Mechanisms Involved in the Binding of Thymocytes to Rat Thymic Dendritic Cells

Developmental Immunology

Volumn 5, Issue 1, 1996, Pages 37-51

  Čolić, Miodrag ^a   Ilić, Vesna ^a   Pavlović, Miloš D ^a   Tamatani, Takuya ^a   Miyasaka, Masayuki ^b  

^a UNIVERSITY OF DEFENCE   (Serbia)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

adhesion molecules; rosettes; signaling; Thymic dendritic cells; thymocytes

Indexed keywords

CALCIUM ION; CD4 ANTIGEN; CD8 ANTIGEN; CELL SURFACE PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIVALENT CATION; MAGNESIUM ION; MONOCLONAL ANTIBODY; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN KINASE C; PROTEIN TYROSINE PHOSPHATASE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL ADHESION; CONTROLLED STUDY; CYTOSKELETON; DENDRITIC CELL; FEMALE; FLOW CYTOMETRY; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; ROSETTE FORMATION; THYMOCYTE;

ANIMALS; CATIONS, DIVALENT; CELL ADHESION; FLOW CYTOMETRY; PHENOTYPE; RATS; ROSETTE FORMATION; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0029813642     PISSN: 10446672     EISSN: None     Source Type: Journal    
DOI: 10.1155/1996/18312     Document Type: Article

References (44)

