Leukotriene B4 activates the NADPH oxidase in eosinophils by a pertussis toxin-sensitive mechanism that is largely independent of arachidonic acid mobilization

Journal of Immunology

Volumn 160, Issue 9, 1998, Pages 4526-4534

  Lindsay, Mark A ^a   Perkins, Rosie S ^a   Barnes, Peter J ^a   Giembycz, Mark A ^a,b  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN PEROXIDE; LEUKOTRIENE B4; LEUKOTRIENE RECEPTOR; MEPACRINE; PERTUSSIS TOXIN; PROTEIN KINASE C INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; ARACHIDONIC ACID; BORDETELLA VIRULENCE FACTOR; LEUKOTRIENE B4 RECEPTOR;

ARACHIDONIC ACID METABOLISM; ARTICLE; CALCIUM MOBILIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GUINEA PIG; HYDROLYSIS; PRIORITY JOURNAL; QUALITATIVE DIAGNOSIS; RECEPTOR BINDING; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECT; EOSINOPHIL; METABOLISM;

ANIMALS; ARACHIDONIC ACID; ENZYME ACTIVATION; EOSINOPHILS; GUINEA PIGS; LEUKOTRIENE B4; NADPH OXIDASE; PERTUSSIS TOXIN; RECEPTORS, LEUKOTRIENE B4; SIGNAL TRANSDUCTION; VIRULENCE FACTORS, BORDETELLA;

EID: 0032056356     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (64)

