Selective in vitro protection of SIVagm-induced cytolysis by ajoene, [(E)-(Z)-4,5,9-trithiadodeca-1,6,11-triene-9 oxide]

Biomedicine and Pharmacotherapy

Volumn 52, Issue 5, 1998, Pages 229-235

  Walder, R ^a   Kalvatchev, Z ^a   Apitz Castro, R ^a  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

Author keywords

Ajoene; SIV; Syncytium formation

Indexed keywords

AJOENE; INTEGRIN;

ALLOSTERISM; ANTIVIRAL ACTIVITY; ARTICLE; CELL CONTACT; CELL DEATH; CELL FUSION; CYTOLYSIS; DATA ANALYSIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL; SIMIAN IMMUNODEFICIENCY VIRUS; SYNCYTIUM;

EID: 0032100659     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0753-3322(98)80021-8     Document Type: Article

References (25)

1. 1 Stoll A, Seebeck E. Chemical investigations on alliim, the specific principle of garlic. Adv Enzymol 1951 ; 11 : 377-400
2. 2 Hughes B, Murray J, North A, Lawson L. Antiviral constituents from Allium sativum. Planta Med 1989 ; 55 : 114
3. 3 Tsai Y, Cole L, Davis L, Lockwood S, Simmons V, Wild G. Antiviral properties of garlic : in vitro effects on influenza B, herpes simplex and coxsackie viruses. Planta Med 1985 ; 51 : 460-1
4. 4 Weber N, Andersen D, North J, Murray B, Lawson L, Hughes B. In vitro virucidal effects of Allium sativum (Garlic) extract and compounds. Planta Med 1992 ; 58 : 417-23
5. 5 Apitz-Castro R, Escalante J, Vargas R, Jain M. Ajoene, the antiplatelet principle of garlic, synergistically potentiates the antiaggregatory action of prostacyclin, forskolin, indomethacin and dypiridamole on human platelets. Thromb Res 1986 ; 42 : 303-11
6. 6 Block E, Ahmad S, Jain MK, Crecely R, Apitz-Castro R, Cruz M. (E,Z)-ajoene : a potent antithrombotic agent from garlic. J Am Chem Soc 1984 ; 106 : 8295-6
7. 7 Block E, Ahmad S, Catalfamo J, Jain M, Apitz-Castro R. Antithrombotic organosulfur compounds from garlic : structural, mechanistic and synthetic studies. J Am Chem Soc 1986 ; 108 : 7045-55
8. 8 Apitz-Castro R, Ledezma E, Escalante J, Jain M. The molecular basis of the antiplatelet action of ajoene : direct interaction with the fibrinogen receptor. Biochem Biophys Res Commun 1986 ; 141 : 145-50
9. 9 Shimizu Y, Van Seventer GA, Horgan KJ, Shaw S. Roles of adhesion molecules in T-cell recognition : fundamental similarities between four integrins on resting human T cells (LFA-1, VLA-4, VLA-5, VLA-6) in expression, binding, and costimulation. Immunol Rev 1990 ; 114 : 109-43
10. 10 Philips D, Charo I, Parise L, Fitzgerald L. The platelet membrane glycoprotein IIb-IIa complex. Blood 1988 ; 71 : 831-43
11. 11 Hildreth J, Orentas R. Involvement of a leukocyte adhesion receptor (LFA-1) in HIV-induced syncytium formation. Science 1989 ; 244 : 1075-8
12. + T lymphocytes genetically deficient in LFA-1 : LFA-1 is required for HIV-mediated cell fusion but not for viral transmission. J Exp Med 1991 ; 173 : 511-14
13. 13 Deng HK, Choe S, Ellmeier W, Liu R, Unutmaz D, Burkhart M et al. Identification of a major co-receptor for primary isolates of HIV-1. Nature 1996 ; 381 : 661-6
14. + cells is mediated by the chemokine receptor CC-CKR-5. Nature 1996 ; 381 : 667-73
15. 15 Feng Y, Broder CC, Kennedy PE, Berger EA. HIV-1 entry cofactor : functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 1996 ; 272 : 872-6
16. 16 Zhang L, Huang Y, He T, Cao Y, Ho DD. HIV-1 subtype and second-receptor use. Nature 1996 ; 383 : 768
17. 17 Walder R, Kalvatchev Z, Garzaro D, Barrios M. In vitro antiviral activity of extracts from Polyporaceae against human immunodeficiency virus. Phytother Res 1996 ; 10 : 497-503
18. 18 Kalvatchev Z, Walder R, Garzaro D. Anti-HIV activity of extracts from Calendula officinalis flowers. Biomed Pharmacother 1997 ; 4 : 176-80
19. 19 Tochikura T, Nakashima H, Tanabe A, Yamamoto N. Human immunodeficiency virus (HIV)-induced cell fusion : qualification and its application for the simple and rapid screening of anti-HIV substances in vitro. Virology 1988 ; 164 : 542-6
20. 20 Levy J. Pathogenesis of human immunodeficiency virus infection. Microbiol Rev 1993 ; 57 : 183-289
21. 21 Baba M, Pauwels R, Balzarini J, Arnout J, Desmyter J, De Clercq E. Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. Proc Natl Acad Sci USA 1988 ; 85 : 6132-6
22. 22 Schols D, Pauwels R, Desmyter J, De Clercq E. Dextran sulfate and other polyanionic anti-HIV compounds specifically interacted with the viral gp120 glycoprotein expressed by T-cells persistently infected with HIV-1. Virology 1990 ; 175 : 556-61
23. 23 Lapman CK, Ouyang J, Chandrasekhar B, Nguyen NY, Dimitrov DS, Golding H. Evidence for cell-surface association between fusin and the CD4-gp 120 complex in human cell lines. Science 1996 ; 274 : 602-4
24. 24 Debouzy J, Neumann J, Herve M, Daveloose D, Viret J, Apitz-Castro R. Interaction of antiaggregant molecule ajoene with membranes. Eur Biophys J 1989 ; 17 : 211-16
25. 25 Tatarintsev A, Vrzheshch P, Schegolev A. Ajoene antagonizes integrin-dependent processes in HIV-infected T-lymphoblasts. AIDS 1992 ; 6 : 1215-17