A relevant dose of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is extensively metabolized and rapidly absorbed in the canine tracheal mucosa

Cancer Research

Volumn 58, Issue 7, 1998, Pages 1417-1422

  Gerde, Per ^a,b,c   Muggenburg, Bruce A ^a   Stephens, Tony ^a   Lewis, Johnnye L ^a,d   Pyon, Kee H ^a,e   Dahl, Alan R ^a  

^a LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c NATIONAL INSTITUTE FOR WORKING LIFE   (Sweden)

^d UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^e RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; TOBACCO SMOKE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENIC ACTIVITY; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DOG; LUNG CANCER; LUNG CARCINOGENESIS; NONHUMAN; PRIORITY JOURNAL; SMOKING; TOXICOKINETICS; TRACHEA MUCOSA;

ABSORPTION; ADMINISTRATION, INHALATION; ANIMALS; BIOTRANSFORMATION; CARCINOGENS; DOGS; EPITHELIUM; FEMALE; LUNG NEOPLASMS; MUCOUS MEMBRANE; NITROSAMINES; TRACHEA;

EID: 0032054312     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Wynder, E. L., and Graham, E. A. Tobacco smoking as a possible etiologic factor in bronchiogenic carcinoma. J. Am. Med. Assoc., 143: 329-336, 1950.
2. Doll, R., and Peto, R. Cigarette smoking and bronchial carcinomas: dose and time relationships among regular smokers and lifelong non-smokers. J. Epidemiol. Community Health, 32: 303-313, 1978.
3. Steinfeld, J. L. Smoking and lung cancer: a milestone in awareness. J. Am. Med. Assoc., 253: 2992-2997, 1985.
4. Wynder, E. L., and Hoffmann, D. Smoking and lung cancer: scientific challenges and opportunities. Cancer Res., 54: 5284-5295, 1994.
5. Hoffmann, D., and Hoffmann, I. The changing cigarette, 1950-1995. J. Toxicol. Environ. Health, 50: 307-364, 1997.
6. Gerde, P., Muggenburg, B. A., Thornton-Manning, J. R., Lewis, J. L., Pyon, K. H., and Dahl, A. R. Benzo(a)pyrene at an environmentally relevant dose is slowly absorbed by, and extensively metabolized in, tracheal epithelium. Carcinogenesis (Lond.), 18: 1825-1832, 1997.
7. Gerde, P., Muggenburg, B. A., Scott, G. G., Lewis, J. L., Pyon, K. H., and Dahl, A. R. Local metabolism in lung airways increases the uncertainty of pyrene as a biomarker of polycyclic aromatic hydrocarbon exposure. Carcinogenesis (Lond.), in press, 1998.
8. Gerde, P., Stephens, T., and Dahl, A. R. A rapid combustion method for the accurate determination of low levels of tritium in biological samples. Toxicol. Methods, in press, 1998.
9. Scott, G. G., Stephens, J. A., Rohrbacher, K. D., Thornton-Manning, J. R., Gerde, P., and Dahl, A. R. HPLC determination of tritiated polycyclic aromatic hydrocarbon metabolites in the sub-femtomole range. Toxicol. Methods, in press, 1998.
10. Auerbach, O., Cuyler Hammond, E., Kirman, D., and Garfield, L. Effects of cigarette smoking in dogs. II. Pulmonary neoplasms. Arch. Environ. Health, 21: 754-768, 1970.
11. Hoover, M. D., Harkema, J. R., Muggenburg. B. A., Spoo, J. W., Gerde, P., Staller, H. J., and Hotchkiss, J. A. A microspray nozzle for local administration of liquids or suspensions to lung airways via bronchoscopy. J. Aerosol Med., 6: 67-72, 1993.
12. Brunnemann, K. D., Prokopczyk, B., Djordjevic, M. V., and Hoffmann, D. Formation and analysis of tobacco-specific N-nitrosamines. Crit. Rev. Toxicol., 26: 121-137, 1996.
13. Hinds, W., First, M. W., Huber, G. L., and Shea, J. W. A method for measuring respiratory deposition of cigarette smoke during smoking. Am. Ind. Hyg. Assoc. J., 44: 113-118, 1983.
14. Weibel, E. R. Morphometry of the Human Lung, pp. 25-163. Berlin: Springer-Verlag, 1963.
15. Gerde, P., and Scholander, P. A mathematical model of the penetration of polycyclic aromatic hydrocarbons through the bronchial lining layer. Environ. Res., 44: 321-334, 1987.
16. Idris, A. M., Nair, J., Friesen, M., Ohsima, H., Brouet, I., Faustman, E. M., and Bartsch, H. Carcinogenic tobacco-specific nitrosamines are present at unusually high levels in the saliva of oral snuff users in Sudan. Carcinogenesis (Lond.), 13: 1001-1005, 1992.
17. Plopper, C. G., Mariassy, A. T., and Lollini, L. O. Structure as revealed by airway dissection. A comparison of mammalian lungs. Am. Rev. Respir. Dis., 128 (Suppl.): S4-S7, 1983.
