Detection of Local and Systemic Cytokines in Adult Periodontitis

Journal of Periodontology

Volumn 67, Issue 5, 1996, Pages 515-522

  Prabhu, Anila ^a   Michalowicz, Bryan S ^b   Mathur, Ambika ^a,c  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Minnesota Clin Oral Research Center

^c Department of Pediatrics ^*  (United States)

Author keywords

Antigens, CD56; Antigens, surface; Cytokines; IFN ; Interleukin 6; Periodontitis; Receptors, IgG

Indexed keywords

ALPHA INTERFERON; CD56 ANTIGEN; CYTOKINE; FC RECEPTOR; IMMUNOGLOBULIN G; INTERLEUKIN 6; LEUKOCYTE ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MESSENGER RNA;

ADULT; AGED; BIOSYNTHESIS; BLOOD; FEMALE; HUMAN; IMMUNOLOGY; IMMUNOPHENOTYPING; MALE; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; PERIODONTITIS;

ADULT; AGED; ANTIGENS, CD; ANTIGENS, CD56; CYTOKINES; FEMALE; HUMANS; IMMUNOGLOBULIN G; IMMUNOPHENOTYPING; INTERFERON-ALPHA; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; PERIODONTITIS; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, IGG; RNA, MESSENGER;

EID: 0030137644     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.1996.67.5.515     Document Type: Article

References (44)

