-245 bp of 5'-flanking region from the human platelet factor 4 gene is sufficient to drive megakaryocyte-specific expression in vivo

Blood

Volumn 91, Issue 7, 1998, Pages 2326-2333

  Cui, Zheng ^b   Reilly, Michael P ^b   Surrey, Saul ^b   Schwartz, Elias ^b   McKenzie, Steven E ^a  

^a NEMOURS ALFRED I DUPONT HOSPITAL FOR CHILDREN   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; MESSENGER RNA; THROMBOCYTE FACTOR 4;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; GENE EXPRESSION; GENE STRUCTURE; GENE TARGETING; IMMUNOHISTOCHEMISTRY; MEGAKARYOCYTE; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

EID: 0032055179     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.7.2326.2326_2326_2333     Document Type: Article

References (44)

1. Doi T, Greenberg SM, Rosenberg RD: Structure of rat platelet factor 4 gene: A marker for megakaryocyte differentiation. Mol Cell Biol 7:898, 1987
2. Zucker MB, Katz J: Platelet factor 4: Production, structure, and physiologic and immunologic action. Exp Biol Med 198:693, 1991
3. Conley CL, Hartman RC, Lalley JS: The relationship of heparin activity to platelet concentration. Proc Soc Exp Biol Med 69:248, 1948
4. Broekman MJ, Handin RI, Cohen P: Distribution of fibrinogen and platelet factor 4 and XII in subcellular fractions of human platelet. Br J Haematol 31:51, 1975
5. Kaplan KL, Broekman MJ, Chernoff A, Lesznik GR, Drillings M: Platelet α-granule proteins: Studies on release and subcellular localization. Blood 53:604, 1979
6. Ryo R, Nakeff A, Huang SS, Ginsberg M, Deuel TF: New synthesis of a platelet-specific protein: Platelet factor 4 synthesis in a megakaryocyte-rabbit bone marrow culture system. J Cell Biol 96:515, 1983
7. Walz DA, Hung G-L: In vivo studies on the binding of heparin and its fraction with platelet factor 4. Thromb Haemost 11:40, 1985
8. Senior RM, Griffin GL, Huang JS, Walz DA, Deuel TF: Chemotactic activity of platelet Alpha granule proteins for fibroblasts. J Cell Biol 96:382, 1983
9. Bebawy ST, Gorka J, Hyers TM, Webster RO: In vitro effects of platelet factor 4 normal human neutrophil functions. J Leukoc Biol 39:434, 1986
10. Ravid K, Doi T, Beeler DL, Kuter D, Rosenberg RD: Transcriptional regulation of the rat platelet factor 4 gene: Interaction between an enhancer/silencer domain and the GATA site. Mol Cell Biol 11:6116, 1991
11. Ravid K, Beeler DL, Rabin MS, Ruley HE, Rosenberg RD: Selective targeting of gene products with the megakaryocyte platelet factor 4 promoter. Proc Natl Acad Sci 88:1521, 1991
12. Robinson MO, Zhou W, Hokom M, Danilenki DM, Hsu RY, Atherton RE, Xu W, Mu S, Saris CJ, Swift S, Elliot G, Castillo JD, Hunt P, Bosselman RA: The tsA58 simian virus 40 large tumor antigen disrupts megakaryocyte differentiation in transgenic mice. Proc Natl Acad Sci 95:12798, 1994
13. Guy CT, Zhou W, Kaufman S, Robinson MO: E2F-1 blocks terminal differentiation and causes proliferation in transgenic megakaryocytes. Mol Cell Biol 16:685, 1996
14. Thompson A, Zhang Y, Kamen D, Jackson CW, Cardiff RD, Ravid K: Deregulated expression of c-myc in megakaryocytes of transgenic mice increases megakaryopoiesis and decreases polyploidization. J Biol Chem 271:22976, 1996
15. Ravid K, Li YC, Rayburn HB, Rosenberg RD: Targeted expression of a conditional oncogene in hematopoietic cells of transgenic mice. J Cell Biol 123:1545, 1993
16. Ramachandran B, Surrey S, Schwartz E: Megakaryocyte-specific positive regulatory sequence 5′ to the human PF4 gene. Exp Hematol 23:49, 1995
17. Papayannopoulou T, Nakamoto B, Yokochi T, Chait A, Kannagi R: Human erythroleukemia cell line (HEL) undergoes a drastic macrophage-like shift with TPA. Blood 62:832, 1983
18. Papayannopoulou T, Nakamoto B, Kurachi S, Tweeddale M, Messner H: Surface antigenic profile and globin phenotype of two new human erythroleukemia lines: Characterization and interpretations. Blood 72:1029, 1988
19. Eisman R, Surrey S, Ramachandran B, Schwartz E, Poncz M: Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. Blood 76:336, 1990
20. Drews R, Drohan WN, Lubon H: Transgene detection in mouse tail digests. Biotechniques 17:866, 1994
21. Alonso S, Minty A, Bourlet Y, Buckingham M: Comparison of three actin-coding sequence in the mouse; Evolutionary relationship between the actin genes of warm-blooded vertebrates. J Mol Evol 23:11, 1986