1. Adkins B., Mueller C., Okada C., Reichert R., Weissmann I., and Spahgrude G. (1986). Early events in T-cell maturation. Annu. Rev. Immunol. 5: 325–365.
2. Barclay A.N., and Mayrhofer G. (1981). Bone-marrow origin of Ia positive cells in the medulla of rat thymus. J. Exp. Med. 153: 1666–1671.
3. Bernard G., Zoccola D., Ticchioni M., Breitmayer J.-P, Aussel C., and Bernard A. (1994). Engagement of the CD45 molecule induces homotypic adhesion of human thymocytes through LFA-1/ICAM-3 dependent pathway. J. Immunol. 152: 5161–5170.
4. Carlow D.A., van Oers N.S., Teh S.J., and Teh H.S. (1992). Deletion of antigen specific thymocytes by dendritic cells requires LFA-1/ICAM-1 interactions. J. Immunol. 148: 1595–603.
5. Caux C., Vanbervliet B., Massacrier C., Azuma M., Okumura K., Lanier L.L., and Bancherau J. (1994). B70/B7–2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells. J. Exp. Med. 180: 1841–1847.
6. Čolić M., Gašić S., Stojanović N., Popović Lj., and Dujić A. (1992). Phenotypic and ultrastructural characterization of an epithelial cell line established from rat thymic cultures. Immunol. 77: 201–207.
7. Čolić M., Ilić V., Tamatani T., Miyasaki M., and Pavlović M.D. (1994). Role of ß2 integrins in the binding of thymocytes to rat thymic macrophages. Dev. Immunol. 4: 65–77.
8. Damoiseaux J.G.M.C., Dopp E.A., Neefjes J.J., Beelen R.H.J., and Dijkstra C.D. (1989). Heterogeneity of macrophages in rat evidenced by variability in determinants. Two new anti-rat macrophage antibodies against a heterodimer of 160 and 95 kd (CD11/CD18). J. Leuko. Biol. 46: 556–564.
9. Damoiseaux J.G.M.C. (1991). Macrophage heterogeneity in the rat. Doctoral thesis, Free University, Amsterdam, pp. 107–121.
10. Duijvestijn A.M., Sminia T., Kohler Y.G., Janse E.M., and Hoefsmit E.C.M. (1984). Ontogeny of the rat thymus microenvironment: Development of the interdigitating cells and macrophage populations. Dev. Comp. Immunol. 8: 451–460.
11. Dustin M.L., and Springer T.A. (1989). T cell receptor crosslinking transiently stilmulates adhesiveness through LFA-1. Nature 341: 619–624.
12. Fine J.S., and Kruisbeek A.M. (1991). The role of LFA-1/ICAM-1 interactions during murine T lymphocyte development. J. Immunol. 147: 2852–2859.
13. Fawcett J., Holness C.L., Needham L.A., Turley., Gatter K.C., Mason D.Y., and Simmons D.L. (1992). Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting lymphocytes. Nature 360: 481–484.
14. Hamblin A.S., and Edgeworth J.D. (1988). Does antigen presentation occur in the thymus. In: Thymus update 1. The microenvironment of the human thymus, Kendall M.D., and Ritter, M.A., Eds. (London: Harwood Academic Publishers), pp. 135–153.
15. Hunig T., Wallny H.-J., Hartley J.K., Lawetzky A., and Tiefenthaler A. (1989). A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. Differential reactivity with subset of immature and mature T lymphocytes. J. Exp. Med. 169: 73–86.
16. Ilić V., Čolić M., and Kosec D. (In press). Isolation, cultivation and phenotypic characterization of rat thymic dendritic cells. Thymus.
17. Inaba K., Romani N., Steinman R. (1989). An antigen independent contact mechanism as an early step in T cell-proliferative responses to dendritic cells. J. Exp. Med. 170: 527–542.
18. Inaba K., Witmer-Pack M., Inaba M., Hathcock K.S., Sakuta H., Azuma M., Yagita H., Okumura K., Linsley P.S., Ikehara S., Maramatsu S., Hodes R.J., and Steinman R.M. (1994). The tissue distribution of B7–2 costimulator in mice: Abundant Expression on dendritic cells in situ and during maturation in vitro. J. Exp. Med. 180: 1849–1860.
19. Janossy G., Tidman N., and Selby W.S. (1980). Human T lymphocytes of inducer and suppressor type occupy different microenvironments. Nature 288: 81–84.
20. Kampinga J., and Aspinall R. (1990). Thymocyte differentiation and thymic micro-environment development in the fetal rat thymus: An immunohistological approach. In: Thymus update 3. The role of the thymus in tolerance induction, Kendall, M.D., and Ritter, M. A. Eds. (London: Harwood Academic Publisher), pp. 149–186.
21. Kansas G.S., and Tedder T.F. (1991). Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway. J. Immunol. 147: 4094–4102.
22. Killen N., Moessner R., Arvieux J., Willis A., and Williams A.F. (1988). The MRC OX-45 antigen of rat leukocytes and endothelium is in a subset of the immunoglobulin superfamily with CD2, LFA-3 and carcinoembrionic antigens. EMBO J. 10: 3087–3091.