1. Williams RC. Periodontal disease. N Engl J Med 1990;322:373-376.
2. Slots J. The predominant cultivable microflora of advanced periodontitis. Scand J Dent Res 1977;85:114-121.
3. Romagnani S. Human Th 1 and Th 2 subsets: Doubt no more. Immunol Today 1991;12:256-257.
4. Kono Y, Beagley KW, Fujihashi K, et al. Cytokine regulation of localized inflammation. J immunol 1991;146:1812-1821.
5. Takeichi O, Saito I, Tsurumachi T, Saito T, Moro I. Human polymorphonuclear leukocytes derived from chronically inflamed tissues express inflammatory cytokines in vivo. Cell Immunol 1994;156:296-309.
6. Payne JB, Reinhardt RA, Masala MP, DuBois LM, Allison AC. Gingival crevicular fluid IL-8: Correlation with IL-1β levels and patient estrogen status. J Periodont Res 1993;28:451-453.
7. Geivelis M, Turner DW, Peterson ED, Lamberts BL. Measurements of interleukin-6 in gingival crevicular fluid from adults with destructive periodontal disease. J Periodontol 1993;64:980-983.
8. Matsuki Y, Yamamoto T, Hara K. Localization of interleukin-1 (IL-1) mRNA-expressing macrophages in human inflamed gingiva and IL-1 activity in gingival crevicular fluid. J Periodont Res 1993;28:35-42.
9. Fujihashi K, Beagley KW, Kono Y, et al. Gingival mononuclear cells from chronic inflammatory periodontal tissues produce IL-5 and IL-6 but not IL-2 and IL-4. Am J Pathol 1993;142:1239-1250.
10. Tonetti MS, Imboden MA, Gerber L, Lang NP, Laissue J, Mueller C. Localized expression of mRNA for phagocytic-specific chemotactic cytokines in human periodontal infections. Infect Immun 1994;62:4005-4014.
11. Lundqvist C, Baranov V, Teglund S, Hammarstrom S, Hammarstrom M-L. Cytokine profile and ultrastructure of intraepithelial 78 T cells in chronically inflamed human gingiva suggest a cytotoxic effector function. J Immunol 1994;153:2302-2312.
12. Yamamura Y, Uyemura K, Deans RJ, et al. Defining protective responses to pathogens. Science 1991;254:277-279.
13. James SP. Detection of cytokine mRNA expression by PCR. In: Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W, eds. Current Protocols in Immunology. Secaucus, NJ: John Wiley and Sons Inc.; 1991:10.
14. Renz H, Enssle K, Lauffer L, Kurrle R, Gelfand EW. Inhibition of allergen-induced IgE and IgGl production by soluble IL-4 receptor. Int Arch Allergy Immunol 1995;106:46-54.
15. Choi Y, Kotzin B, Herron L, Callahan J, Marrack P, Kappler J. Interactions of Staphylococcus toxin superantigens with human T cells. Proc Natl Acad Sci (USA) 1989;86:8941-8945.
16. Flament C, Benmerah A, Bonneville M, Triebel F, Mami-Chouaib F. Human TCR γδ alloreactive response to HLA-DR molecules. J Immunol 1994;153:2890-2904.
17. Stashenko P, Jandinski JJ, Fujiyoshi P, Rynar J, Socransky SS. Tissue levels of bone resorptive cytokines in periodontal disease. J Periodontol 1991;62:504-509.
18. Gemmell E, Seymour GJ. IL 1, IL 6 and TGF-β production by human gingival mononuclear cells following stimulation with P. gingivalis and F. nucleatum. J Periodont Res 1993;28:122-129.
19. Kimura S, Fujimoto N, Okada H. Impaired autologous mixed-lymphocyte reaction of peripheral blood lymphocytes in adult periodontitis. Infect Immun 1991;59:4418-4424.
20. Nasal A, Takahashi K, Sato B, et al. Abnormal proportion of 78 T cells in peripheral blood is frequently detected in patients with periodontitis. J Periodontol 1993;64:963-967.
21. Afar B, Engel D, Clark EA. Activated lymphocyte subsets in adult periodontitis. J Periodont Res 1992;27:126-133.
22. Kobayashi M, Fitz L, Ryan M, et al. Identification and characterization of the natural killer cell stimulatory factor (NKSF), a cyto- kine with multiple biological effects on human lymphocytes. J Exp Med 1989;170:827-845.
23. Seymour GJ, Cole KL, Powell RN, Lewins E, Cripps AW, Clancy RL. Interleukin-2 production and bone-resorption activity in vitro by unstimulated lymphocytes extracted from chronically-inflamed human periodontal tissues. Arch Oral Biol 1985;30:481-484.
24. Manhart SS, Reinhardt RA, Payne JB, et al. Gingival cell IL-2 and IL-4 in early onset periodontitis. J Periodontol 1994;65:807-813.
25. Ebersole JL, Singer RE, Steffensen B, Filloon T, Kornman KS. Inflammatory mediators and immunoglobulins in the GCF from healthy, gingivitis and periodontitis sites. J Periodont Res 1993;28:543-546.
26. Seymour GJ, Greenspan JS. The phenotypic characterization of lymphocyte subpopulations in established human periodontal disease. J Periodont Res 1979;14:39-46.
27. Okada H, Kida T, Yamagami H. Identification and distribution of immunocompetent cells in inflamed gingiva of human chronic periodontitis. Infect Immun 1983;41:365-374.
28. Minami Y, Kono T, Miyazaki T, Taniguchi T. The IL-2 receptor complex: Its structure, function, and target genes. Ann Rev Immunol 1993;11:245-268.
29. Splawski JB, McAnally LM, Lipsky PE. IL-2 dependence of the promotion of human B cell differentiation by IL-6 (BSF-2). J Immunol 1990;144:562-569.
30. Follows GA, Munk ML, Gatrill AJ, Conradt P, Kaufmann SH. Gamma interferon and interleukin 2, but not interleukin 4, are detectable in gamma/delta T-cell cultures after activation with bacteria. Infect Immun 1992;60:1229-1231.
31. Kjeldsen-Kragh J, Quayle AJ, Skalhegg BS, Stout M, Forre O. Selective activation of resting human gamma delta T lymphocytes by interleukin-2. Ear J Immunol 1993;3:2092-2099.
32. Gotlieb WH, Bristol LA, Weissman AM, Durum SK, Takacs L. Upregulation of T cell receptor gamma chain transcription by interleukin-2. Cell Immunol 1993;151:345-355.
33. Lundqvist C, Hammarstrom M-L. T-cell receptor γδ-expressing in- traepithelial lymphocytes are present in normal and chronically inflamed gingiva. Immunol 1993;79:38-45.
34. Gowan M, Wood DD, Ihrie EJ, McGuire MKB, Russell RGG. An IL 1-like factor stimulates bone resorption in vitro. Nature 1983;306:378-379.
35. Genco RJ. Host responses in periodontal diseases: Current concepts. J Periodontol 1992;63:338-355.
36. Greenway AL, Overall ML, Sattayasai N, et al. Selective production of interferon-alpha subtypes by cultured peripheral blood mononuclear cells and lymphoblastoid cell lines. Immunol 1992;75:182-188.
37. Dotker WH, Esslink MT, Sierdsema SJ, Halie MR. Transcriptional and posttranscriptional regulation of the IL-4 and IL-3 genes in human T cells. Blood 1993;81:35-40.
38. Birkedal-Hansen H. Role of cytokines and inflammatory mediators in tissue destruction. J Periodont Res 1993;28:500-510.
39. Wahl SM, Costa GL, Mizel DE, Allen JB, Skaleric U, Mangan DE Role of transforming growth factor beta in the pathophysiology of chronic inflammation. J Periodontol 1993;64:450-455.
40. Takahashi K, Takigawa M, Takashiba S, et al. Role of cytokine in the induction of adhesion molecules on cultured human gingival fibroblasts. J Periodontol 1994;65:230-235.
41. Bartold PM, Haynes DR. Interleukin-6 production by human gingival fibroblasts. J Periodont Res 1991;26:339-345.
42. Van Snick J. Interleukin-6: An overview. Ann Rev Immunol 1990;8:253-278.
43. Zurawski G, de Vries JE. Interleukin 13, an IL 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol Today 1994;15:19-26.
44. Meyaard L; Otto SA, Keel IP, van Lier RA, Miedema F. Changes in cytokine secretion patterns of CD4+ T-cell clones in human immunodeficiency virus infection. Blood 1994;84:4262-4268.