18. Cuddihy, R. G., Hall, R. P., Hobbs, C. H., Boecker, B. B., and Muggenburg, B. A. Tissue blood volumes and weights in adult beagle dogs. Staff of the Fission Product Inhalation Program. Fission Product Inhalation Program Annual Report, pp. 119-128. Albuquerque, NM: Lovelace Foundation for Medical Education and Research, 1972.
19. Staretz, M. E., Foiles, P. G., Miglietta, L. M., and Hecht, S. S. Evidence for an important role of DNA pyridyloxobutylation in the rat lung carcinogenesis by 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone: effects of dose and phenethyl isothiocyanate. Cancer Res., 57: 259-266, 1997.
20. Hecht, S. S., Spratt, T. E., and Thrushin, N. Evidence for 4-(3-pyridyl)-4-oxobutylation of DNA in F344 rats treated with the tobacco-specific nitrosamines 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone and N′-nitrosonornicotine. Carcinogenesis (Lond.), 9: 161-165, 1988.
21. Adams, J. D., La Voie, E. J., and Hoffmann, D. On the pharmacokinetics of tobacco-specific N-nitrosamines in Fisher rats. Carcinogenesis (Lond.), 6: 509-511, 1985.
22. Hecht, S. S., Trushin, N., Reid-Quinn, C. A., Burak, E. S., Butler Jones, A., Southers, J. L., Gombar, C. T., Carmella, S. G., Anderson, L. M., and Rice, J. M. Metabolism of the tobacco-specific nitrosamine 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone in the patas monkey: pharmacokinetics and characterization of glucoronide metabolites. Carcinogenesis (Lond.), 14: 229-236, 1993.
23. Gupta, P. C., Murti, P. R., and Bhonsle, R. B. Epidemiology of cancer by tobacco products and the significance of TSNA. Crit. Rev. Toxicol., 26: 183-198, 1996.
24. Idris, A. M., Ahmed, H. M., Mukhtar, B. I., Gadir, A. F., and El-Beshir, E. I. Descriptive epidemiology of oral neoplasms in Sudan 1970-1985 and the role of toombak. Int. J. Cancer, 61: 155-158, 1995.
25. Kresty, L., Carmella, S., Borukhova, A., Akerkar, S., Gopalakrishnan, R., Harris, R., Stoner, G., and Hecht, S. Metabolites of a tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), in the urine of smokeless tobacco users: relationship between urinary biomarkers and oral leukoplakia. Cancer Epidemiol. Biomark. Prev., 5: 521-525, 1996.
26. Dahl, A. R., and Lewis, J. L. Respiratory tract uptake of inhalants and metabolism of xenobiotics. Annu. Rev. Pharmacol. Toxicol., 32: 383-407, 1993.
27. Tjälve, H., and Castonguay, A. The in vivo tissue disposition and in vitro target-tissue metabolism of the tobacco-specific carcinogen 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone in Syrian golden hamsters. Carcinogenesis (Lond.), 4: 1259-1265, 1983.
28. Ramphal, R., Lhermitte, M., Filliat, M., and Roussel, P. The binding of antipseudomonal antibiotics to macromolecules from cystic fibrosis sputum. J. Antimicrob. Chemother., 22: 483-490, 1988.
29. Auerbach, O., and Garfinkel, L. The changing pattern of lung carcinoma. Cancer, 68: 1973-1977, 1991.
30. Wynder, E. L., and Muscat, J. E. The changing epidemiology of smoking and lung cancer histology. Environ. Health Perspect., 103 (Suppl. 8): 143-148, 1995.
31. Hecht, S. S., Morse, M. A., Amin, S., Stoner, G. D., Jordan, K. G., Choi, C-I., and Chung, F-L. Rapid single-dose model for lung tumor induction in A/J mice by 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone and the effect of diet. Carcinogenesis (Lond.), 10: 1901-1904, 1989.
32. Hoffmann, D., Rivenson, A., Amin, S., and Hecht, S. S. Dose-response study of the carcinogenicity of tobacco-specific N-nitrosamines in F344 rats. J. Cancer Res. Clin. Oncol., 108: 81-86, 1984.
33. 6-methylguanine formation in Clara cells and induction of pulmonary neoplasia in the rat by 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res., 50: 3772-3780, 1990.
34. Hoffmann, D., Rivenson, A., Murphy, S. E., Chung, F-L., Amin, S., and Hecht, S. S. Cigarette smoking and adenocarcinoma of the lung: the relevance of nicotine-derived N-nitrosamines. J. Smoking-Related Dis., 4: 165-189, 1993.
35. Nakanishi, K. Alveolar epithelial hyperplasia and adenocarcinoma of the lung. Arch. Pathol. Lab. Med., 114: 363-368, 1990.
36. Yang, C. P., Gallagher, R. P., Weiss, N. S., Band, P. R., Thomas, D. B., and Russell, D. A. Differences in incidence rates of cancers of the respiratory tract by anatomical subsite and histological type: an etiologic implication. J. Natl. Cancer Inst., 81: 1828-1831, 1989.