on arterial resistance vessels in vitro and in vivo. European Journal of Pharmacology 161, 121-133.
22. THOMAS, T., ELNAZIR, B. K. & MARSHALL, J. M. (1994). Differentiation of the peripherally mediated from the centrally mediated influences of adenosine in the rat during systemic hypoxia. Experimental Physiology 79, 809-822.
23. ZANZINGER, J., CZACHURSKI, J. & SELLER, H. (1994). Inhibition of sympathetic vasoconstriction is a major principle of vasodilatation by nitric oxide in vivo. Circulation Research 75, 1073-1077.