CD34+CD38-lin- cord blood cells develop into dendritic cells in human thymic stromal monolayers and thymic nodules

Journal of Immunology

Volumn 160, Issue 7, 1998, Pages 3290-3298

  Miralles, G Diego ^a   Smith, Clayton A ^a   Whichard, Leona P ^a   Morse, Michael A ^a   Haynes, Barton F ^a   Patel, Dhavalkumar D ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD1 ANTIGEN; CD11 ANTIGEN; CD2 ANTIGEN; CD34 ANTIGEN; CD38 ANTIGEN; CD4 ANTIGEN; CD40 ANTIGEN; CD45 ANTIGEN; CD86 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANTIGEN EXPRESSION; ARTICLE; CELL ISOLATION; CELL MATURATION; CELL PROLIFERATION; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNOGENICITY; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; THYMUS; UMBILICAL CORD BLOOD;

ADP-RIBOSYL CYCLASE; ANTIGENS, CD; ANTIGENS, CD1; ANTIGENS, CD14; ANTIGENS, CD34; ANTIGENS, CD38; ANTIGENS, DIFFERENTIATION; CELL DIFFERENTIATION; CELLS, CULTURED; COCULTURE TECHNIQUES; DENDRITIC CELLS; EPITHELIAL CELLS; FETAL BLOOD; FIBROBLASTS; HUMANS; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; NAD+ NUCLEOSIDASE; STROMAL CELLS; THYMUS GLAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032055589     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. Steinman, R. M., M. Witmer-Pack, and K. Inaba. 1993. Dendritic cells: antigen presentation, accessory function and clinical relevance. Adv. Exp. Med. Biol. 329:1.
2. Steinman, R. M. 1996. Dendritic cells and immune-based therapies. Exp. Hematol. 24:859.
3. Young, J. W., and R. M. Steinman. 1996. The hematopoietic development of dendritic cells: a distinct pathway for myeloid differentiation. Stem Cells 14:376.
4. Steinman, R., M. Pack, and K. Inaba. 1997. Dendritic cells in the T-cell areas of lymphoid organs. Immunol. Rev. 156:25.
5. Caux, C., and J. Banchereau. 1996. In vitro regulation of dendritic cell development and function. Blood Cell Biochem. 7:263.
6. + hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF + TNF alpha. J. Exp. Med. 184:695.
7. + T cells and process soluble antigen. J. Immunol. 155:5427.
8. Chu, T., and R. Jaffe. 1994. The normal Langerhans cell and the LCH cell. Br. J. Cancer Suppl. 23:S4.
9. + cord blood progenitor cells. Adv. Exp. Med. Biol. 378:371.
10. Wu, L., C. L. Li, and K. Shortman. 1996. Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny. J. Exp. Med. 184:903.
11. Shortman, K., and L. Wu. 1996. Early T lymphocyte progenitors. Annu. Rev. Immunol. 14:29.
12. Res, P., B. Blom, T. Hori, K. Weijer, and H. Spits. 1997. Downregulation of CD1 marks acquisition of functional maturation of human thymocytes and defines a control point in late stages of human T cell development. J. Exp. Med. 185:141.
13. Mommaas, A. M., A. A. Mulder, C. J. Out, G. Girolomoni, H. K. Koerten, B. J. Vermeer, and F. Koning. 1995. Distribution of HLA class II molecules in epidermal Langerhans cells in situ. Eur. J. Immunol. 25:520.
14. Mackensen, A., B. Herbst, G. Kohler, G. Wolff-Vorbeck, F. M. Rosenthal, H. Veelken, P. Kulmburg, H. E. Schaefer, R. Mertelsmann, and A. Lindemann. 1995. Delineation of the dendritic cell lineage by generating large numbers of Birbeck granule-positive Langerhans cells from human peripheral blood progenitor cells in vitro. Blood 86:2699.
15. Caux, C., B. Vanbervliet, C. Massacrier, M. Azuma, K. Okumura, L. L. Lanier, and J. Banchereau. 1994. B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells. J. Exp. Med. 180:1841.
16. Steinman, R. 1991. The dendritic cell system and its role in immunogemcity. Annu. Rev. Immunol. 9:271.
17. Shortman, K., L. Wu, G. Suss, V. Kronin, K. Winkel, D. Saunders, and D. Vremec. 1997. Dendritic cells and T lymphocytes: developmental and functional interactions [in process citation]. Ciba Found. Symp. 204:130.