1. Babior, B. M., R. S. Kipnes, and J. T. Curnutte. 1973. Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent. J. Clin. Invest. 52:741.
2. Weiss, S. J., S. T. Test, C. M. Eckmann, D. Roos, and S. Regiani. 1986. Brominating oxidants generated by human eosinophils. Science 234:200.
3. Mayeno, A. N., A. J. Curran, R. L. Roberts, and C. S. Foote. 1989. Eosinophils preferentially use bromide to generate halogenating agents. J. Biol. Chem. 264: 5660.
4. Motojima, S., E. Frigas, D. A. Loegering, and G. J. Gleich. 1989. Toxicity of eosinophil cationic proteins for guinea pig tracheal epithelium in vitro. Am. Rev. Respir. Dis. 139:801.
5. Agosti, J. M., L. C. Altman, G. H. Ayars, D. A. Loegering, G. J. Gleich, and S. J. Klebanoff. 1987. The injurious effect of eosinophil peroxidase, hydrogen peroxide, and halides on pneumocytes in vitro. J. Allergy Clin. Immunol. 79:496.
6. Henderson, W. R., E. Y. Chi, and S. J. Klebanoff. 1980. Eosinophil peroxidase-induced mast cell secretion. J. Exp. Med. 152:265.
7. 2+, protein kinase C and phospholipases C and D. Biochem. J. 310:795.
8. 4 induced steady state calcium rise and superoxide anion generation in guinea pig eosinophils are not related events. Biochem. Biophys. Res. Commun. 187:670.
9. Kroegel, C., E. R. Chilvers, M. A. Giembycz, R. A. Challiss, and P. J. Barnes. 1991. Platelet-activating factor stimulates a rapid accumulation of inositol(1,4,5)trisphosphate in guinea pig eosinophils: relationship to calcium mobilization and degranulation. J. Allergy Clin. Immunol. 88:114.
10. Kroegel, C., R. Pleass, T. Yukawa, K. F. Chung, J. Westwick, and P. J. Barnes. 1989. Characterization of platelet-activating factor-induced elevation of cytosolic free calcium concentration in eosinophils. FEBS Lett. 243:41.
11. Uings, I. J., N. T. Thompson, R. W. Randall, G. D. Spacey, R. W. Bonser, A. T. Hudson, and L. G. Garland. 1992. Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil. Biochem. J. 281:597.
12. Reinhold, S. L., S. M. Prescott, G. A. Zimmerman, and T. M. McIntyre. 1990. Activation of human neutrophil phospholipase D by three separable mechanisms. FASEB J. 4:208.
13. 4-induced phospholipase D activation and degranulation of human neutrophils. Biochem. Pharmacol. 46:139.
14. Agwu, D. E., C. E. McCall, and L. C. McPhail. 1991. Regulation of phospholipase D-induced hydrolysis of choline-containing phosphoglycerides by cyclic AMP in human neutrophils. J. Immunol. 146:3895.
15. Arcaro, A., and M. P. Wymann. 1993. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem. J. 296:297.
16. Ding, J., C. J. Vlahos, R. Liu, R. F. Brown, and J. A. Badwey. 1995. Antagonists of phosphatidylinositol 3-kinase block activation of several novel protein kinases in neutrophils. J. Biol. Chem. 270:11684.
17. Vlahos, C. J., W. F. Matter, R. F. Brown, A. E. Traynor Kaplan, P. G. Heyworth, E. R. Prossnitz, R. D. Ye, P. Marder, J. A. Schelm, K. J. Rothfuss, B. S. Serlin, and P. J. Simpson. 1995. Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase. J. Immunol. 154:2413.
18. Watson, F., J. Robinson, and S. W. Edwards. 1991. Protein kinase C-dependent and -independent activation of the NADPH oxidase of human neutrophils. J. Biol. Chem. 266:7432.
19. Morel, F., J. Doussiere, and P. V. Vignais. 1991. The superoxide-generating oxidase of phagocytic cells: physiological, molecular and pathological aspects. Eur. J. Biochem. 201:523.
20. Elsner, J., R. Hochstetter, D. Kimmig, and A. Kapp. 1996. Human eotaxin represents a potent activator of the respiratory burst of human eosinophils. Eur. J. Immunol. 26:1919.
21. 2 activity on superoxide generation by human neutrophils. FEBS Lett. 234:235.
22. Bromberg, Y., and E. Pick. 1983. Unsaturated fatty acids as second messengers of superoxide generation by macrophages. Cell Immunol. 79:240.
23. 2 in intact human neutrophils but not in the cell-free system. Biochem. Biophys. Res. Commun. 138:1099.
24. Aebischer, C. P., I. Pasche, and A. Jorg. 1993. Nanomolar arachidonic acid influences the respiratory burst in eosinophils and neutrophils induced by GTP-binding protein: a comparative study of the respiratory burst in bovine eosinophils and neutrophils. Eur. J. Biochem. 218:669.
25. Badwey, J. A., J. T. Curnutte, J. M. Robinson, C. B. Berde, M. J. Karnovsky, and M. L. Karnovsky. 1984. Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils: reversibility by albumin. J. Biol. Chem. 259:7870.
26. Curnutte, J. T., J. A. Badwey, J. M. Robinson, M. J. Karnovsky, and M. L. Karnovsky. 1984. Studies on the mechanism of superoxide release from human neutrophils stimulated with arachidonate. J. Biol. Chem. 259:11851.
27. Henderson, L. M., S. K. Moule, and J. B. Chappell. 1993. The immediate activator of the NADPH oxidase is arachidonate not phosphorylation. Eur. J. Biochem. 211:157.
28. Sakata, A., E. Ide, M. Tominaga, and K. Onoue. 1987. Arachidonic acid acts as an intracellular activator of NADPH oxidase in Fcγ receptor-mediated superoxide generation in macrophages. J. Immunol. 138:4353.