22. Burstein SA, Friese P, Downs T, Mei R: Characteristics of a novel rat anti-mouse platelet monoclonal antibody: Application to studies of megakaryocytes. Exp Hematol 20:1170, 1992
23. Martin DIK, Zon L, Mutter G, Orkin SH: Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages. Nature 344:444, 1990
24. Romeo P-H, Prandini M-H, Joulin V, Mignotte V, Prenant M, Vainchenker W, Marguerie G, Uzan G: Megakaryocytic and erythrocytic lineages share specific transcription factor. Nature 344:447, 1990
25. Weiss MJ, Orkin SH: GATA transcription factors: Key regulators of hematopoiesis. Exp Hematol 23:99, 1995
26. Martin F, Prandini M-H, Thevenon D, Marguerie G, Uzan G: The transcription factor GATA-1 regulates the promoter activity of the platelet glycoprotein IIb gene. J Biol Chem 268: 21606, 1993
27. Aird WC, Parvin JD, Rosenberg RD: The interaction of GATA-binding proteins and basal transcription factors with GATA box-containing core promoters. J Biol Chem 269:883, 1994
28. Uzan G, Prenant M, Prandini M-H, Martin F, Marguerie G: Tissue-specific expression of the platelet GPIIb gene. J Biol Chem 266:8932, 1991
29. Prandini M-H, Uzan G, Martin F, Thevenon D, Marguerie G: Characterization of a specific erythromegakaryocytic enhancer within the glycoprotein lib promoter. J Biol Chem 267:10370, 1992
30. Block KL, Ravid K, Phung QH, Poncz M: Characterization of regulatory elements in the 5′-flanking region of the rat GPIIb gene by studies in a primary rat marrow culture system. Blood 84:3385, 1994
31. Ware J, Russell SR, Marchese P, Ruggeri ZM: Expression of human platelet glycoprotein Iba in transgenic mice. J Biol Chem 268:8376, 1993
32. Ludlow LB, Schick BP, Budarf ML, Driscoll DA, Zackai EH, Cohen A, Konkle BA: Identification of a mutation in a GATA binding site of the platelet glycoprotein Ibβ promoter resulting in the Bernard-Soulier syndrome. J Biol Chem 271:22076, 1996
33. Kiss C, Surrey S, Schreiber AD, Schwartz E, McKenzie SE: Human c-kit ligand induces platelet Fc receptor expression in megakaryoblastic cells. Exp Hematol 24:1004, 1996
34. Gumina RJ, Kirschbaum NE, Piotrowski K, Newman PJ: Characterization of the human platelet/endothelial cell adhesion molecule-1 promoter: Identification of a GATA-2 binding element required for optimal transcriptional activity. Blood 89:1260, 1997
35. Tronik-LeRoux D, Roullot V, Schweitzer A, Berthier R, Marguerie G: Suppression of erythro-megakaryocytopoiesis and the induction of reversible thrombocytopenia in mice transgenic for the thymidine kinase gene targeted by the platelet glycoprotein αIIb promoter. J Exp Med 181:2141, 1995
36. Kitaguchi T, Murata M, Kuramochi T, Kobayashi K, Ito M, Ueyama Y, Nomura T, Hikichi K, Miyakawa Y, Handa M, Hiraoka Y, Aiso S, Ikeda Y: Establishment and characterization of transgenic mice expressing human glycoprotein Iba. Biochem Biophys Res Commun 218:418, 1996
37. McKenzie SE, Cui Z, Taylor S, Malladi P, Yuhan H, Chien C, Surrey S, Schwartz E: Models of human platelet gene expression in vivo. Blood 88:26a, 1996 (abstr)
38. Felsenfeld G: Chromatin as an essential part of the transcriptional mechanism. Nature 355:219, 1992
39. Dillon N, Grosveld F: Transcriptional regulation of multigene loci: Multilevel control. Trends Genet 9:134, 1993
40. Adachi M, Ryo R, Sato T, Yamaguchi N: Platelet factor 4 gene expression in a human megakaryocytic leukemia cell line (CMK) and its differentiated subclone (CMK11-5). Exp Hematol 19:923, 1991
41. Ogura M, Morishima Y, Okumura M, Hotta T, Takamoto S, Ohno R, Hirabayashi N, Nagura H, Saito H: Functional and morphological differentiation induction of human megakaryoblastic leukemia cell line (MEG-01s) by phorbol diesters. Blood 72:49, 1988
42. Komatsu N, Suda T, Moroi M, Tokuyama N, Sakata Y, Okada M, Nishida T, Hirai Y, Sato T, Fuse A, Miura Y: Growth and differentiation of a human megakaryoblastic cell line, CMK. Blood 74:42, 1989
43. Shimohama S, Rosenberg MB, Fagan AM, Wolff JA, Short MP, Breakefield XO, Firedmann T, Gage FH: Grafting genetically modified cells into the rat brain: Characteristics of E. coli beta-galactosidase as a reporter gene. Mol Brain Res 5:271, 1989
44. Couffinhal T, Kearney M, Sullivan A, Silver M, Tsurumi Y, Isner JM: Histochemical staining following LacZ gene transfer underestimates transfection efficiency. Human Gene Ther 8:929, 1997