18. Shortman, K., L. Wu, C. Ardavin, D. Vremec, F. Stozik, K. Winkel, and G. Suss. 1995. Thymic dendritic cells: surface phenotype, developmental origin and function. Adv. Exp. Med. Biol. 378:21.
19. Saunders, D., K. Lucas, J. Ismaili, L. Wu, E. Maraskovsky, A. Dunn, and K. Shortman. 1996. Dendritic cell development in culture from thymic precursor cells in the absence of granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 184:2185.
20. Ardavin, C., L. Wu, C. L. Li, and K. Shortman. 1993. Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population. Nature 362:761.
21. Ardavin, C., L. Wu, I. Ferrero, and K. Shortman. 1993. Mouse thymic dendritic cell subpopulations. Immunol. Lett. 38:19.
22. Ardavin, C., and K. Shortman. 1992. Cell surface marker analysis of mouse thymic dendritic cells. Eur. J. Immunol. 22:859.
23. Suss, G., and K. Shortman. 1996. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis. J. Exp. Med. 183:1789.
24. Winkel, K., F. Sotzik, D. Vremec, P. U. Cameron, and K. Shortman. 1994. CD4 and CD8 expression by human and mouse thymic dendritic cells. Immunol. Lett. 40:93.
25. Caux, C., C. Dezutter-Dambuyant, D. Schmitt, and J. Banchereau. 1992. GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells. Nature 360:258.
26. + hematopoietic precursor cells. Blood 87:535.
27. Szabolcs, P., D. Avigan, S. Gezelter, D. H. Ciocon, M. A. Moore, R. M. Steinman, and J. W. Young. 1996. Dendritic cells and macrophages can mature independently from a human bone marrow-derived, post-colony-forming unit intermediate. Blond 87:4520.
28. + bone marrow progenitors that are expanded by c-kit-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tumor necrosis factor alpha. J. Exp. Med. 182:1111.
29. Li, C. L., L. Wu, M. Antica, K. Shortman, and G. R. Johnson. 1995. Purified murine long-term in vivo hematopoietic repopulating cells are not prothymocytes. Exp. Hematol. 23:21.
30. Maraskovsky, E., K. Brasel, M. Teepe, E. R. Roux, S. D. Lyman, K. Shortman, and H. J. McKenna. 1996. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified. J. Exp. Med. 184:1953.
31. Sotzik, F., Y. Rosenberg, A. W. Boyd, M. Honeyman, D. Metcalf, R. Scollay, L. Wu, and K. Shortman. 1994. Assessment of CD4 expression by early T precursor cells and by dendritic cells in the human thymus. J. Immunol. 152:3370.
32. Ardavin, C. 1997. Thymic dendritic cells. Immunol. Today 18:350.
33. Lafontaine, M., D. Landry, and S. Montplaisir. 1992. The human thymic dendritic cell phenotype and its modification in culture. Cell. Immunol. 142:238.
34. Shortman, K., and L. Wu. 1996. Early T lymphocyte progenitors. Annu. Rev. Immunol. 14:29.
35. + progenitors in human bone marrow. J. Immunol. 149:2681.
36. Santiago-Schwarz, F., E. Belilos, B. Diamond, and S. E. Carsons. 1992. TNF in combination with GM-CSF enhances the differentiation of neonatal cord blood stem cells into dendritic cells and macrophages. J. Leukocyte Biol. 52:274.
37. + hematopoietic progenitor cells. Blood 87:1292.
38. Colic, M., V. Ilic, M. D. Pavlovic, T. Tamatani, and M. Miyasaka. 1996. Mechanisms involved in the binding of thymocytes to rat thymic dendritic cells. Dev. Immunol. 5:37.
39. Tanaka, Y., C. Mamalaki, B. Stockinger, and D. Kioussis. 1993. In vitro negative selection of alpha beta T cell receptor transgenic thymocytes by conditionally immortalized thymic cortical epithelial cell lines and dendritic cells. Eur. J. Immunol. 23:2614.
40. Douek, D. C., K. T. Corley, T. Zal, A. Mellor, P. J. Dyson, and D. M. Altmann. 1996. Negative selection by endogenous antigen and superantigen occurs at multiple thymic sites. Int. Immunol. 8:1413.
41. - cells in human thymic organ culture. J. Exp. Med. 180:123.
42. dim cells in the human thymus can differentiate into T, natural killer, and dendritic cells but are distinct from pluripotent stem cells. Blood 87:5196.