23. King P.D., and Katz D.R. (1989). Human tonsillar dendritic cell-induced T cell responses: analysis of molecular mechanisms using monoclonal antibodies. Eur. J. Immunol. 19: 581–587.
24. King P.D., Batchelor A.H., Lawlor P., and Katz D.R. (1990). The role of CD44, CD45, CD45RO, CD46 and CD55 as potential anti-adhesion molecules involved in the binding of human tonsillar T cells to phorbol 12-myristate 13-acetate-differentiated U-937 cells. Eur. J. Immunol. 20: 363–368.
25. Kyewski B.A., Rouse R.V., and Kaplan H.S. (1982). Thymocytes rosettes: Multicellular complex of lymphocytes and bone marrow-derived stromal cells in the murine thymus. Proc. Natl. Acad. Sci. USA 79: 5646–5650.
26. Kyewski B.A., Fathman C.G., and Rouse R.V. (1986). Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells. J. Exp. Med. 163: 231–246.
27. Kyewski B. (1988). Unraveling the complexity of intrathymic cellcell interaction. APMIS 96: 1049–1060.
28. Landry D., Doyon L., Poudrier J., Lanfontaine M., Pelletier M., and Montplaisir S. (1990). Accessory function of human thymic dendritic cells in Con A-induced proliferation of autologous thymocyte subset. J. Immunol. 144: 836–843.
29. + thymocyte subset trough an LFA-1 dependent adhesion-deadhesion mechanism. Int. Immunol. 2: 1021–1032.
30. Lorenz H.M., Harrer T., Lagoo A.S., Baur A., Eger G., and Kalden J.R. (1993). CD45 mAb induces cell adhesion in peripheral blood mononuclear cells via lymphocyte function-associated antigen-1 (LFA-1) and intercellular cell adhesion molecule 1 (ICAM-1). Cell Immunol. 147: 110–128.
31. Patarroyo M., Prieto J., Rincon J., Timonen T., Lundberg C., Lindbom L., Asjo B., and Gahmberg C. (1990). Leukcocyte-cell adhesion: A molecular process fundamental in leukocyte physiology. Jmmunol. Rev. 114: 67–108.
32. Pavlović M., Čolić M., Pejnović N., Tamatani T., Miyasaka M., and DujiČ A. (1994). A novel anti-rat CD18 mAb triggers lymphocyte homotypic aggregation and granulocyte adhesion to plastic: Different intracellular signaling pathways in resting versus activated thymocytes. Eur. J. Immunol. 24: 1640–1648.
33. + thymocytes in vitro does not require dedicated antigen-presenting cells. Eur. J. Immunol. 23: 669–674.
34. Prickett T.C., and Hart D.N. (1990). Anti-leukocyte common (CD45) antibodies inhibit dendritic cell stimulation of CD4 and CD8 T-lymphocyte proliferation. Immunology 69: 250–256.
35. Ramsdell F., and Fowlkes B.J. (1990). Clonal deletion verus clonal anergy: The role of the thymus in inducing self tolerance. Science 248: 1342–1348.
36. Shortman K., and Vremec D. (1991). Different subpopulations of developing thymocytes are associated with adherent (macrophage) and nonadherent (dendritic) thymic rosettes. Dev. Immunol. 1: 225–235.
37. Scheeren R.A., Koopman G., Van der Baan S., Meijer C.J.L.M. and Pals S.T. (1991). Adhesion receptors involved in clustering of blood dendritic cells and T lymphocytes. Eur. J. Immunol. 21: 1101–1105.
38. Springer T.A. (1990). Adhesion receptor of the immune system. Nature 346: 425–434.
39. Staunton D.E., Dustin M.L., and Springer T.A. (1989). Functional cloning of ICAM-2, cell adhesion ligand for LFA-1 homologous to ICAM-1. Nature 339: 61–64.
40. Tamatani T., and Miyasaka M. (1990). Identification of monoclonal antibodies reactive with the rat homologue of ICAM-1, and evidence for a differential involvement of ICAM-1 in the adherence of resting versus activated lymphocytes to high endothelial cells. Int. Immunol. 2: 165–171.
41. Tamatani T., Kotani M., and Miyasaka M. (1991a). Characterization of rat leukocyte intergrin, CD11/CD18, by the use of LFA-1 subunit-specific monoclonal antibodies. Eur. J. Immunol. 21: 627–633.
42. Tamatani T., Kotani M., Tanaka T., and Miyasaka M. (1991b). Molecular mechanisms underlying lymphocyte recirculation. II. Differential regulation in the interaction between lymphocytes and high endothelial cells. Eur. J. Immunol. 21: 855–858.
43. Van Kooyk Y., Van de Wiel-van Kemende P., Weder P., Kuijpers T.W., and Figdor C.D. (1989). Enhancement of LFA-1 mediated cell adhesion by triggering through CD2 and CD3 on T lymphocytes. Nature 324: 811–813.
44. Xu H., Friedrichs U., Gieseler R.K., Ruppert J., Ocklind G., and Prters J.H. (1992). Human blood dendritic cells exhibit a distinct T-cell-stimulating mechanism and differentiation pattern. Scand. J. Immunol. 36: 689–696.