Prosubstrates of CYP3A4, the major human hepatic cytochrome P450: Transformation into substrates by other P450 isoforms

Biochemical Pharmacology

Volumn 55, Issue 11, 1998, Pages 1861-1871

  Stresser, David M ^a   Kupfer, David ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

2 hydroxyestradiol; Aromatic hydroxylation; CYP2C19; CYP2C9; CYP2D6; CYP3A4; Cytochrome P450; Estradiol 3 methyl ether; Methoxychlor; Ortho hydroxylation; Prosubstrate

Indexed keywords

2 HYDROXYESTRADIOL; CYTOCHROME P450; CYTOCHROME P450 ISOENZYME; ESTRADIOL 3 METHYL ETHER; METHOXYCHLOR;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; DEMETHYLATION; ENZYME ANALYSIS; ENZYME ASSAY; HUMAN; HUMAN TISSUE; HYDROXYLATION; LIVER MICROSOME; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 ENZYME SYSTEM; DNA, COMPLEMENTARY; ESTRADIOL; HUMANS; HYDROXYLATION; ISOENZYMES; METHOXYCHLOR; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES; SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED;

EID: 0032101172     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00060-4     Document Type: Article

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