43. Singer, K., R. Scearce, D. Tuck, L. Whichard, S. Denning, and B. Haynes. 1989. Removal of fibroblasts from human epithelial cell cultures with the use of a complement fixing monoclonal antibody reactive with human fibroblasts and monocytes/macrophages. J. Invest. Dermatol. 92:166.
44. Singer, K. H., E. A. Harden, A. L. Robertson, D. F. Lobach, and B. F. Haynes. 1985. In vitro growth and phenotypic characterization of mesodermal-derived and epithelial components of normal and abnormal human thymus. Hum. Immunol. 13:161.
45. McMichael, A. J., J. R. Pilch, G. Galfre, D. Y. Mason, J. W. Fabre, and C. Milstein. 1979. A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody. Eur. J. Immunol. 9:205.
46. Haynes, B. F., G. S. Eisenbarth, and A. S. Fauci. 1979. Production of a monoclonal antibody that defines functional thymus-derived subsets. Proc. Natl. Acad. Sci. USA 76:5829.
47. Dimitriu-Bona, A., G. R. Burmester, S. J. Waters, and R. J. Winchester. 1983. Human mononuclear phagocyte differentiation antigens. I. Patterns of antigenic expression on the surface of human monocytes and macrophages defined by monoclonal antibodies. J. Immunol. 130:145.
48. Woodcock-Mitchell, J., R. Eichner, W. G. Nelson, and T. T. Sun. 1982. Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies. J. Cell Biol. 95:580.
49. McDonald, J. A., T. J. Broekelmann, M. L. Matheke, E. Crouch, M. Koo, and C. Kuhn. 1986. A monoclonal antibody to the carboxyterminal domain of procollagen type I visualizes collagen-synthesizing fibroblasts. J. Clin. Invest. 78:1237.
50. + cell subpopulations from normal human peripheral blood. Stem Cells 12:187.
51. - progenitor cells. Blood 77:1218.
52. Spits, H., L. L. Lanier, and J. H. Phillips. 1995. Development of human T and natural killer cells. Blood 85:2654.
53. Haynes, B. F., R. M. Scearce, D. F. Lobach, and L. L. Hensley. 1984. Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironment. J. Exp. Med. 159:1149.
54. Haynes, B. F., M. J. Telen, T. J. Palker, E. Harden, and R. M. Scearce. 1984. Monoclonal antibody defines human cell surface protein p80 on intrathymic T cells. J. Immunol. 132:2678 (Letter)
55. Patel, D. D., L. P. Whichard, G. Radcliff, S. M. Denning, and B. F. Haynes. 1995. Characterization of human thymic epithelial cell surface antigens: phenotypic similarity of thymic epithelial cells to epidermal keratinocytes. J. Clin. Immunol. 15:80.
56. Patel, D. D., L. Hale, and B. F. Haynes. 1996. HIV in lymph node and thymus. In Immunology of HIV Infection. S. Gupta, ed. Plenum Publishing Corp., New York, pp. 95-121.
57. Stockinger, B., and B. Hausmann. 1994. Functional recognition of m vivo self antigen. Int. Immunol. 6:247.
58. Inaba, M., K. Inaba, M. Hosono, T. Kumamoto, T. Ishida, S. Muramatsu, T. Masuda, and S. Ikehara. 1991. Distinct mechanisms of neonatal tolerance induced by dendritic cells and thymic B cells. J. Exp. Med. 173:549.
59. + dendritic cells. Proc. Natl. Acad. Sci. USA 93: 2588.
60. Morse, M., L. Zhou, T. Tedder, H. Lyerly, and C. Smith. 1997. Generation of dendritic cells in vitro from peripheral blood mononuclear cells with GM-CSF, IL-4, and TNF-α. Ann. Surg. 226:6.
61. + compartment of adult bone marrow. Blood 85:2770.
62. Galy, A., M. Travis, D. Cen, and B. Chen. 1995. Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset. Immunity 3:459.
63. + hematopoietic progenitor cells of the bone marrow and peripheral blood. Cancer Res. 55:1099.
64. + hemopoietic progenitors. J. Immunol. 157:1499.
65. Schluns, K., P. Grutkoski, J. Cook, G. Engelmann, and P. T. Le. 1995. Human thymic epithelial cells produce TGF-beta 3 and express TGF-beta receptors. Int. Immunol. 7:1681.
66. + cells in vitro. Nature Med. 2:46.
67. + progenitor cells. Blood 87:4040.