29. Abramson, S. B., J. Leszczynska-Piziak, and G. Weissmann. 1991. Arachidonic acid as a second messenger:interaction with a GTP-binding protein of human neutrophils. J. Immunol. 147:231.
30. Hardy, S. J., B. S. Robinson, A. Poulus, D. P. Harvey, A. Ferrante, and A. W. Murray. 1991. The neutrophil respiratory burst: responses to fatty acids, N-formylmethionylleucylphenylalanine and phorbol ester suggest divergent signalling mechanisms. Eur. J. Biochem. 198:801.
31. phox and co-stimulation of protein kinase C. Cell. Signalling 8:397.
32. Sawai, T., M. Asada, H. Nunoi, I. Matsuda, S. Ando, T. Sasaki, K. Kaibuchi, Y. Takai, and K. Katayama. 1993. Combination of arachidonic acid and guanosine 5′-O-(3-thiotriphosphate) induce translocation of rac p21s to membrane and activation of NADPH oxidase in a cell-free system. Biochem. Biophys. Res. Commun. 195:264.
33. 2 in the activation of the NADPH oxidase. Biochem. J. 264:249.
34. 2 for activation of the assembled NADPH oxidase in human neutrophils. Biochem. J. 297:217.
35. 2. J. Clin. Invest. 91:2118.
36. 2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells. Proc. Natl. Acad. Sci. USA 83:7201.
37. 2 activation regulated by G-proteins? Biochem. Soc. Trans. 19:333.
38. Nielson, C. P., J. Stutchfield, and S. Cockcroft. 1991. Chemotactic peptide stimulation of arachidonic acid release in HL60 cells, an interaction between G protein and phospholipase C mediated signal transduction. Biochim. Biophys. Acta 1095:83.
39. 2. Proc. Natl. Acad. Sci. USA 84:6374.
40. 2 activation in rabbit platelets. J. Biol. Chem. 265:4290.
41. 2(s): comparison of arachidonoyl-selective and non-selective enzymes. FASEB J. 7:339.
42. 2. In Immunopharmacology of Neutrophils. P. G. Hellewell and T. J. Williams, eds. Academic Press, London, p. 159.
43. 2 in RAW 264.7 macrophages. Br. J. Pharmacol. 119:261.
44. 2 activation and exocytosis in HL60 cells and human neutrophils. Biochem. J. 263:715.
45. 2 and C: relationship to the activation of the NADPH oxidase. Am. J. Respir. Crit. Care Med. 151:A680 (Abstr.).
46. Gartner, I. 1980. Separation of human eosinophils in density gradients of polyvinylpyrrolidone-coated silica gel (Percoll). Immunology 40:133.
47. 2 Release from human granulocytes during phagocytosis. J. Clin. Invest. 55:945.
48. Karnovsky, M. L. 1973. Chronic granulomatous disease - pieces of a cellular and molecular puzzle. Fed. Proc. 32:1527.
49. Downes, C. P., P. T. Hawkins, and R. F. Irvine. 1986. Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland. Biochem. J. 238:501.
50. Challiss, R. A., I. H. Batty, and S. R. Nahorski. 1988. Mass measurements of inositol(1,4,5)trisphosphate in rat cerebral cortex slices using a radioreceptor assay: effects of neurotransmitters and depolarization. Biochem. Biophys. Res. Commun. 157:684.
51. 4- and C5a-induced eosinophil homotypic aggregation in vitro and recruitment in vivo. Blood 89:4566.
52. 2 activity in guinea pig eosinophils by human recombinant IL-1β. J. Immunol. 149:1374.
53. 2 and E-series prostaglandins. J. Immunol. 144:3489.
54. Kusner, E. J., C. K. Buckner, D. M. Dea, C. J. DeHaas, R. L. Marks, and R. D. Krell. 1994. The 5-lipoxygenase inhibitors ZD2138 and ZM230487 are potent and selective inhibitors of several antigen-induced guinea pig pulmonary responses. Eur. J. Pharmacol. 257:285.
55. 4 myotropic activity by the 2,6 disubstituted pyridine analog U-75302: characterization on lung parenchyma strips. J. Lipid Mediat. 1:3.
56. Ryu, S. H., U. H. Kim, M. I. Wahl, A. B. Brown, G. Carpenter, K. P. Huang, and S. G. Rhee. 1990. Feedback regulation of phospholipase C-β by protein kinase C. J. Biol. Chem. 265:17941.
57. McPhail, L. C., P. S. Shirley, C. C. Clayton, and R. Snyderman. 1985. Activation of the respiratory burst enzyme from human neutrophils in a cell-free system: evidence for a soluble cofactor. J. Clin. Invest. 75:1735.
58. 2+ mobilization by arachidonic acid: comparison with myo-inositol 1,4,5-trisphosphate in isolated pancreatic islets. J. Biol. Chem. 261:3501.
59. Lacy, P., N. Thompson, M. Tian, R. Solari, I. Hide, T. M. Newman, and B. D. Gomperts. 1995. A survey of GTP-binding proteins and other potential key regulators of exocytotic secretion in eosinophils: apparent absence of rab3 and vesicle fusion protein homologues. J. Cell Sci. 108:3547.
60. 2+ ionophore A23187. J. Biol. Chem. 260:12484.
61. 4 by human neutrophils: involvement of protein kinase C activation in regulation of the 5-lipoxygenase pathway. J. Immunol. 138:3396.
62. 2 enzymes: regulation and inhibition. Trends Pharmacol. Sci. 14:92.
63. Wilkinson, S. E., P. J. Parker, and J. S. Nixon. 1993. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem. J. 294: 335.
64. Twomey, B., R. E. Muid, J. S. Nixon, A. D. Sedgwick, S. E. Wilkinson, and M. M. Dale. 1990. The effect of new potent selective inhibitors of protein kinase C on the neutrophil respiratory burst. Biochem. Biophys. Res. Commun. 171: 1087.